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1. 发明申请

US20050085708A1 System and method for preparation of cells for 3D image acquisition 审中-公开
标题翻译：用于3D图像采集的细胞的制备和方法
公开(公告)号：US20050085708A1
公开(公告)日：2005-04-21
申请号：US10968645
申请日：2004-10-19
申请人： Mark Fauver , Alan Nelson , John Rahn , Eric Seibel , Florence Patten , Shawn McGuire
发明人： Mark Fauver , Alan Nelson , John Rahn , Eric Seibel , Florence Patten , Shawn McGuire
IPC分类号： G01N21/17 , A61B10/00 , G01N15/14 , G01N21/21 , G01N21/47 , A61B5/05
CPC分类号： G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/4795 , G01N2015/1006 , G01N2015/1075 , G01N2201/0813 , G01N2223/612 , G06T11/006 , G06T2211/421
摘要： The present invention provides a method for embedding particles in a solid structure including the steps of extruding a slurry of particles and a polymeric solution into a linear polymer medium having particles embedded into a polymer portion; and curing the polymer portion of the linear polymer medium.
摘要翻译：本发明提供一种嵌入固体结构的颗粒的方法，包括以下步骤：将颗粒浆料和聚合物溶液挤出到具有嵌入聚合物部分中的颗粒的线性聚合物介质中; 并固化线性聚合物介质的聚合物部分。

2. 发明申请

US20050085721A1 System and method for processing specimens and images for optical tomography 有权
标题翻译：用于光学层析成像的标本和图像处理系统和方法
公开(公告)号：US20050085721A1
公开(公告)日：2005-04-21
申请号：US10964508
申请日：2004-10-13
申请人： Mark Fauver , John Rahn , Eric Seibel , Alan Nelson
发明人： Mark Fauver , John Rahn , Eric Seibel , Alan Nelson
IPC分类号： A61B5/05 , G02B21/00 , G02B21/36
CPC分类号： G02B21/002 , G02B21/365
摘要： A scanning method for scanning samples of biological cells using optical tomography includes preparing, acquiring, reconstructing and viewing three-dimensional images of cell samples. Concentration and enrichment of the cell sample follows. The cell sample is stained. Cells are isolated from the cell sample and purified. A cell/solvent mixture is injected into a gel by centrifugation. A cell/gel mixture is injected into a capillary tube until a cell appears centered in a field of view using a step flow method. An optical imaging system, such as a fixed or variable motion optical tomography system acquires a projection image. The sample is rotated about a tube axis to generate additional projections. Once image acquisition is completed, the acquired shawdowgrams or image projections are corrected for errors. A computer or other equivalent processor is used to compute filtered backprojection information for 3D reconstruction.
摘要翻译：使用光学断层摄影扫描生物细胞样本的扫描方法包括准备，获取，重建和观察细胞样品的三维图像。细胞样品的浓缩和浓缩如下。细胞样品染色。细胞从细胞样品中分离并纯化。通过离心将细胞/溶剂混合物注入凝胶。将细胞/凝胶混合物注入毛细管中，直到细胞在视野中以步进流动法出现中心。诸如固定或可变运动光学断层摄影系统的光学成像系统获取投影图像。样品围绕管轴旋转以产生额外的突起。一旦完成图像采集，就可以纠正所获取的肖像图或图像投影。计算机或其他等效处理器用于计算用于3D重建的滤波反投影信息。

3. 发明申请

US20060096358A1 Optical projection tomography microscope 审中-公开
标题翻译：光学投影断层显微镜
公开(公告)号：US20060096358A1
公开(公告)日：2006-05-11
申请号：US10975162
申请日：2004-10-28
申请人： Mark Fauver , Alan Nelson
发明人： Mark Fauver , Alan Nelson
IPC分类号： G01N30/00
CPC分类号： G02B21/0004 , B82Y10/00 , B82Y20/00 , G01N15/147 , G01N15/1475 , G01N2021/1787
摘要： A rotational system including a cylindrical container with a cylindrical container axis. The cylindrical container is inserted into at least one pair of opposing polymer grippers. A motor is coupled to rotate the cylindrical container.
摘要翻译：一种旋转系统，包括具有圆柱形容器轴线的圆柱形容器。将圆筒形容器插入至少一对相对的聚合物夹持器中。电动机联接以旋转圆柱形容器。

