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1. 发明授权

US09561078B2 Multi-cladding optical fiber scanner 有权
标题翻译：多层光纤扫描仪
公开(公告)号：US09561078B2
公开(公告)日：2017-02-07
申请号：US12281251
申请日：2006-03-03
申请人： Eric Seibel , Richard Johnston , Charles David Melville
发明人： Eric Seibel , Richard Johnston , Charles David Melville
IPC分类号： A61N5/06 , A61B18/22 , A61B1/00 , A61B1/07
CPC分类号： A61B18/22 , A61B1/0008 , A61B1/0017 , A61B1/00172 , A61B1/07 , A61B2018/2238 , A61B2090/373
摘要： A multi-cladding optical fiber includes a core that conveys visible light used by a scanner for imaging a site within a patient's body, and an inner cladding that conveys high-power light, such as infrared light, used for providing therapy to site. The distal end of multi-cladding optical fiber is driven to scan the site when imaging or rendering therapy using an actuator. High-power light is coupled into inner cladding at proximal end of optical fiber using several different techniques. Some techniques use an axicon to direct the high-power light into the inner cladding, while visible light is coupled directly into the core. Another technique uses a multimode optical fiber in a coupling relationship with the multi-cladding optical fiber, to transfer high-power light from a core of the multimode fiber into the inner cladding of the multi-cladding optical fiber.
摘要翻译：多层包层光纤包括传送用于对患者体内部位进行成像的扫描器所使用的可见光的芯，以及传送用于提供现场治疗的高功率光（例如红外光）的内包层。当使用致动器进行成像或渲染治疗时，驱动多包层光纤的远端来扫描现场。使用几种不同的技术将大功率光耦合到光纤近端的内包层。一些技术使用旋转三棱镜将高功率光引导到内包层中，而可见光直接耦合到芯中。另一种技术使用与多包层光纤耦合关系的多模光纤，将大功率光从多模光纤的芯转移到多包层光纤的内包层。

2. 发明申请

US20070299309A1 MONITORING DISPOSITION OF TETHERED CAPSULE ENDOSCOPE IN ESOPHAGUS 有权
标题翻译：在ESOPHAGUS中监测治疗的胶囊内窥镜的处理
公开(公告)号：US20070299309A1
公开(公告)日：2007-12-27
申请号：US11852227
申请日：2007-09-07
申请人： Eric Seibel , Richard Johnston
发明人： Eric Seibel , Richard Johnston
IPC分类号： A61B1/00
CPC分类号： A61B1/2733 , A61B1/00009 , A61B1/00055 , A61B1/0008 , A61B1/00087 , A61B1/00147 , A61B1/00172 , A61B1/015 , A61B1/041 , A61B1/043 , A61B1/0638 , A61B1/0661 , A61B1/07 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/1455 , A61B5/14556 , A61B5/4233 , A61N5/0603 , A61N5/062 , A61N2005/0609
摘要： A scanning flexible endoscope includes a tether attached to a capsule. The tether controls a disposition of the capsule within a body lumen such as the esophagus. A scanning device in the capsule optically scans the adjacent tissue on the inside surface of the body lumen as the capsule is moved axially through the body lumen. A non-contact sensor responds to indicia on the tether to measure a relative position of the tether and the capsule in the body lumen. The indicia can be analog or digital in form and the sensor can be either magnetic, or optical. A wiper is optionally provided to remove bodily fluids from the tether when pulled from the body lumen past the sensor. A pulse of fluid can be delivered to the distal end of the tether to cause the body lumen to distend, facilitating free movement of the capsule in the lumen.
摘要翻译：扫描柔性内窥镜包括附接到胶囊的系绳。系绳控制胶囊在诸如食道的体腔内的布置。当胶囊沿轴向移动通过体腔时，胶囊中的扫描装置对体腔的内表面上的相邻组织进行光学扫描。非接触传感器对系绳上的标记进行响应以测量系链和胶囊在体腔中的相对位置。标记可以是模拟或数字形式，传感器可以是磁性的或光学的。可选地提供擦拭器以当从身体腔腔被拉出传感器时从体系中除去体液。流体脉冲可以被输送到系绳的远端，以使体腔扩张，促进胶囊在内腔中的自由运动。

