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1. 发明申请

US20110108422A1 EX VIVO MULTI-DIMENSIONAL SYSTEM FOR THE SEPARATION AND ISOLATION OF CELLS, VESICLES, NANOPARTICLES AND BIOMARKERS 审中-公开
标题翻译：用于分离和分离细胞，VESICLES，NANOPARTICLES和生物标记物的VIVO多维体系
公开(公告)号：US20110108422A1
公开(公告)日：2011-05-12
申请号：US12936147
申请日：2009-04-03
申请人： Michael Heller , Benjamin Sullivan , Rajaram Krishnan , Dennis Carson , Sadik Esener
发明人： Michael Heller , Benjamin Sullivan , Rajaram Krishnan , Dennis Carson , Sadik Esener
IPC分类号： G01N27/447 , G01N27/403
CPC分类号： B03C5/005 , G01N27/447 , G01N30/0005 , G01N33/491
摘要： Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices. The devices and techniques described can also carry out the assisted self-assembly of molecules, polymers, nanocomponents and mesoscale entities into three dimensional higher order structures.
摘要翻译：描述了涉及多维电动，介电泳，电泳和流体力的组合的装置和技术，以及用于在高电导（离子）强度生物样品和缓冲液中分离细胞，纳米囊，纳米颗粒和生物标志物（DNA，RNA，抗体，蛋白质）的作用。在所公开的实施例中，连续和/或脉冲介电电泳（DEP）力，连续和/或脉冲场DC电泳力，微电泳和受控流体学的组合被利用于电极阵列。特别地，使用腔室DEP装置和结合流体，电泳和DEP力的适当缩放的相对较大的电极阵列装置的使用使得血液，血清，血浆或其它样品的较大和/或临床相关体积能够更直接地，快速有效地分析。本发明能够创建“无缝”的样本到应答诊断系统和设备。所描述的装置和技术还可以将分子，聚合物，纳米组分和中尺度实体的辅助自组装执行成三维高阶结构。

2. 发明授权

US07052812B1 Three-dimensional optical data storage in fluorescent dye-doped photopolymer 失效
标题翻译：荧光染料掺杂光聚合物中的三维光学数据存储
公开(公告)号：US07052812B1
公开(公告)日：2006-05-30
申请号：US09547395
申请日：2000-04-11
申请人： Mark Wang , Sadik Esener
发明人： Mark Wang , Sadik Esener
IPC分类号： G03C3/00 , G03H1/04
CPC分类号： G11B7/246 , B82Y10/00 , G03H1/02 , G03H2001/026 , G03H2260/12 , G11B7/00455 , G11B7/24038 , G11B7/245 , G11B2007/24624 , G11C13/0014 , G11C13/0016 , G11C13/041
摘要： A host matrix—normally a binder such as cellulose acetate propionate in a solvent such as acetone—contains a radiation-polymerizable photopolymer—normally a monomer like dipentaerythritol pentaacrylate in combination with a crosslinker like 1-vinyl-2-pyrrolidinone, an initiator like N-phenyl glycine, and/or a photosensitizer like camphor quinone—that is initially uniformly doped with a stable dye—typically Rhodamine B and/or Bodipy Red—that photoinitiates photopolymerization. Upon selective exposure of certain regions of the matrix by radiation, most normally laser light radiation, the dye will initially migrate and redistribute itself to radiatively-exposed regions until, dye migration being substantially complete, photopolymerization will occur, locking the migrated dye in place at a relatively higher concentration at the selectively exposed regions. The dye therein stably located can be optically detected by, preferably, light-radiation-stimulated fluorescence. The medium thus serves as an optical memory, including of the volume type, that can be reliably permanently written quickly and inexpensively at high density.
摘要翻译：主要基质 - 通常为粘合剂，如溶剂如丙酮中的乙酸丙酸纤维素，含有辐射聚合光聚合物 - 通常为单体，如二季戊四醇五丙烯酸酯与交联剂如1-乙烯基-2-吡咯烷酮，N， - 苯基甘氨酸和/或光敏剂如樟脑醌，其最初均匀掺杂有稳定的染料 - 通常为罗丹明B和/或Bodipy Red - 光引发光聚合。通过辐射选择性地暴露基质的某些区域，大多数通常是激光辐射，染料将首先迁移并重新分布到辐射暴露的区域，直到染料迁移基本上完成，将发生光聚合，将迁移的染料锁定在在选择性暴露区域的浓度相对较高。其中稳定位置的染料可以通过优选光辐射刺激的荧光进行光学检测。该介质因此用作包括体积型的光学存储器，其能够以高密度快速且廉价地可靠地永久地写入。

