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1. 发明申请

WO2011108155A1 PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES 审中-公开
标题翻译：生产吡啶衍生物的方法
公开(公告)号：WO2011108155A1
公开(公告)日：2011-09-09
申请号：PCT/JP2010/070414
申请日：2010-11-10
申请人： MEIJI SEIKA KAISHA, LTD. , FUKUDA, Yoshimasa , ANDO, Takashi , GOTO, Kimihiko , NAKANISHI, Nozomu , WATANABE, Takashi , KURIHARA, Kenichi , MINOWA, Nobuto , MITOMI, Masaaki
发明人： FUKUDA, Yoshimasa , ANDO, Takashi , GOTO, Kimihiko , NAKANISHI, Nozomu , WATANABE, Takashi , KURIHARA, Kenichi , MINOWA, Nobuto , MITOMI, Masaaki
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula Bl through one to three steps with an acylating agent in the presence or absence of a base.
摘要翻译：公开了一种有效生产在1-位和11位上具有酰氧基并在7-位具有羟基的吡啶并苯衍生物的方法。该方法包括在存在或不存在碱的情况下，用酰化剂选择性地将式B1化合物的1位和11位羟基选择性酰化1-3步。

2. 发明申请

WO1994018197A1 COMPOUND WITH ANTIPSYCHOTIC EFFECT 审中-公开
标题翻译：具有抗生素效应的化合物
公开(公告)号：WO1994018197A1
公开(公告)日：1994-08-18
申请号：PCT/JP1994000159
申请日：1994-02-03
申请人： MEIJI SEIKA KABUSHIKI KAISHA , FUKUDA, Yoshimasa , SASAKI, Toshiro , NAKATANI, Yuuko , ICHIMARU, Yasuyuki , IMANISHI, Taiichiro
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： A compound represented by general formula (I) and a pharmacologically acceptable salt thereof, reduced in the adverse effect against the extrapyramidal system and hence useful as an antipsychotic agent with few side effects.
摘要翻译：由通式（I）表示的化合物及其药学上可接受的盐减少对锥体束系统的不利影响，因此可用作具有少量副作用的抗精神病药。

3. 发明申请

WO1996016968A1 BICYCLIC THIAZOLE COMPOUND 审中-公开
标题翻译：双环噻唑化合物
公开(公告)号：WO1996016968A1
公开(公告)日：1996-06-06
申请号：PCT/JP1995002412
申请日：1995-11-27
申请人： MEIJI SEIKA KABUSHIKI KAISHA , FUKUDA, Yoshimasa , HASEGAWA, Toshifumi , NAKATANI, Yuuko , MURASE, Kenshi , FUJI, Kazuyuki
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07D519/00
CPC分类号： C07D513/04
摘要： A compound having a psychotropic effect and represented by general formula (I) and a pharmaceutically acceptable salt thereof, wherein one of R and R represents W-(CH2)m-, wherein m is an integer of from 1 to 4, and another represents hydrogen or optionally substituted lower alkyl; W represents a group represented by formula (i) (wherein R represents hydrogen or halogeno; A represents oxygen or sulfur; B represents nitrogen or CH and Y represents CH or nitrogen); and the cyclic structure -D- represents one member selected from among those represented by formulae (a) to (d), wherein n represents an integer of 0 to 2; R independently represent hydrogen, lower alkyl, hydroxy, alkoxy, alkoxycarbonyl or aminocarbonyl; and the solid line accompanied by the dotted line represents either a single bond or a double bond.
摘要翻译：具有精神作用并由通式（I）表示的化合物及其药学上可接受的盐，其中R 1和R 2之一表示W-（CH 2）m - ，其中m为1的整数至4，另一个表示氢或任选取代的低级烷基; W表示由式（i）表示的基团（其中R 3表示氢或卤素; A表示氧或硫; B表示氮或CH，Y表示CH或氮）; 环状结构-D-表示选自由式（a）〜（d）表示的那些，其中，n表示0〜2的整数。 [R <4？和R 5>独立地表示氢，低级烷基，羟基，烷氧基，烷氧基羰基或氨基羰基; 伴随虚线的实线表示单键或双键。