3. 发明申请

US20060149134A1 Catheterscope 3D guidance and interface system 有权
公开(公告)号：US20060149134A1
公开(公告)日：2006-07-06
申请号：US11342074
申请日：2006-01-27
申请人： Timothy Soper , Robb Glenny , Eric Seibel
发明人： Timothy Soper , Robb Glenny , Eric Seibel
IPC分类号： A61B1/04 , A61B1/06
CPC分类号： A61B5/066 , A61B1/00009 , A61B1/00016 , A61B1/00045 , A61B1/0008 , A61B1/00172 , A61B1/005 , A61B1/04 , A61B1/07 , A61B1/2676 , A61B5/06 , A61B5/062 , A61B5/065 , A61B5/08 , A61B5/0816 , A61B5/7285 , A61B6/541 , A61B34/20 , A61B2034/2051 , A61B2090/3762
摘要： Visual-assisted guidance of an ultra-thin flexible endoscope to a predetermined region of interest within a lung during a bronchoscopy procedure. The region may be an opacity-identified by non-invasive imaging methods, such as high-resolution computed tomography (HRCT) or as a malignant lung mass that was diagnosed in a previous examination. An embedded position sensor on the flexible endoscope indicates the position of the distal tip of the probe in a Cartesian coordinate system during the procedure. A visual display is continually updated, showing the present position and orientation of the marker in a 3-D graphical airway model generated from image reconstruction. The visual display also includes windows depicting a virtual fly-through perspective and real-time video images acquired at the head of the endoscope, which can be stored as data, with an audio or textual account.

4. 发明申请

US20050173817A1 OPTICAL BEAM SCANNING SYSTEM FOR COMPACT IMAGE DISPLAY OR IMAGE ACQUISITION 有权
标题翻译：用于紧凑图像显示或图像获取的光束扫描系统
公开(公告)号：US20050173817A1
公开(公告)日：2005-08-11
申请号：US11074241
申请日：2005-03-02
申请人： Mark Fauver , Eric Seibel , Janet Crossman-Bosworth
发明人： Mark Fauver , Eric Seibel , Janet Crossman-Bosworth
IPC分类号： A61B19/00 , G02B6/00 , G02B6/25 , G02B6/255 , G02B6/26 , G02B6/32 , G02B26/08 , G02B26/10 , G02B6/42 , B29D11/00
CPC分类号： G02B26/0875 , A61B2090/3614 , G02B6/25 , G02B6/2552 , G02B6/262 , G02B6/32 , G02B26/101 , G02B2006/0098
摘要： An optical fiber having a reduced cross-sectional region adjacent to its distal end, which is fused to an optical component, is vibrated, rotating the optical component to scan a region. The optical component has a back focal point that is substantially coincident with an effective light source of the optical fiber, so that the light emanating from the optical component is either substantially collimated or convergent. The optical component is either a ball lens, a drum lens, a graded index lens, or a diffractive optical element. A vibratory node is also made substantially coincident with the back focal point of the optical component, producing a compact scanner with extensive field of view. The optical fiber is preferably reduced in cross-sectional area after the optical component is fused to the optical fiber, by immersion in a three-layer etch apparatus having an etch-stop layer, an etch layer, and a solvent layer.
摘要翻译：具有与其远端相邻的与光学部件熔合的横截面减小的光纤振动，旋转光学部件以扫描区域。光学部件具有与光纤的有效光源基本一致的后焦点，使得从光学部件发出的光基本上准直或收敛。光学部件是球形透镜，鼓形透镜，渐变折射率透镜或衍射光学元件。振动节点也基本上与光学部件的后焦点重合，产生具有广泛视场的紧凑型扫描仪。光学元件通过浸入具有蚀刻停止层，蚀刻层和溶剂层的三层蚀刻装置中而在光学元件熔合到光纤之后，优选地减小横截面积。

