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1. 发明申请

US20140120604A1 Biological Detection System and Method of Use 审中-公开
标题翻译：生物检测系统及其使用方法
公开(公告)号：US20140120604A1
公开(公告)日：2014-05-01
申请号：US14110635
申请日：2012-04-06
申请人： Mauro Aguanno , Brian Barrett , Brian Chawke , Kieran Curran , Damian Curtin , Tara Dalton , Mark Davies , Xiaona Hou , David Kinahan , Damien King , Mark Korenke , Conor McCarthy , David McGuire , Michael Sayers , Noel Sirr , Ryan J. Talbot
发明人： Mauro Aguanno , Brian Barrett , Brian Chawke , Kieran Curran , Damian Curtin , Tara Dalton , Mark Davies , Xiaona Hou , David Kinahan , Damien King , Mark Korenke , Conor McCarthy , David McGuire , Michael Sayers , Noel Sirr , Ryan J. Talbot
IPC分类号： G01N21/64 , B01F13/00
CPC分类号： C12Q1/686 , B01F13/0005 , B01F13/0071 , B01F15/00214 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L7/525 , B01L2200/143 , B01L2300/06 , B01L2300/0654 , B01L2300/0867 , G01N21/6428 , G01N35/00623 , G01N2021/6439 , G01N2021/6441 , G01N2035/00465 , G01N2201/062
摘要： Provided herein is a biological detection system and method of use wherein the biological detection system comprises at least one mixer or liquid bridge for combining at least two liquid droplets and an error correction system for detecting whether or not proper mixing or combining of the two component droplets have occurred.
摘要翻译：本文提供了一种生物检测系统和使用方法，其中生物检测系统包括用于组合至少两个液滴的至少一个混合器或液体桥，以及用于检测是否适当混合或组合两个组分液滴的误差校正系统已经发生

2. 发明授权

US07993911B2 Microfluidic droplet queuing network 有权
标题翻译：微流控液滴排队网络
公开(公告)号：US07993911B2
公开(公告)日：2011-08-09
申请号：US12097455
申请日：2007-02-07
申请人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
发明人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： C12M1/34
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

3. 发明申请

US20100015606A1 MICROFLUIDIC DROPLET QUEUING NETWORK 有权
标题翻译：微型流体排队网络
公开(公告)号：US20100015606A1
公开(公告)日：2010-01-21
申请号：US12097455
申请日：2007-02-07
申请人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
发明人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： C12Q1/68 , B01L3/00 , G01N1/00
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

4. 发明授权

US08563244B2 Microfluidic droplet queuing network 有权
标题翻译：微流控液滴排队网络
公开(公告)号：US08563244B2
公开(公告)日：2013-10-22
申请号：US13177437
申请日：2011-07-06
申请人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
发明人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

5. 发明申请

US20120003658A1 MICROFLUIDIC DROPLET QUEUING NETWORK 有权
标题翻译：微型流体排队网络
公开(公告)号：US20120003658A1
公开(公告)日：2012-01-05
申请号：US13177437
申请日：2011-07-06
申请人： Mark DAVIES , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
发明人： Mark DAVIES , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： C12Q1/68
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

6. 发明申请

US20140127701A1 End-Point Optical System and Method of Use 审中-公开
标题翻译：端点光学系统及其使用方法
公开(公告)号：US20140127701A1
公开(公告)日：2014-05-08
申请号：US14110649
申请日：2012-04-06
申请人： Mauro Aguanno , Damian Curtin , Damien King
发明人： Mauro Aguanno , Damian Curtin , Damien King
IPC分类号： G01N21/64
CPC分类号： C12Q1/686 , G01N21/253 , G01N21/55 , G01N21/6452 , G01N21/6486 , G01N2201/0631 , G01N2201/0638
摘要： Systems and methods are used to detect spectral and spatial information in a continuous flow PCR system. An incident beam of electromagnetic radiation is emitted using a laser. The incident beam is received from the laser and incident beam is transformed into an incident line of electromagnetic radiation using a line generator. The incident line is received from the line generator using a tube array that includes one or more transparent tubes in fluid communication with one or more micro-channels. Reflected electromagnetic radiation is received from the tube array and the reflected electromagnetic radiation is focused using an imaging lens. The focused reflected electromagnetic radiation is received from the imaging lens and a spectral intensity is detected from the focused reflected electromagnetic radiation using a spectrograph. The focused reflected electromagnetic radiation is received from the imaging lens and a location of the spectral intensity is detected using an imager.
摘要翻译：系统和方法用于检测连续流PCR系统中的光谱和空间信息。使用激光发射入射的电磁辐射光束。从激光器接收入射光束，并且使用线发生器将入射光束变换成电磁辐射的入射线。使用管阵列从线发生器接收入射线，该管阵列包括与一个或多个微通道流体连通的一个或多个透明管。从管阵列接收反射的电磁辐射，并且使用成像透镜聚焦反射的电磁辐射。从成像透镜接收聚焦的反射电磁辐射，并且使用光谱仪从聚焦的反射电磁辐射检测光谱强度。从成像透镜接收聚焦的反射电磁辐射，并使用成像器检测光谱强度的位置。

