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1. 发明申请

US20110108422A1 EX VIVO MULTI-DIMENSIONAL SYSTEM FOR THE SEPARATION AND ISOLATION OF CELLS, VESICLES, NANOPARTICLES AND BIOMARKERS 审中-公开
标题翻译：用于分离和分离细胞，VESICLES，NANOPARTICLES和生物标记物的VIVO多维体系
公开(公告)号：US20110108422A1
公开(公告)日：2011-05-12
申请号：US12936147
申请日：2009-04-03
申请人： Michael Heller , Benjamin Sullivan , Rajaram Krishnan , Dennis Carson , Sadik Esener
发明人： Michael Heller , Benjamin Sullivan , Rajaram Krishnan , Dennis Carson , Sadik Esener
IPC分类号： G01N27/447 , G01N27/403
CPC分类号： B03C5/005 , G01N27/447 , G01N30/0005 , G01N33/491
摘要： Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices. The devices and techniques described can also carry out the assisted self-assembly of molecules, polymers, nanocomponents and mesoscale entities into three dimensional higher order structures.
摘要翻译：描述了涉及多维电动，介电泳，电泳和流体力的组合的装置和技术，以及用于在高电导（离子）强度生物样品和缓冲液中分离细胞，纳米囊，纳米颗粒和生物标志物（DNA，RNA，抗体，蛋白质）的作用。在所公开的实施例中，连续和/或脉冲介电电泳（DEP）力，连续和/或脉冲场DC电泳力，微电泳和受控流体学的组合被利用于电极阵列。特别地，使用腔室DEP装置和结合流体，电泳和DEP力的适当缩放的相对较大的电极阵列装置的使用使得血液，血清，血浆或其它样品的较大和/或临床相关体积能够更直接地，快速有效地分析。本发明能够创建“无缝”的样本到应答诊断系统和设备。所描述的装置和技术还可以将分子，聚合物，纳米组分和中尺度实体的辅助自组装执行成三维高阶结构。

2. 发明申请

US20050176029A1 Nanoscale transduction systems for detecting molecular interactions 审中-公开
标题翻译：用于检测分子相互作用的纳米尺度转导系统
公开(公告)号：US20050176029A1
公开(公告)日：2005-08-11
申请号：US10970756
申请日：2004-10-20
申请人： Michael Heller , Benjamin Sullivan , Sanja Zlatanovic , Sadik Esener , Dietrich Dehlinger
发明人： Michael Heller , Benjamin Sullivan , Sanja Zlatanovic , Sadik Esener , Dietrich Dehlinger
IPC分类号： C12Q1/68 , G01N20060101 , G01N33/00 , G01N33/53 , G01N33/543 , H01L21/00
CPC分类号： G01N33/54346 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00
摘要： The present invention relates to nanoscale transduction systems that produce reversible signals to facilitate detection. In one respect, the invention relates to the analysis of molecular binding events using higher order signaling nanoscale constructs, or “nanomachines”, that allow nanostructures to be individually detectable, even in the midst of high background noise. Such systems are particularly useful for improving the performance of rare target detection methods, as well as being generally useful in any field in which sensitivity, discrimination and confidence in detection are important.
摘要翻译：本发明涉及产生可逆信号以促进检测的纳米尺度转导系统。在一个方面，本发明涉及使用更高级信号的纳米尺度构建体或“纳米机器”的分子结合事件的分析，即使在高背景噪声中也允许纳米结构单独检测。这种系统对于改善稀有目标检测方法的性能特别有用，并且在敏感性，鉴别和检测置信度重要的任何领域中通常是有用的。

3. 发明授权

US08202689B2 Nanofabrication processes and devices for the controlled assembly of functionalized nanostructures 有权
标题翻译：用于受控组装功能化纳米结构的纳米加工工艺和装置
公开(公告)号：US08202689B2
公开(公告)日：2012-06-19
申请号：US11914122
申请日：2006-05-11
申请人： Michael Heller , Benjamin Sullivan , Dietrich Dehlinger
发明人： Michael Heller , Benjamin Sullivan , Dietrich Dehlinger
IPC分类号： C12Q1/68
CPC分类号： G01N33/531 , B82Y30/00 , C12Q1/68 , G01N33/48721
摘要： The invention relates to processes and devices for the controlled fabrication of nanostructures from starting components that have high fidelity recognition properties and multiple binding groups. In one embodiment, the invention relates to the formation of nanostructures using controlled sequential addition of nanocomponents at regular intervials via sequential formation of binding pairs or other chemical binding reactions.
摘要翻译：本发明涉及用于从具有高保真度识别特性和多个结合基团的起始组分控制制造纳米结构的方法和装置。在一个实施方案中，本发明涉及使用通过连续形成结合对或其它化学结合反应在常规间隔区内以受控顺序添加纳米组分形成纳米结构。

