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1. 发明申请

US20060252797A1 Receptor regulator 审中-公开
标题翻译：受体调节剂
公开(公告)号：US20060252797A1
公开(公告)日：2006-11-09
申请号：US10533833
申请日：2003-11-05
申请人： Masahiro Kajino , Shuji Hinuma , Naoki Tarui , Toshiro Yamashita , Yutaka Nakayama
发明人： Masahiro Kajino , Shuji Hinuma , Naoki Tarui , Toshiro Yamashita , Yutaka Nakayama
IPC分类号： A61K31/4545 , A61K31/454 , C07D401/02 , C07D417/02
CPC分类号： C07D401/04 , A61K31/4468 , A61K31/454 , A61K31/4545 , C07D211/58 , C07D211/66 , C07D401/06 , C07D409/14 , C07D417/04 , C07D417/14
摘要： A compound having a partial structure represented by the formula (A) (wherein ring Xa represents a nitrogen-containing ring and R represents optionally substituted amino) or a salt thereof. The compound or salt is highly effective in regulating neuromedin U receptors and is useful as a preventive/therapeutic agent for hypertension, etc.
摘要翻译：具有由式（A）表示的部分结构的化合物（其中环Xa表示含氮环，R表示任选取代的氨基）或其盐。该化合物或盐在调节神经介肽U受体方面非常有效，并且可用作高血压等的预防/治疗剂。

2. 发明授权

US06953789B2 Thiol compounds, their production and use 失效
标题翻译：硫醇化合物，其生产和使用
公开(公告)号：US06953789B2
公开(公告)日：2005-10-11
申请号：US10757325
申请日：2004-01-13
申请人： Toshiro Yamashita , Hiroshi Nara , Masayuki Takizawa , Koji Yoshimura
发明人： Toshiro Yamashita , Hiroshi Nara , Masayuki Takizawa , Koji Yoshimura
IPC分类号： A61P19/02 , A61P19/10 , C07D207/26 , C07D207/273 , C07D207/40 , C07D207/416 , C07D209/48 , C07D211/76 , C07D211/78 , C07D211/88 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D223/10 , A61K31/4025 , A61K31/55 , C07D207/50
CPC分类号： C07D207/273 , C07D207/40 , C07D207/416 , C07D209/48 , C07D211/76 , C07D211/78 , C07D211/88 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12
摘要： The present invention provides a compound represented by Formula: wherein ring A and ring B may be same or different and each is an optionally substituted homocyclic or heterocyclic ring and the like, each R1 may be same or different and is a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group, an optionally substituted heterocyclic group or SR2, etc., X1 is a bond, an optionally substituted divalent C1-3 aliphatic hydrocarbon group or —NR3—, etc, X2 is a bond, an optionally substituted divalent C1-3 aliphatic hydrocarbon group, —NR4—, —O— or —S(O)p— (wherein p is 0, 1 or 2), each Y may be same or different and is a hydrogen atom, an optionally substituted hydrocarbon group, a halogen atom, a carboxyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, SR5, an oxo group, a thioxo group, an optionally substituted imino group, a nitro group, a cyano group, etc., each m may be same or different and is 0 or 1, n is an integer of 1 to 3, q1 is an integer of 1 to 2n+4, q2 is an integer of 0 to 2n+3, and the sum of q1 and q2 is 2n+4 or a salt thereof.
摘要翻译：本发明提供由下式表示的化合物：其中环A和环B可以相同或不同，并且各自为任选取代的杂环或杂环等，每个R 1可以相同或不同并且是氢原子，任选取代的烃基，酰基，任选取代的杂环基或SR 2等，X 1是一个键，任选地取代的二价C 1-3 - 脂族烃基或-NR 3 - 等，X 2是一个键，任选取代的二价C < -SO 3 - 脂族烃基，-NR 4 - ， - O-或-S（O）p - （其中p为0,1）或2）中，每个Y可以相同或不同，为氢原子，任选取代的烃基，卤素原子，羧基，酰基，任选取代的羟基，任选取代的氨基，SR

