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1. 发明申请

US20060252797A1 Receptor regulator 审中-公开
标题翻译：受体调节剂
公开(公告)号：US20060252797A1
公开(公告)日：2006-11-09
申请号：US10533833
申请日：2003-11-05
申请人： Masahiro Kajino , Shuji Hinuma , Naoki Tarui , Toshiro Yamashita , Yutaka Nakayama
发明人： Masahiro Kajino , Shuji Hinuma , Naoki Tarui , Toshiro Yamashita , Yutaka Nakayama
IPC分类号： A61K31/4545 , A61K31/454 , C07D401/02 , C07D417/02
CPC分类号： C07D401/04 , A61K31/4468 , A61K31/454 , A61K31/4545 , C07D211/58 , C07D211/66 , C07D401/06 , C07D409/14 , C07D417/04 , C07D417/14
摘要： A compound having a partial structure represented by the formula (A) (wherein ring Xa represents a nitrogen-containing ring and R represents optionally substituted amino) or a salt thereof. The compound or salt is highly effective in regulating neuromedin U receptors and is useful as a preventive/therapeutic agent for hypertension, etc.
摘要翻译：具有由式（A）表示的部分结构的化合物（其中环Xa表示含氮环，R表示任选取代的氨基）或其盐。该化合物或盐在调节神经介肽U受体方面非常有效，并且可用作高血压等的预防/治疗剂。

2. 发明授权

US07972800B2 Screening method for binding property or signal transduction alterations 有权
标题翻译：结合性质或信号转导改变的筛选方法
公开(公告)号：US07972800B2
公开(公告)日：2011-07-05
申请号：US12428877
申请日：2009-04-23
申请人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
发明人： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
IPC分类号： G01N33/53 , C07K14/435
CPC分类号： G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
摘要： By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.
摘要翻译：通过使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和可电离金属元素或其盐可以有效地筛选上述受体蛋白质或其拮抗剂的激动剂或其盐。

3. 发明申请

US20070202550A1 Novel G protein-coupled receptor protein, its DNA and ligand thereof 失效
标题翻译：新型G蛋白偶联受体蛋白，其DNA及其配体
公开(公告)号：US20070202550A1
公开(公告)日：2007-08-30
申请号：US11701719
申请日：2007-02-02
申请人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
发明人： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
IPC分类号： G01N33/567 , C07H21/04 , C07K14/47 , C07K16/28 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
摘要： The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
摘要翻译：本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。

4. 发明申请

US20070117840A1 Receptor antagonist 审中-公开
标题翻译：受体拮抗剂
公开(公告)号：US20070117840A1
公开(公告)日：2007-05-24
申请号：US10549889
申请日：2004-03-16
申请人： Fumio Itoh , Shuji Hinuma , Naoyuki Kanzaki , Yoshihiro Banno , Hiromi Yoshida , Hirokazu Matsumoto
发明人： Fumio Itoh , Shuji Hinuma , Naoyuki Kanzaki , Yoshihiro Banno , Hiromi Yoshida , Hirokazu Matsumoto
IPC分类号： A61K31/4704
CPC分类号： A61K31/4704
摘要： A compound represented by the formula (I): wherein ring A represents an aromatic ring; X represents a bond, oxygen, NR4 (R4 represents hydrogen, a hydrocarbon group, or a heterocyclic group), or alkylene; R1 represents a hydrocarbon group, or a heterocyclic group; R2 represents —COYR5 (Y represents a bond, alkylene, oxygen, sulfur, or NR6 (R6 represents hydrogen, a hydrocarbon group, or a heterocyclic group), and R5 represents a hydrocarbon group, or a heterocyclic group), a hydrocarbon group, or a heterocyclic group; and R3 represents a hydrocarbon group, a heterocyclic group, optionally substituted hydroxy, optionally substituted amino, or —S(O)nR7 (R7 represents a hydrocarbon group, or a heterocyclic group, and n is 0 to 2), a salt of the compound, or a prodrug or either is useful as an agent for modulating the function of an RFRP receptor.
摘要翻译：由式（I）表示的化合物：其中环A表示芳环; X表示键，氧，NR 4（R 4表示氢，烃基或杂环基）或亚烷基; R 1表示烃基或杂环基; R 2表示-COYR 5（Y表示键，亚烷基，氧，硫或NR 6（R 6） SUP>表示氢，烃基或杂环基），R 5表示烃基或杂环基），烃基或杂环基; 和R 3表示烃基，杂环基，任选取代的羟基，任选取代的氨基或-S（O）n R 7 （R 7表示烃基或杂环基，n为0〜2），化合物或前药的盐或其可用作调节其功能的试剂 RFRP受体。

