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1. 发明授权

US06942777B2 Sample analysis system with chip-based electrophoresis device 失效
标题翻译：带芯片电泳装置的样品分析系统
公开(公告)号：US06942777B2
公开(公告)日：2005-09-13
申请号：US09880801
申请日：2001-06-15
申请人： Shu-Hui Chen , Gwo-Bin Lee , Chung-Shi Yang , Yi-Hung Lin , Wan-Chou Sung , Guan-Ruey Huang
发明人： Shu-Hui Chen , Gwo-Bin Lee , Chung-Shi Yang , Yi-Hung Lin , Wan-Chou Sung , Guan-Ruey Huang
IPC分类号： G01N27/447 , C25B11/00 , G01N27/453
CPC分类号： G01N27/44743 , G01N27/44721 , G01N27/44791
摘要： The present invention relates to a sample analysis system with chip-based electrophoresis device, particularly, the chip electrophoresis is connected to the dynamic flow-based auto-sampling device to introduce the sample into the chip-based electrophoresis device. By utilizing the derivatization biochemistry method to have a surface modification on the sample loading channel, it prevents the sample from being adhered to the wall of the sample loading channel, and hence increases the sample loading rate, reduces cross-contamination of samples and performs specific bio-reaction by using the immobilization of matter including antigen, antibody, protein, or enzyme. This invention makes use of the continuous split flow and electric voltage control to work with the detecting unit, signal collecting unit, and signal processing unit so that the sample undergoes a timely, fast, continuous analysis without having interference from the sample of other time.
摘要翻译：本发明涉及一种具有基于芯片的电泳装置的样品分析系统，特别地，芯片电泳连接到基于动态流量的自动采样装置，以将样品引入基于芯片的电泳装置。通过利用衍生生物化学方法在样品加载通道上进行表面改性，可以防止样品粘附到样品加载通道的壁上，从而增加样品加载速率，减少样品的交叉污染，并执行特定的通过使用固定化物质（包括抗原，抗体，蛋白质或酶）进行生物反应。本发明利用连续分流和电压控制与检测单元，信号采集单元和信号处理单元一起工作，使得样品经过及时，快速，连续的分析，而不会受到其他时间样品的干扰。

2. 发明授权

US07387765B2 Microfluidic chip system integrated with nano-electrospray interface and method using thereof 有权
标题翻译：集成纳米电喷雾界面的微流控芯片系统及其使用方法
公开(公告)号：US07387765B2
公开(公告)日：2008-06-17
申请号：US10822650
申请日：2004-04-13
申请人： Shu-Hui Chen , Wang-Chou Sung , Pao-Chi Liao , Gwo-Bin Lee
发明人： Shu-Hui Chen , Wang-Chou Sung , Pao-Chi Liao , Gwo-Bin Lee
IPC分类号： B01L3/02 , G01N1/10
CPC分类号： H01J49/04 , G01N27/44717 , Y10T436/24 , Y10T436/2575
摘要： The present invention provides an integrated microfluidic electrospray chip system and analytical method thereof, characterized in which the proteinase reaction, solid-phase extraction mechanism, electrophoresis and mass spectrometry are integrated into one system. This system allows continuous, fast and on-line detection and identification of a sample, where the sample is firstly hydrolyzed and desalted, and then introduced into the microfluidic electrospray chip to undergo electrophoresis. Finally, the separated sample is introduced into a mass spectrometer by means of electrospray for continuous detection and identification. This system applies mainly in the identification of biochemical substances, such as proteins.
摘要翻译：本发明提供了一种集成微流体电喷雾芯片系统及其分析方法，其特征在于将蛋白酶反应，固相萃取机理，电泳和质谱法整合到一个体系中。该系统允许连续，快速和在线检测和鉴定样品，样品首先水解和脱盐，然后引入微流控电喷雾芯片进行电泳。最后，通过电喷雾将分离的样品引入质谱仪进行连续检测和鉴定。该系统主要适用于生物化学物质如蛋白质的鉴定。

