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    • 1. 发明授权
    • Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-AMP
    • 核苷酸还原酶抑制剂3-AP和3-AMP的前药形式
    • US5767134A
    • 1998-06-16
    • US856568
    • 1997-05-15
    • Jun LiChuan-Sheng NiuXiuyan LiTerrence W. DoyleShu-Hui Chen
    • Jun LiChuan-Sheng NiuXiuyan LiTerrence W. DoyleShu-Hui Chen
    • C07D213/74A61K31/44A61K31/4409A61P35/00A61P43/00C07D213/75C07F9/09C07F9/58C07D213/02
    • C07D213/75C07F9/588
    • The present invention relates to novel prodrug forms of ribonucleoside diphosphate reductase inhibitors 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) which have increased water solubility, bioavailablity and resistance to in vivo acetylation of their amino functions. Novel compounds according to the present invention relate to those of the formula: ##STR1## where R.sup.4 is H or CH.sub.3 and R.sup.5 is CHR, benzyl or ortho or para substituted benzyl; R is H, CH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 CH.sub.3 or ##STR2## R' is a free acid phosphate, phosphate salt or an --S--S--R" group; R" is CH.sub.2 CH.sub.2 NHR.sup.6, CH.sub.2 CH.sub.2 OH, CH.sub.2 COOR.sup.7, an ortho or para substituted alkylphenyl and ortho or para substituted nitro-phenyl; R.sup.6 is H, C.sub.1 -C.sub.4 acyl group, trifluoroacetyl, benzoyl or substituted benzoyl group, and R.sup.7 is H, C.sub.1 -C.sub.4 alkyl or a benzyl or substituted benzyl.
    • 本发明涉及核糖核苷二磷酸还原酶抑制剂3-氨基吡啶-2-甲醛缩氨基硫脲(3-AP)3-氨基-4-甲基吡啶-2-甲醛缩氨基硫脲(3-AMP)的新型前药形式,其具有增加的水溶性,生物可利用性 和其对氨基功能的体内乙酰化的抗性。 根据本发明的新化合物涉及下式的化合物:其中R 4是H或CH 3且R 5是CHR,苄基或邻位或对位取代的苄基; R是H,CH 3,CH 2 CH 3,CH 2 CH 2 CH 3或R 3是游离酸式磷酸酯,磷酸盐或-S-S-R“基团; R“是CH 2 CH 2 NHR 6,CH 2 CH 2 OH,CH 2 COOR 7,邻或对位取代的烷基苯基和邻位或对位取代的硝基苯基; R6是H,C1-C4酰基,三氟乙酰基,苯甲酰基或取代的苯甲酰基,R7是H,C1-C4烷基或苄基或取代的苄基。
    • 10. 发明授权
    • Method for semantics based trick mode play in video system
    • 视频系统中基于语义的特技模式播放方法
    • US09438876B2
    • 2016-09-06
    • US13824344
    • 2010-09-17
    • Jun LiXiaojun MaJun Xu
    • Jun LiXiaojun MaJun Xu
    • H04N9/80G11B27/00G11B27/28H04N5/783
    • H04N9/80G11B27/005G11B27/28H04N5/783
    • Trick mode play for controlling video content playback can be realized using a semantic based criterion in order to achieve a more uniform playback experience for the viewer, when that viewer wishes to observe the video content presented according to a selected semantic. In one embodiment of the method, semantics associated with shorter time intervals in the video content are replayed in trick mode play proportionally slower than semantics associated with longer time intervals, wherein the proportionally is determined, at least in part, to the time interval associated with each semantic. In various embodiments, semantics can include scenes, audio, metadata, tags, and the like. The semantics based trick mode play approach allows for a more uniform viewing experience, on a time duration basis, from one semantic to the next.
    • 可以使用基于语义的标准来实现用于控制视频内容回放的模式播放,以便当观众希望观察根据所选语义呈现的视频内容时,为观众提供更均匀的播放体验。 在该方法的一个实施例中,与特征模式播放相关联的与视频内容中较短时间间隔相关联的语义比与较长时间间隔相关联的语义成比例地慢,其中,至少部分地至少部分地确定与 每个语义。 在各种实施例中,语义可以包括场景,音频,元数据,标签等。 基于语义的特技模式播放方法允许在时间基础上从一个语义到另一个语义的更均匀的观看体验。