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1. 发明申请

US20160369232A1 PLURIPOTENT STEM CELL THAT CAN BE ISOLATED FROM BODY TISSUE 审中-公开
标题翻译：可以从身体组织分离出的多种干细胞
公开(公告)号：US20160369232A1
公开(公告)日：2016-12-22
申请号：US15189215
申请日：2016-06-22
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
IPC分类号： C12N5/074 , C12N5/073 , C12N5/0775
CPC分类号： C12N5/0607 , A61K35/12 , A61K35/28 , A61K35/50 , A61K35/51 , A61K2035/124 , C12N5/0605 , C12N5/0662 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12N2500/02 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/734 , C12N2501/998 , C12N2502/025
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.
摘要翻译：本发明的目的是提供直接获得不具有来自身体组织和由此获得的多能干细胞的致瘤性的多能干细胞的方法。本发明涉及可从身体组织分离的SSEA-3（+）多能干细胞。

2. 发明申请

US20120244129A1 PLURIPOTENT STEM CELL THAT CAN BE ISOLATED FROM BODY TISSUE 审中-公开
标题翻译：可以从身体组织分离出的多种干细胞
公开(公告)号：US20120244129A1
公开(公告)日：2012-09-27
申请号：US13435703
申请日：2012-03-30
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
IPC分类号： C12N5/074 , C12N13/00 , A61K35/12 , C12N5/0775
CPC分类号： C12N5/0607 , A61K35/12 , A61K35/28 , A61K35/50 , A61K35/51 , A61K2035/124 , C12N5/0605 , C12N5/0662 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12N2500/02 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/734 , C12N2501/998 , C12N2502/025
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.
摘要翻译：本发明的目的是提供直接获得不具有来自身体组织和由此获得的多能干细胞的致瘤性的多能干细胞的方法。本发明涉及可从身体组织分离的SSEA-3（+）多能干细胞。

3. 发明授权

US09550975B2 SSEA-3 pluripotent stem cell isolated from body tissue 有权
标题翻译：从身体组织分离的SSEA-3多能干细胞
公开(公告)号：US09550975B2
公开(公告)日：2017-01-24
申请号：US12836264
申请日：2010-07-14
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao
IPC分类号： C12N15/02 , C12N5/00 , C12N5/074 , C12N15/113 , C12N5/0775 , C12N15/86 , C12N5/073 , A61K35/50 , A61K35/12 , A61K35/28
CPC分类号： C12N5/0607 , A61K35/12 , A61K35/28 , A61K35/50 , C12N5/0605 , C12N5/0662 , C12N5/0663 , C12N5/0667 , C12N5/0668 , C12N5/0696 , C12N15/1138 , C12N15/86 , C12N2506/1353 , C12N2509/00
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.
摘要翻译：本发明的目的是提供从身体组织和由此获得的多能干细胞直接获得多能干细胞的方法。本发明涉及可从身体组织分离的SSEA-3（+）多能干细胞。

4. 发明申请

US20180355313A1 PLURIPOTENT STEM CELL THAT CAN BE ISOLATED FROM BODY TISSUE 审中-公开
公开(公告)号：US20180355313A1
公开(公告)日：2018-12-13
申请号：US16104224
申请日：2018-08-17
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima , Shohei Wakao , Masanori Yoshida , Yasumasa Kuroda
IPC分类号： C12N5/074 , C12N5/0775 , A61K35/28
CPC分类号： C12N5/0607 , A61K35/12 , A61K35/28 , A61K35/50 , A61K35/51 , A61K2035/124 , C12N5/0605 , C12N5/0662 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12N2500/02 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/734 , C12N2501/998 , C12N2502/025
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stern cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stern cells that can be isolated from body tissue.

5. 发明授权

US09399758B2 SSEA3(+) pluripotent stem cell that can be isolated from body tissue 有权
标题翻译：可以从身体组织分离的SSEA3（+）多能干细胞
公开(公告)号：US09399758B2
公开(公告)日：2016-07-26
申请号：US13435703
申请日：2012-03-30
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima
IPC分类号： C12N15/02 , C12N5/00 , C12N5/074 , A61K35/28 , C12N5/0775 , A61K35/51 , C12N5/073 , A61K35/12 , A61K35/50
CPC分类号： C12N5/0607 , A61K35/12 , A61K35/28 , A61K35/50 , A61K35/51 , A61K2035/124 , C12N5/0605 , C12N5/0662 , C12N5/0663 , C12N5/0665 , C12N5/0667 , C12N2500/02 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/734 , C12N2501/998 , C12N2502/025
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.
摘要翻译：本发明的目的是提供直接获得不具有来自身体组织和由此获得的多能干细胞的致瘤性的多能干细胞的方法。本发明涉及可从身体组织分离的SSEA-3（+）多能干细胞。

6. 发明授权

US11261426B2 Pluripotent stem cell that can be isolated from body tissue 有权
公开(公告)号：US11261426B2
公开(公告)日：2022-03-01
申请号：US15189215
申请日：2016-06-22
申请人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima
发明人： Mari Dezawa , Yoshinori Fujiyoshi , Youichi Nabeshima
IPC分类号： A61K35/28 , C12N5/074 , C12N5/073 , C12N5/0775 , A61K35/51 , A61K35/12 , A61K35/50
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.

