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1. 发明申请

US20140120604A1 Biological Detection System and Method of Use 审中-公开
标题翻译：生物检测系统及其使用方法
公开(公告)号：US20140120604A1
公开(公告)日：2014-05-01
申请号：US14110635
申请日：2012-04-06
申请人： Mauro Aguanno , Brian Barrett , Brian Chawke , Kieran Curran , Damian Curtin , Tara Dalton , Mark Davies , Xiaona Hou , David Kinahan , Damien King , Mark Korenke , Conor McCarthy , David McGuire , Michael Sayers , Noel Sirr , Ryan J. Talbot
发明人： Mauro Aguanno , Brian Barrett , Brian Chawke , Kieran Curran , Damian Curtin , Tara Dalton , Mark Davies , Xiaona Hou , David Kinahan , Damien King , Mark Korenke , Conor McCarthy , David McGuire , Michael Sayers , Noel Sirr , Ryan J. Talbot
IPC分类号： G01N21/64 , B01F13/00
CPC分类号： C12Q1/686 , B01F13/0005 , B01F13/0071 , B01F15/00214 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L7/525 , B01L2200/143 , B01L2300/06 , B01L2300/0654 , B01L2300/0867 , G01N21/6428 , G01N35/00623 , G01N2021/6439 , G01N2021/6441 , G01N2035/00465 , G01N2201/062
摘要： Provided herein is a biological detection system and method of use wherein the biological detection system comprises at least one mixer or liquid bridge for combining at least two liquid droplets and an error correction system for detecting whether or not proper mixing or combining of the two component droplets have occurred.
摘要翻译：本文提供了一种生物检测系统和使用方法，其中生物检测系统包括用于组合至少两个液滴的至少一个混合器或液体桥，以及用于检测是否适当混合或组合两个组分液滴的误差校正系统已经发生

2. 发明授权

US08697011B2 Sampling device with immiscible fluid supply tube in counter-flow arrangement 有权
标题翻译：采样装置具有不兼容的流体供应管的逆流布置
公开(公告)号：US08697011B2
公开(公告)日：2014-04-15
申请号：US12468367
申请日：2009-05-19
申请人： David McGuire , Kieran Curran , Julie Garvey , Damian Curtain
发明人： David McGuire , Kieran Curran , Julie Garvey , Damian Curtain
IPC分类号： B01L3/02
CPC分类号： C12Q1/6806 , B01L3/021 , B01L3/0293 , B01L7/52 , B01L2200/0642 , C12Q1/686
摘要： The present invention generally relates to devices, systems, and methods for acquiring and/or dispensing a sample without introducing a gas into a microfluidic system, such as a liquid bridge system. An exemplary embodiment provides a sampling device including: a sampling member for acquiring or dispensing a sample; and a supply of a fluid that is immiscible with the sample; in which the device is configured to provide a continuous flow of immiscible fluid enveloping the sampling member.
摘要翻译：本发明一般涉及用于获取和/或分配样品而不将气体引入诸如液体桥系统的微流体系统中的装置，系统和方法。示例性实施例提供一种采样装置，包括：用于获取或分配样本的采样部件; 和与样品不混溶的流体供应; 其中所述装置被配置为提供包围所述采样构件的不混溶流体的连续流。

3. 发明申请

US20070239166A1 Surgical Device for Anterolateral and Posterolateral Reconstruction 审中-公开
公开(公告)号：US20070239166A1
公开(公告)日：2007-10-11
申请号：US11740607
申请日：2007-04-26
申请人： David McGuire , Jeffrey Wolchok , Steven Hendricks
发明人： David McGuire , Jeffrey Wolchok , Steven Hendricks
IPC分类号： A61F5/01
CPC分类号： A61B17/1714 , A61B17/1764 , A61B2090/061
摘要： An isometer for determining isometric graft tunnel placement for lateral side surgical augmentation or reconstruction for anterolateral or posterior lateral rotary knee instability. This graft tunnel placement isometry assessment and measurement device is designed to be used with a graft and an extra-articular technique that restores rotatory, lateral, and anterior/posterior knee stability when used by itself or in combination with intra-articular ACL/PCL reconstruction. The isometer includes an elongated body with a slider rod that slides horizontally within the body and a cannulated fixed stylus attached transversely to the first end of the elongated body. Within that cannulated fixed stylus is a guide pin that slides freely but that can also be fixed using a fixed-stylus set screw. Similarly, a cannulated movable stylus is attached transversely to the first end of the slider rod, and within that cannulated movable stylus is a guide pin that slides freely but that can also be fixed using a movable-stylus set screw. There is a pointer encircling the slider rod that slides with the slider rod, but whose position along the slider rod can also be adjusted manually. The slider rod may also have a rotatable member that allows each end of the slider rod to rotate relative to the other end. The rotatable member obviates slider rod impingement during operation. To determine rotary knee isometry during knee reconstructive surgery, the guide pins are positioned over previously identified lateral reconstruction tunnel sites. The guide pins are then driven into the bone tunnel sites and the knee put through a full range of motion by flexing and extending the knee while the isometer position is maintained and the pointer movement is monitored. If movement of the pointer is unacceptably large, the guide pins are re-set, re-positioned and re-driven into different pre-identified lateral reconstruction tunnel sites, and pointer movement during full range motion is again monitored until movement is acceptably small.

