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1. 发明申请

WO2005062940A2 METHOD AND APPARATUS FOR IN VIVO COLLECTION AND SURVEILLANCE OF CIRCULATING BIOLOGICAL COMPONENTS 审中-公开
标题翻译：循环生物组分收集和监测的方法和装置
公开(公告)号：WO2005062940A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043376
申请日：2004-12-22
申请人： JOHN WAYNE CANCER INSTITUTE , HOON, David , TABACK, Bret , SHAOLIAN, Samuel
发明人： HOON, David , TABACK, Bret , SHAOLIAN, Samuel
IPC分类号： C12Q1/68
CPC分类号： G01N33/54366 , B82Y30/00
摘要： The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers is provided. A combination of detection methods may be provided on the same probe or probe system. A partial or complete analytic/detection assembly may also be integrated with the probe.
摘要翻译：本发明一般涉及使用收集探针体内收集循环分子，肿瘤细胞和其他生物学标记物。探针配置为在活体内长时间放置以提供足够的生物标志物用于分析。在本发明的一些实施方案中，提供了生物标志物的主动吸引。可以在相同的探针或探针系统上提供检测方法的组合。部分或完整的分析/检测组件也可以与探头集成。

2. 发明申请

WO2004086949A2 DNA MARKERS FOR MANAGEMENT OF CANCER 审中-公开
标题翻译：癌症管理的DNA标记
公开(公告)号：WO2004086949A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/009525
申请日：2004-03-25
申请人： JOHN WAYNE CANCER INSTITUTE , HOON, Dave, S.B. , TABACK, Bret
发明人： HOON, Dave, S.B. , TABACK, Bret
IPC分类号： A61B
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , Y10T436/143333
摘要： A method is provided for assessing allelic losses and hypermethylation of genes in CpG tumor promotor region on specific chromosomal regions in cancer patients, including melanoma, neuroblastoma breast, colorectal, and prostate cancer patients. The method relies on the evidence that free DNA and hypermethylation of genes in CpG tumor promotor region may be identified in the bone marrow, serum, plasma, and tumor tissue samples of cancer patients. Methods of melanoma, neuroblastoma, colorectal cancer, breast cancer and prostate cancer detection, staging, and prognosis are also provided.
摘要翻译：提供了一种方法，用于评估癌症患者（包括黑素瘤，神经母细胞瘤乳腺癌，结肠直肠癌和前列腺癌患者）特定染色体区域CpG肿瘤启动子区域中的等位基因损失和高甲基化。该方法依赖于可以在癌症患者的骨髓，血清，血浆和肿瘤组织样品中鉴定CpG肿瘤启动子区域中的游离DNA和基因的高甲基化的证据。还提供了黑色素瘤，神经母细胞瘤，结肠直肠癌，乳腺癌和前列腺癌检测，分期和预后的方法。

3. 发明申请

WO2004086949A3 DNA MARKERS FOR MANAGEMENT OF CANCER 审中-公开
标题翻译：癌症管理的DNA标记
公开(公告)号：WO2004086949A3
公开(公告)日：2005-03-24
申请号：PCT/US2004009525
申请日：2004-03-25
申请人： WAYNE JOHN CANCER INST , HOON DAVE S B , TABACK BRET
发明人： HOON DAVE S B , TABACK BRET
IPC分类号： A61B20060101 , C07H19/00 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , Y10T436/143333
摘要： A method is provided for assessing allelic losses and hypermethylation of genes in CpG tumor promotor region on specific chromosomal regions in cancer patients, including melanoma, neuroblastoma breast, colorectal, and prostate cancer patients. The method relies on the evidence that free DNA and hypermethylation of genes in CpG tumor promotor region may be identified in the bone marrow, serum, plasma, and tumor tissue samples of cancer patients. Methods of melanoma, neuroblastoma, colorectal cancer, breast cancer and prostate cancer detection, staging, and prognosis are also provided.
摘要翻译：提供了一种方法，用于评估癌症患者（包括黑素瘤，神经母细胞瘤乳腺癌，结肠直肠癌和前列腺癌患者）特定染色体区域CpG肿瘤启动子区域中的等位基因损失和高甲基化。该方法依赖于可以在癌症患者的骨髓，血清，血浆和肿瘤组织样品中鉴定CpG肿瘤启动子区域中的游离DNA和基因的高甲基化的证据。还提供了黑色素瘤，神经母细胞瘤，结肠直肠癌，乳腺癌和前列腺癌检测，分期和预后的方法。