3. 发明授权

US06605453B2 Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells 失效
公开(公告)号：US06605453B2
公开(公告)日：2003-08-12
申请号：US09728801
申请日：2000-12-01
申请人： Mihrimah Ozkan , Sadik Esener , Sangeeta Bhatia
发明人： Mihrimah Ozkan , Sadik Esener , Sangeeta Bhatia
IPC分类号： C12N1300
CPC分类号： C12N15/1006 , B01J19/0046 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00646 , B01J2219/00653 , B01J2219/00659 , B01J2219/0072 , B01J2219/00743
摘要： Any of inorganic and bio-organic substances and molecules, and beads, pucks and like small things, that are both (i) electrically charged to a first polarity, and (ii) immersed in a fluid transport medium within (iii) an electrochemical cell, are assembled and patterned by action of moving these inorganic and bio-organic substances and molecules, etc. to a patterned electrode having an opposite, second, polarity under force of an applied electric field. The electrode patterned with conductive areas may be further, separately, patterned with chemicals, for example agarose gel, that chemically accept or reject the substances and molecules, etc., especially as are biological in origin. Living cells of plant, bacterial and animal types may be assembled. A semiconductor electrode may be patterned by masked laser light passed through the other electrode, which is transparent.

4. 发明授权

US06501571B1 Three-dimensional holographic stamping of multi-layer bit-oriented non-linear optical media 失效
标题翻译：多层位向非线性光学介质的三维全息冲压
公开(公告)号：US06501571B1
公开(公告)日：2002-12-31
申请号：US09547396
申请日：2000-04-11
申请人： Mark Wang , Sadik Esener
发明人： Mark Wang , Sadik Esener
IPC分类号： G03H120
CPC分类号： G03H1/0248 , G03H1/0402 , G03H1/265 , G03H1/32 , G03H2260/12 , G11B7/0065 , G11B7/26 , G11B7/28 , G11B2007/240025 , G11C13/042
摘要： A master hologram is generated in a first optical medium by use of a plurality m of different reference beams, each beam bearing information suitably recorded in one or more of a plurality n layers of the second optical medium that are distinct from layers in which information in all other beams is suitably recorded. The generated master hologram is then used to optically holographically stamp, or record, multi-layer bit-oriented optical media by writing all n layers of the volume of the blank optical medium with m recording beams produced by simultaneously illuminating the master hologram with all m different reference beams, each illuminating reference beam being at a different reference angle and from a coherent light source which is incoherent with respect to every other illuminating reference beam. By this generating and this using a high degree of incoherency is obtained, making that during subsequent readout of a selected, focused, layer of the recorded optical medium signals from all other layers will become as background noise having nearly uniform intensity. The method requires a highly non-linear optical medium: a new dye-doped photopolymer is preferred.
摘要翻译：通过使用多个m个不同的参考光束在第一光学介质中产生主全息图，每个波束承载信息适当地记录在第二光学介质的多个n层中的一个或多个中，其与第所有其他光束被适当地记录。然后使用所产生的主全息图通过用空白光学介质的所有体积的N层写入全息图来全息地印记或记录，其中m个记录光束通过全部m同时照射主全息图而产生不同的参考光束，每个照明参考光束处于不同的参考角度，并且相对于每隔一个照明参考光束不相干的相干光源。通过这种产生，并且获得这种使用高度不一致性的功能，使得在随后读出来自所有其它层的所记录的光学介质信号的选定的聚焦层将成为具有几乎均匀强度的背景噪声。该方法需要高度非线性的光学介质：优选新的掺杂染料的光聚合物。