4. 发明申请

US20050149033A1 Bioabsorbable fasteners for preparing and securing ligament replacement grafts 审中-公开
标题翻译：用于制备和固定韧带置换移植物的生物可吸收紧固件
公开(公告)号：US20050149033A1
公开(公告)日：2005-07-07
申请号：US10971721
申请日：2004-10-22
申请人： David McGuire , Stephen Hendricks
发明人： David McGuire , Stephen Hendricks
IPC分类号： A61B17/16 , A61B17/17 , A61F2/08 , A61B17/56
CPC分类号： A61F2/0811 , A61B17/1635 , A61B17/1714 , A61B17/1764 , A61F2002/0829 , A61F2002/087 , A61F2002/0882 , A61F2210/0004 , A61F2240/005
摘要： A bioabsorbable implantable device for replacing sutures in construction of a composite graft in ligament replacement surgery. In certain embodiments the device has a female component and a male component where the female component receives and secures the male component. In other embodiments the components of the device are in the shape of a rivet or a staple. The bioabsorbable implantable devices can be used for securing tendon grafts to bone blocks and for holding together the fibers of the tendon graft when the bone-tendon-bone graft is inserted into a patient during surgery. The bioabsorbable implantable device may also be part of a package for use in surgery. The package includes a sterile container for holding at least a graft that is of a predetermined length and width. The package may also include bone blocks. The package is marked as to the graft size including the width and the length of the graft. The graft and the bone blocks may be autogenous, allogenic or constructed from man-made materials.
摘要翻译：一种生物可吸收的可植入装置，用于在韧带置换手术中替代复合移植物的结构中的缝合线。在某些实施例中，该装置具有阴部件和阳部件，其中阴部件接收并固定阳部件。在其它实施例中，装置的部件是铆钉或钉的形状。生物可吸收的可植入装置可以用于将腱移植物固定到骨块上，并且当在手术期间将骨腱 - 骨移植物插入患者时，将腱移植物的纤维保持在一起。生物可吸收可植入装置也可以是用于手术的包装的一部分。该包装包括用于至少保持具有预定长度和宽度的移植物的无菌容器。包装还可以包括骨块。包装被标记为移植物尺寸，包括移植物的宽度和长度。移植物和骨块可以是自生的，同种异体的或由人造材料构成的。

