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1. 发明授权

US6147123A Treatment and prevention of hepatic disorders 失效
公开(公告)号：US6147123A
公开(公告)日：2000-11-14
申请号：US274624
申请日：1999-03-23
申请人： Mario Chojkier , Dennis Carson
发明人： Mario Chojkier , Dennis Carson
IPC分类号： A61K31/05 , A61K31/355 , A61K31/522 , C07C39/04
CPC分类号： A61K31/355 , A61K31/05 , A61K31/522 , Y10S514/893 , Y10S514/894
摘要： New methods are described for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high doses of vitamin E is effective in treating chronic hepatitis C in patients refractory to interferon. In addition, new methods are described for the treatment of hepatic fibrosis and hepatic conditions manifesting hepatic fibrosis involving the administration of butylated hydroxytoluene and a metabolite of pentoxifylline, 1-[3-carboxypropyl]-3, 7-dimethylxanthine.

2. 发明授权

US6075027A Treatment and prevention of hepatic disorders 失效
标题翻译：治疗和预防肝功能障碍
公开(公告)号：US6075027A
公开(公告)日：2000-06-13
申请号：US274625
申请日：1999-03-23
申请人： Mario Chojkier , Dennis Carson
发明人： Mario Chojkier , Dennis Carson
IPC分类号： A61K31/05 , A61K31/355 , A61K31/522 , A61K31/505 , C07D487/04
CPC分类号： A61K31/355 , A61K31/05 , A61K31/522 , Y10S514/893 , Y10S514/894
摘要： New methods are described for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high doses of vitamin E is effective in treating chronic hepatitis C in patients refractory to interferon. In addition, new methods are described for the treatment of hepatic fibrosis and hepatic conditions manifesting hepatic fibrosis involving the administration of butylated hydroxytoluene and a metabolite of pentoxifylline, 1-[3-carboxypropyl]-3, 7-dimethylxanthine.
摘要翻译：描述了用于治疗涉及维生素E和具有抗氧化性质的其它化合物的病毒性丙型肝炎的新方法。用高剂量的维生素E治疗可有效治疗难治性干扰素患者的慢性丙型肝炎。此外，描述了治疗肝纤维化和表现肝纤维化的肝脏病症的新方法，涉及施用丁基化羟基甲苯和己酮可可碱1- [3-羧基丙基] -3,7-二甲基黄嘌呤的代谢物。

3. 发明申请

US20060040934A1 Use of STAT-6 inhibitors as therapeutic agents 审中-公开
公开(公告)号：US20060040934A1
公开(公告)日：2006-02-23
申请号：US11077986
申请日：2005-03-11
申请人： Howard Cottam , Lorenzo Leoni , Dennis Carson
发明人： Howard Cottam , Lorenzo Leoni , Dennis Carson
IPC分类号： A61K31/5377 , A61K31/429 , A61K31/424 , A61K31/4188
CPC分类号： C07D513/04 , A61K31/519 , C07D487/04
摘要： The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments.

4. 发明申请

US20100266675A1 LIPOPROTEINS, LIPOPEPTIDES AND ANALOGS, AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：脂蛋白，脂蛋白和类似物，以及制备和使用它们的方法
公开(公告)号：US20100266675A1
公开(公告)日：2010-10-21
申请号：US12600930
申请日：2008-05-21
申请人： William Gerwick , Wolfgang Wrasidlo , Dennis Carson , Dwayne Stupack , Takashi Suyama
发明人： William Gerwick , Wolfgang Wrasidlo , Dennis Carson , Dwayne Stupack , Takashi Suyama
IPC分类号： A61K9/127 , C07K2/00 , A61K38/00 , A61P35/00
CPC分类号： C07C323/60 , C07C233/47
摘要： The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor.
摘要翻译：本发明提供了新颖的组合物 - 脂肽和类似物，包括胞质酰胺A和胞囊酰胺A变体和类似物，以及包含它们的药物组合物，脂质体和纳米颗粒，以及制备和使用它们的方法。在一个实施方案中，这些脂肽和类似物用于诱导细胞凋亡，细胞可以是正常细胞，功能障碍细胞和/或癌症（肿瘤）细胞。在替代实施方案中，本发明的组合物，包括本发明的脂肽和类似物以及包含它们的药物组合物用于治疗或改善（包括减缓正常，功能障碍（例如异常增殖）和/ 或肿瘤相关血管，包括内皮细胞和/或毛细胞生长; 包括与肿瘤相关的新血管生成（内部，提供血液供应）。

