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1. 发明申请

US20050261662A1 Lateral needle injection apparatus and method 有权
公开(公告)号：US20050261662A1
公开(公告)日：2005-11-24
申请号：US11189795
申请日：2005-07-27
申请人： Maria Palasis , Arthur Rosenthal
发明人： Maria Palasis , Arthur Rosenthal
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61M25/00 , A61M31/00
CPC分类号： A61B17/3478 , A61B17/3207 , A61B18/1477 , A61B18/1492 , A61B2017/00247 , A61B2017/22077 , A61B2018/00214 , A61B2018/00291 , A61B2018/00392 , A61B2018/00589 , A61B2018/1425 , A61B2218/002 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/0089
摘要： A device and method for delivering and injecting fluid into heart tissue utilizing a laterally directed needle to increase injectate (fluid) retention in the heart tissue. The device may comprise a catheter having a shaft wherein the distal end of the shaft includes a primary penetrating member and a secondary penetrating member. The secondary penetrating member includes an injection lumen in fluid communication with a pressurized fluid source. The primary penetrating member penetrates the heart tissue at the injection site in a first direction, and the secondary penetrating member penetrates the heart tissue in a second direction different from the first direction such that fluid leakage from the injection site is reduced and the volume of treated tissue is increased.

2. 发明授权

US06319230B1 Lateral needle injection apparatus and method 失效
标题翻译：侧针注射装置及方法
公开(公告)号：US06319230B1
公开(公告)日：2001-11-20
申请号：US09457254
申请日：1999-12-08
申请人： Maria Palasis , Arthur Rosenthal
发明人： Maria Palasis , Arthur Rosenthal
IPC分类号： A61M5178
CPC分类号： A61B17/3478 , A61B17/3207 , A61B18/1477 , A61B18/1492 , A61B2017/00247 , A61B2017/22077 , A61B2018/00214 , A61B2018/00291 , A61B2018/00392 , A61B2018/00589 , A61B2018/1425 , A61B2218/002 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/0089
摘要： A device and method for delivering and injecting fluid into heart tissue utilizing a laterally directed needle to increase injectate (fluid) retention in the heart tissue. The device may comprise a catheter having a shaft wherein the distal end of the shaft includes a primary penetrating member and a secondary penetrating member. The secondary penetrating member includes an injection lumen in fluid communication with a pressurized fluid source. The primary penetrating member penetrates the heart tissue at the injection site in a first direction, and the secondary penetrating member penetrates the heart tissue in a second direction different from the first direction such that fluid leakage from the injection site is reduced and the volume of treated tissue is increased.
摘要翻译：一种用于使用横向定向的针将流体输送和注入心脏组织以增加心脏组织中的注射（流体）保留的装置和方法。该装置可以包括具有轴的导管，其中轴的远端包括主要穿透构件和次要穿透构件。次级穿透构件包括与加压流体源流体连通的注射腔。主要穿透构件在第一方向上在注射部位处穿透心脏组织，并且次要穿透构件沿与第一方向不同的第二方向穿透心脏组织，使得来自注射部位的流体泄漏减少，并且经处理的体积组织增加。

3. 发明授权

US07537588B2 Lateral needle injection apparatus and method 有权
公开(公告)号：US07537588B2
公开(公告)日：2009-05-26
申请号：US11189795
申请日：2005-07-27
申请人： Maria Palasis , Arthur Rosenthal
发明人： Maria Palasis , Arthur Rosenthal
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B17/3207 , A61B18/1477 , A61B18/1492 , A61B2017/00247 , A61B2017/22077 , A61B2018/00214 , A61B2018/00291 , A61B2018/00392 , A61B2018/00589 , A61B2018/1425 , A61B2218/002 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/0089
摘要： A device and method for delivering and injecting fluid into heart tissue utilizing a laterally directed needle to increase injectate (fluid) retention in the heart tissue. The device may comprise a catheter having a shaft wherein the distal end of the shaft includes a primary penetrating member and a secondary penetrating member. The secondary penetrating member includes an injection lumen in fluid communication with a pressurized fluid source. The primary penetrating member penetrates the heart tissue at the injection site in a first direction, and the secondary penetrating member penetrates the heart tissue in a second direction different from the first direction such that fluid leakage from the injection site is reduced and the volume of treated tissue is increased.