5. 发明申请

US20050159662A1 Methods for assessing a physiological state of a mammalian retina 有权
标题翻译：用于评估哺乳动物视网膜的生理状态的方法
公开(公告)号：US20050159662A1
公开(公告)日：2005-07-21
申请号：US10926780
申请日：2004-08-26
申请人： Yoshikazu Imanishi , Krzysztof Palczewski , Bryan Sires , Eric Seibel
发明人： Yoshikazu Imanishi , Krzysztof Palczewski , Bryan Sires , Eric Seibel
IPC分类号： A61B3/12 , A61B5/00
CPC分类号： A61B5/0059 , A61B3/10 , A61B3/1025
摘要： In one aspect the present invention provides methods for assessing a physiological state of a mammalian retina in vivo, the methods of this aspect of the invention each include the steps of: (a) irradiating a portion of a mammalian retina, in vivo, with light having a wavelength in the range of from 600 nm to 1000 nm at an intensity sufficient to stimulate two-photon-induced fluorescence in the retina; and (b) assessing a physiological state of the retina by analyzing the fluorescence.
摘要翻译：一方面，本发明提供了用于评估体内哺乳动物视网膜的生理状态的方法，本发明的这个方面的方法各自包括以下步骤：（a）在体内用光照射哺乳动物视网膜的一部分具有在600nm至1000nm范围内的波长，其强度足以刺激视网膜中的双光子诱导荧光; 和（b）通过分析荧光来评估视网膜的生理状态。

6. 发明授权

US08396535B2 Integrated optical scanning image acquisition and display 有权
标题翻译：集成光学扫描图像采集和显示
公开(公告)号：US08396535B2
公开(公告)日：2013-03-12
申请号：US12434129
申请日：2009-05-01
申请人： Wei-Chih Wang , Eric Seibel , Per Reinhall , Mark Fauver , Chris Brown
发明人： Wei-Chih Wang , Eric Seibel , Per Reinhall , Mark Fauver , Chris Brown
IPC分类号： A61B6/00
CPC分类号： A61B5/0062 , A61B1/00048 , A61B1/0008 , A61B1/00165 , A61B1/00167 , A61B1/00172 , A61B1/00183 , A61B1/00193 , A61B1/0051 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1076 , A61N5/0601 , A61N5/062 , G02B6/262 , G02B6/32 , G02B6/3502 , G02B6/3566 , G02B6/357 , G02B6/3572 , G02B6/3578 , G02B23/2484 , G02B26/0875 , G02B26/10 , G02B26/101
摘要： An apparatus and method for providing image acquisition and/or image display in a limited region of interest (ROI). The apparatus comprises a micro-electro-mechanical system (MEMS), preferably integrating a light source, a cantilever, a lens, an actuator, a light detector, and a position sensor. The light source provides light for illuminating the ROI, displaying an image, providing a therapy, and/or performing other functions. The cantilever comprises a resin waveguide with a fixed end attached to a substrate that supports many or all other components. A free end of the cantilever is released from the substrate during fabrication and includes the lens. The actuator scans the free end in orthogonal directions to illuminate the ROI or display an image. The position sensors detect the position of the free end for control. The light detector receives light backscattered from the ROI separate from, or at the fixed end of the cantilever.
摘要翻译：一种用于在有限的感兴趣区域（ROI）中提供图像获取和/或图像显示的装置和方法。该装置包括微机电系统（MEMS），优选地集成光源，悬臂，透镜，致动器，光检测器和位置传感器。光源提供用于照亮ROI，显示图像，提供治疗和/或执行其他功能的光。悬臂包括具有固定端连接到支撑多个或所有其它部件的基板的树脂波导。在制造过程中，悬臂的自由端从基板释放并且包括透镜。致动器沿正交方向扫描自由端以照亮ROI或显示图像。位置传感器检测自由端的位置进行控制。光检测器从与悬臂的固定端分离或在悬臂的固定端接收来自ROI的反向散射光。

