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1. 发明申请

US20140120604A1 Biological Detection System and Method of Use 审中-公开
标题翻译：生物检测系统及其使用方法
公开(公告)号：US20140120604A1
公开(公告)日：2014-05-01
申请号：US14110635
申请日：2012-04-06
申请人： Mauro Aguanno , Brian Barrett , Brian Chawke , Kieran Curran , Damian Curtin , Tara Dalton , Mark Davies , Xiaona Hou , David Kinahan , Damien King , Mark Korenke , Conor McCarthy , David McGuire , Michael Sayers , Noel Sirr , Ryan J. Talbot
发明人： Mauro Aguanno , Brian Barrett , Brian Chawke , Kieran Curran , Damian Curtin , Tara Dalton , Mark Davies , Xiaona Hou , David Kinahan , Damien King , Mark Korenke , Conor McCarthy , David McGuire , Michael Sayers , Noel Sirr , Ryan J. Talbot
IPC分类号： G01N21/64 , B01F13/00
CPC分类号： C12Q1/686 , B01F13/0005 , B01F13/0071 , B01F15/00214 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L7/525 , B01L2200/143 , B01L2300/06 , B01L2300/0654 , B01L2300/0867 , G01N21/6428 , G01N35/00623 , G01N2021/6439 , G01N2021/6441 , G01N2035/00465 , G01N2201/062
摘要： Provided herein is a biological detection system and method of use wherein the biological detection system comprises at least one mixer or liquid bridge for combining at least two liquid droplets and an error correction system for detecting whether or not proper mixing or combining of the two component droplets have occurred.
摘要翻译：本文提供了一种生物检测系统和使用方法，其中生物检测系统包括用于组合至少两个液滴的至少一个混合器或液体桥，以及用于检测是否适当混合或组合两个组分液滴的误差校正系统已经发生

2. 发明授权

US08563244B2 Microfluidic droplet queuing network 有权
标题翻译：微流控液滴排队网络
公开(公告)号：US08563244B2
公开(公告)日：2013-10-22
申请号：US13177437
申请日：2011-07-06
申请人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
发明人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

3. 发明申请

US20120003658A1 MICROFLUIDIC DROPLET QUEUING NETWORK 有权
标题翻译：微型流体排队网络
公开(公告)号：US20120003658A1
公开(公告)日：2012-01-05
申请号：US13177437
申请日：2011-07-06
申请人： Mark DAVIES , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
发明人： Mark DAVIES , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： C12Q1/68
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

4. 发明申请

US20100304446A1 DEVICES, SYSTEMS, AND METHODS FOR AMPLIFYING NUCLEIC ACIDS 审中-公开
标题翻译：用于放大核酸的装置，系统和方法
公开(公告)号：US20100304446A1
公开(公告)日：2010-12-02
申请号：US12732596
申请日：2010-03-26
申请人： Mark Davies , Tara Dalton
发明人： Mark Davies , Tara Dalton
IPC分类号： C12P19/34 , C12M1/34 , C12M1/00
CPC分类号： B01L7/525 , B01L3/502784 , B01L2200/0673 , B01L2400/0457 , B01L2400/0487 , C12Q1/6851 , C12Q2565/629 , C12Q2561/113
摘要： The present invention generally relates to a devices, systems, and methods for amplifying nucleic acids in flowing droplets. In certain embodiments, the invention provides a device for amplifying nucleic acids including at least one channel through which sample droplets including nucleic acids flow, in which the nucleic acids in the droplets are optically detectable while the droplets are flowing through the channel, and a plurality of temperature zones in thermal contact with the channel, in which the zones are located at different locations along the channel and the zones are separated from each other.
摘要翻译：本发明一般涉及用于放大流动液滴中的核酸的装置，系统和方法。在某些实施方案中，本发明提供了一种用于扩增核酸的装置，其包括至少一个通道，通过该通道，包含核酸的样品液滴通过该通道流动，其中液滴中的核酸在液滴流过通道时是可光学检测的，的温度区域与通道热接触，其中区域沿着通道位于不同的位置，并且区域彼此分离。

5. 发明申请

US20100297685A1 METHODS FOR CULTURING AND ANALYZING CELLS 有权
标题翻译：培养和分析细胞的方法
公开(公告)号：US20100297685A1
公开(公告)日：2010-11-25
申请号：US12732769
申请日：2010-03-26
申请人： Mark Davies , Tara Dalton
发明人： Mark Davies , Tara Dalton
IPC分类号： C12Q1/02 , C12N5/071 , C12N5/02 , G01N33/48 , C12N5/079 , C12N5/073
CPC分类号： B01F5/0057 , B01F13/0059 , B01F13/0071 , B01L3/502784 , B01L7/525 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/185 , B01L2400/0409 , B01L2400/0487 , G01N33/5008 , G01N35/08 , G01N35/1095 , G01N2035/00514
摘要： The present invention generally relates to methods for culturing and analyzing cells using liquid bridges.
摘要翻译：本发明一般涉及使用液桥培养和分析细胞的方法。

