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1. 发明专利

JP2005328716A Rattrap 审中-公开
标题翻译： RATTRAP
公开(公告)号：JP2005328716A
公开(公告)日：2005-12-02
申请号：JP2004147970
申请日：2004-05-18
申请人： Nobuo Seki , 信夫関
发明人： SEKI NOBUO
IPC分类号： A01M23/20
摘要： PROBLEM TO BE SOLVED: To provide a rattrap designed to surely capture a rat with a simple structure.
SOLUTION: A door for opening and closing one opened surface of a casing is provided and a thread attached to the door is tied to a first trick rod and the opening and closing door is lifted in a state opened to an extent so as to invade a rat with a second trick rod acting in cooperation with the first trick rod. When the rat invades the interior of the casing and treads the second trick rod, the tension of the thread pulling the door is loosened to drop the door by gravity. Thereby, the rat is captured.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供设计成可靠地捕获具有简单结构的大鼠的鼠捕捉器。解决方案：提供用于打开和关闭壳体的一个开口表面的门，并且将附接到门的螺纹连接到第一特技杆，并且打开和关闭门在一定程度上被提升，以便用第二个特技杆与第一个窍门相配合地入侵一只老鼠。当大鼠入侵套管内部并踏上第二个窍门时，拉动门的线的张力被松动以使重力下降。由此，捕获大鼠。版权所有（C）2006，JPO＆NCIPI

2. 发明授权

US07037377B2 Process for producing lacturose-containing powder composition, lacturose-containing powder composition obtained by the process and feed additive 失效
标题翻译：用于制备含有内含头骨的粉末组合物的方法，通过该工艺和饲料添加剂获得的含有内含头孢的粉末组合物
公开(公告)号：US07037377B2
公开(公告)日：2006-05-02
申请号：US10516362
申请日：2003-05-28
申请人： Mamoru Tomita , Sadayuki Kokubo , Teruhiko Mizota , Nobuo Ichihashi , Nobuo Seki , Kenji Nishi
发明人： Mamoru Tomita , Sadayuki Kokubo , Teruhiko Mizota , Nobuo Ichihashi , Nobuo Seki , Kenji Nishi
IPC分类号： C13F3/00 , C13D3/16
CPC分类号： A61K31/7016 , A23K20/163 , A23V2002/00 , A23V2250/614 , A23V2250/54246 , A23V2250/1582 , A23V2250/54252 , A23V2250/5488
摘要： A lactulose-containing powder composition is produced by preparing a raw material liquid so that a lactulose content within a powder produced following spray drying is 10 to 50% by weight, a protein content is 0.2 to 9.0 parts by weight per 1 part by weight of lactulose, and a chlorine content is no more than 0.08 parts by weight per 1 part by weight of protein, and subsequently subjecting this raw material liquid to spray drying.
摘要翻译：通过制备原料液制备含乳果糖的粉末组合物，使得喷雾干燥后产生的粉末中的乳果糖含量为10〜50重量％，蛋白质含量为每1重量份的蛋白质含量为0.2〜9.0重量份乳果糖和氯含量相对于每1重量份蛋白质不超过0.08重量份，随后使该原料液体喷雾干燥。

3. 发明授权

US5644050A Method for manufacturing lactulose anhydride 失效
标题翻译：制造乳果糖酐的方法
公开(公告)号：US5644050A
公开(公告)日：1997-07-01
申请号：US500858
申请日：1995-09-01
申请人： Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Itsuko Suzawa , Nobuo Seki
发明人： Seiichi Shimamura , Yoshitaka Tamura , Teruhiko Mizota , Itsuko Suzawa , Nobuo Seki
IPC分类号： A61K31/70 , A61K31/7016 , A61P1/16 , C07H1/00 , C07H3/04 , C13K13/00
CPC分类号： C07H3/04
摘要： The present invention provides a method for manufacturing lactulose anhydride, which comprises drying lactulose trihydrate at a temperature within a range of from 45.degree. to 75.degree. C. and a degree of vacuum within a range of from 25 to 100 Torr to remove water of crystallization.The method of the present invention permits manufacture of lactulose anhydride through a simple process, at a high yield and at a low cost, and is therefore suitable for mass production of lactulose anhydride in an industrial scale.
摘要翻译： PCT No.PCT / JP93 / 00841 Sec。 371 1995年9月1日 102（e）1995年9月1日PCT PCT日期：1993年6月22日PCT公布。公开号WO94 / 18213 日本1994年8月18日本发明提供了一种制造乳果糖酐的方法，其包括在45-75℃的温度范围内干燥乳果糖三水合物，并且在25至100托的范围内的真空度去除结晶水。本发明的方法允许通过简单的方法以高产率和低成本制造乳果糖酐，因此适合于大规模生产工业规模的乳果糖酐。

