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1. 发明申请

WO2008006002A2 METHODS AND SYSTEMS FOR CARDIAC REMODELING VIA RESYNCHRONIZATION 审中-公开
标题翻译：通过再同步化进行心脏重塑的方法和系统
公开(公告)号：WO2008006002A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/072786
申请日：2007-07-03
申请人： MICARDIA CORPORATION , MOADDEB, Shahram , SHAOLIAN, Samuel M. , SHAOULIAN, Emanuel
发明人： MOADDEB, Shahram , SHAOLIAN, Samuel M. , SHAOULIAN, Emanuel
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/0597 , A61N1/3622 , A61N1/3968
摘要： Systems, methods and devices are provided for improving the hemodynamic efficiency of a patient's heart by implanting one or more reinforcement elements on or with the heart and providing electrical stimulation to the heart. The reinforcement elements may include magnetic and/or shape memory material and are configured to reshape the heart so as to boost the heart's mechanical energy during a response to the electrical stimulation. In some embodiments, at least one reinforcement element includes an electrode configured to sense electrocardiogram signals within the heart. An electrical stimulation device such as an implantable or external pacemaker/defibrillator may be configured to control delivery of electrical pulses to the heart based on the sensed electrocardiogram signals. In addition, or in other embodiments, at least one reinforcement element includes an electrode configured to deliver the electrical pulses to the heart.
摘要翻译：提供系统，方法和装置，用于通过在心脏上或与心脏一起植入一个或多个加强元件并向心脏提供电刺激来改善患者心脏的血液动力学效率。加强元件可以包括磁性和/或形状记忆材料，并且被配置成重塑心脏以便在对电刺激的响应期间增强心脏的机械能量。在一些实施例中，至少一个加强元件包括被配置为感测心脏内的心电图信号的电极。基于所感测的心电图信号，诸如植入式或外部起搏器/除颤器之类的电刺激设备可以被配置为控制向心脏的电脉冲的输送。此外，或者在其他实施例中，至少一个加强元件包括被配置为将电脉冲输送到心脏的电极。

2. 发明申请

WO2006012038A2 SELECTIVELY ADJUSTABLE CARDIAC VALVE IMPLANTS 审中-公开
标题翻译：选择性可调节的心脏瓣膜植入物
公开(公告)号：WO2006012038A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/021324
申请日：2005-06-16
申请人： MICARDIA CORPORATION , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , MOADDEB, Shahram
发明人： SHAOULIAN, Emanuel , SHAOLIAN, Samuel , MOADDEB, Shahram
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, a body member (2100) of an annuloplasty ring includes a first shape memory material (2114) configured to transform the body member (2100) from a first configuration having a first size of a dimension to a second configuration having a second size of the dimension. The second size is less than said first size in septal lateral distance. The body member (2100) also includes a second shape memory material (2116) configured to transform the body member (2100) from the second configuration to a third configuration having a third size of the dimension, wherein the second size is less than the third size in septal lateral distance.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给予患者身体的能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节装置的尺寸和/或形状以提供持续的加强。在一个实施例中，瓣膜成形术环的主体部件（2100）包括第一形状记忆材料（2114），其被配置为将主体部件（2100）从具有第一尺寸尺寸的第一构造转换成具有第二构造的第二构造尺寸尺寸。第二尺寸小于所述第一尺寸的间隔横向距离。主体构件（2100）还包括构造成将主体构件（2100）从第二构造转换成具有尺寸的第三尺寸的第三构造的第二形状记忆材料（2116），其中第二尺寸小于第三尺寸大小间隔横向距离。

3. 发明申请

WO2006086627A2 DYNAMICALLY ADJUSTABLE GASTRIC IMPLANTS AND METHODS OF TREATING OBESITY USING DYNAMICALLY ADJUSTABLE GASTRIC IMPLANTS 审中-公开
标题翻译：动态可调节的植入式植入物和使用动态可调节的植入物处理肥胖的方法
公开(公告)号：WO2006086627A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/004728
申请日：2006-02-10
申请人： MICARDIA CORPORATION , LEMBO, Nicholas, J. , MOADDEB, Shahram , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , HENSON, Michael, R.
发明人： LEMBO, Nicholas, J. , MOADDEB, Shahram , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , HENSON, Michael, R.
IPC分类号： A61C8/00
CPC分类号： A61F5/0079 , A61F5/0053 , A61F5/0086 , A61F2002/044
摘要： Implants for treatment of obesity may be placed within the stomach and/or esophagus or around the outside surface of the stomach and/or esophagus. The implants comprise at least a portion constructed of a shape memory material. The implants are thus adapted to be implanted in a deformed shape, and then to be transformed through the application of activation energy into a memorized shape. The shape and/or size transformation induces a change in shape of the stomach and/or esophagus, thus altering the normal digestive path of food entering the patient's gastrointestinal tract.
摘要翻译：用于治疗肥胖的植入物可以放置在胃和/或食道内或胃和/或食道的外表面周围。植入物包括由形状记忆材料构成的至少一部分。因此，植入物适于以变形的形状植入，然后通过将活化能量施加到记忆形状中而变形。形状和/或尺寸转换引起胃和/或食道的形状变化，从而改变进入患者胃肠道的食物的正常消化道。