5. 发明授权

US4927421A Process of endosteal fixation of a ligament 失效
标题翻译：韧带内固定过程
公开(公告)号：US4927421A
公开(公告)日：1990-05-22
申请号：US352153
申请日：1989-05-15
申请人： E. Marlowe Goble , W. Karl Somers , David McGuire
发明人： E. Marlowe Goble , W. Karl Somers , David McGuire
IPC分类号： A61F2/08
CPC分类号： A61F2/0811 , A61F2/0805 , A61F2002/0841 , A61F2002/0858 , A61F2002/087 , A61F2002/0882
摘要： A cannulated interference screw (10) and process for human implantation in an arthroscopic surgical procedure for replacement of a ligament, or the like. The interference screw is provided with a drill end (11) that extends longitudinally from an end of a cylindrical body (14), which drill end includes equally spaced flutes (12) therearound. The flutes extend into first and second cutting threads (15a) and (15b), respectively which cutting threads and threads (15) are formed around the cylindrical body. A center longitudinal passage (16) is formed through the interference screw drill end and cylindrical body, which passage is stepped outwardly within the cylindrical body into a hexagonal sided section (18) that is for receiving a sided end (20) of a driver (19) that is fitted therein. In practice, the cannulated interference screw is installed by sliding it along a guide rod (25) that is fitted in a prepared ligament tunnel (22) through a bone mass, alongside a bone block portion of a ligament (23) within the bone endosteum, which ligament is maintained in that tunnel under tension. The driver is also holed longitudinally to travel along the guide rod to fit into and turn the interference screw, providing fixation of the ligament in that tunnel.
摘要翻译：插管式干涉螺钉（10）以及用于人工植入用于替换韧带的关节镜外科手术的方法等。干涉螺钉设置有从圆柱形主体（14）的端部纵向延伸的钻头（11），该钻头端部包括等间隔的凹槽（12）。凹槽分别延伸到第一和第二切割螺纹（15a）和（15b）中，切割螺纹和螺纹（15）围绕圆柱体形成。中心纵向通道（16）通过干涉螺丝钻头和圆筒体形成，该通道在圆柱体内部向外延伸成六边形部分（18），该六边形部分用于接纳驱动器的侧端（20） 19）。在实践中，插管的干涉螺钉通过沿着固定在制备的韧带隧道（22）中的导杆（25）沿着骨块内的韧带（23）的骨块部分沿骨内骨骼的骨块部分滑动而安装该韧带在紧张情况下保持在该隧道内。驾驶员还沿着纵向移动以沿着导杆行进以适应并转动干涉螺钉，从而提供韧带在该隧道中的固定。

6. 发明授权

US1702603A Concrete-testing apparatus 失效
标题翻译：混凝土试验装置
公开(公告)号：US1702603A
公开(公告)日：1929-02-19
申请号：US21684627
申请日：1927-09-01
申请人： HARDIN HANSARD ORREN , DAVID MCGUIRE DONALD
发明人： HARDIN HANSARD ORREN , DAVID MCGUIRE DONALD
IPC分类号： G01N3/20
CPC分类号： G01N3/20

7. 发明申请

US20140111901A1 System and Method for Charging Fluids 审中-公开
标题翻译：充液系统及方法
公开(公告)号：US20140111901A1
公开(公告)日：2014-04-24
申请号：US14110678
申请日：2012-04-06
申请人： Brian Chawke , Kieran Curran , David McGuire , Michael Sayers , Noel Sirr
发明人： Brian Chawke , Kieran Curran , David McGuire , Michael Sayers , Noel Sirr
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01F13/0071 , B01F13/0076 , B01J19/087 , B01L3/502715 , B01L3/502784 , B01L3/52 , B01L3/56 , B01L2200/0673 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B05B5/035 , C12Q1/686 , G01N1/38 , G01N2001/4038
摘要： Devices, systems, and methods for charging fluids are disclosed. The charging of fluids improves the mixing of fluids in microfluidic systems. The charging is performed by producing an ion field (50) between an ionizing electrode (20) and an opposed ground electrode (30). A fluid-containing vessel (40) is positioned between the opposed electrodes and the ion field charges the fluid (41) in the vessel.
摘要翻译：公开了用于充液的装置，系统和方法。流体充液改善了微流体系统中流体的混合。通过在电离电极（20）和相对的接地电极（30）之间产生离子场（50）来进行充电。流体容纳容器（40）位于相对的电极之间，离子场对容器中的流体（41）充电。

8. 发明授权

US5549478A Universal trailer light locator 失效
标题翻译：通用拖车灯定位器
公开(公告)号：US5549478A
公开(公告)日：1996-08-27
申请号：US376030
申请日：1995-01-20
申请人： David McGuire
发明人： David McGuire
IPC分类号： B60D1/62 , B60L1/00
CPC分类号： B60D1/62
摘要： A versatile, water-resistant trailer interface device that is capable of adaptation to a variety of connector assemblies. The mechanical and electrical apparatus is comprised of versatile connectors, a circuit board, indicator lights, resistors, a test circuit, wires and a casing. The user can test and connect each pin separately without the need for special tools. The large resistor prevents the destruction of automobile or trailer fuses.
摘要翻译：一种多功能，防水的拖车接口设备，能够适应各种连接器组件。机电设备由通用连接器，电路板，指示灯，电阻器，测试电路，电线和外壳组成。用户可以单独测试和连接每个引脚，而无需特殊工具。大电阻防止汽车或拖车保险丝的破坏。