6. 发明申请

US20100109320A1 MICROFLUIDIC CONNECTOR 失效
标题翻译：微流连接器
公开(公告)号：US20100109320A1
公开(公告)日：2010-05-06
申请号：US12443303
申请日：2007-09-27
申请人： Mark Davies , Tara Dalton
发明人： Mark Davies , Tara Dalton
IPC分类号： F16L27/00
CPC分类号： F16L41/18 , B01L3/5027 , B01L3/5635 , B01L3/565 , B01L2200/027 , F16L39/00 , Y10T137/0318
摘要： A microfluidic connector (1) comprises an enclosure (6, 7), a fluidic inlet port (2) and a fluidic outlet port (3), in the enclosure, in which the inlet and outlet ports (2, 3) are movable with respect to each other, for example, mutual spacing between the inlet and outlet ports (2, 3) is variable. A port (2) is in a fixed part (6) of the enclosure, and another port (3) is in a part (7) of the enclosure which slides with respect to the fixed part. There may be multiple inlet ports (22, 23) and/or multiple outlet ports (24, 25). Also, there may be an auxiliary port (45) for introduction of fluid into the enclosure (47, 48) or removal of fluid from the enclosure.
摘要翻译：微流体连接器（1）包括外壳中的外壳（6,7），流体入口端口（2）和流体出口端口（3），入口端口和出口端口（2,3）可通过外壳彼此相对，例如，入口端口（3）之间的相互间隔是可变的。端口（2）位于外壳的固定部分（6）中，另一个端口（3）位于外壳的相对于固定部分滑动的部分（7）中。可以有多个入口端口（22,23）和/或多个出口端口（24,25）。而且，可以存在用于将流体引入外壳（47,48）或从外壳移除流体的辅助端口（45）。

7. 发明申请

US20060205062A1 Microfluidic analysis system 有权
标题翻译：微流控分析系统
公开(公告)号：US20060205062A1
公开(公告)日：2006-09-14
申请号：US11366524
申请日：2006-03-03
申请人： Mark Davies , Tara Dalton
发明人： Mark Davies , Tara Dalton
IPC分类号： C12M1/34
CPC分类号： C12Q1/686 , B01F5/0057 , B01F13/0059 , B01L3/50273 , B01L3/502776 , B01L3/502784 , B01L7/525 , B01L2200/0636 , B01L2200/0673 , B01L2200/141 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/185 , B01L2400/0409 , B01L2400/0487 , G01N35/08 , G01N35/1095 , G01N2035/00514
摘要： A microfluidic analysis system (1) performs polymerase chain reaction (PCR) analysis on a bio sample. In a centrifuge (6) the sample is separated into DNA and RNA constituents. The vortex is created by opposing flow of a silicon oil primary carrier fluid effecting circulation by viscous drag. The bio sample exits the centrifuge enveloped in the primary carrier fluid. This is pumped by a flow controller (7) to a thermal stage (9). The thermal stage (9) has a number of microfluidic devices (70) each having thermal zones (71, 72, 73) in which the bio sample is heated or cooled by heat conduction to/from a thermal carrier fluid and the primary carrier fluid. Thus, the carrier fluids envelope the sample, control its flowrate, and control its temperature without need for moving parts at the micro scale.
摘要翻译：微流体分析系统（1）对生物样品进行聚合酶链反应（PCR）分析。在离心机（6）中，将样品分离成DNA和RNA成分。涡流通过由粘性阻力影响循环的硅油主载流体的相反流动而产生。生物样品离开包围在主载体流体中的离心机。这被流量控制器（7）泵送到热级（9）。热级（9）具有多个微流体装置（70），每个微流体装置（70）各自具有热区（71,72,73），其中生物样品通过向热载体流体和主载体流体的热传导而被加热或冷却。因此，载体流体包裹样品，控制其流速，并控制其温度，而不需要微量级的移动部件。