4. 发明授权

US06969371B2 Lateral needle injection apparatus and method 失效
标题翻译：侧针注射装置及方法
公开(公告)号：US06969371B2
公开(公告)日：2005-11-29
申请号：US09982934
申请日：2001-10-22
申请人： Maria Palasis , Arthur Rosenthal
发明人： Maria Palasis , Arthur Rosenthal
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61M25/00 , A61M31/00 , A61M5/178
CPC分类号： A61B17/3478 , A61B17/3207 , A61B18/1477 , A61B18/1492 , A61B2017/00247 , A61B2017/22077 , A61B2018/00214 , A61B2018/00291 , A61B2018/00392 , A61B2018/00589 , A61B2018/1425 , A61B2218/002 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/0089
摘要： A device and method for delivering and injecting fluid into heart tissue utilizing a laterally directed needle to increase injectate (fluid) retention in the heart tissue. The device may comprise a catheter having a shaft wherein the distal end of the shaft includes a primary penetrating member and a secondary penetrating member. The secondary penetrating member includes an injection lumen in fluid communication with a pressurized fluid source. The primary penetrating member penetrates the heart tissue at the injection site in a first direction, and the secondary penetrating member penetrates the heart tissue in a second direction different from the first direction such that fluid leakage from the injection site is reduced and the volume of treated tissue is increased.
摘要翻译：一种用于使用横向定向的针将流体输送和注入心脏组织以增加心脏组织中的注射（流体）保留的装置和方法。该装置可以包括具有轴的导管，其中轴的远端包括主要穿透构件和次要穿透构件。次级穿透构件包括与加压流体源流体连通的注射腔。主要穿透构件在第一方向上在注射部位处穿透心脏组织，并且次要穿透构件沿与第一方向不同的第二方向穿透心脏组织，使得来自注射部位的流体泄漏减少，并且经处理的体积组织增加。

5. 发明授权

US07402155B2 Injection apparatus for delivering therapeutic 有权
标题翻译：用于输送治疗剂的注射装置
公开(公告)号：US07402155B2
公开(公告)日：2008-07-22
申请号：US10079505
申请日：2002-02-22
申请人： Maria Palasis , Arthur Rosenthal
发明人： Maria Palasis , Arthur Rosenthal
IPC分类号： A61M5/32
CPC分类号： A61B17/32037 , A61B2017/00247 , A61B2018/00392 , A61M5/30 , A61M5/3291 , A61M25/007 , A61M25/0084 , A61M2025/0089 , A61M2210/125
摘要： A catheter for delivering therapeutic to an injection site within the body is provided. This catheter can include a shaft having a proximal end, a distal end, and an infusion lumen extending therein; a penetrating member coupled to the shaft and extendable from the distal end of the shaft, and a stabilizer positioned towards the distal end of the shaft. The catheter could also include a delivery system, able to be calibrated to deliver therapeutic through an injection port at a rate less than the therapeutic absorption rate of the injection site.
摘要翻译：提供用于将治疗剂递送到体内的注射部位的导管。该导管可以包括具有近端，远端和在其中延伸的输液腔的轴; 耦合到所述轴并且可从所述轴的远端延伸的穿透构件以及朝向所述轴的远端定位的稳定器。导管还可以包括输送系统，其能够被校准以通过注射端口以低于注射部位的治疗吸收速率的速率输送治疗剂。

6. 发明授权

US06613026B1 Lateral needle-less injection apparatus and method 失效
公开(公告)号：US06613026B1
公开(公告)日：2003-09-02
申请号：US09457193
申请日：1999-12-08
申请人： Maria Palasis , Arthur Rosenthal
发明人： Maria Palasis , Arthur Rosenthal
IPC分类号： A61M532
CPC分类号： A61B17/32037 , A61B2017/00247 , A61B2018/00392 , A61M5/30 , A61M5/3291 , A61M25/007 , A61M25/0084 , A61M2025/0089 , A61M2210/125
摘要： A device and method for delivering and injecting fluid into heart tissue utilizing laterally directed injection ports to increase injectate (fluid) retention in the heart tissue. The catheter includes a shaft having an infusion lumen extending therethrough, wherein the distal end of the shaft includes a penetrating member having one or more injection ports. The penetrating member penetrates the heart tissue in a first direction, and the injection port or ports direct fluid in a second direction different from the first direction. By injecting the fluid or fluid in a direction different than the penetration direction, fluid leakage from the injection site is reduced and a greater volume of tissue is treated for a single primary injection.

