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    • 1. 发明申请
    • System and method for processing specimens and images for optical tomography
    • 用于光学层析成像的标本和图像处理系统和方法
    • US20050085721A1
    • 2005-04-21
    • US10964508
    • 2004-10-13
    • Mark FauverJohn RahnEric SeibelAlan Nelson
    • Mark FauverJohn RahnEric SeibelAlan Nelson
    • A61B5/05G02B21/00G02B21/36
    • G02B21/002G02B21/365
    • A scanning method for scanning samples of biological cells using optical tomography includes preparing, acquiring, reconstructing and viewing three-dimensional images of cell samples. Concentration and enrichment of the cell sample follows. The cell sample is stained. Cells are isolated from the cell sample and purified. A cell/solvent mixture is injected into a gel by centrifugation. A cell/gel mixture is injected into a capillary tube until a cell appears centered in a field of view using a step flow method. An optical imaging system, such as a fixed or variable motion optical tomography system acquires a projection image. The sample is rotated about a tube axis to generate additional projections. Once image acquisition is completed, the acquired shawdowgrams or image projections are corrected for errors. A computer or other equivalent processor is used to compute filtered backprojection information for 3D reconstruction.
    • 使用光学断层摄影扫描生物细胞样本的扫描方法包括准备,获取,重建和观察细胞样品的三维图像。 细胞样品的浓缩和浓缩如下。 细胞样品染色。 细胞从细胞样品中分离并纯化。 通过离心将细胞/溶剂混合物注入凝胶。 将细胞/凝胶混合物注入毛细管中,直到细胞在视野中以步进流动法出现中心。 诸如固定或可变运动光学断层摄影系统的光学成像系统获取投影图像。 样品围绕管轴旋转以产生额外的突起。 一旦完成图像采集,就可以纠正所获取的肖像图或图像投影。 计算机或其他等效处理器用于计算用于3D重建的滤波反投影信息。
    • 6. 发明授权
    • Control of an optical fiber scanner
    • 控制光纤扫描仪
    • US06845190B1
    • 2005-01-18
    • US10305914
    • 2002-11-26
    • Quinn Y. J. SmithwickEric J. SeibelMark Fauver
    • Quinn Y. J. SmithwickEric J. SeibelMark Fauver
    • G02B6/26G02B6/32G02B6/35G02B26/10
    • G02B26/10A61B1/0008A61B1/00172G02B6/262G02B6/32G02B6/3504G02B6/359
    • Controls for an optical scanner, such as a single fiber scanning endoscope (SFSE) that includes a resonating optical fiber and a single photodetector to produce large field of view, high-resolution images. A nonlinear control scheme with feedback linearization is employed in one type of control to accurately produce a desired scan. Open loop and closed loops controllers are applied to the nonlinear optical scanner of the SFSE. A closed loop control (no model) uses either phase locked loop and PID controllers, or a dual-phase lock-in amplifier and two PIDs for each axis controlled. Other forms of the control that employ a model use a frequency space tracking control, an error space tracking control, feedback linearizing controls, an adaptive control, and a sliding mode control.
    • 用于光学扫描器的控制,例如包括谐振光纤的单个光纤扫描内窥镜(SFSE)和用于产生大视野的单个光电检测器,高分辨率图像。 在一种类型的控制中采用具有反馈线性化的非线性控制方案来精确地产生期望的扫描。 开环和闭环控制器应用于SFSE的非线性光学扫描仪。 闭环控制(无模型)使用锁相环和PID控制器,或双相锁定放大器和每个控制轴的两个PID。 使用模型的其他形式的控制使用频率空间跟踪控制,误差空间跟踪控制,反馈线性化控制,自适应控制和滑动模式控制。