4. 发明申请

US20120263839A1 METHOD FOR MANUFACTURING LOW-PHOSPHORUS WHEY 有权
标题翻译：制造低磷白蛋白的方法
公开(公告)号：US20120263839A1
公开(公告)日：2012-10-18
申请号：US13497646
申请日：2010-09-24
申请人： Nobuo Seki , Masatoshi Ohnishi , Kie Kinoshita , Yoshitaka Tamura , Hitoshi Saito , Hiroshi Ochi , Takafumi Kimura
发明人： Nobuo Seki , Masatoshi Ohnishi , Kie Kinoshita , Yoshitaka Tamura , Hitoshi Saito , Hiroshi Ochi , Takafumi Kimura
IPC分类号： A23C21/00
CPC分类号： A23C9/1425 , A23C9/146 , A23J3/08 , A23L33/40 , A23V2002/00 , A23V2250/54252 , A23V2300/30 , A23V2300/34
摘要： A method of manufacturing a low-phosphorus whey, the method including subjecting a raw whey liquid to a demineralization treatment using a nanofiltration method to obtain a low-chloride whey liquid in which the chloride content has been reduced to not more than 30 mmol per 100 g of solids, and passing the low-chloride whey liquid through an ion exchange resin to obtain an ion-exchanged whey liquid having a reduced phosphorus content, wherein the ion exchange resin is composed of an anion exchange resin, and at least an anion exchange resin in chloride form is used as the anion exchange resin. The method of manufacturing a low-phosphorus whey can reduce the phosphorus content within the whey while suppressing reduction in the calcium and magnesium content.
摘要翻译：一种低磷乳清的制造方法，其特征在于，使用纳滤法对原料乳清液进行脱盐处理，得到氯化物含量降低至不足30mmol / L以下的低氯化物乳清液 g的固体，并使低氯化物乳清液通过离子交换树脂，得到具有降低的磷含量的离子交换乳清液，其中所述离子交换树脂由阴离子交换树脂构成，并且至少阴离子交换使用氯化物形式的树脂作为阴离子交换树脂。制备低磷乳清的方法可以降低乳清中的磷含量，同时抑制钙和镁含量的降低。

5. 发明申请

US20120009310A1 METHOD FOR PRODUCING DESALTED MILK, AND DESALTED MILK 审中-公开
标题翻译：生产脱硫奶酪和脱硫奶酪的方法
公开(公告)号：US20120009310A1
公开(公告)日：2012-01-12
申请号：US13124899
申请日：2010-03-30
申请人： Nobuo Seki , Kie Kinoshita , Hitoshi Saito , Masatoshi Ohnishi , Yoshitaka Tamura , Hiroshi Koishihara , Mirei Odaka
发明人： Nobuo Seki , Kie Kinoshita , Hitoshi Saito , Masatoshi Ohnishi , Yoshitaka Tamura , Hiroshi Koishihara , Mirei Odaka
IPC分类号： A23C9/146 , A23C19/05 , A23C21/00 , A23C9/142
CPC分类号： A23C9/146 , A23C9/1422 , A23C19/045 , A23C19/05 , A23C21/00
摘要： The present invention relates to a process for producing a demineralized milk that enables excellent reduction in the amount of monovalent minerals while suppressing any reduction in the amount of divalent minerals, as well as a demineralized milk produced using the above process, a process for producing a cheese and whey from the demineralized milk, and a cheese and whey produced using the above process. In the present invention, a demineralized milk having a significantly reduced amount of monovalent minerals is obtained by passing a raw milk solution through an anion exchange resin in chloride form, and then removing the monovalent minerals contained within the raw milk solution using a membrane separation process. Further, a cheese and whey can be produced by heating the obtained demineralized milk to produce a curd, and then separating the curd from the liquid other than the curd by solid-liquid separation.
摘要翻译：本发明涉及一种能够极大地降低一价矿物质量同时抑制二价矿物质的量减少的软化牛奶的制造方法以及使用上述方法生产的软化牛奶的方法。来自软化牛奶的乳酪和乳清，以及使用上述方法生产的奶酪和乳清。在本发明中，通过使生奶溶液通过氯化物形式的阴离子交换树脂，然后使用膜分离方法除去原料乳液中所含的一价矿物质，得到具有显着降低的一价矿物质量的脱矿质乳。此外，可以通过加热获得的软化牛奶以产生凝乳，然后通过固液分离将凝乳与凝乳以外的液体分离，从而可以生产干酪和乳清。

