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    • 1. 发明申请
    • Medical device for delivering biologically active material
    • 用于输送生物活性物质的医疗装置
    • US20050113903A1
    • 2005-05-26
    • US10987284
    • 2004-11-11
    • Arthur RosenthalJames BarryMatthew Miller
    • Arthur RosenthalJames BarryMatthew Miller
    • A61L27/00A61F2/00A61F2/90A61K31/337A61K31/436A61K31/517A61K31/573A61K38/00A61F2/06
    • A61F2/90A61F2/91A61F2/915A61F2002/91525A61F2002/91533A61F2002/91575A61F2250/0014A61F2250/0067A61L31/16A61L31/18A61L2300/00
    • This invention relates generally to medical devices, such as stents, for delivering a biologically active material to a desired location within the body of a patient. In particular, the invention relates generally to a medical device for delivering a biologically active material to a surface of a body lumen. More particularly, the invention is directed to a medical device comprising two opposing end sections, each having a surface, and a middle portion. The middle portion comprises a plurality of struts and the two opposing end sections comprises non-structural elements. The end sections of the surface either (1) contain a greater amount of a biologically active material per unit length of the surface or (2) have a greater capacity per unit length to contain such material than the middle section of the surface by having a greater surface area per unit length of the surface than the middle section or having a greater affinity for the biologically active material per unit length of the surface than the middle section. The struts and the non-structural elements comprise biologically active materials. The invention is also directed to a method for delivering the biologically active material to the body tissue of a patient by inserting this medical device into the body of the patient. Still further, the invention is directed to a method of treating a body lumen surface by preventing or treating restenosis or hyperplasia, using the system of the invention. Still further, the invention is directed to a stent having a sidewall which comprises a middle section, a first end section and a second end section. The stent also comprises a band comprising a biologically active material. The band is connected to the first end section and/or second end section of the stent.
    • 本发明一般涉及用于将生物活性材料递送到患者体内期望位置的医疗装置,例如支架。 具体地,本发明一般涉及用于将生物活性物质输送到体腔表面的医疗装置。 更具体地,本发明涉及一种医疗装置,其包括两个相对的端部部分,每个端部部分具有表面和中间部分。 中间部分包括多个支柱,并且两个相对的端部部分包括非结构元件。 表面的端部(1)在表面的每单位长度上含有更多量的生物活性材料,或(2)通过具有 比中间部分表面单位长度更大的表面积,或者比中间部分具有比表面单位长度更高的生物活性物质的亲和力。 支柱和非结构元件包括生物活性材料。 本发明还涉及一种通过将该医疗装置插入患者体内将生物活性物质递送到患者的身体组织的方法。 此外,本发明涉及使用本发明的系统通过预防或治疗再狭窄或增生来治疗体腔表面的方法。 此外,本发明涉及具有侧壁的支架,该侧壁包括中间部分,第一端部部分和第二端部部分。 支架还包括包含生物活性材料的带。 带子连接到支架的第一端部段和/或第二端部分。
    • 2. 发明授权
    • Medical device for delivering biologically active material
    • 用于输送生物活性物质的医疗装置
    • US07445629B2
    • 2008-11-04
    • US10987284
    • 2004-11-11
    • Arthur RosenthalJames J. BarryMatthew Miller
    • Arthur RosenthalJames J. BarryMatthew Miller
    • A61F2/06
    • A61F2/90A61F2/91A61F2/915A61F2002/91525A61F2002/91533A61F2002/91575A61F2250/0014A61F2250/0067A61L31/16A61L31/18A61L2300/00
    • This invention relates generally to medical devices, such as stents, for delivering a biologically active material to a desired location within the body of a patient. In particular, the invention relates generally to a medical device for delivering a biologically active material to a surface of a body lumen. More particularly, the invention is directed to a medical device comprising two opposing end sections, each having a surface, and a middle portion. The middle portion comprises a plurality of struts and the two opposing end sections comprises non-structural elements. The end sections of the surface either (1) contain a greater amount of a biologically active material per unit length of the surface or (2) have a greater capacity per unit length to contain such material than the middle section of the surface by having a greater surface area per unit length of the surface than the middle section or having a greater affinity for the biologically active material per unit length of the surface than the middle section. The struts and the non-structural elements comprise biologically active materials. The invention is also directed to a method for delivering the biologically active material to the body tissue of a patient by inserting this medical device into the body of the patient. Still further, the invention is directed to a method of treating a body lumen surface by preventing or treating restenosis or hyperplasia, using the system of the invention. Still further, the invention is directed to a stent having a sidewall which comprises a middle section, a first end section and a second end section. The stent also comprises a band comprising a biologically active material. The band is connected to the first end section and/or second end section of the stent.