5. 发明申请

US20060199795A1 Receptor agonists 失效
标题翻译：受体激动剂
公开(公告)号：US20060199795A1
公开(公告)日：2006-09-07
申请号：US10543997
申请日：2004-01-27
申请人： Fumio Itoh , Shuji Hinuma , Naoyuki Kanzaki , Takashi Miki , Yuji Kawamata , Satoru Oi , Taisuke Tawaraishi , Yuji Ishichi , Mariko Hirohashi
发明人： Fumio Itoh , Shuji Hinuma , Naoyuki Kanzaki , Takashi Miki , Yuji Kawamata , Satoru Oi , Taisuke Tawaraishi , Yuji Ishichi , Mariko Hirohashi
IPC分类号： A61K31/554 , A61K31/553 , A61K31/5513
CPC分类号： C07D267/14 , A61K31/4353 , A61K31/5513 , A61K31/553
摘要： The present invention provides a TGR5 receptor agonist comprising a fused ring compound represented by the formula wherein ring A is an optionally substituted aromatic ring; and ring B′ is a 5- to 8-membered ring having one or more substituents or a salt thereof or a prodrug thereof, which is useful for the treatment of various diseases.
摘要翻译：本发明提供一种TGR5受体激动剂，其包含由下式表示的稠环化合物：其中环A为任选取代的芳环; 环B'是具有一个或多个取代基的5-至8-元环或其盐或其前药，其可用于治疗各种疾病。

6. 发明授权

US07045497B1 Use of peptide 失效
标题翻译：使用肽
公开(公告)号：US07045497B1
公开(公告)日：2006-05-16
申请号：US09868885
申请日：1999-12-22
申请人： Hirokazu Matsumoto , Chieko Kitada , Shuji Hinuma
发明人： Hirokazu Matsumoto , Chieko Kitada , Shuji Hinuma
IPC分类号： A61K38/11 , A61K38/16 , C07K14/00 , C07H21/04
CPC分类号： A61K38/2257
摘要： The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on oxytocin secretion, it is useful as a drug for ameliorating, preserving or treating various diseases related to oxytocin secretion such as uterine inertia, atonic hemorrhage, placental expulsion, subinvolution and the like.
摘要翻译：本发明涉及G蛋白偶联受体蛋白识别为配体的肽的用途。由于本发明的配体多肽对催产素分泌具有刺激作用，因此可用作改善，保存或治疗与催产素分泌相关的各种疾病如子宫惯性，失声性出血，胎盘排出，亚溶解等的药物。

7. 发明授权

US06492324B1 APJ ligand polypeptides 失效
标题翻译： APJ配体多肽
公开(公告)号：US06492324B1
公开(公告)日：2002-12-10
申请号：US09255518
申请日：1999-02-22
申请人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
发明人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
IPC分类号： C07K400
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
摘要翻译：本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物，例如艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。

8. 发明授权

US06228984B1 Polypeptides their production and use 失效
标题翻译：多肽的生产和使用
公开(公告)号：US06228984B1
公开(公告)日：2001-05-08
申请号：US08776971
申请日：1997-02-07
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K1447
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译：本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选的药物候选化合物。特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