3. 发明授权

US08350243B2 Optically induced dielectrophoresis chip for control and analysis of bio-molecules 有权
标题翻译：光学诱导介电电泳芯片，用于生物分子的控制和分析
公开(公告)号：US08350243B2
公开(公告)日：2013-01-08
申请号：US12461899
申请日：2009-08-27
申请人： Gwo-Bin Lee , Tzung-Fang Guo , Wei Wang , Yen-Heng Lin
发明人： Gwo-Bin Lee , Tzung-Fang Guo , Wei Wang , Yen-Heng Lin
IPC分类号： G01N21/86 , G01V8/00
CPC分类号： G01N27/447 , B03C5/005 , B03C5/026
摘要： An optically-induced dielectrophoresis chip including a substrate, a first electrode layer disposed on the substrate, and an interface modification layer disposed on the first electrode layer. A photo-conductive layer is disposed on the interface modification layer and includes an optical absorbent polymeric material. A barrier layer is disposed on the photo-conductive layer, and a compartment forming layer is disposed on the barrier layer defining a compartment. A second electrode layer covers the compartment forming layer.
摘要翻译：一种光诱导介电电泳芯片，其包括基板，设置在基板上的第一电极层和设置在第一电极层上的界面改性层。光导电层设置在界面改性层上并且包括光学吸收聚合材料。阻挡层设置在光导层上，隔层形成层设置在限定隔间的势垒层上。第二电极层覆盖隔室形成层。

4. 发明授权

US08277110B2 Micromixer biochip 有权
标题翻译： Micromixer生物芯片
公开(公告)号：US08277110B2
公开(公告)日：2012-10-02
申请号：US12588194
申请日：2009-10-07
申请人： Gwo-Bin Lee , Sung-Yi Yang
发明人： Gwo-Bin Lee , Sung-Yi Yang
IPC分类号： B01F5/02
CPC分类号： B01F5/0068 , B01F11/0071 , B01F13/0059
摘要： The present invention provides a micromixer biochip, comprising: a substrate having a surface; a fluidic channel layer disposed above the surface of the substrate, including a mixing chamber and a single-opening fluidic channel, wherein one end of the single-opening fluidic channel is closed and the other end of the single-opening fluidic channel connects to the mixing chamber, and a top portion of the single-opening fluidic channel is made of a flexible material; and an air chamber layer disposed above the top portion of the fluidic channel layer, including an air pore, at least one chamber, and an air channel connecting the chamber and the air pore, wherein the number and position of the air chamber correspond to the number and position of the single-opening fluidic channel of the fluidic channel layer.
摘要翻译：本发明提供一种微混合器生物芯片，包括：具有表面的基底; 设置在所述基板的表面上方的流体通道层，包括混合室和单开口流体通道，所述单开口流体通道的一端封闭，并且所述单开口流体通道的另一端连接到混合室，单开口流体通道的顶部由柔性材料制成; 以及设置在流体通道层的顶部上方的空气室层，包括空气孔，至少一个室和连接室和空气孔的空气通道，其中空气室的数量和位置对应于流体通道层的单开口流体通道的数量和位置。

5. 发明申请

US20100246315A1 Micromixer biochip 有权
标题翻译： Micromixer生物芯片
公开(公告)号：US20100246315A1
公开(公告)日：2010-09-30
申请号：US12588194
申请日：2009-10-07
申请人： Gwo-Bin Lee , Sung-Yi Yang
发明人： Gwo-Bin Lee , Sung-Yi Yang
IPC分类号： B01F5/06 , B01F13/02
CPC分类号： B01F5/0068 , B01F11/0071 , B01F13/0059
摘要： The present invention provides a micromixer biochip, comprising: a substrate having a surface; a fluidic channel layer disposed above the surface of the substrate, including a mixing chamber and a single-opening fluidic channel, wherein one end of the single-opening fluidic channel is closed and the other end of the single-opening fluidic channel connects to the mixing chamber, and a top portion of the single-opening fluidic channel is made of a flexible material; and an air chamber layer disposed above the top portion of the fluidic channel layer, including an air pore, at least one chamber, and an air channel connecting the chamber and the air pore, wherein the number and position of the air chamber correspond to the number and position of the single-opening fluidic channel of the fluidic channel layer
摘要翻译：本发明提供一种微混合器生物芯片，包括：具有表面的基底; 设置在所述基板的表面上方的流体通道层，包括混合室和单开口流体通道，所述单开口流体通道的一端封闭，并且所述单开口流体通道的另一端连接到混合室，单开口流体通道的顶部由柔性材料制成; 以及设置在流体通道层的顶部上方的空气室层，包括空气孔，至少一个室和连接室和空气孔的空气通道，其中空气室的数量和位置对应于流体通道层的单开口流体通道的数量和位置