    • 本发明一般涉及用于将生物活性材料递送到患者体内期望位置的医疗装置,例如支架。 具体地,本发明一般涉及用于将生物活性物质输送到体腔表面的医疗装置。 更具体地,本发明涉及一种医疗装置,其包括两个相对的端部部分,每个端部部分具有表面和中间部分。 中间部分包括多个支柱,并且两个相对的端部部分包括非结构元件。 表面的端部(1)在表面的每单位长度上含有更多量的生物活性材料,或(2)通过具有 比中间部分表面单位长度更大的表面积,或者比中间部分具有比表面单位长度更高的生物活性物质的亲和力。 支柱和非结构元件包括生物活性材料。 本发明还涉及一种通过将该医疗装置插入患者体内将生物活性物质递送到患者的身体组织的方法。 此外,本发明涉及使用本发明的系统通过预防或治疗再狭窄或增生来治疗体腔表面的方法。 此外,本发明涉及具有侧壁的支架,该侧壁包括中间部分,第一端部部分和第二端部部分。 支架还包括包含生物活性材料的带。 带子连接到支架的第一端部段和/或第二端部分。
    • 6. 发明申请
    • Topic and Time Based Media Affinity Estimation
    • 主题和基于时间的媒体亲和度估计
    • US20130018896A1
    • 2013-01-17
    • US13548901
    • 2012-07-13
    • Michael Ben FleischmanDeb Kumar RoyJeremy RishelAnjali MidhaMatthew Miller
    • Michael Ben FleischmanDeb Kumar RoyJeremy RishelAnjali MidhaMatthew Miller
    • G06F17/30
    • G06F17/30017G06F17/30029G06F17/30528G06Q30/0278G06Q50/01
    • An affinity server estimates an affinity between two different time based media events (e.g., TV, radio, social media content stream), between a time based media event and a specific topic, or between two different topics, where the affinity score represents an intersection between the populations of social media users who have authored social media content items regarding the two different events and/or topics. The affinity score represents an estimation of the real world affinity between the real world population of people who have an interest in both time based media events, both topics, or in a time based media event and a topic. One possible threshold for including a social media user in a population may be based on a confidence score that indicates the confidence that one or more social media content items authored by the social media user are relevant to the topic or event in question.
    • 亲和度服务器估计在基于时间的媒体事件和特定话题之间的两个不同的基于时间的媒体事件(例如,TV,无线电,社交媒体内容流)之间或两个不同主题之间的亲和度,其中亲和度分数表示交集 在两个不同的事件和/或主题之间创作社交媒体内容的社交媒体用户之间。 亲和度分数表示对现实世界中有时间的媒体事件,两个主题或基于时间的媒体事件和主题感兴趣的人之间的真实世界关系的估计。 将社交媒体用户包括在群体中的一个可能的阈值可以基于置信度得分,该置信度得分指示由社交媒体用户创作的一个或多个社交媒体内容项目与所讨论的主题或事件相关的置信度。
    • 7. 发明授权
    • Reconfigurable interface operable with multiple types of sensors and actuators
    • 可重构接口可与多种类型的传感器和执行器一起使用
    • US08149102B1
    • 2012-04-03
    • US12410746
    • 2009-03-25
    • Matthew MillerAlan S. Broad
    • Matthew MillerAlan S. Broad
    • G08B29/00
    • H04W4/38Y02D70/00
    • An interface is provided that configures itself dynamically based on sensor information received from a sensor assembly or actuator information received from an actuator assembly. The interface may be configured to interoperate with sensor assemblies including analog transducers, smart transducers providing digital outputs and various actuators. The sensor information or the actuator information may include information for managing power consumption associated with the operation of the sensor or the actuator. Using the sensor information or the actuator information, a power management scheme may be implemented to reduce power consumption and extend the operational time of a module. The sensor information also includes information about the sensor signal generated by the sensor. The information about the sensor signal allows the module to interoperate with more diverse types of sensors.
    • 提供了一种接口,其基于从传感器组件接收的传感器信息或从致动器组件接收的致动器信息动态地配置自身。 接口可以被配置为与传感器组件互操作,包括模拟换能器,提供数字输出的智能换能器和各种致动器。 传感器信息或致动器信息可以包括用于管理与传感器或致动器的操作相关联的功率消耗的信息。 使用传感器信息或致动器信息,可实施功率管理方案以降低功耗并延长模块的操作时间。 传感器信息还包括关于由传感器产生的传感器信号的信息。 关于传感器信号的信息允许模块与更多种类型的传感器进行互操作。