4. 发明申请

WO2006019520A2 MAGNETIC DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 审中-公开
标题翻译：磁性装置和用于重新整理心脏解剖的方法
公开(公告)号：WO2006019520A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/022461
申请日：2005-06-23
申请人： MICARDIA CORPORATION , MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
发明人： MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
IPC分类号： A61F2/00
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用磁力重塑心脏解剖结构来治疗心脏扩张。这种再成形改变了心脏部分，特别是右心室或左心室的几何形状，以增加心室的收缩性，从而增加心搏量，这又增加了心脏的心输出量。通过使用一个或多个磁性元件来施加磁力，所述磁性元件植入心脏组织内或附着在心脏表面的外部和/或内部。磁力的各种电荷相互作用导致相关的心脏组织区域重新调整位置，例如以减小心室的宽度。这种重新定位通过磁性元件的力持续保持一段时间，允许心脏扩张的破坏性作用减缓进展或逆转。

5. 发明申请

WO2007030417A2 SLOTTED ANNULOPLASTY RING 审中-公开
标题翻译：缝合ANNULOPLASTY环
公开(公告)号：WO2007030417A2
公开(公告)日：2007-03-15
申请号：PCT/US2006/034428
申请日：2006-09-01
申请人： MICARDIA CORPORATION , SHAOLIAN, Samuel, M. , RHEE, Richard, S. , SHAOULIAN, Emanuel , MOADDEB, Shahram
发明人： RHEE, Richard, S. , SHAOULIAN, Emanuel , MOADDEB, Shahram
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2250/0001 , A61F2250/0004
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices (3500) comprise a shape memory material, and further include a body member (3502) and an insert member (3504). The body member (3502) has a circumference and a slot (3506) that extends at least partially along the circumference of the body (3502). The insert member (3504) extends at least partially along the circumference of the body (3502). The device (3500) has a first shape in a first configuration and a second shape in a second configuration, and is configured to transform from a first configuration to a second configuration in response to a first activation energy applied thereto.
摘要翻译：提供了用于支撑身体结构的方法和装置。这些装置可以以微创或非侵入性方式在患者体内进行调节，例如通过经皮或外部对患者身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，瓣膜成形术环的尺寸和/或形状可被调节以提供持续的加强。在某些实施例中，装置（3500）包括形状记忆材料，并且还包括主体构件（3502）和插入构件（3504）。主体构件（3502）具有至少部分地沿主体（3502）的圆周延伸的圆周和狭槽（3506）。插入构件（3504）至少部分地沿主体（3502）的圆周延伸。设备（3500）具有第一配置的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的第一激活能量而从第一配置变换到第二配置。

6. 发明申请

WO2006019521A2 SHAPE MEMORY DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 审中-公开
标题翻译：形状记忆装置和用于重建心脏解剖的方法
公开(公告)号：WO2006019521A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/022462
申请日：2005-06-23
申请人： MICARDIA CORPORATION , MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
发明人： MOADDEB, Shahram , SHAOLIAN, Samuel, M. , SHAOULIAN, Emanuel , RHEE, Richard , ANDERSON, Seteven, C.
IPC分类号： A61F2/00
CPC分类号： A61F2/2478 , A61B17/3468 , A61B2017/00876 , A61F2/2481 , A61F2/2487 , A61F2002/249 , A61F2210/009
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加脑室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。形状记忆元件具有原始形状和至少一种存储器形状。当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。元件然后被激活以从原始形状转换到至少一个存储器形状之一。元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