5. 发明申请

US20070299042A1 USE OF ETODOLAC TO TREAT HYPERPLASIA 审中-公开
公开(公告)号：US20070299042A1
公开(公告)日：2007-12-27
申请号：US11615396
申请日：2006-12-22
申请人： Dennis Carson , Lorenzo Leoni , Mary Corr
发明人： Dennis Carson , Lorenzo Leoni , Mary Corr
IPC分类号： A61K31/407 , A61K31/496 , A61K31/56 , A61P35/00
CPC分类号： A61K31/12 , A61K31/18 , A61K31/40 , A61K31/407 , A61K31/4745 , A61K31/496 , A61K31/50 , A61K31/56 , A61K31/675 , A61K31/7052
摘要： The present invention provides a therapeutic method to treat non-malignant diseases characterized by the excessive tissue growth, e.g., hyperplastic diseases, comprising administering to a mammal (e.g., human) afflicted with excessive tissue growth, an effective amount of a derivative of an indole compound of formula (I):formula (I): wherein R1 is lower alkyl, (hydroxy)lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, phenyl, benzyl or 2-thienyl; R2, R3, R4 and R5 are the same or different and are each hydrogen or lower alkyl; each R6 is individually hydrogen, lower alkyl, hydroxy, (hydroxy)lower alkyl, lower alkoxy, benzyloxy, lower alkanoyloxy, nitro or halo, R7 is hydrogen, lower alkyl or lower alkenyl, X is oxy and thio, Y is carbonyl, —(CH2)1-3—, —(C1-C3)alkyl(CO)—, or —(CH2)1-3SO2—; Z is hydroxy, lower alkoxy, (C2-C4)acyloxy, —N(R8)(R9), phenylamino, (ω-(4-pyridyl)(C2-C4 alkoxy), (ω-((R8)(R9) amino)(C2-C4 alkoxy), an amino acid ester of (ω-(HO)(C2-C4))alkoxy, —N(R8)CH(R8)CO2H, 1′-D-glucuronyloxy, —SO3H, —PO4H2, —N(NO)(OH), —SO2NH2, —PO(OH)(NH2), —OCH2CH2N(CH3)3+, or tetrazolyl; wherein R8 and R9 are each H, (C1-C3)alkyl or together with N are a 5- or 6-membered heterocyclic ring comprising 1-3 N(R8), S or nonperoxide O; n is 0, 1, 2, or 3; wherein R8 and R9 are each H, (C1-C3)alkyl or together with N are a 5- or 6-membered heterocyclic ring comprising 1-3 N(R8), S or nonperoxide O; each alkyl or phenyl group of R1, R2, R3, R4,R5, R6, R7 and Z is optionally substituted with 1, 2, or 3 (C1-C4)alkyl groups; or a pharmaceutically acceptable salt thereof.

6. 发明申请

US20070218077A1 Lipid-Mediated Polynucleotide Administration to Deliver a Biologically Active Peptide and to Induce a Cellular Immune Response 审中-公开
标题翻译：脂质介导的多核苷酸管理以提供生物活性肽并诱导细胞免疫应答
公开(公告)号：US20070218077A1
公开(公告)日：2007-09-20
申请号：US11749509
申请日：2007-05-16
申请人： Phillip FELGNER , Jon Wolff , Gary Rhodes , Robert Malone , Dennis Carson
发明人： Phillip FELGNER , Jon Wolff , Gary Rhodes , Robert Malone , Dennis Carson
IPC分类号： A61K39/385 , A61K31/715 , A61K39/12
CPC分类号： A61K39/00 , A61K9/1272 , A61K48/00 , A61K2039/53 , A61K2039/55555 , C07K14/005 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering a naked or isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of a naked polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译：一种用于将裸露或分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将裸多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并发挥治疗效果在脊椎动物上。该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因治疗。

7. 发明申请

US20050239752A1 Indole compounds useful for the treatment of cancer 失效
标题翻译：吲哚化合物可用于治疗癌症
公开(公告)号：US20050239752A1
公开(公告)日：2005-10-27
申请号：US11013955
申请日：2004-12-16
申请人： Dennis Carson , Howard Cottam , Lorenzo Leoni
发明人： Dennis Carson , Howard Cottam , Lorenzo Leoni
IPC分类号： A61K31/407 , A61K31/4439 , A61K31/7052 , C07D491/02 , C07D491/04 , C07D498/02
CPC分类号： C07D491/04
摘要： The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments.
摘要翻译：本发明提供了可用于抑制癌症或使癌细胞对化学治疗剂，辐射或其它抗癌治疗敏感的新型吲哚衍生物。