6. 发明授权

US09086409B2 Immunoassay biochip 有权
标题翻译：免疫测定生物芯片
公开(公告)号：US09086409B2
公开(公告)日：2015-07-21
申请号：US12659422
申请日：2010-03-09
申请人： Gwo-Bin Lee , Huan-Yao Lei , Yu-Fang Lee , Kang-Yi Lien
发明人： Gwo-Bin Lee , Huan-Yao Lei , Yu-Fang Lee , Kang-Yi Lien
IPC分类号： G01N33/543
CPC分类号： G01N33/54386 , B01F11/0051 , B01F13/0059
摘要： The present invention is about a microfluidic chip for rapid detection of different target proteins and a method for using the same. The microfluidic chip utilizes antibody-conjugated magnetic beads to bind to the target proteins to form a magnetic complex, and then use the signal labeled-antibodies that can recognize said magnetic complex. Purifying said magnetic complex by the micro-magnetic field on biochip, and introducing said purified magnetic complex into the fluorescent detection area on the chip to detect the amount of the target protein in said purified complex immediately.
摘要翻译：本发明涉及用于快速检测不同靶蛋白的微流控芯片及其使用方法。微流体芯片利用抗体缀合的磁珠结合靶蛋白以形成磁性复合物，然后使用可识别所述磁性复合物的信号标记的抗体。通过生物芯片上的微磁场对所述磁性复合物进行纯化，并将所述纯化的磁性复合物引入芯片上的荧光检测区域，以立即检测所述纯化复合物中靶蛋白的量。

7. 发明申请

US20120209053A1 Electromagnetic Thermotherapeutic Apparatus 有权
标题翻译：电磁热疗仪
公开(公告)号：US20120209053A1
公开(公告)日：2012-08-16
申请号：US13358824
申请日：2012-01-26
申请人： Gwo-Bin Lee , Xi-Zhang Lin , Sheng-Chieh Huang , Yi-Yuan Chang , Yan-Shen Shan , Sheng-Jye Hwang , Tung-Jen Lee , Szu-Yin Chen , Ping-Hen Chen
发明人： Gwo-Bin Lee , Xi-Zhang Lin , Sheng-Chieh Huang , Yi-Yuan Chang , Yan-Shen Shan , Sheng-Jye Hwang , Tung-Jen Lee , Szu-Yin Chen , Ping-Hen Chen
IPC分类号： A61N2/02
CPC分类号： A61B18/04 , A61B2018/00589
摘要： An electromagnetic thermotherapeutic apparatus includes: a plurality of needle units respectively having head portions and needle portions; a base unit having a base plate that is formed with a plurality of first through holes, and a base pad that is formed with a plurality of second through holes, the needle portions of the needle units removably extending through the second and first through holes, the head portions of the needle units abutting against the base pad; a temperature monitor disposed between the base plate and the base pad; an upper unit disposed above the base pad and abutting against the head portions; and a clamp unit clamping and pressing the base unit against the upper unit.
摘要翻译：一种电磁热治疗装置，包括：分别具有头部和针部的多个针单元; 具有形成有多个第一通孔的基板的基座单元和形成有多个第二通孔的基座，所述针单元的针部可移除地延伸穿过第二通孔和第一通孔，针单元的头部抵靠基座; 设置在所述基板和所述基座之间的温度监视器; 上部单元，设置在所述基座的上方并抵靠所述头部; 夹紧单元夹紧并将基座压靠在上部单元上。