4. 发明申请

WO2004016154A2 MOLECULAR LYMPHATIC MAPPING OF SENTINEL LYMPH NODES 审中-公开
标题翻译： SENTINEL LYMPH NODES的分子淋巴映射
公开(公告)号：WO2004016154A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025553
申请日：2003-08-15
申请人： JOHN WAYNE CANCER INSTITUTE , HOON, David, S., B. , TABACK, Bret
发明人： HOON, David, S., B. , TABACK, Bret
IPC分类号： A61B
CPC分类号： A61K49/006 , C12Q1/6886 , C12Q2600/112
摘要： The present invention describes a method for identification and labeling of sentinel lymph nodes (SLNs) and the presence or absence of lymph node metastases as an important diagnostic and prognostic factor in early stage cancers of all types. The method, know as Molecular Lymphatic Mapping, uses traditional dye/radioactive tracer based techniques in conjunction with a nucleic acid marker to identify and label the SLN, not only for current diagnostic methods, but for archival purposes. In addition, MLM can be used to deliver a therapeutic gene or genes to the SLN to activate tumor immunity to tumor cells, and/or to inhibit tumor metastases. The methods may be combined with therapeutic intervention including chemotherapy and radiotherapy.
摘要翻译：本发明描述了用于前哨淋巴结（SLN）的鉴定和标记以及淋巴结转移的存在或不存在作为所有类型的早期癌症中的重要诊断和预后因素。该方法称为分子淋巴绘图（Molecular Lymphatic Mapping），将传统的基于染料/放射性示踪剂的技术与核酸标记结合使用，以识别和标记SLN，不仅用于当前的诊断方法，而且用于存档目的。此外，MLM可用于将治疗基因或基因递送至SLN以激活对肿瘤细胞的肿瘤免疫，和/或抑制肿瘤转移。这些方法可以与包括化疗和放疗在内的治疗干预相结合。

5. 发明申请

WO2005062940A3 METHOD AND APPARATUS FOR IN VIVO COLLECTION AND SURVEILLANCE OF CIRCULATING BIOLOGICAL COMPONENTS 审中-公开
标题翻译：用于体内循环生物组分收集和监测的方法和设备
公开(公告)号：WO2005062940A3
公开(公告)日：2005-09-09
申请号：PCT/US2004043376
申请日：2004-12-22
申请人： WAYNE JOHN CANCER INST , HOON DAVID , TABACK BRET , SHAOLIAN SAMUEL
发明人： HOON DAVID , TABACK BRET , SHAOLIAN SAMUEL
IPC分类号： C12Q1/68
CPC分类号： G01N33/54366 , B82Y30/00
摘要： The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers is provided. A combination of detection methods may be provided on the same probe or probe system. A partial or complete analytic/detection assembly may also be integrated with the probe.
摘要翻译：本发明一般涉及使用采集探针在体内收集循环分子，肿瘤细胞和其他生物标志物。探针被配置用于放置在活体内长时间以提供用于分析的足够产量的生物标记。在本发明的一些实施方式中，提供了生物标记的主动吸引。可以在相同的探针或探针系统上提供检测方法的组合。部分或完整的分析/检测组件也可以与探针集成。

6. 发明申请

WO2004016154A3 MOLECULAR LYMPHATIC MAPPING OF SENTINEL LYMPH NODES 审中-公开
标题翻译： SENTINEL LYMPH NODES的分子LYMPHAIC MAPPING
公开(公告)号：WO2004016154A3
公开(公告)日：2004-10-07
申请号：PCT/US0325553
申请日：2003-08-15
申请人： WAYNE JOHN CANCER INST , HOON DAVID S B , TABACK BRET
发明人： HOON DAVID S B , TABACK BRET
IPC分类号： A61B20060101 , A61K49/00 , C07H21/00 , C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： A61K49/006 , C12Q1/6886 , C12Q2600/112
摘要： The present invention describes a method for identification and labeling of sentinel lymph nodes (SLNs) and the presence or absence of lymph node metastases as an important diagnostic and prognostic factor in early stage cancers of all types. The method, know as Molecular Lymphatic Mapping, uses traditional dye/radioactive tracer based techniques in conjunction with a nucleic acid marker to identify and label the SLN, not only for current diagnostic methods, but for archival purposes. In addition, MLM can be used to deliver a therapeutic gene or genes to the SLN to activate tumor immunity to tumor cells, and/or to inhibit tumor metastases. The methods may be combined with therapeutic intervention including chemotherapy and radiotherapy.
摘要翻译：本发明描述了前哨淋巴结（SLN）的鉴定和标记方法以及淋巴结转移的存在或不存在，作为所有类型早期癌症的重要诊断和预后因素。该方法称为分子淋巴图，使用传统的基于染料/放射性示踪剂的技术结合核酸标记物来鉴定和标记SLN，不仅用于当前的诊断方法，而且用于归档目的。此外，MLM可用于将治疗性基因或基因递送至SLN以激活对肿瘤细胞的肿瘤免疫，和/或抑制肿瘤转移。这些方法可以与包括化学疗法和放射治疗在内的治疗干预相结合。

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