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1. 发明授权

US09272120B2 Stretch valve balloon catheter and methods for producing and using same 有权
标题翻译：弹力气囊导管及其制造和使用方法
公开(公告)号：US09272120B2
公开(公告)日：2016-03-01
申请号：US14024151
申请日：2013-09-11
申请人： Leonard Pinchuk , Gary A. Kalser , Gregory L. Mayback , James Leone
发明人： Leonard Pinchuk , Gary A. Kalser , Gregory L. Mayback , James Leone
IPC分类号： A61M31/00 , A61M37/00 , A61M27/00 , A61M25/00 , A61M25/10
CPC分类号： A61M25/0017 , A61M25/04 , A61M25/10 , A61M25/1018 , A61M25/10186 , A61M25/1027 , A61M2025/1093 , A61M2210/1085
摘要： A safety catheter for draining a given fluid includes a hollow stretch valve and a flexible, multi-lumen, balloon drainage catheter having a proximal catheter end, a balloon defining a balloon interior to be inflated with an inflation fluid, a drain lumen. and a balloon drainage port fluidically connecting the balloon interior to the drain lumen. The hollow stretch valve is shaped to permit the given fluid to pass therethrough and is positioned in the drain lumen to at least partially slide therein such that, in a steady state, the stretch valve prevents the inflation fluid from passing through the drainage port, and, in a stretched state when the proximal catheter end is stretched, the distal sliding portion slides within the drain lumen to permit the inflation fluid to pass through the drainage port and into the drain lumen.
摘要翻译：用于排出给定流体的安全导管包括中空拉伸阀和具有近端导管末端的柔性多腔气囊排出导管，气囊限定用充气流体充气的气囊内部，排液腔。以及将气囊内部流体连接到排泄管腔的气囊引流口。中空拉伸阀被成形为允许给定的流体通过，并且定位在排水管腔中以在其中至少部分地滑动，使得在稳定状态下，拉伸阀阻止膨胀流体通过排水口，并且当拉伸近端导管末端时处于拉伸状态，远端滑动部分在排水管内滑动，以使膨胀流体通过排水口并进入排水管腔。

2. 发明授权

US08696699B2 Microvalve protection device and method of use for protection against embolization agent reflux 有权
标题翻译：微阀保护装置及其用于防止栓塞剂回流的方法
公开(公告)号：US08696699B2
公开(公告)日：2014-04-15
申请号：US13280608
申请日：2011-10-25
申请人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
发明人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61M25/005 , A61M25/0075 , A61M2025/0004 , A61M2025/0042 , A61M2025/0076 , A61M2025/0681
摘要： An endovascular valve device for use in a vessel during a therapy procedure includes a catheter having at its distal end a valve. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. The first filaments have a spring bias that radially expands the valve. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the catheter is in communication with the center of the valve.
摘要翻译：在治疗过程中在血管中使用的血管内瓣膜装置包括在其远端具有阀的导管。该阀由细长的第一丝的编织物构成，该编织物在其近端处以这样的方式联接在一起，使得第一细丝沿其长度相对于彼此可移动。第一个细丝具有径向扩张阀的弹簧偏压。向通过静电沉积或将聚合物第二长丝纺丝到编织的第一丝上形成的编织物提供过滤器。导管的内腔与阀的中心连通。