7. 发明申请

US20080113435A1 Method for Inducing Differentiation to Skeletal Muscle Cells 有权
标题翻译：诱导骨骼肌细胞分化的方法
公开(公告)号：US20080113435A1
公开(公告)日：2008-05-15
申请号：US11722602
申请日：2005-12-22
申请人： Mari Dezawa , Yo-ichi Nabeshima , Mikio Hoshino
发明人： Mari Dezawa , Yo-ichi Nabeshima , Mikio Hoshino
IPC分类号： C12N15/09 , C12N5/08
CPC分类号： C12N5/0658 , C12N2500/90 , C12N2501/01 , C12N2501/115 , C12N2501/135 , C12N2501/195 , C12N2501/42
摘要： A method of efficiently and conveniently inducing differentiation from bone marrow stromal cells to skeletal muscle cells, which comprises the steps of: (a) the step of adding one or more kinds of substances selected from the group consisting of a cyclic AMP increasing agent, a cAMP analogue, and a cell differentiation stimulating factor to a culture of bone marrow stromal cells, wherein said bone marrow stromal cells are not treated with a demethylating agent, and culturing the cells; (b) the step of introducing a Notch gene and/or a Notch signaling related gene into the cells obtained in the step (a), and culturing the cells to obtain a culture of myoblasts, provided that said culture does not contain the cells introduced with the gene and non-introduced cells; and (c) the step of adding a Notch ligand to the culture of myoblasts obtained in the step (b), and culturing the cells.
摘要翻译：一种有效且方便地诱导从骨髓基质细胞分化为骨骼肌细胞的方法，包括以下步骤：（a）添加一种或多种选自下列的物质的步骤：环AMP增加剂， cAMP类似物和对骨髓基质细胞培养物的细胞分化刺激因子，其中所述骨髓基质细胞不用去甲基化剂处理，并培养细胞; （b）将Notch基因和/或Notch信号传导相关基因导入到步骤（a）中获得的细胞中的步骤，并培养细胞以获得成肌细胞培养物，条件是所述培养物不含引入的细胞与基因和未引入的细胞; 和（c）向步骤（b）中获得的成肌细胞培养物中加入Notch配体并培养细胞的步骤。

8. 发明申请

US20060216276A1 Use of materials for treatment of central nervous system lesions 审中-公开
标题翻译：使用材料治疗中枢神经系统病变
公开(公告)号：US20060216276A1
公开(公告)日：2006-09-28
申请号：US11368919
申请日：2006-03-06
申请人： Mari Dezawa , Keita Mori
发明人： Mari Dezawa , Keita Mori
IPC分类号： A61K35/30 , C12N5/08
CPC分类号： A61K35/30
摘要： Disclosed are methods and materials for treatment of central nervous system lesions. Preferred methods and materials comprise neuronal precursor cells and/or marrow adherent stem cell-derived neuronal cells.
摘要翻译：公开了用于治疗中枢神经系统病变的方法和材料。优选的方法和材料包括神经元前体细胞和/或骨髓粘附的干细胞衍生的神经元细胞。

9. 发明授权

US08092792B2 Use of materials for treatment of central nervous system lesions 有权
标题翻译：使用材料治疗中枢神经系统病变
公开(公告)号：US08092792B2
公开(公告)日：2012-01-10
申请号：US12462143
申请日：2009-07-30
申请人： Mari Dezawa , Keita Mori
发明人： Mari Dezawa , Keita Mori
IPC分类号： A61K35/12
CPC分类号： A61K35/30
摘要： Disclosed are methods and materials for treatment of central nervous system lesions. Preferred methods and materials comprise neuronal precursor cells and/or marrow adherent stem cell-derived neuronal cells.
摘要翻译：公开了用于治疗中枢神经系统病变的方法和材料。优选的方法和材料包括神经元前体细胞和/或骨髓粘附的干细胞衍生的神经元细胞。

10. 发明申请

US20100144034A1 Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of Notch gene 有权
标题翻译：通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法
公开(公告)号：US20100144034A1
公开(公告)日：2010-06-10
申请号：US12658104
申请日：2010-02-02
申请人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
发明人： Mari Dezawa , Hajime Sawada , Hiroshi Kanno , Masahiko Takano
IPC分类号： C12N5/071 , C12N5/00
CPC分类号： C12N5/0619 , A61K9/0085 , A61K35/28 , A61K35/30 , A61K2035/124 , C12N5/0618 , C12N5/0658 , C12N5/0663 , C12N2501/42 , C12N2502/1358 , C12N2506/1353 , C12N2510/00
摘要： There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which method comprises introducing a Notch gene and/or a Notch signaling related gene into the cells, wherein the finally obtained differentiated cells are the result of cell division of the bone marrow stromal cells into which the Notch gene and/or Notch signaling related gene have been introduced. The invention also provides a method of inducing further differentiation of the differentiation-induced neural cells to dopaminergic neurons or acetylcholinergic neurons. The invention yet further provides a treatment method for neurodegenerative and skeletal muscle degenerative diseases which employs neural precursor cells, neural cells or skeletal muscle cells produced by the method of the invention.
摘要翻译：提供了通过引入Notch基因诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法。具体地说，本发明提供了一种在体外诱导骨髓基质细胞分化为神经细胞或骨骼肌细胞的方法，该方法包括将Notch基因和/或Notch信号传导相关基因引入细胞，其中最终获得的分化细胞是引入了Notch基因和/或Notch信号传导相关基因的骨髓基质细胞的细胞分裂的结果。本发明还提供了诱导分化诱导的神经细胞进一步分化为多巴胺能神经元或乙酰胆碱能神经元的方法。本发明还进一步提供了一种神经变性和骨骼肌退行性疾病的治疗方法，其采用通过本发明的方法生产的神经前体细胞，神经细胞或骨骼肌细胞。

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