4. 发明申请

US20070071357A1 METHOD FOR CORRECTION OF RELATIVE OBJECT-DETECTOR MOTION BETWEEN SUCCESSIVE VIEWS 有权
标题翻译：校正相关对象检测器运动的方法
公开(公告)号：US20070071357A1
公开(公告)日：2007-03-29
申请号：US11558593
申请日：2006-11-10
申请人： John Rahn , Alan Nelson
发明人： John Rahn , Alan Nelson
IPC分类号： G06K9/40 , G06K9/00
CPC分类号： G02B21/26 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/05 , G01N21/4795 , G01N2015/1006 , G01N2015/1075 , G01N2021/0346 , G01N2021/1787 , G01N2201/0813 , G01N2223/612 , G02B21/365 , G06T11/005 , G06T11/006 , G06T2211/412 , G06T2211/421
摘要： An apparatus and method for correction of relative object-detector motion between successive views during optical tomographic imaging in three dimensions. An object of interest is illuminated to produce an image. A lateral offset correction value is determined for the image. An axial offset correction value is determined for the image. The lateral offset correction value and the axial offset correction value are applied to the image to produce a corrected file image.
摘要翻译：一种用于在三维尺度下在光学层析成像期间校正连续视图之间的相对物体检测器运动的装置和方法。感兴趣的对象被照亮以产生图像。确定图像的横向偏移校正值。为图像确定轴向偏移校正值。将横向偏移校正值和轴向偏移校正值应用于图像以产生校正的文件图像。

5. 发明申请

US20050010108A1 Method for correction of relative object-detector motion between successive views 有权
标题翻译：在连续视图之间校正相对物体检测器运动的方法
公开(公告)号：US20050010108A1
公开(公告)日：2005-01-13
申请号：US10876328
申请日：2004-06-24
申请人： John Rahn , Alan Nelson
发明人： John Rahn , Alan Nelson
IPC分类号： G01N21/17 , A61B10/00 , G01N15/14 , G01N21/21 , G01N21/47 , A61B5/05
CPC分类号： G02B21/26 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/05 , G01N21/4795 , G01N2015/1006 , G01N2015/1075 , G01N2021/0346 , G01N2021/1787 , G01N2201/0813 , G01N2223/612 , G02B21/365 , G06T11/005 , G06T11/006 , G06T2211/412 , G06T2211/421
摘要： Registration correction for optical tomographic imaging in three dimensions. An object of interest is illuminated to produce an image. A lateral offset correction value is determined for the image. An axial offset correction value is determined for the image. The lateral offset correction value and the axial offset correction value are applied to the image to produce a corrected file image.
摘要翻译：光学层析成像三维注册校正。感兴趣的对象被照亮以产生图像。确定图像的横向偏移校正值。为图像确定轴向偏移校正值。将横向偏移校正值和轴向偏移校正值应用于图像以产生校正的文件图像。

6. 发明申请

US20060023219A1 Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification 审中-公开
标题翻译：使用平行射线照明和样本后光学放大的小物体的光学层析成像
公开(公告)号：US20060023219A1
公开(公告)日：2006-02-02
申请号：US11203878
申请日：2005-08-15
申请人： Michael Meyer , John Rahn , Alan Nelson , Roger Johnson
发明人： Michael Meyer , John Rahn , Alan Nelson , Roger Johnson
IPC分类号： G01N21/00
CPC分类号： G01N21/4795 , G01N15/147 , G01N15/1475
摘要： A shadowgram optical tomography system for imaging an object of interest. The shadowgram optical tomography system includes a parallel ray light source for illuminating the object of interest with a plurality of parallel radiation beams, an object containing tube, where the object of interest is held within the object containing tube such that it is illuminated by the plurality of parallel radiation beams to produce emerging radiation from the object containing tube, a detector array located to receive the emerging radiation, and a system and mehtod for tracking an image of the object of interest.
摘要翻译：一种用于对感兴趣对象进行成像的阴影图光学层析成像系统。阴影图光学层析成像系统包括用于利用多个平行辐射束照射感兴趣物体的平行射线光源，物体容纳管，其中感兴趣的物体被保持在物体容纳管内，使得其被多个的平行辐射束以产生来自物体容纳管的出射辐射，位于接收出射辐射的检测器阵列，以及用于跟踪感兴趣对象的图像的系统和设备。