3. 发明授权

US06699881B2 Thiol compounds, their production and use 失效
标题翻译：硫醇化合物，其生产和使用
公开(公告)号：US06699881B2
公开(公告)日：2004-03-02
申请号：US10161289
申请日：2002-06-03
申请人： Toshiro Yamashita , Hiroshi Nara , Masayuki Takizawa , Koji Yoshimura
发明人： Toshiro Yamashita , Hiroshi Nara , Masayuki Takizawa , Koji Yoshimura
IPC分类号： C07D21198
CPC分类号： C07D207/273 , C07D207/40 , C07D207/416 , C07D209/48 , C07D211/76 , C07D211/78 , C07D211/88 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12
摘要： The present invention provides a compound represented by Formula: wherein ring A and ring B may be same or different and each is an optionally substituted homocyclic or heterocyclic ring and the like, each R1 may be same or different and is a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group, an optionally substituted heterocyclic group or SR2, etc., X1 is a bond, an optionally substituted divalent C1-3 aliphatic hydrocarbon group or —NR3—, etc, X2 is a bond, an optionally substituted divalent C1-3 aliphatic hydrocarbon group, —NR4—, —O— or —S(O)p— (wherein p is 0, 1 or 2), each Y may be same or different and is a hydrogen atom, an optionally substituted hydrocarbon group, a halogen atom, a carboxyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, SR5, an oxo group, a thioxo group, an optionally substituted imino group, a nitro group, a cyano group, etc., each m may be same or different and is 0 or 1, n is an integer of 1 to 3, q1 is an integer of 1 to 2n+4, q2 is an integer of 0 to 2n+3, and the sum of q1 and q2 is 2n+4 or a salt thereof.
摘要翻译：本发明提供由下式表示的化合物：其中环A和环B可以相同或不同，并且各自为任选取代的杂环或杂环等，各R 1可以相同或不同，为氢原子，任选取代的烃基，酰基，任选取代的杂环基或SR 2等，X 1是键，任选取代的二价C 1-3脂族烃基或-NR 3 - 等等，X 2是键，任选取代的二价C 1-3脂族烃基，-NR 4 - ， - O-或-S（O）p - （其中p是0,1或2）每个Y可以相同或不同，为氢原子，任选取代的烃基，卤素原子，羧基，酰基，任选取代的羟基，任选取代的氨基，SR 5，氧代基，硫代基，任选取代的亚氨基，硝基，氰基等，各m可以相同或不同，为0o r 1，n为1〜3的整数，q1为1〜2n + 4的整数，q2为0〜2n + 3的整数，q1和q2的和为2n +4或其盐。

4. 发明授权

US06420415B1 Thiol compounds, their production and use 失效
标题翻译：硫醇化合物，其生产和使用
公开(公告)号：US06420415B1
公开(公告)日：2002-07-16
申请号：US09787623
申请日：2001-03-20
申请人： Toshiro Yamashita , Hiroshi Nara , Masayuki Takizawa , Koji Yoshimura
发明人： Toshiro Yamashita , Hiroshi Nara , Masayuki Takizawa , Koji Yoshimura
IPC分类号： C07D20750
CPC分类号： C07D207/273 , C07D207/40 , C07D207/416 , C07D209/48 , C07D211/76 , C07D211/78 , C07D211/88 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12
摘要： Compounds represented by general formula (1) or salts thereof which have a matrix metalloprotease inhibitory activity and are useful as drugs, wherein the rings A and B represent each an optionally substituted homocycle or heterocycle, etc.; R1s are the same or different and each represents hydrogen, optionally substituted hydrocarbyl, acyl, etc.; X1 represents a bond, optionally substituted divalent aliphatic hydrocarbyl, etc.; X2 represents a bond, optionally substituted divalent aliphatic hydrocarbyl, —O—, etc.; Ys are the same or different represents hydrogen, optionally substituted hydrocarbyl, oxo, etc.; m is 0 or 1; n is an integer of 1 to 3; q1 is an integer of 1 to 2n+4; and q2 is an integer of 0 to 2n+3, provided that q1+q2 is 2n+4.
摘要翻译：由通式（1）表示的化合物或其盐具有基质金属蛋白酶抑制活性，可用作药物，其中环A和B各自表示任选取代的杂环或杂环等; R 1相同或不同，各自表示氢，任选取代的烃基，酰基等; X1表示键，任选取代的二价脂族烃基等; X 2表示键，任选取代的二价脂族烃基，-O-等; Y相同或不同，表示氢，任选取代的烃基，氧代等; m为0或1; n为1〜3的整数。 q1为1〜2n + 4的整数，并且q2为0〜2n + 3的整数，条件是q1 + q2为2n + 4。