7. 发明申请

WO2006019943A1 IMPLANTS AND METHODS FOR RESHAPING HEART VALVES 审中-公开
标题翻译：用于修复心脏瓣膜的植入物和方法
公开(公告)号：WO2006019943A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/025044
申请日：2005-07-14
申请人： MICARDIA CORPORATION , MOADDEB, Shahram , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , HENSON, Michael, R. , RHEE, Richard, S. , ANDERSON, Steven, C.
发明人： MOADDEB, Shahram , SHAOULIAN, Emanuel , SHAOLIAN, Samuel , HENSON, Michael, R. , RHEE, Richard, S. , ANDERSON, Steven, C.
IPC分类号： A61F2/06
CPC分类号： A61F2/2442 , A61B17/3468 , A61B2017/00243 , A61F2/2451 , A61F2002/249 , A61F2210/0076
摘要： Tissue shaping methods and devices are provided for reinforcing and/or remodeling heart valves. Magnetic tissue shaping devices (302) are implanted in tissue adjacent heart valve leaflets (204, 206). The devices (302) are mutually attractive or repulsive to remodel the heart tissue, improving heart valve function. In other embodiments, one or more tissue shaping devices are implanted in a patient's body adjacent a heart valve leaflet (204, 206). The shape memory material of the devices can be activated within the patient less invasively, such as by applying energy percutaneously or external to the patient. The shape memory devices (502) are implanted in a first configuration and then activated, remembering a second configuration that displaces tissue that remodels heart valve geometry. In other embodiments, a brace (1900) is crimped to the base of a heart valve leaflet (204, 206) to support the leaflet and improve valve closure.
摘要翻译：提供组织成形方法和装置用于加强和/或改造心脏瓣膜。将磁组织成形装置（302）植入邻近心脏瓣膜小叶（204,206）的组织中。装置（302）相互吸引或排斥以改善心脏组织，改善心脏瓣膜功能。在其它实施例中，将一个或多个组织成形装置植入患者体内邻近心脏瓣膜小叶（204,206）。装置的形状记忆材料可以在患者内较少侵入地被激活，例如通过经皮或外部施加能量。形状记忆装置（502）以第一构型植入，然后被激活，记住移位重塑心脏瓣膜几何形状的组织的第二构型。在其他实施例中，将支架（1900）卷曲到心脏瓣膜小叶（204,206）的底部以支撑小叶并改善瓣膜关闭。

8. 发明申请

WO2006012068A3 THERMAL CONDUCTOR FOR ADJUSTABLE CARDIAC IMPLANT 审中-公开
公开(公告)号：WO2006012068A3
公开(公告)日：2006-02-02
申请号：PCT/US2005/021597
申请日：2005-06-17
申请人： MICARDIA CORPORATION , RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
发明人： RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
IPC分类号： A61F2/24
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (2600) includes a body member (800) including a shape memory material. The shape memory material is configured to transform the body member 800 from a first shape to a second shape in response to being heated. The annuloplasty ring (2600) also includes a thermally insulative material (912) at least partially covering the body member (800) and a thermally conductive material (2610, 2612, 2614) extending into the thermally insulative material (912). The thermally conductive material (2610, 2612, 2614) is configured to communicate thermal energy to the body member (800).

9. 发明申请

WO2006012013A2 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调节心脏瓣膜植入物，具有选择性的尺寸调整
公开(公告)号：WO2006012013A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/021141
申请日：2005-06-15
申请人： MICARDIA CORPORATION , RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
发明人： RHEE, Richard , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the devices can be adjusted to provide continued reinforcement. In one embodiment, an annuloplasty ring (1826) includes an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The annuloplasty ring (1826) has a first shape in a first configuration and a second shape in a second configuration and is configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，当身体结构改变尺寸和/或形状时，可以调节装置的尺寸和/或形状以提供持续的加强。在一个实施例中，瓣膜成形术环（1826）包括前部，后部和对应于前部和后部的交叉点的两个侧部。瓣膜成形术环（1826）具有第一构造的第一形状和第二构造的第二形状，并且被配置为响应于施加到其上的活化能量而从第一构型变换到第二构造。该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。

10. 发明申请

WO2006116129A3 DYNAMICALLY ADJUSTABLE IMPLANTS AND METHODS FOR RESHAPING TISSUE 审中-公开
公开(公告)号：WO2006116129A3
公开(公告)日：2006-11-02
申请号：PCT/US2006/015165
申请日：2006-04-21
申请人： MICARDIA CORPORATION , SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel, M.
发明人： SHAOULIAN, Emanuel , MOADDEB, Shahram , SHAOLIAN, Samuel, M.
IPC分类号： A61F2/24
摘要： Tissue shaping devices and methods are provided. The devices (120) can be adjusted within the body of a patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external (1300) to the patient's body. In one example, the device (120) is positioned within the coronary sinus (104) of the patient so as to effect changes in at least one dimension of the mitral valve annulus (116). The device (120) may also advantageously include a shape memory material that is responsive to changes in temperature and/or exposure to a magnetic field. In one example, the shape memory material is responsive to energy, such as electromagnetic or acoustic energy, applied from an energy source located outside the coronary sinus (104). A material having enhanced absorption characteristics with respect to the desired heating energy may also be used to facilitate heating and adjustment of the tissue shaping device (120).

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