4. 发明申请

WO2010131676A1 PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVE 审中-公开
标题翻译：生产吡啶衍生物的方法
公开(公告)号：WO2010131676A1
公开(公告)日：2010-11-18
申请号：PCT/JP2010058040
申请日：2010-05-12
申请人： MEIJI SEIKA KAISHA , FUKUDA YOSHIMASA , ANDO TAKASHI , GOTO KIMIHIKO , NAKANISHI NOZOMU , WATANABE TAKASHI , KURIHARA KENICHI , MINOWA NOBUTO , MITOMI MASAAKI
发明人： FUKUDA YOSHIMASA , ANDO TAKASHI , GOTO KIMIHIKO , NAKANISHI NOZOMU , WATANABE TAKASHI , KURIHARA KENICHI , MINOWA NOBUTO , MITOMI MASAAKI
IPC分类号： C07D405/04 , C07B61/00
CPC分类号： C07D493/04
摘要： A process for efficiently producing a pyripyropene derivative having acyloxy groups in the 1- and 11- positions and a hydroxy group in the 7-position. The process comprises a step in which the hydroxy groups in the 1- and 11-positions of the compound represented by formula (B1) are selectively acylated with an acylating agent in the presence or absence of a base in one to three stages.
摘要翻译：一种在1-位和11位有效生产具有酰氧基的吡啶并苯衍生物和7-位羟基的方法。该方法包括在碱存在或不存在下，在一到三个阶段中，用酰化剂选择性地酰化由式（B1）表示的化合物的1位和11位中的羟基。

5. 发明申请

WO1996033194A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A RECEPTOR COMPLEX 审中-公开
标题翻译：苯并咪唑化合物及其作为GABA受体复合物的调节剂
公开(公告)号：WO1996033194A1
公开(公告)日：1996-10-24
申请号：PCT/EP1996001606
申请日：1996-04-17
申请人： NEUROSEARCH A/S , MEIJI SEIKA KAISHA, LTD. , TEUBER, Lene , WÄTJEN, Frank , FUKUDA, Yoshimasa , USHIRODA, Osamu , SASAKI, Toshiro
发明人： NEUROSEARCH A/S , MEIJI SEIKA KAISHA, LTD.
IPC分类号： C07D405/14
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof or an oxide thereof, wherein R is (II), wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH; R is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, phenyl, halogen, CF3, amino, nitro, cyano, acyl, acylamino, phenyl and monocyclic heteroaryl; and one of R and R is hydrogen and the other is furanyl or isoxazolyl each of which may be substituted one or more times with substituents selected from halogen, alkyl, alkoxy and phenyl. The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
摘要翻译：本专利申请公开了具有式（I）的化合物或其药学上可接受的盐或其氧化物，其中R 3为（II），其中A，B和D各自为CH，或A，B中的一种或两种 D为N，其余为CH; R 11是苯基，苯并咪唑基或单环杂芳基，其全部可以被选自烷基，烷氧基，苯基，卤素，CF 3，氨基，硝基，氰基，酰基，酰氨基，苯基和单环杂芳基的取代基取代一次或多次 ; R 6和R 7中的一个是氢，另一个是可以被选自卤素，烷基，烷氧基和苯基的取代基取代一次或多次的呋喃基或异恶唑基。该化合物可用于治疗各种中枢神经系统疾病如癫痫和其他惊厥性疾病，焦虑症，睡眠障碍和记忆障碍。

