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1. 发明授权

US09492068B2 Nasal aerosol delivery system 有权
标题翻译：鼻气雾剂输送系统
公开(公告)号：US09492068B2
公开(公告)日：2016-11-15
申请号：US13701992
申请日：2011-06-03
申请人： Mark J. Papania , James J. Barry , Mark C. Bagley , Eric M. Friets , Darin A. Knaus
发明人： Mark J. Papania , James J. Barry , Mark C. Bagley , Eric M. Friets , Darin A. Knaus
IPC分类号： A61M15/08 , A61B1/233 , A61M11/00 , A61B1/04 , A61B1/06 , A61M15/00 , A61M16/04 , A61M16/00
CPC分类号： A61B1/233 , A61B1/00045 , A61B1/04 , A61B1/06 , A61M11/00 , A61M11/005 , A61M11/006 , A61M11/007 , A61M15/0098 , A61M15/08 , A61M16/0488 , A61M16/107 , A61M31/00 , A61M2016/0024 , A61M2016/0042 , A61M2205/3365 , A61M2205/3375 , A61M2205/43 , A61M2205/502 , A61M2205/581 , A61M2205/6036 , A61M2205/6054 , A61M2205/6063
摘要： A nasal delivery device can include a nasal prong and an activation member. The nasal prong can comprises an opening at a top and bottom portion of the prong to allow for the passage of an aerosolized treatment agent through the nasal prong. The activation member can be positioned on the nasal delivery device at a location that is spaced apart from the subject's oral cavity when the nasal prong is received into the nostril of the subject. The activation member can be configured to detect a desired exhalation state of the subject and upon detection of the desired exhalation state, the activation member activates the delivery of the aerosolized treatment agent.
摘要翻译：鼻输送装置可以包括鼻针和激活构件。鼻插管可以包括在插脚的顶部和底部的开口，以允许雾化处理剂通过鼻插管。当鼻塞被插入到受试者的鼻孔中时，激活构件可以在与受试者的口腔间隔开的位置处定位在鼻输送装置上。激活构件可以被配置为检测对象的期望呼气状态，并且在检测到所需的呼气状态时，激活构件激活雾化处理剂的输送。

2. 发明申请

US20120118283A1 Systems and methods for aerosol delivery of agents 有权
标题翻译：用于药剂气溶胶输送的系统和方法
公开(公告)号：US20120118283A1
公开(公告)日：2012-05-17
申请号：US11796313
申请日：2007-04-27
申请人： Mark James Papania , James J. Barry , Nabil A. Elkouh , Mark C. Bagley
发明人： Mark James Papania , James J. Barry , Nabil A. Elkouh , Mark C. Bagley
IPC分类号： A61M11/02
CPC分类号： A61M11/005 , A61M11/001 , A61M11/06 , A61M15/0033 , A61M15/0066 , A61M15/0085 , A61M15/08 , A61M16/0057 , A61M16/0666 , A61M16/107 , A61M16/14 , A61M2205/07 , A61M2205/071 , A61M2205/3606 , A61M2205/8206 , A61M2205/8225 , A61M2205/825
摘要： Aerosol delivery systems and methods for delivering an agent to a patient are described herein. The present invention includes embodiments comprising an insulated receptacle connected to a body to hold a vial of an agent to be delivered to a patient. The vial is located in an inverted position within the receptacle and connected to the housing. One or more reusable thermal packs can be located on the inner sides of the receptacle, to maintain a selected temperature surrounding the vial. The agent is administered to a patient by placing a prong into one of the patient's orifices and then activating an aerosol delivery system. Such systems comprise jet aerosolization and pneumatic and ultrasonic nebulizers and preferably are portable.
摘要翻译：本文描述了用于将药剂递送至患者的气溶胶递送系统和方法。本发明包括实施例，该实施例包括连接到身体的绝缘插座，用于保持要递送给患者的药剂瓶。小瓶位于插座内的倒置位置并连接到外壳。一个或多个可重复使用的热包装可以位于容器的内侧，以保持围绕小瓶的选定温度。通过将一个插入物插入患者的一个孔中，然后激活气雾剂输送系统，向患者施用该药剂。这样的系统包括喷雾雾化和气动和超声雾化器，并且优选是便携式的。