7. 发明授权

US5246859A Method of stabilizing a carbon dioxide sensor 失效
标题翻译：稳定二氧化碳传感器的方法
公开(公告)号：US5246859A
公开(公告)日：1993-09-21
申请号：US888550
申请日：1992-05-22
申请人： Alan Nelson , Henry K. Hui , Monte Bennett , Soonkap Hahn , Charles S. Bankert , Jeffrey T. Jackson
发明人： Alan Nelson , Henry K. Hui , Monte Bennett , Soonkap Hahn , Charles S. Bankert , Jeffrey T. Jackson
IPC分类号： A61B5/145 , A61B5/1459 , G01N31/22 , G01N33/49 , G01N33/84
CPC分类号： G01N33/84 , G01N31/223 , Y10T436/102499 , Y10T436/108331 , Y10T436/20 , Y10T436/204998 , Y10T436/255
摘要： The method of stabilizing a carbon dioxide sensor involves formulation of a bicarbonate buffer solution in the sensor with a bicarbonate ion concentration of from about 100 mM to about 200 mM bicarbonate. The method also involves treatment of the sensor to reduce the instability that may occur in carbon dioxide sensors when such sensors are exposed to either very low or very high carbon dioxide levels for extended periods of time. The sensor is treated by exposing the sensor to an aqueous solution containing at least 2 weight percent carbon dioxide, for from several days to several months. The solution may be prepared in advance, or may be dynamically infused with carbon dioxide to provide the desired carbon dioxide content.
摘要翻译：稳定二氧化碳传感器的方法包括在传感器中配制碳酸氢盐缓冲溶液，碳酸氢根离子浓度为约100mM至约200mM碳酸氢盐。该方法还涉及传感器的处理，以减少二氧化碳传感器当这种传感器长时间暴露于非常低或非常高的二氧化碳水平时可能发生的不稳定性。通过将传感器暴露于含有至少2重量％二氧化碳的水溶液中来处理传感器，持续数天至数月。该溶液可以预先制备，或者可以动态地注入二氧化碳以提供所需的二氧化碳含量。

8. 发明申请

US20060172889A1 Low foaming formulation of gylphosate 审中-公开
标题翻译：草甘膦的低起泡配方
公开(公告)号：US20060172889A1
公开(公告)日：2006-08-03
申请号：US10509400
申请日：2003-03-21
申请人： Clyde Barnes , Alan Baylis , Jeffrey Fowler , Alan Nelson
发明人： Clyde Barnes , Alan Baylis , Jeffrey Fowler , Alan Nelson
IPC分类号： A01N57/18 , A01N25/16
CPC分类号： A01N57/20 , A01N25/30 , A01N2300/00
摘要： A low-foaming herbicidal composition comprises glyphosate and a poly(alkylene oxide)alkanol having the formula R1R2CH—R3—(OR4)n—OH (I) wherein R1 and R2 are methyl or ethyl, R3 is a straight chain alkylene group containing from 5 to 12 carbon atoms, R4 is an alkylene group containing 2 or 3 carbon atoms and n is from 4 to 20. Especially preferred is ethoxylated, propoxylated or mixed alkoxylated/propoxylated iso-tridecyl alcohol wherein the degree of alkoxylation is from 6 to 14, for example iso-tridecyl alcohol having 8 polyethylene oxide units. Preferred compositions additionally contain an alkylglycoside.
摘要翻译：低发泡除草组合物包含草甘膦和具有下式的聚（环氧烷）烷醇：R 1 R 2 CH-R 3 - （其中R 1和R 2均为甲基或乙基，其中R 1，R 2，R 2， SUB 3是含有5至12个碳原子的直链亚烷基，R 4是含有2或3个碳原子的亚烷基，n是4至20.特别优选的是乙氧基化的，丙氧基化的或混合的烷氧基化/丙氧基化的异十三烷醇，其中烷氧基化度为6至14，例如具有8个聚环氧乙烷单元的异十三醇。优选的组合物另外含有烷基糖苷。