6. 发明申请

WO1996033191A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX 审中-公开
标题翻译：苯并咪唑化合物及其作为GABA A受体复合物的调节剂
公开(公告)号：WO1996033191A1
公开(公告)日：1996-10-24
申请号：PCT/EP1996001649
申请日：1996-04-19
申请人： NEUROSEARCH A/S , MEIJI SEIKA KAISHA, LTD. , TEUBER, Lene , WÄTJEN, Frank , FUKUDA, Yoshimasa , USHIRODA, Osamu , SASAKI, Toshiro
发明人： NEUROSEARCH A/S , MEIJI SEIKA KAISHA, LTD.
IPC分类号： C07D401/10
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R is (II) wherein A, B, and D each is CH, or one or two of A, B and D is N and the others are CH; R is phenyl, benzimidazolyl, or monocyclic heteroaryl, all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, halogen, CF3, amino, nitro, cyano, acylamino, acyl, phenyl and monocyclic heteroaryl; one of R and R is hydrogen and the other is -CR'=NOR'', wherein R' and R'' each independently are hydrogen, alkyl, alkenyl, alkynyl or phenyl. The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
摘要翻译：本专利申请公开了具有式（I）化合物或其药学上可接受的盐或其氧化物，其中R 3为（II）其中A，B和D各自为CH，或A，B和 D为N，其余为CH; R 11是苯基，苯并咪唑基或单环杂芳基，它们都可以被选自烷基，烷氧基，卤素，CF 3，氨基，硝基，氰基，酰氨基，酰基，苯基和单环杂芳基的取代基取代一次或多次。 R 6和R 7中的一个是氢，另一个是-CR'= NOR“，其中R'和R”各自独立地是氢，烷基，烯基，炔基或苯基。该化合物可用于治疗各种中枢神经系统疾病如癫痫和其他惊厥性疾病，焦虑症，睡眠障碍和记忆障碍。

7. 发明申请

WO1994001392A1 (-)-RITODRINE 审中-公开
标题翻译：（ - ） - 利托君
公开(公告)号：WO1994001392A1
公开(公告)日：1994-01-20
申请号：PCT/JP1993000896
申请日：1993-06-30
申请人： MEIJI SEIKA KABUSHIKI KAISHA , YAMAZAKI, Naoki , FUKUDA, Yoshimasa , SHIBAZAKI, Yoshiaki , NIIZATO, Tetsutarou , KOSUGI, Isao , YOSHIOKA, Shin
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07C215/60
CPC分类号： C07C215/60 , A61K31/135
摘要： (-)-Ritodrine, i.e. (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-pr opanol, which is substantially free from the (+)-isomer, or a salt thereof. This compound has a potent effect of inhibiting uterine contraction as compared with (+/-)-ritodrine and (+)-ritodrine and a toxicity comparable to those of the other ritodrines, and hence is usable as a highly safe remedy for threatened premature birth and abortion and a remedy for dysmenorrhea.
摘要翻译：（ - ） - 基本上不含（+） - 异构体的（ - ） - 赤 - 1-（对羟基苯基）-2- [2-（对羟基苯基）乙基氨基] ，或其盐。与（+/-） - 利培酮和（+） - 利培酮相比，该化合物具有抑制子宫收缩的有效作用，其毒性与其他孕妇相当，因此可用作威胁性早产的高度安全补救措施堕胎和痛经补救。

8. 发明专利

JPH02167016A DUPLEX FLOWERPOT WITH FEED WATER PIPE 失效
公开(公告)号：JPH02167016A
公开(公告)日：1990-06-27
申请号：JP32018188
申请日：1988-12-19
申请人： FUKUDA YOSHIMASA
发明人： FUKUDA YOSHIMASA
IPC分类号： A01G25/00 , A01G9/02
摘要： PURPOSE:To obtain the title flowerpot capable of simple, sure, efficient, and economical water feed without the need for manpower by engaging an outer pot having at least one feed water pipe with an inner pot having water feed- water discharge holes. CONSTITUTION:The objective flowerpot can be obtained by engaging an outer pot 1 having at least one feed water pipe 2 with an inner pot 3 having a plurality of water feed-water discharge hole 4 with a diameter of 5-7mm so as to produce a space 5. This flowerpot can be antomatically fed with water even in one's absence. These flowerpots are arranged, for example, in tiers so that hoses are connected to these pots so as to feed tap water from the lower side, the amount of the water is regulated with a flow control pipe fitted at the tip of the hoses, and excess water is discharged with a drain valve.

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