8. 发明授权

US08968659B2 Sample dispensing 有权
标题翻译：样品分配
公开(公告)号：US08968659B2
公开(公告)日：2015-03-03
申请号：US12683882
申请日：2010-01-07
申请人： Mark Davies , Tara Dalton
发明人： Mark Davies , Tara Dalton
IPC分类号： G01N1/18 , G01N1/00 , G01N33/00 , C40B60/14 , B01F5/00 , B01F13/00 , B01L3/00 , B01L7/00 , G01N35/08 , G01N35/10 , G01N35/00
CPC分类号： B01F5/0057 , B01F13/0059 , B01F13/0071 , B01L3/50273 , B01L7/525 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , B01L2300/185 , B01L2400/0409 , B01L2400/0487 , G01N35/08 , G01N35/1095 , G01N2035/00514
摘要： The present invention generally relates to systems and methods for mixing and dispensing a sample droplet from a microfluidic system, such as a liquid bridge system. In certain embodiments, the invention provides systems for mixing and dispensing sample droplets, including a sample acquisition stage, a device for mixing sample droplets to form sample droplets wrapped in an immiscible carrier fluid, a dispensing port, and at least one channel connecting the stage, the droplet mixing device, and the port, in which the system is configured to establish a siphoning effect for dispensing the droplets.
摘要翻译：本发明一般涉及用于从微流体系统（例如液桥系统）混合和分配样品液滴的系统和方法。在某些实施方案中，本发明提供了用于混合和分配样品液滴的系统，包括样品采集阶段，用于混合样品液滴以形成包裹在不混溶载体流体中的样品液滴的装置，分配端口和连接该阶段，液滴混合装置和端口，其中系统被配置成建立用于分配液滴的虹吸效应。

9. 发明授权

US08550503B2 Microfluidic connector 失效
标题翻译：微流体连接器
公开(公告)号：US08550503B2
公开(公告)日：2013-10-08
申请号：US12443303
申请日：2007-09-27
申请人： Mark Davies , Tara Dalton
发明人： Mark Davies , Tara Dalton
IPC分类号： F16L39/04
CPC分类号： F16L41/18 , B01L3/5027 , B01L3/5635 , B01L3/565 , B01L2200/027 , F16L39/00 , Y10T137/0318
摘要： A microfluidic connector (1) comprises an enclosure (6, 7), a fluidic inlet port (2) and a fluidic outlet port (3), in the enclosure, in which the inlet and outlet ports (2, 3) are movable with respect to each other, for example, mutual spacing between the inlet and outlet ports (2, 3) is variable. A port (2) is in a fixed part (6) of the enclosure, and another port (3) is in a part (7) of the enclosure which slides with respect to the fixed part. There may be multiple inlet ports (22, 23) and/or multiple outlet ports (24, 25). Also, there may be an auxiliary port (45) for introduction of fluid into the enclosure (47, 48) or removal of fluid from the enclosure.
摘要翻译：微流体连接器（1）包括外壳中的外壳（6,7），流体入口端口（2）和流体出口端口（3），入口端口和出口端口（2,3）可通过外壳彼此相对，例如，入口端口（3）之间的相互间隔是可变的。端口（2）位于外壳的固定部分（6）中，另一个端口（3）位于外壳的相对于固定部分滑动的部分（7）中。可以有多个入口端口（22,23）和/或多个出口端口（24,25）。而且，可以存在用于将流体引入外壳（47,48）或从外壳移除流体的辅助端口（45）。

10. 发明申请

US20100216128A1 METHODS FOR ANALYZING AGRICULTURAL AND ENVIRONMENTAL SAMPLES 有权
标题翻译：分析农业和环境样品的方法
公开(公告)号：US20100216128A1
公开(公告)日：2010-08-26
申请号：US12469339
申请日：2009-05-20
申请人： Mark Davies , Tara Dalton
发明人： Mark Davies , Tara Dalton
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/566 , G01N33/92 , G01N33/00
CPC分类号： G01N1/38 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01L3/502784 , B01L3/5088 , B01L2200/10 , B01L2300/0816 , B01L2300/0864 , B01L2300/165 , G01N33/5308 , G01N2035/00237
摘要： The present invention generally relates methods for analyzing agricultural and/or environmental samples using liquid bridges. In certain embodiments, the invention provides a method for analyzing an agricultural sample for a desired trait including obtaining a gene or gene product from an agricultural sample, in which the gene or gene product is in a first fluid; providing a liquid bridge for mixing the gene or gene product with at least one reagent to form a mixed droplet that is wrapped in an immiscible second fluid; and analyzing the mixed droplet to detect a desired trait of the agricultural sample.
摘要翻译：本发明一般涉及使用液体桥分析农业和/或环境样品的方法。在某些实施方案中，本发明提供了一种用于分析所需性状的农业样品的方法，包括从农业样品获得基因或基因产物，其中所述基因或基因产物处于第一种流体中; 提供用于将基因或基因产物与至少一种试剂混合以形成被包裹在不混溶的第二流体中的混合液滴的液体桥; 并分析混合液滴以检测农业样品的期望性状。

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