3. 发明申请

US20130237966A1 Stretch Valve Balloon Catheter and Methods for Producing and Using Same 有权
标题翻译：伸展阀气球导管及其生产和使用方法
公开(公告)号：US20130237966A1
公开(公告)日：2013-09-12
申请号：US13868376
申请日：2013-04-23
申请人： Leonard Pinchuk , Gary A. Kalser , Gregory L. Mayback , James Leone
发明人： Leonard Pinchuk , Gary A. Kalser , Gregory L. Mayback , James Leone
IPC分类号： A61M25/00
CPC分类号： A61M25/0017 , A61B5/205 , A61M25/04 , A61M25/10181 , A61M25/10184 , A61M25/10185 , A61M2025/1093 , A61M2210/1085
摘要： A safety catheter includes a flexible, multi-lumen shaft having an outer diameter, a distal tip, a proximal catheter end with a drain end and a proximal inflation end. The multi-lumen shaft defines a drain lumen, a distal hollow balloon portion, at least one inflation lumen, and a drainage port. A hollow stretch valve is coaxially disposed in the drainage lumen and has a radially self-expandable proximal section fixedly connected within the drain lumen by self-expansion, a flexible intermediate section longitudinally movable within the drain lumen, and a distal plug movably positioned in the drain lumen to prevent fluid from passing through the drainage port in a steady state and being slidably disposed within the drain lumen such that, in a stretched state when the proximal catheter end is stretched, the distal plug slides within the drain lumen to permit the inflation fluid to pass through the drainage port.
摘要翻译：安全导管包括具有外径，远侧末端，具有排水端和近侧充气端的近侧导管端的柔性多腔轴。多腔轴限定排水腔，远端中空球囊部分，至少一个充气腔和排水口。中空拉伸阀同轴地布置在排水腔中，并且具有通过自膨胀固定地连接在排水管腔内的径向自扩张近端部分，可在排液腔内纵向移动的柔性中间部分和可移动地定位在排液腔内的远端塞排水管腔，以防止流体在稳定状态下通过排水口并且可滑动地设置在排水管腔内，使得当拉伸近端导管端时处于拉伸状态，远端塞在排液管内滑动以允许膨胀流体通过排水口。

4. 发明申请

US20130184631A1 Method, Surgical Kit and Device for Treating Glaucoma 有权
标题翻译：方法，手术套件和治疗青光眼的装置
公开(公告)号：US20130184631A1
公开(公告)日：2013-07-18
申请号：US13348931
申请日：2012-01-12
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F9/00736 , A61F2009/00891 , A61M27/002 , A61M2210/0612
摘要： A surgical kit includes at least one instrument and at least one implant device. The instrument has a needle body used to form a surgical passage through ocular tissue. The device includes a flexible tube that defines a duct for diverting aqueous humor with an outer surface having a maximal cross-sectional dimension that is less than the maximal cross-sectional dimension of the needle body. The device incorporates sealing means including at least one element that define a maximal cross-sectional dimension that is greater that the maximal cross-sectional dimension of the needle body and that are operably disposed within the surgical passage and form a seal between the surrounding ocular tissue and the element(s) as well as fixate the device in the surgical passage. The kit (and devices thereof) can be used as part of a surgical method to divert aqueous humor to a space formed in ocular tissue.
摘要翻译：手术套件包括至少一个仪器和至少一个植入装置。仪器具有用于通过眼组织形成手术通道的针体。该装置包括柔性管，其限定用于将房水转移到具有小于针体的最大横截面尺寸的最大横截面尺寸的外表面的管道。该装置包括密封装置，其包括至少一个元件，其限定最大横截面尺寸，其大于针体的最大横截面尺寸并且可操作地设置在手术通道内并在周围的眼组织之间形成密封和元件以及将装置固定在手术通道中。该套件（及其装置）可用作手术方法的一部分，以将房水转移到眼组织中形成的空间。

5. 发明申请

US20120116351A1 Method of Operating a Microvalve Protection Device 有权
标题翻译：操作微型阀保护装置的方法
公开(公告)号：US20120116351A1
公开(公告)日：2012-05-10
申请号：US13306105
申请日：2011-11-29
申请人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
发明人： James E. Chomas , Leonard Pinchuk , John Martin , Aravind Arepally , Brett E. Naglreiter , Norman R. Weldon , Bryan M. Pinchuk
IPC分类号： A61M25/14
CPC分类号： A61F2/013 , A61B17/00491 , A61B17/12186 , A61B2017/22082 , A61F2/01 , A61F2/2412 , A61F2/2436 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0076 , A61F2230/008 , A61M25/005 , A61M25/0075 , A61M2025/0004
摘要： An endovascular valve device for use in a vessel during a therapy procedure includes a catheter having at its distal end a valve. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. The first filaments have a spring bias that radially expands the valve. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the catheter is in communication with the center of the valve. The device is used to provide a therapy in which a therapeutic agent is infused into an organ.
摘要翻译：在治疗过程中在血管中使用的血管内瓣膜装置包括在其远端具有阀的导管。该阀由细长的第一丝的编织物构成，该编织物在其近端处以这样的方式联接在一起，使得第一细丝沿其长度相对于彼此可移动。第一个细丝具有径向扩张阀的弹簧偏压。向通过静电沉积或将聚合物第二长丝纺丝到编织的第一丝上形成的编织物提供过滤器。导管的内腔与阀的中心连通。该装置用于提供其中将治疗剂输注到器官中的治疗。