7. 发明申请

US20090137893A1 ADDING IMAGING CAPABILITY TO DISTAL TIPS OF MEDICAL TOOLS, CATHETERS, AND CONDUITS 审中-公开
标题翻译：将成像能力提高到医疗工具，导管和导管的距离
公开(公告)号：US20090137893A1
公开(公告)日：2009-05-28
申请号：US11945884
申请日：2007-11-27
申请人： Eric Seibel , Michael Kimmey , Richard Johnston
发明人： Eric Seibel , Michael Kimmey , Richard Johnston
IPC分类号： A61B5/05
CPC分类号： G02B23/2407 , A61B1/0005 , A61B1/00096 , A61B1/00167 , A61B1/00172 , A61B1/00181 , A61B1/00183 , A61B1/00193 , A61B1/0638 , A61B1/0669 , A61B1/07 , A61B5/0062 , A61B5/0068 , G02B6/06 , G02B26/103
摘要： One or more scan illuminators and a plurality of light receivers are provided on the distal end of a tool or other component, so that a plurality of images of a site can be provided in response to output signals from the plurality of light receivers. The output signals from the plurality of light receivers are combined to produce an overall image of the site or a plurality of different images from disparate positions. The plurality of images can be viewed separately to produce a stereo or perspective view, or can be produced using different wavebands of light to provide enhanced information about the site that facilitates use of one or more tools or components at the site. The scan illuminator(s) and plurality of light receivers can be configured to be added to an existing tool or component.
摘要翻译：一个或多个扫描照明器和多个光接收器设置在工具或其他部件的远端上，使得可以响应于来自多个光接收器的输出信号来提供现场的多个图像。来自多个光接收器的输出信号被组合以从不同位置产生位置的整体图像或多个不同图像。多个图像可以单独观看以产生立体视图或透视图，或者可以使用不同的光波段来产生，以便提供有助于在站点上使用一个或多个工具或组件的站点的增强信息。扫描照明器和多个光接收器可以被配置为被添加到现有的工具或部件。

8. 发明申请

US20080058629A1 OPTICAL FIBER SCOPE WITH BOTH NON-RESONANT ILLUMINATION AND RESONANT COLLECTION/IMAGING FOR MULTIPLE MODES OF OPERATION 审中-公开
标题翻译：具有多次非共振照明和共振收集/成像的光纤范围，用于多种操作模式
公开(公告)号：US20080058629A1
公开(公告)日：2008-03-06
申请号：US11465988
申请日：2006-08-21
申请人： Eric Seibel , Richard S. Johnston , Timothy Soper , Charles D. Melville
发明人： Eric Seibel , Richard S. Johnston , Timothy Soper , Charles D. Melville
IPC分类号： A61B5/00
CPC分类号： A61B1/04 , A61B1/0008 , A61B1/00165 , A61B1/00172 , A61B1/07
摘要： A scanning fiber endoscope (SFE) system selectively operable in a plurality of different modes. One or more illumination optical fibers convey different types of light to an internal site. A scanner that is resonantly driven in a desired pattern collects light from the internal site. The scanner can be a cantilevered distal end of a scanning optical fiber or a scanning mirror. The illumination optical fiber(s) can be moved in a non-resonant manner to alter the direction at which the light is emitted. In a therapy mode, a relatively high-power light can be applied to the site, while in a monitoring mode, the scanner can be used to image the tissue at the internal site after or during therapy. Exemplary SFE probes are disclosed for measuring scattering angle (which can detect larger cancer cell nuclear-to-cytoplasmic ratio), absorption depth, axial distance to tissue, and other conditions at the internal site.
摘要翻译：一种扫描光纤内窥镜（SFE）系统，其选择性地以多种不同的模式操作。一个或多个照明光纤将不同类型的光传送到内部位置。以期望的图案共振地驱动的扫描仪从内部位置收集光。扫描仪可以是扫描光纤或扫描镜的悬臂式末端。照明光纤可以以非共振的方式移动以改变发射光的方向。在治疗模式中，可以将相对高功率的光施加于该部位，而在监测模式中，扫描器可用于在治疗之后或治疗期间对内部部位的组织进行成像。公开了示例性的SFE探针，用于测量散射角（其可以检测更大的癌细胞核 - 细胞质比），吸收深度，到组织的轴向距离以及内部部位的其它条件。