8. 发明授权

US08021582B2 Method for producing microparticles in a continuous phase liquid 失效
标题翻译：在连续相液体中生产微粒的方法
公开(公告)号：US08021582B2
公开(公告)日：2011-09-20
申请号：US12548365
申请日：2009-08-26
申请人： Gwo-Bin Lee , Cheng-Tso Chen
发明人： Gwo-Bin Lee , Cheng-Tso Chen
IPC分类号： B29B9/00
CPC分类号： B01J19/0093 , B01F3/0807 , B01F11/0042 , B01F13/0062 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/00889 , B01J2219/00907
摘要： A continuous phase liquid and a dispersed phase liquid are permitted to flow together through a co-flow channel. Preferably, the dispersed phase liquid is arranged to flow within the flowing body of the continuous phase liquid in the co-flow channel so that the dispersed phase liquid is sheathed by the continuous phase liquid. The continuous phase and dispersed phase liquids are comminuted into microparticles in the co-flow channel by intermittently blocking the co-flow channel.
摘要翻译：允许连续相液体和分散相液体通过共流通道一起流动。优选地，分散相液体布置成在共流通道中在连续相液体的流动体内流动，使得分散相液体被连续相液体包覆。连续相和分散相液体通过间歇地阻塞共流通道而在共流通道中粉碎成微粒。

9. 发明申请

US20070000548A1 Method and device for producing microparticles in a continuous phase liquid 审中-公开
标题翻译：用于在连续相液体中生产微粒的方法和装置
公开(公告)号：US20070000548A1
公开(公告)日：2007-01-04
申请号：US11338193
申请日：2006-01-23
申请人： Gwo-Bin Lee , Cheng-Tso Chen
发明人： Gwo-Bin Lee , Cheng-Tso Chen
IPC分类号： F15C1/08
CPC分类号： B01F3/0807 , B01F13/0062 , Y10T137/2207
摘要： A continuous phase liquid and a dispersed phase liquid are permitted to flow together through a co-flow channel. Preferably, the dispersed phase liquid is arranged to flow within the flowing body of the continuous phase liquid in the co-flow channel. The continuous phase and dispersed phase liquids are comminuted intermittently by intermittently moving a comminuting member transversely into the co-flow channel, thereby producing microparticles of the dispersed phase liquid. A chip device for producing the microparticles is also disclosed.
摘要翻译：允许连续相液体和分散相液体通过共流通道一起流动。优选地，分散相液体布置成在共流动通道中在连续相液体的流动体内流动。连续相和分散相液体通过间歇地将粉碎部件横向移动到共流通道中间歇地粉碎，从而产生分散相液体的微粒。还公开了一种用于生产微粒的芯片器件。

10. 发明授权

US06577431B2 System of angular displacement control for micro-mirrors 失效
公开(公告)号：US06577431B2
公开(公告)日：2003-06-10
申请号：US09880813
申请日：2001-06-15
申请人： Cheng-Tang Pan , Shin-Chou Chen , Gwo-Bin Lee , Hsien-Min Yang , Chen-Sho Shey
发明人： Cheng-Tang Pan , Shin-Chou Chen , Gwo-Bin Lee , Hsien-Min Yang , Chen-Sho Shey
IPC分类号： G02F109
CPC分类号： B81B3/0062 , G02B26/0833 , G02B26/0841 , G02B26/085 , G02B26/0866 , H01H50/005
摘要： A system of angular displacement control for micro mirrors includes a stationary vertical element, a stationary horizontal element and an interference eliminator. Alternatively, the stationary horizontal element holds micro mirrors in place during transportation for avoiding vibration and collision. The stationary vertical element orientates the micro mirrors in the vertical position. The interference eliminator eliminates magnetic interference that could affect the operation of the micro mirrors. The micro mirrors having interference eliminators are capable of remaining unaffected by operations of other micro mirrors.

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