7. 发明授权

US07445629B2 Medical device for delivering biologically active material 有权
标题翻译：用于输送生物活性物质的医疗装置
公开(公告)号：US07445629B2
公开(公告)日：2008-11-04
申请号：US10987284
申请日：2004-11-11
申请人： Arthur Rosenthal , James J. Barry , Matthew Miller
发明人： Arthur Rosenthal , James J. Barry , Matthew Miller
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2250/0014 , A61F2250/0067 , A61L31/16 , A61L31/18 , A61L2300/00
摘要： This invention relates generally to medical devices, such as stents, for delivering a biologically active material to a desired location within the body of a patient. In particular, the invention relates generally to a medical device for delivering a biologically active material to a surface of a body lumen. More particularly, the invention is directed to a medical device comprising two opposing end sections, each having a surface, and a middle portion. The middle portion comprises a plurality of struts and the two opposing end sections comprises non-structural elements. The end sections of the surface either (1) contain a greater amount of a biologically active material per unit length of the surface or (2) have a greater capacity per unit length to contain such material than the middle section of the surface by having a greater surface area per unit length of the surface than the middle section or having a greater affinity for the biologically active material per unit length of the surface than the middle section. The struts and the non-structural elements comprise biologically active materials. The invention is also directed to a method for delivering the biologically active material to the body tissue of a patient by inserting this medical device into the body of the patient. Still further, the invention is directed to a method of treating a body lumen surface by preventing or treating restenosis or hyperplasia, using the system of the invention. Still further, the invention is directed to a stent having a sidewall which comprises a middle section, a first end section and a second end section. The stent also comprises a band comprising a biologically active material. The band is connected to the first end section and/or second end section of the stent.
摘要翻译：本发明一般涉及用于将生物活性材料递送到患者体内期望位置的医疗装置，例如支架。具体地，本发明一般涉及用于将生物活性物质输送到体腔表面的医疗装置。更具体地，本发明涉及一种医疗装置，其包括两个相对的端部部分，每个端部部分具有表面和中间部分。中间部分包括多个支柱，并且两个相对的端部部分包括非结构元件。表面的端部（1）在表面的每单位长度上含有更多量的生物活性材料，或（2）通过具有比中间部分表面单位长度更大的表面积，或者比中间部分具有比表面单位长度更高的生物活性物质的亲和力。支柱和非结构元件包括生物活性材料。本发明还涉及一种通过将该医疗装置插入患者体内将生物活性物质递送到患者的身体组织的方法。此外，本发明涉及使用本发明的系统通过预防或治疗再狭窄或增生来治疗体腔表面的方法。此外，本发明涉及具有侧壁的支架，该侧壁包括中间部分，第一端部部分和第二端部部分。支架还包括包含生物活性材料的带。带子连接到支架的第一端部段和/或第二端部分。

