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1. 发明申请

WO2005070945A8 NOVEL AMINOGLYCOSIDE ANTIBIOTIC EFFECTIVE AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) 审中-公开
标题翻译：新型氨基糖苷类抗生素对耐甲氧西林金黄色葡萄球菌（MRSA）
公开(公告)号：WO2005070945A8
公开(公告)日：2005-12-15
申请号：PCT/JP2005000767
申请日：2005-01-21
申请人： MEIJI SEIKA KAISHA , MICROBIAL CHEM RES FOUND , MINOWA NOBUTO , USUI TAKAYUKI , AKIYAMA YOSHIHISA , HIRAIWA YUKIKO , YONEDA TOSHIO , HASEGAWA TOSHIFUMI , MAEBASHI KAZUNORI , IDA TAKASHI , KATSUMATA KAZUKO , OTSUKA KEIKO , IKEDA DAISHIRO
发明人： MINOWA NOBUTO , USUI TAKAYUKI , AKIYAMA YOSHIHISA , HIRAIWA YUKIKO , YONEDA TOSHIO , HASEGAWA TOSHIFUMI , MAEBASHI KAZUNORI , IDA TAKASHI , KATSUMATA KAZUKO , OTSUKA KEIKO , IKEDA DAISHIRO
IPC分类号： A61K31/7036 , C07H15/234 , A61P31/04
CPC分类号： C07H15/234 , A61K31/7036
摘要： A compound represented by, e.g., the general formula (I) or a pharmacologically acceptable salt or solvate thereof. They have excellent antibacterial activity against bacteria causative of severe infectious diseases such as pneumonia and sepsis, in particular against MRSA. Also provided are: an antibacterial containing any of these compounds; and a medicinal composition containing any of these compounds as an active ingredient.
摘要翻译：由例如通式（I）表示的化合物或其药理学上可接受的盐或溶剂合物。它们对由细菌引起的优良抗菌活性成为重要的传染病例如肺炎和败血症，特别是针对MRSA。还提供了：含有任何这些化合物的抗菌剂; 和含有任何这些化合物作为活性成分的药物组合物。

2. 发明申请

WO2010131676A1 PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVE 审中-公开
标题翻译：生产吡啶衍生物的方法
公开(公告)号：WO2010131676A1
公开(公告)日：2010-11-18
申请号：PCT/JP2010058040
申请日：2010-05-12
申请人： MEIJI SEIKA KAISHA , FUKUDA YOSHIMASA , ANDO TAKASHI , GOTO KIMIHIKO , NAKANISHI NOZOMU , WATANABE TAKASHI , KURIHARA KENICHI , MINOWA NOBUTO , MITOMI MASAAKI
发明人： FUKUDA YOSHIMASA , ANDO TAKASHI , GOTO KIMIHIKO , NAKANISHI NOZOMU , WATANABE TAKASHI , KURIHARA KENICHI , MINOWA NOBUTO , MITOMI MASAAKI
IPC分类号： C07D405/04 , C07B61/00
CPC分类号： C07D493/04
摘要： A process for efficiently producing a pyripyropene derivative having acyloxy groups in the 1- and 11- positions and a hydroxy group in the 7-position. The process comprises a step in which the hydroxy groups in the 1- and 11-positions of the compound represented by formula (B1) are selectively acylated with an acylating agent in the presence or absence of a base in one to three stages.
摘要翻译：一种在1-位和11位有效生产具有酰氧基的吡啶并苯衍生物和7-位羟基的方法。该方法包括在碱存在或不存在下，在一到三个阶段中，用酰化剂选择性地酰化由式（B1）表示的化合物的1位和11位中的羟基。

3. 发明专利

CA2654561A1 NOVEL AMINOGLYCOSIDE ANTIBIOTICS 未知
公开(公告)号：CA2654561A1
公开(公告)日：2007-12-13
申请号：CA2654561
申请日：2007-06-01
申请人： MICROBIAL CHEM RES FOUND , MEIJI SEIKA KAISHA
发明人： AKIYAMA YOSHIHISA , TAKAHASHI YOSHIAKI , IKEDA DAISHIRO , ABE MITSUHIRO , MURAKAMI TAKESHI , SASAKI KAZUSHIGE , MIYAKE TOSHIAKI , HOSHIKO SHIGERU , MINOWA NOBUTO , TSUSHIMA MASAKI , HIRAIWA YUKIKO , MURAKAMI SHOICHI , KOBAYASHI YOSHIHIKO
IPC分类号： C07H15/234 , A61K31/7036 , A61P31/04
摘要： Disclosed are: a novel aminoglycoside antibiotic which has an excellent a nti-bacterial activity against an infection-inducing bacterium, particularly MRSA, and also has low renal toxicity; and a process for production of the antibiotic. More specifically, disclosed are: a compound represented by the formula (Ia) or a pharmacologically acceptable salt or solvate thereof, or a diastereomeric mixture of the compound, the salt or the solvate; an antibac terial agent comprising the compound, the salt, the solvate or the diastereo meric mixture; and a process for production of the compound. [Chemical formu la 1] (Ia)