5. 发明授权

US5043459A Saccharoascorbic acid derivatives and production thereof 失效
标题翻译：蔗糖抗坏血酸衍生物及其生产
公开(公告)号：US5043459A
公开(公告)日：1991-08-27
申请号：US473154
申请日：1990-01-31
申请人： Koichi Matsumura , Yoshihiro Sugihara , Yoshiaki Shimizu , Kouichi Iida , Toshiro Yamashita
发明人： Koichi Matsumura , Yoshihiro Sugihara , Yoshiaki Shimizu , Kouichi Iida , Toshiro Yamashita
IPC分类号： C07D307/62
CPC分类号： C07D307/62
摘要： This invention relates to novel saccharoascorbic acid derivatives and their production. The derivatives are represented by the general formula set forth below, for example, an amido, a thioester or carboxylic ester of saccharoascorbic acid, and their salts.The compounds of the present invention are useful for food additives as antioxidants, an intermediate for the production of dichiral compounds and medicines having antithrombotic activity. ##STR1## wherein Z represents ##STR2## --SR.sub.6 or --OR.sub.7, R.sub.4 and R.sub.5 independently represent hydrogen or a hydrocarbon group of 1 to 24 carbon atoms, or R.sub.4 and R.sub.5 may together form --CH.sub.2 --.sub.n in which n is an integer of 4 to 7, R.sub.6 represents a hydrocarbon group of 1 to 24 carbon atoms, R.sub.7 represents hydrogen or a hydrocarbon group of 1 to 24 carbon atoms, R.sub.1, R.sub.2 and R.sub.3 independently represent hydrogen, an acyl group of 1 to 18 carbon atoms or a hydrocarbon group of 1 to 24 carbon atoms, and .about. represents the R-configration or the S-configration; provided that when Z is --OR.sub.7, R.sub.1 and R.sub.2 are not the same and R.sub.3 is hydrogen, or a salt thereof.

6. 发明申请

US20090264650A1 Prophylactic/Therapeutic Agent for Diabetes 审中-公开
标题翻译：糖尿病预防/治疗药物
公开(公告)号：US20090264650A1
公开(公告)日：2009-10-22
申请号：US11887358
申请日：2006-03-31
申请人： Nobuo Cho , Shizuo Kasai , Toshiro Yamashita
发明人： Nobuo Cho , Shizuo Kasai , Toshiro Yamashita
IPC分类号： C07D413/04 , C07D207/38 , C07D405/08 , C07D401/04 , C07D413/12
CPC分类号： C07D211/76 , C07D207/26 , C07D207/50 , C07D223/10 , C07D233/34 , C07D233/36 , C07D235/26 , C07D239/10 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention relates to a 11β-hydroxysteroid dehydrogenase 1 inhibitor comprising a compound represented by the formula (1): wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof. The 11β-hydroxysteroid dehydrogenase 1 inhibitor of the present invention has a superior activity, and is useful as a pharmaceutical agent such as agents for the prophylaxis or treatment of diabetes, insulin resistance, obesity, abnormal lipid metabolism, hypertension and the like, and the like.
摘要翻译：本发明涉及包含由式（1）表示的化合物的11b-羟基类固醇脱氢酶1抑制剂：其中每个符号如说明书中所定义，或其盐或其前药。本发明的11β-羟类固醇脱氢酶1抑制剂具有优异的活性，可用作糖尿病，胰岛素抵抗，肥胖，脂代谢异常，高血压等药物等药剂，喜欢。

