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1. 发明申请

US20160369232A1 PLURIPOTENT STEM CELL THAT CAN BE ISOLATED FROM BODY TISSUE 审中-公开
标题翻译：可以从身体组织分离出的多种干细胞
公开(公告)号：US20160369232A1
公开(公告)日：2016-12-22
申请号：US15189215
申请日：2016-06-22
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
IPC分类号： C12N5/074 , C12N5/073 , C12N5/0775
CPC分类号： C12N5/0607 , A61K35/12 , A61K35/28 , A61K35/50 , A61K35/51 , A61K2035/124 , C12N5/0605 , C12N5/0662 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12N2500/02 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/734 , C12N2501/998 , C12N2502/025
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.
摘要翻译：本发明的目的是提供直接获得不具有来自身体组织和由此获得的多能干细胞的致瘤性的多能干细胞的方法。本发明涉及可从身体组织分离的SSEA-3（+）多能干细胞。

2. 发明申请

US20180355313A1 PLURIPOTENT STEM CELL THAT CAN BE ISOLATED FROM BODY TISSUE 审中-公开
公开(公告)号：US20180355313A1
公开(公告)日：2018-12-13
申请号：US16104224
申请日：2018-08-17
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
IPC分类号： C12N5/074 , C12N5/0775 , A61K35/28
CPC分类号： C12N5/0607 , A61K35/12 , A61K35/28 , A61K35/50 , A61K35/51 , A61K2035/124 , C12N5/0605 , C12N5/0662 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12N2500/02 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/734 , C12N2501/998 , C12N2502/025
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stern cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stern cells that can be isolated from body tissue.

3. 发明授权

US09550975B2 SSEA-3 pluripotent stem cell isolated from body tissue 有权
标题翻译：从身体组织分离的SSEA-3多能干细胞
公开(公告)号：US09550975B2
公开(公告)日：2017-01-24
申请号：US12836264
申请日：2010-07-14
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao
IPC分类号： C12N15/02 , C12N5/00 , C12N5/074 , C12N15/113 , C12N5/0775 , C12N15/86 , C12N5/073 , A61K35/50 , A61K35/12 , A61K35/28
CPC分类号： C12N5/0607 , A61K35/12 , A61K35/28 , A61K35/50 , C12N5/0605 , C12N5/0662 , C12N5/0663 , C12N5/0667 , C12N5/0668 , C12N5/0696 , C12N15/1138 , C12N15/86 , C12N2506/1353 , C12N2509/00
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.
摘要翻译：本发明的目的是提供从身体组织和由此获得的多能干细胞直接获得多能干细胞的方法。本发明涉及可从身体组织分离的SSEA-3（+）多能干细胞。

4. 发明申请

US20120244129A1 PLURIPOTENT STEM CELL THAT CAN BE ISOLATED FROM BODY TISSUE 审中-公开
标题翻译：可以从身体组织分离出的多种干细胞
公开(公告)号：US20120244129A1
公开(公告)日：2012-09-27
申请号：US13435703
申请日：2012-03-30
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
IPC分类号： C12N5/074 , C12N13/00 , A61K35/12 , C12N5/0775
CPC分类号： C12N5/0607 , A61K35/12 , A61K35/28 , A61K35/50 , A61K35/51 , A61K2035/124 , C12N5/0605 , C12N5/0662 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12N2500/02 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/734 , C12N2501/998 , C12N2502/025
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.
摘要翻译：本发明的目的是提供直接获得不具有来自身体组织和由此获得的多能干细胞的致瘤性的多能干细胞的方法。本发明涉及可从身体组织分离的SSEA-3（+）多能干细胞。

5. 发明授权

US09399758B2 SSEA3(+) pluripotent stem cell that can be isolated from body tissue 有权
标题翻译：可以从身体组织分离的SSEA3（+）多能干细胞
公开(公告)号：US09399758B2
公开(公告)日：2016-07-26
申请号：US13435703
申请日：2012-03-30
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima
IPC分类号： C12N15/02 , C12N5/00 , C12N5/074 , A61K35/28 , C12N5/0775 , A61K35/51 , C12N5/073 , A61K35/12 , A61K35/50
CPC分类号： C12N5/0607 , A61K35/12 , A61K35/28 , A61K35/50 , A61K35/51 , A61K2035/124 , C12N5/0605 , C12N5/0662 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12N2500/02 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/734 , C12N2501/998 , C12N2502/025
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.
摘要翻译：本发明的目的是提供直接获得不具有来自身体组织和由此获得的多能干细胞的致瘤性的多能干细胞的方法。本发明涉及可从身体组织分离的SSEA-3（+）多能干细胞。

6. 发明授权

US11261426B2 Pluripotent stem cell that can be isolated from body tissue 有权
公开(公告)号：US11261426B2
公开(公告)日：2022-03-01
申请号：US15189215
申请日：2016-06-22
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima
IPC分类号： A61K35/28 , C12N5/074 , C12N5/073 , C12N5/0775 , A61K35/51 , A61K35/12 , A61K35/50
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.