5. 发明申请

US20190090753A1 METHOD, SYSTEM, SOFTWARE, AND DEVICE FOR REMOTE, MIIATURIZED, AND THREE-DIMENSIONAL IMAGING AND ANALYSIS OF HUMAN LESIONS RESEARCH AND CLINICAL APPLICATIONS THEREOF 审中-公开
公开(公告)号：US20190090753A1
公开(公告)日：2019-03-28
申请号：US16304281
申请日：2017-05-25
申请人： Joseph Carson , Benjamin Carson , Sadik Esener , Kimberly Liu , David Melnick , Elyana Crowder
发明人： Joseph Carson , Benjamin Carson , Sadik Esener , Kimberly Liu , David Melnick , Elyana Crowder
IPC分类号： A61B5/00
摘要： A system, device, and accompanying software for the remote, three-dimensional, and high-throughput imaging and analysis of human lesions, across a range of wavelengths, lens radii and imaging sensors. This system, device, and software generates and analyses of tumor images at infrared wavelengths through the use of miniaturized, liquid lenses. It has a number of clinical, diagnostic, research, and other imaging applications, including the remote, three-dimensional, and high-throughput imaging and analysis of human cancer tumors.

6. 发明授权

US5325324A Three-dimensional optical memory 失效
标题翻译：三维光学记忆
公开(公告)号：US5325324A
公开(公告)日：1994-06-28
申请号：US586456
申请日：1990-09-21
申请人： Peter M. Rentzepis , Sadik Esener
发明人： Peter M. Rentzepis , Sadik Esener
IPC分类号： G02F1/01 , G11B7/0045 , G11C13/04 , G11C11/42
CPC分类号： G02F1/0126 , B82Y10/00 , G11B7/00453 , G11B7/00455 , G11C13/041
摘要： Selected domains, normally 10.sup.3 .times.10.sup.3 such domains arrayed in a plane, within a three-dimensional (3-D) volume of active medium, typically 1 cm.sup.3 of spirobenzopyran containing 10.sup.2 such planes, are temporally and spatially simultaneously illuminated by two radiation beams, normally laser light beams in various combinations of wavelengths 532nm and 1024nm, in order, dependent upon the particular combination of illuminating light, to either write binary data to, or read binary data from, the selected domains by process of two-photon (2-P) absorption. One laser light beam is preferably directed to illuminate all domains of the selected plane in and by a one-dimensional spatial light modular (1-D SLM). The other laser light beam is first spatially encoded with binary information by 2-D SLM, and is then also directed to illuminate the domains of the selected plane. Direction of the binary-amplitude-encoded spatially-encoded light beam is preferably by focusing, preferably in and by a holographic dynamic focusing lens (HDFL). During writing the selected, simultaneously illuminated, domains change their isomeric molecular form by process of 2-P absorption. During reading the selected domains fluoresce dependent upon their individually pre-established, written, states. The domains' fluorescence is focused by the HDFL, and by other optical elements including a polarizer and polarizing beam splitter, to a 10.sup.3 .times.10.sup.3 detector array. I/O bandwidth to each cm.sup.3 of active medium is on the order of 1 Gbit/sec to 1 Tbit/sec.
摘要翻译：通常在三维（3-D）体积的活性介质中，通常为103×103个这样的域排列在三维（3-D）体积的活性介质中，通常为1cm 3的含有102个这样的平面的螺苯并吡喃，在时间和空间上同时被两个辐射束取决于照明光的特定组合依次以532nm和1024nm的波长的各种组合的光束，通过双光子（2-P）的处理将二进制数据写入或从所选域读出二进制数据，吸收。一个激光束优选地被引导以在一维空间光模块（1-D SLM）中和通过一维空间光模块（1-D SLM）照亮所选择的平面的所有域。首先利用二维SLM对其他激光束进行二进制信息空间编码，然后将其指向照亮所选择的平面的域。二进制幅度编码的空间编码光束的方向优选地通过聚焦，优选地通过全息动态聚焦透镜（HDFL）进行聚焦。在书写期间，所选择的同时照亮的结构域通过2-P吸收的过程改变其异构分子形式。在读取所选择的结构域期间，荧光依赖于它们各自预先建立的，写入的状态。领域的荧光被HDFL和包括偏振器和偏振分束器的其它光学元件聚焦到103×103检测器阵列。每cm活动介质的I / O带宽大约为1 Gbit / s到1Tbit / sec。