6. 发明申请

US20050166911A1 Process for producing lacturose-containing powder composition, lacturose-containing powder composition obtained by the process and feed additive 失效
标题翻译：用于制备含有内含头骨的粉末组合物的方法，通过该工艺和饲料添加剂获得的含有内含头孢的粉末组合物
公开(公告)号：US20050166911A1
公开(公告)日：2005-08-04
申请号：US10516362
申请日：2003-05-28
申请人： Mamoru Tomita , Sadayuki Kokubo , Teruhiko Mizota , Nobuo Ichihashi , Nobuo Seki , Kenji Nishi
发明人： Mamoru Tomita , Sadayuki Kokubo , Teruhiko Mizota , Nobuo Ichihashi , Nobuo Seki , Kenji Nishi
IPC分类号： C13B50/00 , A23K1/16 , A23L1/30 , A23P1/06 , A61K31/7016 , A61P1/00 , C13B20/16 , C13K13/00 , C13K5/00
CPC分类号： A61K31/7016 , A23K20/163 , A23V2002/00 , A23V2250/614 , A23V2250/54246 , A23V2250/1582 , A23V2250/54252 , A23V2250/5488
摘要： A lactulose-containing powder composition is produced by preparing a raw material liquid so that a lactulose content within a powder produced following spray drying is 10 to 50% by weight, a protein content is 0.2 to 9.0 parts by weight per 1 part by weight of lactulose, and a chlorine content is no more than 0.08 parts by weight per 1 part by weight of protein, and subsequently subjecting this raw material liquid to spray drying.
摘要翻译：通过制备原料液制备含乳果糖的粉末组合物，使得喷雾干燥后产生的粉末中的乳果糖含量为10〜50重量％，蛋白质含量为每1重量份的蛋白质含量为0.2〜9.0重量份乳果糖和氯含量相对于每1重量份蛋白质不超过0.08重量份，随后使该原料液体喷雾干燥。

7. 发明授权

US06359145B1 Imidazole compounds 失效
标题翻译：咪唑化合物
公开(公告)号：US06359145B1
公开(公告)日：2002-03-19
申请号：US09764995
申请日：2001-03-09
申请人： Tadashi Terasaka , Katsuya Nakamura , Nobuo Seki , Masako Kuno , Susumu Tsujimoto , Akihiro Sato , Isao Nakanishi , Takayoshi Kinoshita , Nobuya Nishio , Hiroyuki Okumura , Kiyoshi Tsuji
发明人： Tadashi Terasaka , Katsuya Nakamura , Nobuo Seki , Masako Kuno , Susumu Tsujimoto , Akihiro Sato , Isao Nakanishi , Takayoshi Kinoshita , Nobuya Nishio , Hiroyuki Okumura , Kiyoshi Tsuji
IPC分类号： C07D23366
CPC分类号： C07D403/04 , C07D233/90 , C07D405/06 , C07F7/1804
摘要： Imidazole compounds having adenosine deaminase inhibitory activity represented by formula (I) wherein R1 is hydrogen, hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s); R2 is hydrogen or lower alkyl; R3 is hydroxy or protected hydroxy; R4 is cyano, (hydroxy)iminoamino(lower)alkyl, carboxy, protected carboxy, heterocyclic group optionally substituted with amino, or carbamoyl optionally substituted with suitable substituent(s); and —A— is —Q— or —O—Q—, wherein Q is single bond or lower alkylene, provided that when R2 is lower alkyl, then R1 is hydroxy, protected hydroxy, or aryl optionally substituted with suitable substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.
摘要翻译：式（I）表示的具有腺苷脱氨酶抑制活性的咪唑化合物，其中R 1为氢，羟基，保护的羟基或任选被合适的取代基取代的芳基; R2是氢或低级烷基; R3是羟基或被保护的羟基; R4是氰基，（羟基）亚氨基氨基（低级）烷基，羧基，受保护的羧基，任选被氨基取代的杂环基或任选被合适的取代基取代的氨基甲酰基; 并且-A-是-Q-或-OQ-，其中Q是单键或低级亚烷基，条件是当R 2是低级烷基时，则R 1是羟基，保护的羟基或任选地被合适的取代基取代的芳基，其前药或其盐。该化合物可用于治疗和/或预防腺苷有效的疾病。