7. 发明授权

US5538998A Halopropiolamide compound, production and use thereof 失效
标题翻译：卤代丙酰胺化合物，其生产和使用
公开(公告)号：US5538998A
公开(公告)日：1996-07-23
申请号：US327396
申请日：1994-10-21
申请人： Yoshihiro Sugihara , Toshiro Yamashita , Sachio Shibata , Koichi Matsumura , Yosei Kuwazuru
发明人： Yoshihiro Sugihara , Toshiro Yamashita , Sachio Shibata , Koichi Matsumura , Yosei Kuwazuru
IPC分类号： A01N37/18 , A01N43/40 , C07C233/09 , C07C233/14 , C07C233/15 , C07D213/40 , C07D295/185
CPC分类号： C07D213/40 , A01N37/18 , A01N43/40 , C07C233/09 , C07C233/14 , C07C233/15 , C07D295/185 , C07C2101/14
摘要： There are provided with a novel N-substituted-3-halopropiolamide compound, a method of producing the compound, and a composition for controlling noxious organisms containing the compound. The present compound exhibits superior antimicrobial and antifungal effects. Pest control agents containing the compound can advantageously be used for wide applications.
摘要翻译：提供了新的N-取代-3-卤代丙酰胺化合物，该化合物的制备方法和用于控制含有该化合物的有害生物的组合物。本发明化合物具有优异的抗菌和抗真菌作用。含有该化合物的害虫控制剂可有利地用于广泛的应用。

8. 发明授权

US06339804B1 Fast-forward/fast-backward intermittent reproduction of compressed digital data frame using compression parameter value calculated from parameter-calculation-target frame not previously reproduced 失效
标题翻译：使用从先前未被再现的参数计算目标帧计算出的压缩参数值来进行压缩数字数据帧的快进/快退间歇再现
公开(公告)号：US06339804B1
公开(公告)日：2002-01-15
申请号：US09233184
申请日：1999-01-20
申请人： Toshiaki Shimoda , Takashi Morita , Toshiro Yamashita , Tetsuya Takahashi , Yoshiro Nishimoto , Kazushige Harada
发明人： Toshiaki Shimoda , Takashi Morita , Toshiro Yamashita , Tetsuya Takahashi , Yoshiro Nishimoto , Kazushige Harada
IPC分类号： G06F1312
CPC分类号： G11B20/00007 , G11B20/10 , G11B27/005 , G11B2220/2529 , G11B2220/2545 , G11B2220/61
摘要： A digital information reproduction apparatus for compressing frames of data so as to intermittently reproduce the data in fast-forward speed. A data re-write device retrieves a reproduction-target frame for the fast-forward reproduction and a parameter-calculation-target frame exclusively for calculation of the frame data parameters. The frames then are transferred to a RAM. A decoder determines the frame data in the RAM, calculates the parameter-calculation frame data, and decodes the reproduction frame data by use of the parameter obtained as above. The described operation prevents expending the reproduction frame data with an incorrect parameter so as to normally fast-forward reproduce the compressed data. Furthermore, the present can select a frame used in the fast forward reproduction according to a feature index so that a section subjected to the fast-forward reproduction can be easily grasped by the user.
摘要翻译：一种用于压缩数据帧以便以快进速度间歇地再现数据的数字信息再现设备。数据重写装置检索用于快进再现的再现目标帧和唯一用于计算帧数据参数的参数计算目标帧。然后将帧传送到RAM。解码器确定RAM中的帧数据，计算参数计算帧数据，并通过使用如上获得的参数对再现帧数据进行解码。所描述的操作防止用不正确的参数来扩展再现帧数据，以便正常快进再现压缩数据。此外，本发明可以根据特征索引来选择在快进再生中使用的帧，从而可以容易地掌握经历快进再现的部分。