4. 发明授权

US08507218B2 Detection of degradative enzymes in bodily fluids 有权
标题翻译：检测体液中的降解酶
公开(公告)号：US08507218B2
公开(公告)日：2013-08-13
申请号：US12866732
申请日：2009-02-09
申请人： Michael Heller , Geert W. Schmid-Schoenbein , Roy B. Lefkowitz , Benjamin Sullivan
发明人： Michael Heller , Geert W. Schmid-Schoenbein , Roy B. Lefkowitz , Benjamin Sullivan
IPC分类号： C12Q1/37
CPC分类号： G01N33/54386 , C07K5/1008 , C07K7/06 , C07K7/08 , C12Q1/34 , C12Q1/37 , G01N33/53 , G01N33/573
摘要： Provided herein are methods useful in detecting degradative enzymes in bodily fluid samples.
摘要翻译：本文提供了可用于检测体液样品中降解酶的方法。

5. 发明申请

US20090221443A1 Nanofabrication processes and devices for the controlled assembly of functionalized nanostructures 有权
标题翻译：用于受控组装功能化纳米结构的纳米加工工艺和装置
公开(公告)号：US20090221443A1
公开(公告)日：2009-09-03
申请号：US11914122
申请日：2006-05-11
申请人： Michael Heller , Benjamin Sullivan , Dietrich Dehlinger
发明人： Michael Heller , Benjamin Sullivan , Dietrich Dehlinger
IPC分类号： C40B60/14 , C40B50/14 , C40B40/00 , C40B40/18 , C40B40/14 , C40B40/06
CPC分类号： G01N33/531 , B82Y30/00 , C12Q1/68 , G01N33/48721
摘要： The invention relates to processes and devices for the controlled fabrication of nanostructures from starting components that have high fidelity recognition properties and multiple binding groups. In one embodiment, the invention relates to the formation of nanostructures using controlled sequential addition of nanocomponents at regular intervials via sequential formation of binding pairs or other chemical binding reactions.
摘要翻译：本发明涉及从具有高保真度识别特性和多个结合基团的起始组分控制制造纳米结构的方法和装置。在一个实施方案中，本发明涉及使用通过连续形成结合对或其它化学结合反应在常规间隔区内以受控顺序添加纳米组分形成纳米结构。

6. 发明申请

US20110065127A1 Detection of Degradative Enzymes and Biomolecules in Bodily Fluids 有权
标题翻译：检测体液中降解酶和生物分子
公开(公告)号：US20110065127A1
公开(公告)日：2011-03-17
申请号：US12866732
申请日：2009-02-09
申请人： Michael Heller , Geert W. Schmid-Schoenbein , Roy B. Lefkowitz , Benjamin Sullivan
发明人： Michael Heller , Geert W. Schmid-Schoenbein , Roy B. Lefkowitz , Benjamin Sullivan
IPC分类号： G01N33/573 , C07K7/06 , C07K7/08 , C07K2/00 , C07H21/00 , C08B37/00 , C07C53/00 , G01N27/447 , B82Y15/00
CPC分类号： G01N33/54386 , C07K5/1008 , C07K7/06 , C07K7/08 , C12Q1/34 , C12Q1/37 , G01N33/53 , G01N33/573
摘要： Provided herein are methods, kits and compositions useful in detecting degradative enzymes and biomolecules in bodily fluid samples.
摘要翻译：本文提供了可用于检测体液样品中降解酶和生物分子的方法，试剂盒和组合物。

7. 发明授权

US08980840B2 Therapeutic modulation of vaginal epithelium boundary lubrication 有权
标题翻译：治疗性调节阴道上皮边界润滑
公开(公告)号：US08980840B2
公开(公告)日：2015-03-17
申请号：US13144203
申请日：2010-01-13
申请人： Edward R. Truitt, III , Benjamin Sullivan , David Sullivan
发明人： Edward R. Truitt, III , Benjamin Sullivan , David Sullivan
IPC分类号： A61K38/14 , A61K9/00 , A61K9/02 , A61K9/06 , A61K31/70 , A61K31/715 , A61K38/13 , A61K38/24 , A61K45/06 , A61K38/17 , A61K38/20
CPC分类号： A61K9/0034 , A61K9/02 , A61K9/06 , A61K31/70 , A61K31/715 , A61K38/13 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the management of vaginal health. In particular, the present invention relates to pharmaceutical compositions, and methods of use thereof, for treating diseases associated with compromised boundary lubrication at the vaginal epithelium.
摘要翻译：本发明涉及阴道健康的管理。特别地，本发明涉及药物组合物及其使用方法，用于治疗与阴道上皮受损的边界润滑有关的疾病。