8. 发明申请

US20050113903A1 Medical device for delivering biologically active material 有权
标题翻译：用于输送生物活性物质的医疗装置
公开(公告)号：US20050113903A1
公开(公告)日：2005-05-26
申请号：US10987284
申请日：2004-11-11
申请人： Arthur Rosenthal , James Barry , Matthew Miller
发明人： Arthur Rosenthal , James Barry , Matthew Miller
IPC分类号： A61L27/00 , A61F2/00 , A61F2/90 , A61K31/337 , A61K31/436 , A61K31/517 , A61K31/573 , A61K38/00 , A61F2/06
CPC分类号： A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2250/0014 , A61F2250/0067 , A61L31/16 , A61L31/18 , A61L2300/00
摘要： This invention relates generally to medical devices, such as stents, for delivering a biologically active material to a desired location within the body of a patient. In particular, the invention relates generally to a medical device for delivering a biologically active material to a surface of a body lumen. More particularly, the invention is directed to a medical device comprising two opposing end sections, each having a surface, and a middle portion. The middle portion comprises a plurality of struts and the two opposing end sections comprises non-structural elements. The end sections of the surface either (1) contain a greater amount of a biologically active material per unit length of the surface or (2) have a greater capacity per unit length to contain such material than the middle section of the surface by having a greater surface area per unit length of the surface than the middle section or having a greater affinity for the biologically active material per unit length of the surface than the middle section. The struts and the non-structural elements comprise biologically active materials. The invention is also directed to a method for delivering the biologically active material to the body tissue of a patient by inserting this medical device into the body of the patient. Still further, the invention is directed to a method of treating a body lumen surface by preventing or treating restenosis or hyperplasia, using the system of the invention. Still further, the invention is directed to a stent having a sidewall which comprises a middle section, a first end section and a second end section. The stent also comprises a band comprising a biologically active material. The band is connected to the first end section and/or second end section of the stent.
摘要翻译：本发明一般涉及用于将生物活性材料递送到患者体内期望位置的医疗装置，例如支架。具体地，本发明一般涉及用于将生物活性物质输送到体腔表面的医疗装置。更具体地，本发明涉及一种医疗装置，其包括两个相对的端部部分，每个端部部分具有表面和中间部分。中间部分包括多个支柱，并且两个相对的端部部分包括非结构元件。表面的端部（1）在表面的每单位长度上含有更多量的生物活性材料，或（2）通过具有比中间部分表面单位长度更大的表面积，或者比中间部分具有比表面单位长度更高的生物活性物质的亲和力。支柱和非结构元件包括生物活性材料。本发明还涉及一种通过将该医疗装置插入患者体内将生物活性物质递送到患者的身体组织的方法。此外，本发明涉及使用本发明的系统通过预防或治疗再狭窄或增生来治疗体腔表面的方法。此外，本发明涉及具有侧壁的支架，该侧壁包括中间部分，第一端部部分和第二端部部分。支架还包括包含生物活性材料的带。带子连接到支架的第一端部段和/或第二端部分。

9. 发明授权

US07708773B2 Modular stent graft employing bifurcated graft and leg locking stent elements 失效
标题翻译：模块化支架移植使用分叉移植和腿部锁定支架元件
公开(公告)号：US07708773B2
公开(公告)日：2010-05-04
申请号：US11336175
申请日：2006-01-20
申请人： Leonard Pinchuk , Arthur Rosenthal
发明人： Leonard Pinchuk , Arthur Rosenthal
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/07 , A61F2/89 , A61F2/91 , A61F2002/061 , A61F2002/067 , A61F2002/075 , A61F2230/0054
摘要： A modular stent graft system and associated surgical methods are provided that incorporates an external stent-based locking mechanism to prevent disarticulation of the legs from the bifurcated graft as well as other features that overcome many of the difficulties of the prior art associated with delivering and securing the bifurcated grafts to the intended deployment site within the human aorta.
摘要翻译：提供了一种组合式支架移植系统和相关的手术方法，其包括外部基于支架的锁定机构，以防止腿部从分叉移植物脱位，以及克服与递送和固定有关的现有技术的许多困难的其它特征分叉移植到人类主动脉内的预期部署地点。

10. 发明申请

US20060217801A1 Device with engineered surface architecture coating for controlled drug release 失效
标题翻译：具有工程表面结构涂层以控制药物释放的装置
公开(公告)号：US20060217801A1
公开(公告)日：2006-09-28
申请号：US11389712
申请日：2006-03-27
申请人： Arthur Rosenthal
发明人： Arthur Rosenthal
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/30322 , A61F2002/91533 , A61F2250/0026 , A61F2250/0036 , A61F2250/0068 , A61F2310/0097 , A61L31/16 , A61L2300/602 , A61L2300/606
摘要： In one embodiment of the present invention a coating topology, or engineered surface architecture that may be referred to as a microdroplet deposited engineered surface architecture is provided. A plurality of drops are placed on the stent with the purpose, of building up individual units of coating material on the outer stent surface. This architecture results in a coating that uses less material, i.e., polymer, solvent, medicine, while at the same time providing for better, and determinable, drug kinetics, approaching 100% delivery and better mechanical operation of the coating binding to the stent.
摘要翻译：在本发明的一个实施例中，提供了可以称为微滴沉积工程表面结构的涂层拓扑结构或工程表面结构。为了在外支架表面上建立单独的涂层材料单元，多个滴放在支架上。这种结构导致使用较少的材料即聚合物，溶剂，药物的涂层，同时提供更好和可确定的药物动力学，接近100％递送和更好地机械操作与支架结合的涂层。

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