7. 发明授权

US4884243A Multi-port, optically addressed RAM 失效
标题翻译：多端口，光地址RAM
公开(公告)号：US4884243A
公开(公告)日：1989-11-28
申请号：US157692
申请日：1988-02-19
申请人： Alan R. Johnston , Robert H. Nixon , Larry A. Bergman , Sadik Esener
发明人： Alan R. Johnston , Robert H. Nixon , Larry A. Bergman , Sadik Esener
IPC分类号： G11C7/00 , G11C8/16
CPC分类号： G11C7/005 , G11C8/16
摘要： A random access memory addressing system utilizing optical links between memory and the read/write logic circuits comprises addressing circuits including a plurality of light signal sources, a plurality of optical gates including optical detectors associated with the memory cells, and a holographic optical element adapted to reflect and direct the light signals to the desired memory cell locations. More particularly, it is a multi-port, binary computer memory for interfacing with a plurality of computers. There are a plurality of storage cells for containing bits of binary information, the storage cells being disposed at the intersections of a plurality of row conductors and a plurality of column conductors. There is interfacing logic for receiving information from the computers directing access to ones of the storage cells. There are first light sources associated with the interfacing logic for transmitting a first light beam with the access information modulated thereon. First light detectors are associated with the storage cells for receiving the first light beam, for generating an electrical signal containing the access information, and for conducting the electrical signal to the one of the storage cells to which it is directed. There are holographic optical elements for reflecting the first light beam from the first light sources to the first light detectors.
摘要翻译：利用存储器与读/写逻辑电路之间的光链路的随机存取存储器寻址系统包括包括多个光信号源的寻址电路，包括与存储单元相关联的光检测器的多个光门，以及适于反射并将光信号引导到期望的存储单元位置。更具体地，它是用于与多个计算机进行接口的多端口二进制计算机存储器。存在用于包含二进制信息位的多个存储单元，存储单元设置在多个行导体和多个列导体的交点处。存在用于从计算机接收指向对存储单元的访问的信息的接口逻辑。存在与用于传输第一光束的接口逻辑相关联的第一光源和其上调制的访问信息。第一光检测器与用于接收第一光束的存储单元相关联，用于产生包含访问信息的电信号，以及用于将电信号传送到其所指向的存储单元中的一个。存在用于将来自第一光源的第一光束反射到第一光检测器的全息光学元件。

8. 发明申请

US20060270755A1 Three-dimensional optical data storage in fluorescent dye-doped photopolymer 失效
标题翻译：荧光染料掺杂光聚合物中的三维光学数据存储
公开(公告)号：US20060270755A1
公开(公告)日：2006-11-30
申请号：US11337741
申请日：2006-01-23
申请人： Mark Wang , Sadik Esener
发明人： Mark Wang , Sadik Esener
IPC分类号： C03C17/00
CPC分类号： G11B7/246 , B82Y10/00 , G03H1/02 , G03H2001/026 , G03H2260/12 , G11B7/00455 , G11B7/24038 , G11B7/245 , G11B2007/24624 , G11C13/0014 , G11C13/0016 , G11C13/041
摘要： A host matrix—normally a binder such as cellulose acetate propionate in a solvent such as acetone—contains a radiation-polymerizable photopolymer—normally a monomer like dipentaerythritol pentaacrylate in combination with a crosslinker like 1-vinyl-2-pyrrolidinone, an initiator like N-phenyl glycine, and/or a photosensitizer like camphor quinine—that is initially uniformly doped with a stable dye—typically Rhodamine B and/or Bodipy Red—that photoinitiates photopolymerization. Upon selective exposure of certain regions of the matrix by radiation, most normally laser light radiation, the dye will initially migrate and redistribute itself to radiatively-exposed regions until, dye migration being substantially complete, photopolymerization will occur, locking the migrated dye in place at a relatively higher concentration at the selectively exposed regions. The dye therein stably located can be optically detected by, preferably, light-radiation-stimulated fluorescence. The medium thus serves as an optical memory, including of the volume type, that can be reliably permanently written quickly and inexpensively at high density.
摘要翻译：主要基质 - 通常为粘合剂，如溶剂如丙酮中的乙酸丙酸纤维素，含有辐射聚合光聚合物 - 通常为单体，如二季戊四醇五丙烯酸酯与交联剂如1-乙烯基-2-吡咯烷酮，N， - 苯基甘氨酸和/或光敏剂如樟脑奎宁，其最初均匀掺杂有稳定的染料 - 通常为罗丹明B和/或Bodipy Red - 光引发光聚合。通过辐射选择性地暴露基质的某些区域，大多数通常是激光辐射，染料将首先迁移并重新分布到辐射暴露的区域，直到染料迁移基本上完成，将发生光聚合，将迁移的染料锁定在在选择性暴露区域的浓度相对较高。其中稳定位置的染料可以通过优选光辐射刺激的荧光进行光学检测。该介质因此用作包括体积型的光学存储器，其能够以高密度快速且廉价地可靠地永久地写入。