3. 发明授权

US08157854B2 Method and system for delivery of coated implants 有权
标题翻译：用于输送涂层植入物的方法和系统
公开(公告)号：US08157854B2
公开(公告)日：2012-04-17
申请号：US12837981
申请日：2010-07-16
申请人： James J. Barry , Sean Gilligan
发明人： James J. Barry , Sean Gilligan
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L29/085 , A61L29/14
摘要： Method and system for delivery of coated implants is provided. One embodiment encompasses a coated implant delivery system. This system includes an implant delivery device having a first end, a second end, and an inner lumen, wherein the first end has a releasable implant retention region with an accessible surface having a coated implant adhesion-resistant treatment. In another embodiment a method of deploying a coated releasable implant at a target site of a vessel using an implant delivery system is provided. This method includes inserting a portion of an implant delivery device having a releasable implant into the vessel, advancing the implant delivery device to the target site, deploying the releasable implant from the delivery device, and withdrawing the inserted portion of the implant delivery device from the vessel. The implant delivery device in this embodiment has a releasable implant retention region with an accessible surface having a coated implant adhesion-resistant treatment and wherein the releasable implant has a first coating that faces the accessible surface of the releasable implant retention region.
摘要翻译：提供了用于递送涂覆植入物的方法和系统。一个实施方案包括涂覆的植入物递送系统。该系统包括具有第一端，第二端和内腔的植入物递送装置，其中第一端具有可释放的植入物保持区域，其具有可涂覆的植入物耐粘附处理的可接近表面。在另一个实施方案中，提供了使用植入物递送系统在容器的靶位点部署涂覆的可释放植入物的方法。该方法包括将具有可释放植入物的植入物递送装置的一部分插入到容器中，将植入物递送装置推进到目标部位，将可释放植入物从输送装置展开，以及将植入物递送装置的插入部分从船只。该实施例中的植入物递送装置具有可释放的植入物保留区域，其具有可涂覆的植入物耐粘附处理的可触及表面，并且其中可释放植入物具有面向可释放植入物保留区域的可接近表面的第一涂层。

4. 发明授权

US07954486B2 Aerosol delivery systems and methods 有权
标题翻译：气溶胶输送系统和方法
公开(公告)号：US07954486B2
公开(公告)日：2011-06-07
申请号：US10587814
申请日：2005-04-01
申请人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
发明人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
IPC分类号： A61M11/00 , A61M15/00 , B05B17/06
CPC分类号： B05B17/0638 , A61M15/0033 , A61M15/0065 , A61M15/0085 , A61M2205/07 , A61M2205/3306 , A61M2205/825 , B05B12/008 , B05B12/082 , B05B17/0623 , B05B17/0676
摘要： Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.
摘要翻译：本文描述了将药剂气雾剂递送至患者的方法和系统。本系统可用于施用各种类型的试剂，例如疫苗或其他类型的药物。本系统的某些实施例利用联接到一次性雾化元件的致动器，其在由致动器作用时使药剂雾化以递送给患者。雾化元件防止试剂与系统的致动器和其他非一次性部件接触，从而不需要或不需要清洁或维护。本系统还可以包括气雾化速率监测器，其监测试剂被雾化的速率，并向使用者提供反馈以确保施用适当的剂量。