6. 发明申请

US20100241208A1 Pacemaker Lead and Method of Making Same 失效
标题翻译：起搏器牵头及其制作方法
公开(公告)号：US20100241208A1
公开(公告)日：2010-09-23
申请号：US12690997
申请日：2010-01-21
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61B5/042 , A61B2562/125
摘要： An improved pacemaker lead including a lead body supporting at least one flexible conductor element that provides an electrical signal path between a proximal connector element and a distal electrode. The lead body includes an insulating structure that protects the flexible conductor element(s) wherein the insulating structure is realized from a polymer blend of a thermoplastic polyurethane elastomer and an isobutylene block copolymer. The mole fraction of the isobutylene block copolymer of the polymer blend is in the range of 2-15% (most preferably on the order of 10%). The polymer blend of the insulating structure has a maximum tensile strength in the range of 20-40 MPa (most preferably in a range of 25-35 MPa). In the preferred embodiment, the hardness of the polymer blend can be characterized by a Shore hardness in a range of 70-80 A. The flexible conductor element(s) preferably include a coiled wire conductor defining a central axis with an outer surface facing radially outward away from the central axis and an inner surface facing radially inward toward the central axis, and the insulating structure surrounds at least the outer surface of the coiled wire conductor (and more preferably encapsulates the coiled wire conductor). The polymer blend of the insulating structure has reduced oxygen permeability, and thus provides improved resistance to environmental stress cracking and metal ion induced oxidation while maintaining the flexibility and desired tensile strength of the lead body.
摘要翻译：一种改进的起搏器引线，包括引导体，其支撑至少一个柔性导体元件，其提供近端连接器元件和远端电极之间的电信号路径。引线体包括保护柔性导体元件的绝缘结构，其中由热塑性聚氨酯弹性体和异丁烯嵌段共聚物的聚合物共混物实现绝缘结构。聚合物共混物的异丁烯嵌段共聚物的摩尔分数在2-15％（最优选约10％）的范围内。绝缘结构的聚合物共混物的最大拉伸强度在20-40MPa的范围内（最优选在25-35MPa的范围内）。在优选实施方案中，聚合物共混物的硬度可以通过肖氏硬度在70-80A的范围内表征。柔性导体元件优选包括限定中心轴线的线圈状导体，其外表面面向径向远离中心轴线的外表面和朝向中心轴线径向向内的内表面，并且绝缘结构至少围绕线圈导线的外表面（更优选地包围线圈导线）。绝缘结构的聚合物共混物具有降低的透氧性，从而提供改善的耐环境应力开裂性和金属离子诱导氧化性，同时保持引线体的柔软性和所需拉伸强度。