9. 发明授权

US07879004B2 Catheter tip displacement mechanism 有权
标题翻译：导管尖端位移机制
公开(公告)号：US07879004B2
公开(公告)日：2011-02-01
申请号：US11610084
申请日：2006-12-13
申请人： Eric Seibel , Per Reinhall
发明人： Eric Seibel , Per Reinhall
IPC分类号： A61M29/00
CPC分类号： A61M25/0158 , A61M25/0141 , A61M25/0155 , A61M2025/0058
摘要： A distal end of a flexible catheter can be selectively deflected in a desired direction by actuating one or more actuators that extend outwardly of an exterior surface of the catheter. Each actuator can be a balloon disposed within a non-extendible balloon or sheath. Inflation of one (or both) of the balloon and the non-extendible balloon with a pressurized fluid can deflect the distal tip of the catheter. Another actuator embodiment comprises a strip of a bimorph material that bends outwardly when actuated, e.g., by heat, applying a force against adjacent tissue to deflect the distal tip. Yet another embodiment includes a strip of material that shortens when heated and can be coupled to a balloon that is inflated outwardly to increase a radial moment arm of the force applied thereby, relative to a neutral axis of the catheter, to more readily deflect the distal tip.
摘要翻译：柔性导管的远端可以通过致动一个或多个从导管的外表面向外延伸的致动器而在期望的方向上选择性地偏转。每个致动器可以是设置在不可扩展的气球或护套内的球囊。一个（或两个）球囊和不可延伸球囊与加压流体的充气可偏转导管的远端。另一致动器实施例包括双压电晶片材料的条带，当致动例如通过加热时向外弯曲，向相邻组织施加力以偏转远侧末端。另一个实施例包括材料条，其在加热时缩短并且可以联接到向外膨胀的球囊，以相对于导管的中性轴线增加由其施加的力的径向力矩臂，以更容易地偏转远端小费。

10. 发明授权

US07616986B2 Optical fiber scanner for performing multimodal optical imaging 有权
标题翻译：用于执行多模光学成像的光纤扫描器
公开(公告)号：US07616986B2
公开(公告)日：2009-11-10
申请号：US10880008
申请日：2004-06-28
申请人： Eric Seibel , Xingde Li , Xiumei Liu
发明人： Eric Seibel , Xingde Li , Xiumei Liu
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B3/102 , A61B5/0062 , A61B5/0066 , A61B5/0068 , B31B2105/001 , G02B6/262 , G02B6/32 , G02B6/3502 , G02B7/08 , G02B21/0028 , G02B21/0036 , G02B21/006 , G02B21/0076 , G02B23/2423 , G02B26/103
摘要： An optical fiber scanner is used for multiphoton excitation imaging, optical coherence tomography, or for confocal imaging in which transverse scans are carried out at a plurality of successively different depths within tissue. The optical fiber scanner is implemented as a scanning endoscope using a cantilevered optical fiber that is driven into resonance or near resonance by an actuator. The actuator is energized with drive signals that cause the optical fiber to scan in a desired pattern at successively different depths as the depth of the focal point is changed. Various techniques can be employed for depth focus tracking at a rate that is much slower than the transverse scanning carried out by the vibrating optical fiber. The optical fiber scanner can be used for confocal imaging, multiphoton fluorescence imaging, nonlinear harmonic generation imaging, or in an OCT system that includes a phase or frequency modulator and delay line.
摘要翻译：光纤扫描器用于多光子激发成像，光学相干断层扫描或用于共焦成像，其中横向扫描在组织内的多个连续不同的深度进行。光纤扫描器被实现为使用由致动器驱动到共振或接近谐振的悬臂光纤的扫描内窥镜。致动器通过驱动信号通电，当驱动信号使焦点的深度改变时，光纤以连续不同的深度以所需的图案扫描。可以采用比由振动光纤执行的横向扫描慢得多的速度进行深度聚焦跟踪的各种技术。光纤扫描器可用于共焦成像，多光子荧光成像，非线性谐波生成成像，或在包括相位或频率调制器和延迟线的OCT系统中。

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