9. 发明授权

US5903218A Pool alarm 失效
标题翻译：游泳池报警
公开(公告)号：US5903218A
公开(公告)日：1999-05-11
申请号：US131767
申请日：1998-08-10
申请人： Alan Nelson
发明人： Alan Nelson
IPC分类号： G08B21/08 , G08B23/00
CPC分类号： G08B21/084
摘要： A wave motion detector system for a swimming pool includes a transducer responsive to positive and negative pressure changes in swimming pool water and operative to generate corresponding electrical signals. Comparators are responsive to the electrical signals, and operative to generate a crest signal while the positive pressure exceeds a predetermined positive threshold level, and a trough signal while the negative pressure exceeds a predetermined negative threshold level. A band pass filter prevents electrical signals having a frequency greater than a predetermined upper frequency, and lower than a predetermined lower frequency from passing from the transducer to the comparators. A pulse width discriminator is responsive to the crest signal and the trough signal and is operative to generate a qualified crest signal if the crest signal remains active for a first predetermined time interval, and a qualified trough signal if the trough signal remains active for a second predetermined time interval. A counter circuit, responsive to the qualified crest signal and the qualified trough signal, determines a count value which is equal to the number of times the qualified trough signal and the qualified crest signal occur during a counting time interval. A processing circuit includes alarm condition detection circuitry responsive to the count value, and operative to generate an alarm signal if the count value is greater than or equal to a predetermined alarm count value. Annunciator means, responsive to the alarm signal, is operative to indicate an alarm condition if the alarm signal is generated.
摘要翻译：用于游泳池的波浪运动检测器系统包括响应于游泳池水中的正压力和负压变化的换能器，并且用于产生相应的电信号。比较器响应于电信号，并且在正压力超过预定的正阈值电平时产生峰值信号，并且在负压超过预定的负阈值电平时产生谷信号。带通滤波器防止具有大于预定上限频率的频率并且低于从传感器传递到比较器的预定较低频率的电信号。脉冲宽度鉴别器响应波峰信号和波谷信号，并且如果波峰信号在第一预定时间间隔内保持有效，并且如果波谷信号保持有效的第二预定时间间隔，则可操作以产生合格的波峰信号预定时间间隔。响应于合格的峰值信号和合格的槽信号的计数器电路确定等于合格的槽信号和合格的峰值信号在计数时间间隔期间发生的次数的计数值。处理电路包括响应于计数值的报警条件检测电路，并且如果计数值大于或等于预定的报警计数值则可操作以产生报警信号。指示器意味着响应于报警信号，如果产生报警信号，则可以指示报警状态。

10. 发明授权

US11052265B2 Fluence map optimization for field-in-field radiation therapy 有权
公开(公告)号：US11052265B2
公开(公告)日：2021-07-06
申请号：US16272230
申请日：2019-02-11
申请人： Troy Long , Alan Nelson
发明人： Troy Long , Alan Nelson
IPC分类号： A61N5/10
摘要： Improved radiation therapy with field-in-field multi-leaf collimator, utilizing leaf sequencing Field-in-Field's (FIF) to accurately reproduce the input fluence map or original optimized dose distribution. The number of apertures used is constrained to a user-specified value all the way down to as few as 2 apertures which significantly magnifies the effect of poorly formed apertures. The disclosed invention further includes producing fluence maps with a homogenous dose throughout the treated volume utilizing leaf-sequencing Field-in-Field that reproduces more precise input fluence maps to yield optimized dose distribution.

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