8. 发明授权

US08628731B2 Systems and methods for collecting tear film and measuring tear film osmolarity 有权
标题翻译：用于收集泪膜并测量泪膜渗透压的系统和方法
公开(公告)号：US08628731B2
公开(公告)日：2014-01-14
申请号：US13299277
申请日：2011-11-17
申请人： Eric Donsky , Benjamin Sullivan
发明人： Eric Donsky , Benjamin Sullivan
IPC分类号： G01N3/00 , G01N33/48
CPC分类号： G01N13/04 , B01L3/502707 , B01L3/502715 , B01L2200/027 , B01L2200/0689 , B01L2300/0645 , B01L2300/0887 , B01L2300/12 , B01L2300/165 , C12Q1/00 , G01N21/553 , G01N21/6428 , G01N21/77 , G01N33/487 , G01N33/68 , G01N33/6854 , G01N33/6863 , G01N2021/7786 , G01N2201/06113 , Y10T436/24
摘要： A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.
摘要翻译：一种样品接收芯片，包括接收样品流体的等分试样体积和基底的样品区域的基底，其尺寸使得样品流体的体积足以可操作地覆盖样品区域的一部分。被送入样品流体的能量被样品区域转导以产生指示样品流体的能量特性的输出信号。样品接收芯片还包括形成在衬底中的通道，通道被配置为收集样品流体的等分试样体积并将等分试样体积的样品流体转移到样品区域。

9. 发明申请

US20110070222A1 Therapeutic Modulation of Ocular Surface Lubrication 有权
标题翻译：眼表润滑的治疗调制
公开(公告)号：US20110070222A1
公开(公告)日：2011-03-24
申请号：US12940425
申请日：2010-11-05
申请人： Benjamin Sullivan , Tannin A. Schmidt , David A. Sullivan
发明人： Benjamin Sullivan , Tannin A. Schmidt , David A. Sullivan
IPC分类号： A61K39/395 , A61K38/00 , A61P27/02
CPC分类号： A61K38/14 , A61K9/0048 , A61K9/0051 , A61K31/568 , A61K31/685 , A61K31/688 , A61K31/715 , A61K31/728 , A61K38/13 , A61K38/17 , A61K38/1709 , A61K38/1841 , A61K45/06 , A61K47/02 , A61K47/24 , A61K2300/00
摘要： Provided herein are ophthalmically acceptable pharmaceutical compositions comprising a PRG4 inducing compound in combination with PRG4 (including a lubricant fragments, homologs, or isoforms thereof), and methods of using the same. The PRG4 inducing compound in the pharmaceutical composition of the present invention upregulates PRG4 expression and localization in the ocular surface for efficient surface boundary lubrication. In some instances, pharmaceutical compositions described herein are utilized for treating ophthalmic conditions, e.g., ocular boundary deficiency and symptoms associated therewith.
摘要翻译：本文提供了包含与PRG4组合的PRG4诱导化合物（包括润滑剂片段，同系物或其同种型）的眼科可接受的药物组合物及其使用方法。本发明的药物组合物中的PRG4诱导化合物上调PRG4在眼表面的表达和定位，以有效的表面边界润滑。在一些情况下，本文所述的药物组合物用于治疗眼科疾病，例如眼睛边界不足和与之相关的症状。

10. 发明申请

US20050120772A1 Systems and methods for calibrating osmolarity measuring devices 有权
标题翻译：用于校准渗透压测量装置的系统和方法
公开(公告)号：US20050120772A1
公开(公告)日：2005-06-09
申请号：US10772084
申请日：2004-02-03
申请人： Benjamin Sullivan , Eric Donsky
发明人： Benjamin Sullivan , Eric Donsky
IPC分类号： G01N13/04 , G01N27/07
CPC分类号： G01N13/04
摘要： An osmolarity measuring system comprising microscale electrode arrays is configured to account for variations and defects in the arrays using a tiered approach comprising several calibration methods. One method accounts for the intrinsic conductivity of the electrodes and subtracts out the intrinsic conductivity on a pair-wise basis, when determining osmolarity of a sample fluid. Other methods in the tiered approach use standards to determine calibration factors for the electrodes that can then be used to adjust subsequent osmolarity measurements for a sample fluid. The use of a standard can also be combined with a washing step.
摘要翻译：包括微电极阵列的渗透压测量系统被配置为使用包括几种校准方法的分层方法来解决阵列中的变化和缺陷。当确定样品流体的渗透压浓度时，一种方法考虑了电极的固有电导率，并在成对的基础上减去固有电导率。分层方法中的其他方法使用标准来确定电极的校准因子，然后其可用于调节样品流体的随后渗透压测量。标准的使用也可以与洗涤步骤相结合。

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