8. 发明授权

US08795750B2 Method for manufacturing low-phosphorus whey 有权
标题翻译：低磷乳清制备方法
公开(公告)号：US08795750B2
公开(公告)日：2014-08-05
申请号：US13497646
申请日：2010-09-24
申请人： Nobuo Seki , Masatoshi Ohnishi , Kie Kinoshita , Yoshitaka Tamura , Hitoshi Saito , Hiroshi Ochi , Takafumi Kimura
发明人： Nobuo Seki , Masatoshi Ohnishi , Kie Kinoshita , Yoshitaka Tamura , Hitoshi Saito , Hiroshi Ochi , Takafumi Kimura
IPC分类号： A23C9/14 , A23C9/142 , A23C9/146 , A23J3/08 , A23L1/29
CPC分类号： A23C9/1425 , A23C9/146 , A23J3/08 , A23L33/40 , A23V2002/00 , A23V2250/54252 , A23V2300/30 , A23V2300/34
摘要： A method of manufacturing a low-phosphorus whey, the method including subjecting a raw whey liquid to a demineralization treatment using a nanofiltration method to obtain a low-chloride whey liquid in which the chloride content has been reduced to not more than 30 mmol per 100 g of solids, and passing the low-chloride whey liquid through an ion exchange resin to obtain an ion-exchanged whey liquid having a reduced phosphorus content, wherein the ion exchange resin is composed of an anion exchange resin, and at least an anion exchange resin in chloride form is used as the anion exchange resin. The method of manufacturing a low-phosphorus whey can reduce the phosphorus content within the whey while suppressing reduction in the calcium and magnesium content.
摘要翻译：一种低磷乳清的制造方法，其特征在于，使用纳滤法对原料乳清液进行脱盐处理，得到氯化物含量降低至不足30mmol / L以下的低氯化物乳清液 g的固体，并使低氯化物乳清液通过离子交换树脂，得到具有降低的磷含量的离子交换乳清液，其中所述离子交换树脂由阴离子交换树脂构成，并且至少阴离子交换使用氯化物形式的树脂作为阴离子交换树脂。制备低磷乳清的方法可以降低乳清中的磷含量，同时抑制钙和镁含量的降低。

9. 发明授权

US06596738B1 Heterocyclic compound, composition and method for inhibiting adenosine deaminase 失效
标题翻译：杂环化合物，抑制腺苷脱氨酶的组合物和方法
公开(公告)号：US06596738B1
公开(公告)日：2003-07-22
申请号：US09926134
申请日：2001-09-07
申请人： Tadashi Terasaka , Nobuo Seki , Kiyoshi Tsuji , Isao Nakanishi , Takayoshi Kinoshita , Katsuya Nakamura
发明人： Tadashi Terasaka , Nobuo Seki , Kiyoshi Tsuji , Isao Nakanishi , Takayoshi Kinoshita , Katsuya Nakamura
IPC分类号： A61K314164
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D233/90 , C07D249/10 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07F7/1804 , Y02P20/55
摘要： Heterocyclic compounds of the following formula: wherein B is [wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or lower alkyl; and X is hydrogen or hydroxy protective group], lower alkanoyl or hydroxyimino(lower)alkyl A is lower alkylene; W is heterocyclic or carbocyclic group, each of which may have one or more substituent(s); Z is heterocyclic group selected from the group consisting of imidazolyl, triazolyl,imidazopyridyl and adenyl, each of which may have one or more substituent(s); or a salt thereof, provided that when W is aryl which may have one or more substituent(s), then (i) Z is triazolyl, imidazopyridyl or adenyl, each of which may have one or more substituent(s); (ii) Z is imidazolyl which may have one or more substituent(s) and B is lower alkanoyl or hydroxyimino(lower)alkyl; or (iii) Z is imidazolyl which may have one or more substituent(s) and R1 and R2 are both lower alkyl. or pharmaceutically acceptable salts thereof, which are useful as a medicament.
摘要翻译：下式的杂环化合物：其中B是[其中R 1是氢或低级烷基; R 2是氢或低级烷基; 和X是氢或羟基保护基]，低级烷酰基或羟基亚氨基（低级）烷基A是低级亚烷基; W是杂环或碳环基，每一个可以具有一个或多个取代基; Z是选自咪唑基，三唑基，咪唑并吡啶基和腺嘌呤，其各自可以具有一个或多个取代基;或其盐，条件是当W是可以具有一个或多个取代基的芳基时，则（i）Z是三唑基，咪唑并吡啶基或腺苷酸，其各自可以具有一个或多个取代基; （ii）Z是可以具有一个或多个取代基的咪唑基，B是低级烷酰基或羟基亚氨基（低级）烷基; 或（iii）Z是可具有一个或多个取代基的咪唑基，R 1和R 2均为低级烷基或其药学上可接受的盐，其可用作药物。

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