9. 发明授权

US06292847B1 Digital information reproducing apparatus and digital information distributing system 失效
标题翻译：数字信息再现装置和数字信息分发系统
公开(公告)号：US06292847B1
公开(公告)日：2001-09-18
申请号：US09203751
申请日：1998-12-02
申请人： Yoshiro Nishimoto , Takashi Morita , Toshiro Yamashita , Tetsuya Takahashi , Toshiaki Shimoda , Kazushige Harada
发明人： Yoshiro Nishimoto , Takashi Morita , Toshiro Yamashita , Tetsuya Takahashi , Toshiaki Shimoda , Kazushige Harada
IPC分类号： G06F300
CPC分类号： G11B20/10527 , G11B20/00007
摘要： A digital information reproducing apparatus in accordance with a prior art that uses a semiconductor memory to realize a memory means cannot reproduce digital data which has been encoded according to a compression coding form different from the one adopted by an incorporated decoding circuit. According to the present invention, a decoding program stored in a second semiconductor memory is selected according to a compression coding form adopted for digital data stored in a first semiconductor memory. The selected decoding program is used to decode the digital data by means of an arithmetic circuit. Thus, digital information can be reproduced irrespective of a compression coding form adopted for provided digital information.
摘要翻译：根据现有技术的使用半导体存储器来实现存储装置的数字信息再现装置不能再现已经根据与内置的解码电路采用的压缩编码形式不同的压缩编码形式来编码的数字数据。根据本发明，根据存储在第一半导体存储器中的数字数据采用的压缩编码形式来选择存储在第二半导体存储器中的解码程序。所选择的解码程序用于通过算术电路解码数字数据。因此，无论为所提供的数字信息采用的压缩编码形式如何，都可以再现数字信息。

10. 发明授权

US06930104B2 Heterocyclic derivatives 失效
标题翻译：杂环衍生物
公开(公告)号：US06930104B2
公开(公告)日：2005-08-16
申请号：US10474963
申请日：2002-04-25
申请人： Mitsuru Kakihana , Kaneyoshi Kato , Masaaki Mori , Toshiro Yamashita
发明人： Mitsuru Kakihana , Kaneyoshi Kato , Masaaki Mori , Toshiro Yamashita
IPC分类号： A61K31/4709 , A61K31/4725 , A61K31/473 , A61K31/496 , A61K31/498 , A61K31/538 , A61K31/5415 , A61K31/55 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07D215/22 , C07D215/233 , C07D215/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/10 , C07D401/02 , A61K31/47
CPC分类号： C07D215/233 , A61K31/4709 , A61K31/4725 , A61K31/473 , A61K31/496 , A61K31/498 , A61K31/538 , A61K31/5415 , A61K31/55 , C07D215/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/10
摘要： The object of the present invention is to provide soluble β-amyloid precursor protein secretory stimulators, which are effective in treating neurodegenerative diseases as well as cerebrovascular disorder-induced neuronopathy. More specifically, the present invention provides a novel compound of the following Formula (I) or a salt or prodrug thereof: [wherein R1 and R2 each represent a hydrogen atom or a lower alkyl group, etc., Ar1 and the ring B each represent an optionally substituted aromatic group, the ring A represents an optionally substituted benzene ring, the ring C represents an optionally substituted 4- to 8-membered ring which may further be condensed with an optionally substituted ring, X represents CH or N, and Y represents CH or N].
摘要翻译：本发明的目的是提供可溶性β-淀粉样蛋白前体蛋白分泌刺激剂，其可有效治疗神经变性疾病以及脑血管障碍诱导的神经元病变。更具体地说，本发明提供下式（I）的新化合物或其盐或前药：其中R 1和R 2各自表示氢原子或低级烷基等，Ar 1和B各自表示任选取代的芳族基团，环A表示任选取代的苯环，环C表示任选取代的4-至可以进一步与任选取代的环稠合的8-元环，X表示CH或N，Y表示CH或N。

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