7. 发明授权

US09897596B2 Microfluidic disc for use in with bead-based immunoassays 有权
公开(公告)号：US09897596B2
公开(公告)日：2018-02-20
申请号：US14123625
申请日：2012-06-05
申请人： Greg Kellogg , Jerry O'Brien , Eoin O'Nuallain , Damian Curtin
发明人： Greg Kellogg , Jerry O'Brien , Eoin O'Nuallain , Damian Curtin
IPC分类号： B01L3/00 , G01N33/53 , G01N33/543
CPC分类号： G01N33/5304 , B01L3/502753 , B01L2200/0636 , B01L2200/0652 , B01L2200/0684 , B01L2300/0681 , B01L2300/0803 , B01L2400/0409 , B01L2400/043 , B01L2400/0677 , B01L2400/0688 , B01L2400/086 , B01L2400/088 , G01N33/543 , G01N33/54366
摘要： The invention relates to a microfluidic system for processing biological samples comprising a rotary motor; a means for controlling said motor; a platform coupled to the rotary motor and adapted to provide at least one particle-washing structure and one particle receiving structure for receiving washed particles; and a detection zone for detection of particles of the sample in the particle receiving structure while the platform rotates. The invention provides a sample processing system that is both automated and prone to fewer errors than manual processing. This is accomplished using a centrifugal microfluidic platform that can process raw biological samples (e.g., blood, sputum, urine,) in order to perform high-quality bead-based immunofluorescent assays. The invention uses a simple rotary motor and custom-designed plastic disc to perform the sample preparation steps outlined above.

8. 发明申请

US20140242721A1 Microfluidic Disc For Use In With Bead-Based Immunoassays 有权
标题翻译：微流控盘用于基于珠的免疫测定
公开(公告)号：US20140242721A1
公开(公告)日：2014-08-28
申请号：US14123625
申请日：2012-06-05
申请人： Greg Kellogg , Jerry O'Brien , Eoin O'Nuallain , Damian Curtin
发明人： Greg Kellogg , Jerry O'Brien , Eoin O'Nuallain , Damian Curtin
IPC分类号： G01N33/53
CPC分类号： G01N33/5304 , B01L3/502753 , B01L2200/0636 , B01L2200/0652 , B01L2200/0684 , B01L2300/0681 , B01L2300/0803 , B01L2400/0409 , B01L2400/043 , B01L2400/0677 , B01L2400/0688 , B01L2400/086 , B01L2400/088 , G01N33/543 , G01N33/54366
摘要： The invention relates to a microfluidic system for processing biological samples comprising a rotary motor; a means for controlling said motor; a platform coupled to the rotary motor and adapted to provide at least one particle-washing structure and one particle receiving structure for receiving washed particles; and a detection zone for detection of particles of the sample in the particle receiving structure while the platform rotates. The invention provides a sample processing system that is both automated and prone to fewer errors than manual processing. This is accomplished using a centrifugal microfluidic platform that can process raw biological samples (e.g., blood, sputum, urine,) in order to perform high-quality bead-based immunofluorescent assays. The invention uses a simple rotary motor and custom-designed plastic disc to perform the sample preparation steps outlined above.
摘要翻译：本发明涉及一种微流体系统，用于处理包括旋转马达的生物样品; 用于控制所述电动机的装置; 耦合到所述旋转马达并适于提供至少一个颗粒洗涤结构和一个用于接收洗涤颗粒的颗粒接收结构的平台; 以及用于在平台旋转时检测颗粒接收结构中的样品的颗粒的检测区域。本发明提供一种自动化的样品处理系统，并且易于比手动处理更少的错误。这是使用可以处理原始生物样品（例如血液，痰液，尿液）的离心微流体平台来实现的，以便进行高质量的基于珠的免疫荧光测定。本发明使用简单的旋转马达和定制设计的塑料盘来执行上述的样品制备步骤。

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