5. 发明授权

US07854743B2 Catheter for the delivery of therapeutic agents to tissues 有权
标题翻译：用于将治疗剂递送至组织的导管
公开(公告)号：US07854743B2
公开(公告)日：2010-12-21
申请号：US11185801
申请日：2005-07-21
申请人： Maria Palasis , James J. Barry , Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang
发明人： Maria Palasis , James J. Barry , Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang
IPC分类号： A61B17/32
CPC分类号： A61B17/3468 , A61B17/3478 , A61B90/39 , A61B2017/00247 , A61B2017/320084 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61L29/16 , A61L2300/258 , A61L2300/414 , A61L2300/64 , A61M25/0084 , A61M37/0069 , A61M2025/0004 , A61M2025/0089
摘要： A catheter for placement of an in situ implant is provided. This catheter may include a first elongate shaft having a proximal end and a distal end, a second elongate shaft having a proximal end and a distal end, a first sharpened distal tip disposed at the distal end of the first shaft and a second sharpened distal tip disposed at the distal end of the second shaft. The first shaft and the second shaft may also be secured to one another at the distal end of the first shaft according to the invention. Still further, according to other teachings, the first sharpened distal tip may extend beyond the second sharpened distal tip in a catheter that practices the invention.
摘要翻译：提供了用于放置原位植入物的导管。该导管可以包括具有近端和远端的第一细长轴，具有近端和远端的第二细长轴，设置在第一轴的远端处的第一尖锐的远侧末端和第二尖锐远端设置在第二轴的远端。根据本发明，第一轴和第二轴也可以在第一轴的远端处彼此固定。此外，根据其他教导，第一锐化的远侧末端可以在实践本发明的导管中延伸超过第二锋利的远侧末端。

6. 发明授权

US06663607B2 Bioactive aneurysm closure device assembly and kit 失效
标题翻译：生物活性动脉瘤闭合装置组件和试剂盒
公开(公告)号：US06663607B2
公开(公告)日：2003-12-16
申请号：US09352187
申请日：1999-07-12
申请人： Paul C. Slaikeu , Michael P. Wallace , Joseph C. Eder , James J. Barry , Robert M. Abrams
发明人： Paul C. Slaikeu , Michael P. Wallace , Joseph C. Eder , James J. Barry , Robert M. Abrams
IPC分类号： A61M2500
CPC分类号： A61F2/82 , A61B17/12022 , A61B17/12118 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61F2/90 , A61F2002/823 , A61L31/043
摘要： This is an implantable medical device assembly for use in surgical procedures. It is most preferably an implantable structure having stenting properties but only partially coated with or partially associated with a material causing a localized angiogenic response. One variation of is an artificial occlusion kit having the inventive implantable stenting structure situatable and vaso-occlusive devices. The implantable stenting structure is typically situated so to prevent migration of artificial occlusion devices or implants from an occlusion site, such as an aneurysm, and into an adjacent body space, such as a blood vessel.
摘要翻译：这是用于外科手术的植入式医疗装置组件。最优选的是具有支架特性的植入式结构，但仅部分涂覆或部分地与导致局部血管生成应答的材料相关联。一种变体是具有本发明的可植入支架结构可置换和血管闭塞装置的人造闭塞试剂盒。植入式支架结构通常被设置为防止人工闭塞装置或植入物从诸如动脉瘤的闭塞部位移动到相邻的身体空间（例如血管）中。

7. 发明授权

US06409716B1 Drug delivery 失效
标题翻译：药物递送
公开(公告)号：US06409716B1
公开(公告)日：2002-06-25
申请号：US08946207
申请日：1997-10-07
申请人： Ronald A. Sahatjian , James J. Barry
发明人： Ronald A. Sahatjian , James J. Barry
IPC分类号： A61M3100
CPC分类号： A61M25/104 , A61F2/90 , A61F2230/0013 , A61F2250/0067 , A61K9/0024 , A61K38/49 , A61K48/00 , A61L29/085 , A61L29/145 , A61L29/16 , A61L31/10 , A61L31/145 , A61L31/16 , A61L33/0023 , A61L33/0029 , A61L2300/256 , A61L2300/258 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61M16/0481 , A61M25/0045 , A61M2025/0046 , A61M2025/0057 , A61M2025/09183 , A61M2025/105 , A61M2025/1086 , A61M2205/0266 , C08L33/02 , C08L35/00
摘要： The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.
摘要翻译：本发明的特征在于导管和用于将药物递送到体腔壁的所需位置处的组织的方法。导管被构造成用于插入体腔，并且具有导管轴和安装在导管轴上的可扩张部分。可膨胀部分可膨胀至受控的压力以填充体腔的横截面并压靠身体腔的壁。在一个实施例中，可膨胀部分的外表面的至少一部分由强力粘附的可溶胀水凝胶聚合物的涂层限定。掺入水凝胶聚合物中的是待递送至组织或斑块的预选药物的水溶液。选择水凝胶聚合物和药物，以便当可膨胀部分膨胀时，水凝胶聚合物涂层在水凝胶聚合物涂层压靠内腔壁时，从水凝胶聚合物涂层快速释放所需剂量的药物。在其它实施方案中，聚合物响应于压力从可膨胀部分释放，以涂覆体腔的壁。