7. 发明授权

US5406087A Specimen-holding device for electron microscope 失效
标题翻译：电子显微镜样品保持装置
公开(公告)号：US5406087A
公开(公告)日：1995-04-11
申请号：US183149
申请日：1994-01-18
申请人： Yoshinori Fujiyoshi , Mikio Naruse
发明人： Yoshinori Fujiyoshi , Mikio Naruse
IPC分类号： B01L3/00 , G01Q30/02 , G01Q30/14 , G01Q30/20 , H01J37/20 , H01J37/26
CPC分类号： H01J37/26 , B01L3/508 , H01J37/20 , H01J2237/2004
摘要： There is disclosed a simple specimen-holding device for use with an electron microscope. The device comprises a pair of films which transmit the electron beam. The films are reinforced with a network of reinforcing members and placed on a specimen stage. A specimen to be investigated is held in a thin space formed between the films, together with moisture. The fringes of the films are compressed together to hermetically isolate the space between the films from the specimen chamber of the microscope which is evacuated. The electron beam passes through the thin space sandwiched between the films. This permits the specimen to be observed in an almost unmodified state with little damage to the specimen.
摘要翻译：公开了一种用于电子显微镜的简单的标本保持装置。该装置包括一对透射电子束的膜。薄膜用加强件网络加固并放置在样品台上。要研究的样品保持在薄膜之间形成的薄薄空间以及水分。膜的条纹被压缩在一起，以将隔离空间的膜与被抽出的显微镜的样品室隔开。电子束通过夹在膜之间的薄空间。这允许在几乎未改变的状态下观察样品，对样品几乎没有损伤。

8. 发明授权

US08008633B2 Specimen stage-moving device for charged-particle beam system 有权
标题翻译：带电粒子束系统的试样台移动装置
公开(公告)号：US08008633B2
公开(公告)日：2011-08-30
申请号：US12057835
申请日：2008-03-28
申请人： Yoshinori Fujiyoshi , Tomohisa Fukuda
发明人： Yoshinori Fujiyoshi , Tomohisa Fukuda
IPC分类号： G01F23/00
CPC分类号： H01J37/20 , H01J37/26 , H01J2237/2001 , H01J2237/20214 , H01J2237/20235 , H01J2237/20278
摘要： A charged-particle beam system is offered which is equipped with a Z-motion mechanism to enable tomography. The Z-motion mechanism includes a rotary disk having three tapering surfaces on which balls are nested. The rotary disk is rotated via a worm gear to cause the balls to go upward along the tapering surfaces. This pushes an overlying elevatable disk upward, i.e., in the Z-direction. Consequently, the specimen stage is pushed up in the Z-direction.
摘要翻译：提供带电粒子束系统，其具有Z运动机制以实现层析成像。 Z运动机构包括具有三个锥形表面的旋转盘，球在其上嵌套。旋转盘通过蜗轮旋转以使球沿着锥形表面向上移动。这向上推动上覆的可升高的盘，即沿Z方向。因此，样品台在Z方向上被向上推。

9. 发明申请

US20090230319A1 Specimen Stage-Moving Device for Charged-Particle Beam System 有权
标题翻译：用于带电粒子束系统的样品台移动装置
公开(公告)号：US20090230319A1
公开(公告)日：2009-09-17
申请号：US12057835
申请日：2008-03-28
申请人： Yoshinori Fujiyoshi , Tomohisa Fukuda
发明人： Yoshinori Fujiyoshi , Tomohisa Fukuda
IPC分类号： G21K5/10
CPC分类号： H01J37/20 , H01J37/26 , H01J2237/2001 , H01J2237/20214 , H01J2237/20235 , H01J2237/20278
摘要： A charged-particle beam system is offered which is equipped with a Z-motion mechanism to enable tomography. The Z-motion mechanism includes a rotary disk having three tapering surfaces on which balls are nested. The rotary disk is rotated via a worm gear to cause the balls to go upward along the tapering surfaces. This pushes an overlying elevatable disk upward, i.e., in the Z-direction. Consequently, the specimen stage is pushed up in the Z-direction.
摘要翻译：提供带电粒子束系统，其具有Z运动机制以实现层析成像。 Z运动机构包括具有三个锥形表面的旋转盘，球在其上嵌套。旋转盘通过蜗轮旋转以使球沿着锥形表面向上移动。这向上推动上覆的可升高的盘，即沿Z方向。因此，样品台在Z方向上被向上推。

10. 发明授权

US06304105B1 Level shifter circuit 失效
标题翻译：电平移位电路
公开(公告)号：US06304105B1
公开(公告)日：2001-10-16
申请号：US09563228
申请日：2000-05-02
申请人： Yoshinori Fujiyoshi
发明人： Yoshinori Fujiyoshi
IPC分类号： H03K1710
CPC分类号： H03K19/018521
摘要： The level shifter circuit includes a low-voltage operating inverter INV4, a high-voltage operating inverter INV5, NMOS transistors NT5 and NT6 and a PMOS transistor PT3. The output from low-voltage operating inverter INV4, the source of NMOS transistor NT6 and the gate of PMOS transistor PT3 are joined. The input to high-voltage operating inverter INV5, the drain of NMOS transistor NT6 and the source of NMOS transistor PT5 and that of PMOS transistor PT3 are joined. The drain of NMOS transistor NT5 and the gates of NMOS transistors NT5 and NT6 are connected to the power feed line of a high-voltage power source. The input to low-voltage operating inverter INV4 forms an input signal terminal Vin2 while the output from high-voltage operating inverter INV5 forms an output signal terminal Vout2.
摘要翻译：电平移位器电路包括低电压工作反相器INV4，高电压工作反相器INV5，NMOS晶体管NT5和NT6以及PMOS晶体管PT3。来自低电压工作逆变器INV4，NMOS晶体管NT6的源极和PMOS晶体管PT3的栅极的输出被连接。高电压工作逆变器INV5的输入，NMOS晶体管NT6的漏极和NMOS晶体管PT5的源极和PMOS晶体管PT3的输入相连接。 NMOS晶体管NT5的漏极和NMOS晶体管NT5和NT6的栅极连接到高压电源的馈电线。低电压工作逆变器INV4的输入形成输入信号端子Vin2，而高电压工作逆变器INV5的输出形成输出信号端子Vout2。

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