7. 发明申请

US20100241046A1 APPARATUS, METHODS AND DEVICES FOR TREATMENT OF OCULAR DISORDERS 审中-公开
标题翻译：用于治疗眼病的装置，方法和装置
公开(公告)号：US20100241046A1
公开(公告)日：2010-09-23
申请号：US12440096
申请日：2007-09-06
申请人： Leonard Pinchuk , Jean-Marie A. Parel , Francisco Fantes
发明人： Leonard Pinchuk , Jean-Marie A. Parel , Francisco Fantes
IPC分类号： A61M1/00
CPC分类号： A61L27/56 , A61F9/00781 , A61L27/48 , A61L31/129 , A61L31/146 , C08L53/02
摘要： Apparatus and methods for relieving and treating glaucoma and other ocular disorders are disclosed. The apparatus includes a thin flexible membrane and preferably a tubular member. In another aspect of the invention, a surgical device for repairing ocular tissue includes a flexible membrane of a polymeric material comprising polyisobutylene. In the preferred embodiment, the polymeric material of the membrane is porous.
摘要翻译：公开了用于缓解和治疗青光眼和其它眼部疾病的装置和方法。该装置包括薄的柔性膜并且优选地为管状构件。在本发明的另一方面，用于修复眼组织的手术装置包括包含聚异丁烯的聚合物材料的柔性膜。在优选的实施方案中，膜的聚合物材料是多孔的。

8. 发明申请

US20100092540A1 DRUG DELIVERY COMPOSITIONS AND MEDICAL DEVICES CONTAINING BLOCK COPOLYMER 有权
标题翻译：药物递送组合物和含有嵌段共聚物的医疗装置
公开(公告)号：US20100092540A1
公开(公告)日：2010-04-15
申请号：US12578362
申请日：2009-10-13
申请人： Leonard Pinchuk , Sepideh Hashemi , Marlene C. Schwarz , Kalpana Kamath , Ni Ding
发明人： Leonard Pinchuk , Sepideh Hashemi , Marlene C. Schwarz , Kalpana Kamath , Ni Ding
IPC分类号： A61F2/00 , A61K31/337 , A61P35/00
CPC分类号： C08L53/00 , A61L27/16 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , C08F293/005 , C08F297/00 , C08F297/04 , C08L53/02 , C09D153/00 , C09D153/02 , C08L2666/02
摘要： A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X-(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.
摘要翻译：提供了用于递送治疗剂的组合物。所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。嵌段共聚物优选为式X-（AB）n，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。根据本发明的另一方面，提供了一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内至少一部分医疗装置上的涂层，其中所述涂层包括上述生物相容性嵌段共聚物。

9. 发明授权

US07622530B2 Drug delivery compositions and medical devices containing block copolymer 有权
标题翻译：药物输送组合物和含有嵌段共聚物的医疗器械
公开(公告)号：US07622530B2
公开(公告)日：2009-11-24
申请号：US11057870
申请日：2005-02-14
申请人： Leonard Pinchuk , Sepideh Hashemi , Marlene C. Schwarz , Kalpana Kamath , Ni Ding
发明人： Leonard Pinchuk , Sepideh Hashemi , Marlene C. Schwarz , Kalpana Kamath , Ni Ding
IPC分类号： C08L33/02 , A61F2/00
CPC分类号： C08L53/00 , A61L27/16 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , C08F293/005 , C08F297/00 , C08F297/04 , C08L53/02 , C09D153/00 , C09D153/02 , C08L2666/02
摘要： A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X-(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.
摘要翻译：提供了用于递送治疗剂的组合物。所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。嵌段共聚物优选为式X-（AB）n，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。根据本发明的另一方面，提供了一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内至少一部分医疗装置上的涂层，其中所述涂层包括上述生物相容性嵌段共聚物。

10. 发明申请

US20090156893A1 FLATTENED TUBULAR MESH SLING AND RELATED METHODS 有权
标题翻译：扁平管网和相关方法
公开(公告)号：US20090156893A1
公开(公告)日：2009-06-18
申请号：US12391995
申请日：2009-02-24
申请人： George Bourne , Leonard Pinchuk
发明人： George Bourne , Leonard Pinchuk
IPC分类号： A61F2/02 , B32B37/00
CPC分类号： A61F2/0045 , A61F2002/0068 , A61F2250/0028 , Y10T156/10
摘要： The invention generally relates to surgically implantable supportive slings. More specifically, in various embodiments, the invention is directed to multilayer mesh slings formed from a tubular mesh material.
摘要翻译：本发明一般涉及可手术植入的支撑吊索。更具体地，在各种实施例中，本发明涉及由管状网状材料形成的多层网状吊索。

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