9. 发明授权

US5241053A Fused proteins comprising glycoprotein gD of HSV-1 and LTB 失效
标题翻译：包含HSV-1和LTB的糖蛋白gD的融合蛋白
公开(公告)号：US5241053A
公开(公告)日：1993-08-31
申请号：US577915
申请日：1990-09-05
申请人： Yukio Fujisawa , Shuji Hinuma , Aki Mayumi , Tatsuo Yamamoto
发明人： Yukio Fujisawa , Shuji Hinuma , Aki Mayumi , Tatsuo Yamamoto
IPC分类号： A61K39/00 , A61K47/48 , C07K14/035 , C07K14/245
CPC分类号： C07K14/245 , A61K47/4833 , C07K14/005 , A61K39/00 , C07K2319/40 , C07K2319/55 , C12N2710/16622
摘要： Disclosed are (1) a fused protein comprising heat-labile enterotoxin B subunit and a protein heterologous to heat-labile enterotoxin, (2) a recombinant DNA containing a nucleotide sequence coding for the above fused protein, (3) a transformant harboring the above recombinant DNA, (4) a method for producing the fused protein which comprises cultivating the above transformant, producing and accumulating the above fused protein in a culture, and collecting the fused protein, and (5) a method for purifying a fused protein comprising a herpes simplex virus surface antigen and heat-labile enterotoxin B subunit, which comprises cultivating a transformant harboring a recombinant DNA containing a nucleotide sequence coding for the fused protein, producing an accumulating the fused protein in a culture, collecting the fused protein and subjecting the collected fused protein to purification processes comprising cationic exchange chromatography and gel permeation chromatography.
摘要翻译：公开了（1）包含热不稳定肠毒素B亚基和与热不稳定肠毒素异源的蛋白质的融合蛋白，（2）含有编码上述融合蛋白的核苷酸序列的重组DNA，（3）含有上述重组DNA，（4）生产融合蛋白的方法，包括培养上述转化体，在培养物中产生和积累上述融合蛋白，并收集融合蛋白，和（5）纯化融合蛋白的方法，单纯疱疹病毒表面抗原和热不稳定肠毒素B亚基，其包括培养含有编码融合蛋白的核苷酸序列的重组DNA的转化体，产生在培养物中积聚融合蛋白，收集融合蛋白并使收集的融合蛋白与包含阳离子交换层析和凝胶渗透色谱的纯化方法。

10. 发明授权

US07927821B2 Methods of screening for compounds which bind G protein-coupled receptors 失效
标题翻译：筛选结合G蛋白偶联受体的化合物的方法
公开(公告)号：US07927821B2
公开(公告)日：2011-04-19
申请号：US11578325
申请日：2005-04-11
申请人： Ryo Fujii , Shoichi Okubo , Kazunori Nishi , Shuji Hinuma , Masaaki Mori
发明人： Ryo Fujii , Shoichi Okubo , Kazunori Nishi , Shuji Hinuma , Masaaki Mori
IPC分类号： G01N33/53 , G01N33/567 , G01N33/566 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： G01N33/76 , A61K31/403 , A61K31/4155 , A61K31/4523 , A61K38/1796 , C07K14/705 , G01N2333/726
摘要： The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.
摘要翻译：本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含使用受体蛋白或其盐和配体或其盐; 本发明可用于预防/治疗例如白细胞减少症，白血病，淋巴瘤，恶性肿瘤，溃疡性结肠炎，类风湿性关节炎，炎性肠病，扁桃体病，胶原病，炎性疾病，白细胞增多症，心脏病失败，遗传性肌肉疾病，肌营养不良症，神经肌肉退行性疾病，心肌梗死，肥胖症，糖尿病，高脂血症，动脉硬化，代谢综合征，血小板减少症，血小板增多症，癌症，肺水肿，多器官衰竭等。

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