4. 发明专利

ZA200810676B Novel aminoglycoside antibiotics 未知
公开(公告)号：ZA200810676B
公开(公告)日：2010-03-31
申请号：ZA200810676
申请日：2007-06-01
申请人： MEIJI SEIKA KAISHA , MICROBIAL CHEM RES FOUND
发明人： KOBAYASHI YOSHIHIKO , AKIYAMA YOSHIHISA , MURAKAMI TAKESHI , MINOWA NOBUTO , TSUSHIMA MASAKI , HIRAIWA YUKIKO , MURAKAMI SHOICHI , ABE MITSUHIRO , SASAKI KAZUSHIGE , HOSHIKO SHIGERU , MIYAKE TOSHIAKI , TAKAHASHI YOSHIAKI , IKEDA DAISHIRO
IPC分类号： A61K20100101 , A61P20100101 , C07H20100101
摘要： This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.

5. 发明公开

EP1710248A4 NOVEL AMINOGLYCOSIDE ANTIBIOTIC EFFECTIVE AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) 审中-公开
标题翻译：新氨基糖甙类抗生素有效对抗耐甲氧西林金黄色葡萄球菌（MRSA）
公开(公告)号：EP1710248A4
公开(公告)日：2009-05-27
申请号：EP05703988
申请日：2005-01-21
申请人： MEIJI SEIKA KAISHA , MICROBIAL CHEM RES FOUND
发明人： MINOWA NOBUTO , USUI TAKAYUKI , AKIYAMA YOSHIHISA , HIRAIWA YUKIKO , YONETA TOSHIO , HASEGAWA TOSHIFUMI , MAEBASHI KAZUNORI , IDA TAKASHI , KATSUMATA KAZUKO , OTSUKA KEIKO , IKEDA DAISHIRO
IPC分类号： C07H15/234 , A61K31/7036
CPC分类号： C07H15/234 , A61K31/7036
摘要： A compound represented by, e.g., the general formula (I) or a pharmacologically acceptable salt or solvate thereof. They have excellent antibacterial activity against bacteria causative of severe infectious diseases such as pneumonia and sepsis, in particular against MRSA. Also provided are: an antibacterial containing any of these compounds; and a medicinal composition containing any of these compounds as an active ingredient.

6. 发明公开

EP2036917A4 NOVEL AMINOGLYCOSIDE ANTIBIOTIC 有权
标题翻译：新氨基糖苷类
公开(公告)号：EP2036917A4
公开(公告)日：2014-09-03
申请号：EP07744596
申请日：2007-06-01
申请人： MEIJI SEIKA PHARMA CO LTD , MICROBIAL CHEM RES FOUND
发明人： KOBAYASHI YOSHIHIKO , AKIYAMA YOSHIHISA , MURAKAMI TAKESHI , MINOWA NOBUTO , TSUSHIMA MASAKI , HIRAIWA YUKIKO , MURAKAMI SHOICHI , ABE MITSUHIRO , SASAKI KAZUSHIGE , HOSHIKO SHIGERU , MIYAKE TOSHIAKI , TAKAHASHI YOSHIAKI , IKEDA DAISHIRO
IPC分类号： C07H15/234 , A61K31/7036 , A61P31/04
CPC分类号： C07H15/234 , C07H15/224

7. 发明专利

IL223411A Method for producing n-substituted-2-amino-4-(hydroxymethylphosphinyl)-2-butenoic acid 未知
公开(公告)号：IL223411A
公开(公告)日：2015-06-30
申请号：IL22341112
申请日：2012-12-03
申请人： MEIJI SEIKA PHARMA CO LTD , ANDO TAKASHI , MINOWA NOBUTO , MITOMI MASAAKI
发明人： ANDO TAKASHI , MINOWA NOBUTO , MITOMI MASAAKI
IPC分类号： C07B20060101 , C07F20060101
摘要： Provided is a method for producing a compound expressed by the following formula (3): [where R 1 represents a hydrogen atom or C 1-4 alkyl group, and R 2 represents C 1-4 alkyl group, C 1-4 alkoxy group, aryl group, aryloxy group or benzyloxy group], the method comprising a reaction of dehydro-condensing a compound expressed by the following formula (1): [where R 1 represents the same meaning as defined above], and a compound expressed by the following formula (2): [where R 2 represents the same meaning as defined above], while being converted to a desired geometric isomer in the presence or absence of an acid catalyst, under a condition that an organic solvent to be used for the reaction is a mixed solvent of acetic acid and a solvent selected from the group consisting of toluene, xylene and chlorobenzene, and a mixing ratio of acetic acid to the other solvent is from 1:3 to 1:5 in volume, wherein the reaction is conducted under heating and refluxing.