8. 发明授权

US06306166B1 Loading and release of water-insoluble drugs 失效
标题翻译：装载和释放不溶于水的药物
公开(公告)号：US06306166B1
公开(公告)日：2001-10-23
申请号：US09172026
申请日：1998-10-14
申请人： James J. Barry , Maria Palasis
发明人： James J. Barry , Maria Palasis
IPC分类号： A61F206
CPC分类号： A61L29/16 , A61F2/82 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/45 , A61L2300/602 , A61L2300/604 , A61L2300/606 , A61M25/10 , A61M25/1027 , A61M29/02 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , A61M2025/1081 , A61M2025/1088 , C08L75/04 , C08L67/04 , C08L33/08
摘要： A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating.
摘要翻译：用于将基本上不溶于水的药物递送到体内所需位置的组织的医疗装置，聚合物组合物和方法。医疗装置的外表面的至少一部分设置有聚合物涂层。掺入聚合物涂层中的是至少一种基本上不溶于水的药物在挥发性有机溶剂中的溶液。医疗装置被定位在体内所需的目标位置，于是药物从聚合物涂层中扩散出来。

9. 发明申请

US20120239001A1 LOADING AND RELEASE OF WATER-INSOLUBLE DRUGS 审中-公开
标题翻译：加载和释放水不溶性药物
公开(公告)号：US20120239001A1
公开(公告)日：2012-09-20
申请号：US13483850
申请日：2012-05-30
申请人： James J. Barry , Maria Palasis
发明人： James J. Barry , Maria Palasis
IPC分类号： A61M25/10 , B05D7/00
CPC分类号： A61L29/16 , A61F2/82 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/45 , A61L2300/602 , A61L2300/604 , A61L2300/606 , A61M25/10 , A61M25/1027 , A61M29/02 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , A61M2025/1081 , A61M2025/1088 , C08L75/04 , C08L67/04 , C08L33/08
摘要： A medical device, polymer composition, and method for delivering substantially water-insoluble drugs to tissue at desired locations within the body. At least a portion of the exterior surface of the medical device is provided with a polymer coating. Incorporated in the polymer coating is a solution of at least one substantially water-insoluble drug in a volatile organic solvent. The medical device is positioned to a desired target location within the body, whereupon the drug diffuses out of the polymer coating.
摘要翻译：用于将基本上不溶于水的药物递送到体内所需位置的组织的医疗装置，聚合物组合物和方法。医疗装置的外表面的至少一部分设置有聚合物涂层。掺入聚合物涂层中的是至少一种基本上不溶于水的药物在挥发性有机溶剂中的溶液。医疗装置被定位在体内所需的目标位置，于是药物从聚合物涂层中扩散出来。

10. 发明申请

US20110203580A1 AEROSOL DELIVERY SYSTEMS AND METHODS 有权
标题翻译：航空运输系统和方法
公开(公告)号：US20110203580A1
公开(公告)日：2011-08-25
申请号：US13099261
申请日：2011-05-02
申请人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
发明人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
IPC分类号： A61M11/00
CPC分类号： B05B17/0638 , A61M15/0033 , A61M15/0065 , A61M15/0085 , A61M2205/07 , A61M2205/3306 , A61M2205/825 , B05B12/008 , B05B12/082 , B05B17/0623 , B05B17/0676
摘要： Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.
摘要翻译：本文描述了将药剂气雾剂递送至患者的方法和系统。本系统可用于施用各种类型的试剂，例如疫苗或其他类型的药物。本系统的某些实施例利用联接到一次性雾化元件的致动器，其在由致动器作用时使药剂雾化以递送给患者。雾化元件防止试剂与系统的致动器和其他非一次性部件接触，从而不需要或不需要清洁或维护。本系统还可以包括气雾化速率监测器，其监测试剂被雾化的速率，并向使用者提供反馈以确保施用适当的剂量。

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