8. 发明申请

US20050130199A1 Mutations in WNT-frizzled signaling pathways associated with osteoarthritis 审中-公开
标题翻译：与骨关节炎相关的WNT-卷曲信号通路中的突变
公开(公告)号：US20050130199A1
公开(公告)日：2005-06-16
申请号：US10947849
申请日：2004-09-22
申请人： Dennis Carson , Mary Corr , John Loughlin
发明人： Dennis Carson , Mary Corr , John Loughlin
IPC分类号： C07H21/04 , C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： C12Q1/6883 , C07H21/04 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： This invention provides methods to identify individuals predisposed to developing osteoarthritis, to diagnose osteoarthritis, and to monitor the progression of the disease. The method also provides methods to identify modulators of bone development that affect a wnt/fzd signaling pathway and methods to prevent or treat osteoarthritis by administering the modulator of bone development.
摘要翻译：本发明提供了鉴定倾向于发展为骨关节炎的个体，诊断骨关节炎以及监测疾病进展的方法。该方法还提供鉴定影响wnt / fzd信号通路的骨发育调节剂的方法以及通过施用骨发育调节剂预防或治疗骨关节炎的方法。

9. 发明申请

US20110231272A1 Retail mobile point-of-sale (POS) software application and retail middleware software application 审中-公开
标题翻译：零售移动销售点（POS）软件应用程序和零售中间件软件应用程序
公开(公告)号：US20110231272A1
公开(公告)日：2011-09-22
申请号：US12928651
申请日：2010-12-16
申请人： Karl Englund , Dennis Carson
发明人： Karl Englund , Dennis Carson
IPC分类号： G06Q20/00
CPC分类号： G06Q20/32 , G06Q20/20 , G06Q20/202 , G06Q30/0603 , G07G1/0081
摘要： A portable electronic device includes a memory and processor. The memory stores instructions, which are part of a retail mobile software purchase software application. The instructions, which when executed by the processor cause the portable electronic device to first transmit a search request for an item. The device receives item information including item description and item price and also receives a selection to purchase the item from a purchaser. The retail mobile software creates an order including the selected item and adds other selected items to the order. The retail mobile software application displays payment options for the order and receives a payment option selection for the order including the selected item. The retail mobile software application receives payment confirmation for the order including the selected item and displays receipt options for the order including the selected item. The retail mobile software application receives a selection of a receipt option and generates an electronic receipt for the order.
摘要翻译：便携式电子设备包括存储器和处理器。存储器存储指令，这是零售移动软件购买软件应用程序的一部分。当由处理器执行时，所述指令使得便携式电子设备首先发送对于物品的搜索请求。设备接收包括项目描述和项目价格的项目信息，并且还从购买者接收购买项目的选择。零售移动软件创建包括所选项目的订单，并将其他所选项目添加到订单中。零售移动软件应用程序显示订单的付款选项，并接收包括所选项目的订单的付款选项选择。零售移动软件应用程序收到包括所选项目在内的订单的付款确认，并显示包含所选项目的订单的收货选项。零售移动软件应用程序接收到收货选项的选择，并为订单生成电子收据。

10. 发明申请

US20110108422A1 EX VIVO MULTI-DIMENSIONAL SYSTEM FOR THE SEPARATION AND ISOLATION OF CELLS, VESICLES, NANOPARTICLES AND BIOMARKERS 审中-公开
标题翻译：用于分离和分离细胞，VESICLES，NANOPARTICLES和生物标记物的VIVO多维体系
公开(公告)号：US20110108422A1
公开(公告)日：2011-05-12
申请号：US12936147
申请日：2009-04-03
申请人： Michael Heller , Benjamin Sullivan , Rajaram Krishnan , Dennis Carson , Sadik Esener
发明人： Michael Heller , Benjamin Sullivan , Rajaram Krishnan , Dennis Carson , Sadik Esener
IPC分类号： G01N27/447 , G01N27/403
CPC分类号： B03C5/005 , G01N27/447 , G01N30/0005 , G01N33/491
摘要： Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices. The devices and techniques described can also carry out the assisted self-assembly of molecules, polymers, nanocomponents and mesoscale entities into three dimensional higher order structures.
摘要翻译：描述了涉及多维电动，介电泳，电泳和流体力的组合的装置和技术，以及用于在高电导（离子）强度生物样品和缓冲液中分离细胞，纳米囊，纳米颗粒和生物标志物（DNA，RNA，抗体，蛋白质）的作用。在所公开的实施例中，连续和/或脉冲介电电泳（DEP）力，连续和/或脉冲场DC电泳力，微电泳和受控流体学的组合被利用于电极阵列。特别地，使用腔室DEP装置和结合流体，电泳和DEP力的适当缩放的相对较大的电极阵列装置的使用使得血液，血清，血浆或其它样品的较大和/或临床相关体积能够更直接地，快速有效地分析。本发明能够创建“无缝”的样本到应答诊断系统和设备。所描述的装置和技术还可以将分子，聚合物，纳米组分和中尺度实体的辅助自组装执行成三维高阶结构。

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