9. 发明授权

US07049579B2 Manipulation of live cells and inorganic objects with optical micro beam arrays 有权
公开(公告)号：US07049579B2
公开(公告)日：2006-05-23
申请号：US09917139
申请日：2001-07-26
申请人： Mihrimah Ozkan , Sadik Esener , Mark Wang
发明人： Mihrimah Ozkan , Sadik Esener , Mark Wang
IPC分类号： H01S3/081
CPC分类号： H05H3/04 , G02B21/32
摘要： One or more microbeams derived from a corresponding number of Vertical Cavity Surface Emitting Lasers (VCSELs) are used to manipulate and to transport inorganic and organic objects. The optical tweezing apparatus and method is compact size, and suitable to manipulate multiple objects in an array concurrently, and in parallel.

10. 发明申请

US20050173249A1 Microelectronic arrays for cell-based functional genomics/ high throughput phenotyping by electrokinetic assembly 失效
标题翻译：用于基于细胞的功能基因组学的微电子阵列/通过电动装配的高通量表型
公开(公告)号：US20050173249A1
公开(公告)日：2005-08-11
申请号：US10450085
申请日：2001-12-08
申请人： Carrolee Barlow , Sangeeta Bhata , Mihrimah Ozkan , Sadik Esener
发明人： Carrolee Barlow , Sangeeta Bhata , Mihrimah Ozkan , Sadik Esener
IPC分类号： B01J19/00 , B01L3/00 , C12Q1/68 , C25B9/00 , C25B11/00 , G01N33/543
CPC分类号： G01N33/5438 , B01J19/0046 , B01J2219/005 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/0063 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00713 , B01J2219/00743 , B01L3/5025 , B01L3/502761 , B01L2200/0668 , B01L2300/0819 , B01L2300/089 , B01L2400/0415 , C12Q1/6897 , C12Q2565/607
摘要： An electrochemical apparatus 1 permits electric-field-assisted fluidic assembly of objects 2 on a patterned silicon substrate 11 by means of electrical addressing. Charged objects 2 such as beads and live cells are moved electrokinetically, like as in electrophoresis, through a solution, typically water 3, towards a micro-patterned charged semiconductor electrode, such as a silicon electrode 11 patterned with silicon dioxide, silicon nitride or agarose gel. The charged objects 2 are thus localized to and assembled, most typically into arrays of multiple or single particles, in accordance with the patterning of the electrode 11. Correlating with theoretical predictions, negatively charged polystyrene beads of 20 μm diameter, or live mammalian cells of 20-30 μm diameter, can be assembled and disassembled on 100 μm feature size micro-patterned substrates by means of electrical addressing. The apparatus 1 has applications in creation of active cellular arrays for cell biology research, drug discovery and tissue engineering.
摘要翻译：电化学装置1通过电寻址允许在图案化的硅衬底11上的物体2的电场辅助的流体组装。带电物体2如珠子和活细胞如电泳那样通过溶液（通常为水3）电动移动到微图案化的带电半导体电极，例如用二氧化硅，氮化硅或琼脂糖图案化的硅电极11 凝胶。因此，根据电极11的图案化，带电对象2因此被定位到并组装，最典型地成为多个或单个颗粒的阵列。与理论预测相关，具有20μm直径的带负电荷的聚苯乙烯珠或活的哺乳动物细胞 20-30毫米直径，可以通过电气寻址在100毫米特征尺寸的微图案基板上组装和拆卸。该装置1可用于创建用于细胞生物学研究，药物发现和组织工程的活性细胞阵列。

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