9. 发明申请

US20060129163A1 Systems and methods for producing osteotomies 审中-公开
公开(公告)号：US20060129163A1
公开(公告)日：2006-06-15
申请号：US11331512
申请日：2006-01-13
申请人： David McGuire
发明人： David McGuire
IPC分类号： A61B17/60
CPC分类号： A61B17/151 , A61B17/0206 , A61B17/15 , A61B17/171 , A61B17/66 , A61B17/683 , A61B17/8891 , Y10S606/907 , Y10S606/916
摘要： Systems and methods for producing minimally invasive osteotomies to correct angular deformities of bones in and about the knee are disclosed. A method includes locating a plane in which the angle exhibited by the deformity is situated. An oblique cut is then made along a surface of the bone, such that the cut is transverse to the plane in which the angle is situated. Thereafter, the bone pieces are rotated about the cut relative to one another until a desired alignment between the bone pieces is achieved. To maintain the bone pieces in alignment, a device having an elongated body for extending into a tunnel between the bone pieces is provided. The system also includes a rigid member fixedly positioned at one end of the body. The rigid member is transverse to the body to engage one bone piece. The system further includes a locking mechanism at an opposite end of the body to engage the other bone piece. The system permits the bone pieces to be pulled against one another between the rigid member and the locking mechanism.

10. 发明申请

US20050261701A1 Surgical device for a anterolateral reconstruction 审中-公开
标题翻译：外侧重建手术装置
公开(公告)号：US20050261701A1
公开(公告)日：2005-11-24
申请号：US11125808
申请日：2005-05-10
申请人： David McGuire , Jeffrey Wolchok , Steven Hendricks
发明人： David McGuire , Jeffrey Wolchok , Steven Hendricks
IPC分类号： A61B17/17 , A61B17/58
CPC分类号： A61B17/1714 , A61B17/1764
摘要： An isometer for determining isometric graft tunnel placement for lateral side surgical augmentation or reconstruction for anterolateral rotatory knee instability. This graft tunnel placement isometry assessment and measurement device is designed to be used with a graft and an extra-articular technique that restores rotatory, lateral, and anterior knee stability when used by itself or in combination with intra-articular ACL reconstruction. The isometer includes an elongated body with a slider rod that slides horizontally within the body and a cannulated fixed stylus attached transversely to the first end of the elongated body. Within that cannulated fixed stylus is a guide pin that slides freely but that can also be fixed using a fixed-stylus set screw. Similarly, a cannulated movable stylus is attached transversely to the first end of the slider rod, and within that cannulated movable stylus is a guide pin that slides freely but that can also be fixed using a movable-stylus set screw. There is a pointer encircling the slider rod that slides with the slider rod, but whose position along the slider rod can also be adjusted manually. To determine rotary knee isometry during knee reconstructive surgery, the guide pins are positioned over previously identified lateral reconstruction tunnel sites. The guide pins are then driven into the bone tunnel sites and the knee put through a full range of motion by flexing and extending the knee while the isometer position is maintained and the pointer movement is monitored. If movement of the pointer is unacceptably large, the guide pins are re-set, re-positioned and re-driven into different pre-identified lateral reconstruction tunnel sites, and pointer movement during full range motion is again monitored until movement is acceptably small.
摘要翻译：用于确定外侧旋转性膝关节不稳定性的侧面手术增大或重建的等距移植物隧道放置的等长计。该移植隧道放置等距评估和测量装置被设计成与移植物和关节外技术一起使用，其在自身使用时或与关节内ACL重建组合使用时恢复旋转，外侧和前膝关节的稳定性。该计时器包括具有滑动杆的细长主体，其在主体内水平滑动，并且插入式固定触针横向于细长主体的第一端附接。在该插管式固定式触控笔中，可以自由滑动的导向销，但也可以使用固定式触针固定螺丝固定。类似地，插入式活动触针横向于滑动杆的第一端附接，并且在该插管式活动触针内是可自由滑动的引导销，但是也可以使用活动触针固定螺钉固定。有一个环绕滑杆的指针，滑杆与滑块一起滑动，但也可以手动调节滑杆的位置。为了确定膝关节重建手术期间的旋转膝关节等距线，引导针位于先前识别的横向重建隧道位置。引导销然后被驱动到骨隧道位置，膝盖通过弯曲和伸展膝盖而保持计尺位置并监视指针运动。如果指针的运动不可接受地大，则引导引脚被重新设置，重新定位并重新驱动到不同的预先确定的横向重建隧道位置，并且在全范围运动期间的指针运动被再次监测，直到运动可接受地较小。

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