8. 发明专利

UA97245C2 未知
公开(公告)号：UA97245C2
公开(公告)日：2012-01-25
申请号：UAA200814109
申请日：2007-06-01
申请人： MEIJI SEIKA FARMA CO LTD , MICROBIAL CHEM RES FOUND
发明人： KOBAYASHI YOSHIHIKO , MURAKAMI TAKESHI , MINOWA NOBUTO , TSUSHIMA MASAKI , HIRAIWA YUKIKO , MURAKAMI SHOICHI , ABE MITSUHIRO , SASAKI KAZUSHIGE , HOSHIKO SHIGERU , MIYAKE TOSHIAKI , TAKAHASHI YOSHIAKI , IKEDA DAISHIRO , AKIYAMA YOSHIHISA
IPC分类号： C07H15/234 , A61K31/7036 , A61P31/04
摘要： Изобретениекасаетсяновыхаминогликозидныхантибиотиков, которыеявляютсяэффективнымипротивбактерий, которыевызываютинфекционныезаболевания, вчастности MRSA, имеютнезначительныйуровеньнефротоксичности, испособаихполучения.Болеедетально, изобретениекасаетсясоединенияформулы (Ia) илиегофармакологическиприемлемойсолиилисольвата, илисмесиегодиастереомеров, антимикробныхсредств, которыеихсодержат, испособаихполучения.(Ia)

9. 发明专利

JP2008230992A PHOSPHORUS-CONTAINING SULFONE, SULFOXIDE DERIVATIVE AND METHOD FOR PRODUCING PHOSPHORUS-CONTAINING α-KETO ACID USING THE SAME AS INTERMEDIATE 有权
标题翻译：含磷硫化物，硫氧化物衍生物和使用其作为中间产物含有含磷酸的α-酮酸的方法
公开(公告)号：JP2008230992A
公开(公告)日：2008-10-02
申请号：JP2007069959
申请日：2007-03-19
申请人： Meiji Seika Kaisha Ltd , 明治製菓株式会社
发明人： MINOWA NOBUTO , MITOMI MASAAKI
IPC分类号： C07F9/32 , B01J31/12 , C07B61/00 , C07F9/30
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently producing 4-(hydroxymethyl-phosphonyl)-2-oxobutanoic acid of an intermediate for producing herbicide L-AMPB. SOLUTION: The method for producing the 4-(hydroxymethyl-phosphonyl)-2-oxobutanoic acid uses a compound represented by formula (5) [wherein, R 1 is an aryl group; R 2 , R 3 and R 4 are each a 1-4C alkyl group; and n is an integer of 1 or 2]. COPYRIGHT: (C)2009,JPO&INPIT

10. 发明专利

JPS5970696A Novel methylphosphinic acid compound and herbicidal and miticidal agent 失效
标题翻译：新型甲基磷酸化合物和除草剂和微生物剂
公开(公告)号：JPS5970696A
公开(公告)日：1984-04-21
申请号：JP17980082
申请日：1982-10-15
申请人： Meiji Seika Kaisha Ltd
发明人： MINOWA NOBUTO , TACHIBANA KUNITAKA , KIKUCHI TAKAHIKO , WATANABE TETSUO , FUKATSU SHIYUNZOU
IPC分类号： A01N57/20 , C07F9/30
摘要： NEW MATERIAL:The compound of formula I [R
1 is H; R
2 is (substituted) 1W4C alkyl, (substituted) 1W4C alkenyl or (substituted) aryl; M
1 and M
2 are H, metallic cation, (substituted) ammonium cation, or cation derived from choline molecule; m is reciprocal number of the ionic value of M
1 cation; n is reciprocal number of the ionic value of M
2 cation].
EXAMPLE: [(3-Phenylmethyleneamino-3-carboxy)-propyl-1]-methylphosphinic acid disodium salt.
USE: A herbicidal and miticidal agent having low toxicity to man and cattle.
PROCESS: For example, the carbonyl compound of formula III, pereferably an aldehyde, is condensed to the methylphosphine compound of formula II preferably at -10W+50°C for 1W24hr is necessary in the presence of a solvent (preferably a lower alkanol).
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I化合物[R 1]为H; R 2是（取代的）1-4C烷基，（取代的）1-4C烯基或（取代的）芳基; M 1和M 2均为H，金属阳离子，（取代的）铵阳离子或衍生自胆碱分子的阳离子; m是M 1离子的离子值的倒数; n是M 2阳离子的离子值的倒数。实施例：[（3-苯基亚甲基氨基-3-羧基） - 丙基] -1-甲基次膦酸二钠盐。用途：对人和牛具有低毒性的除草和杀螨剂。方法：例如，式III的羰基化合物，优选为醛，优选在-10- + 50℃下与式II的甲基膦化合物缩合1-24小时，在溶剂存在下（优选为低级链烷醇）。

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