专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06649896B2 Method and a device for measuring the spatially averaged intensity of a light beam and a method and a device for regulating a light source 有权
公开(公告)号：US06649896B2
公开(公告)日：2003-11-18
申请号：US10168790
申请日：2002-06-21
申请人： Lukas Birrer , Thomas Caratsch , Olivier Elsenhans , Emad Sarofim , Urban Schnell
发明人： Lukas Birrer , Thomas Caratsch , Olivier Elsenhans , Emad Sarofim , Urban Schnell
IPC分类号： H01L3100
CPC分类号： G01J1/4228 , G01J1/04 , G01J1/0429 , G01J1/1626 , G01J1/32 , G01J1/4257
摘要： A photoelectric module (1) comprises an electrically non-conducting support (2) and a photoelectric element including an array of spatially distributed photoelectric members applied to a surface of the support (2). High simplicity and efficiency is obtained by the double function of module (1) for light transmission or reflection, and spatially averaged light measurement. In a preferred application of module (1) a light source (8, LED) is energized by a driving circuit (9) controlled by an electronic circuit (11). The input of this circuit (11) is connected to the photoelectric module (1), the power delivered to the light source (8) and the intensity of the light beam emitted by the light source being regulated preferably to a constant value by the feedback loop consisting of module (1), electronic circuit (11) and driving circuit (9).

2. 发明授权

US07256035B1 System for thermocycling of fluids in cartridges 失效
标题翻译：墨盒中流体热循环系统
公开(公告)号：US07256035B1
公开(公告)日：2007-08-14
申请号：US10070343
申请日：2000-09-02
申请人： Urban Schnell , Olivier Elsenhans , Thomas Caratsch , Lukas Birrer , Emad Sarofim
发明人： Urban Schnell , Olivier Elsenhans , Thomas Caratsch , Lukas Birrer , Emad Sarofim
IPC分类号： C12M1/34
CPC分类号： B01L7/52 , G01N2035/00366
摘要： System for thermocycling of fluids in cartridges comprising a thermocycling unit in thermal contact with a first substantially planar and heat conducting wall of a cartridge, a light source for transmitting light into the interior of said cartridge through a second light transparent wall of said cartridge which is arranged substantially perpendicular to said first wall, a light detector for detecting light emerging from the interior of the cartridge through said second wall and a fluid providing unit coupled to an inlet of the cartridge for providing the cartridge with fluid and an outlet of the cartridge to drain gas when the cartridge is filled with fluid. The invention further concerns a cartridge for conducting the thermal cycling of fluids.
摘要翻译：包括与筒的第一基本上平面和导热壁热接触的热循环单元的热循环系统，用于通过所述盒的第二透光壁将光透射到所述盒的内部的光源，基本上垂直于所述第一壁布置的光检测器，用于检测通过所述第二壁从所述盒的内部出射的光的光检测器;以及耦合到所述盒的入口的流体供应单元，用于向所述盒提供所述盒的流体和出口，当墨盒充满流体时，排出气体。本发明还涉及用于进行流体热循环的筒。

3. 发明授权

US08642293B2 Disposable device for analyzing a liquid sample containing a nucleic acid with a nucleic acid amplification apparatus 有权
标题翻译：用于使用核酸扩增装置分析含有核酸的液体样品的一次性装置
公开(公告)号：US08642293B2
公开(公告)日：2014-02-04
申请号：US12373517
申请日：2007-07-05
申请人： Emad Sarofim , Olivier Elsenhans , Martin Kopp , Hans-Peter Wahl
发明人： Emad Sarofim , Olivier Elsenhans , Martin Kopp , Hans-Peter Wahl
IPC分类号： C12P19/34 , C12M1/00 , C12Q1/68
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/10 , B01L2300/0809
摘要： The invention is directed to a disposable sample holding and processing device (1) dimensioned for being operated in a nucleic acid amplification apparatus for analyzing a liquid sample containing a nucleic acid by a nucleic acid amplification technique. The device (1) comprises chambers (15, 16) and channels (44) designed to perform the steps of capturing, amplification and detection of the nucleic acid within the device (1), and optionally also a lysis chamber (3). The binding chamber (15) contains a solid phase (14) for immobilization of a component of the sample to be analyzed, and the amplification chamber (16) is connected to the binding chamber (15) by a fluid channel (44). The device (1) comprises a rigid body (42) and at least one channel (44), the binding chamber (15) and the amplification chamber (16) are situated on side-surfaces (50) of the body (42), each of those side-surfaces (50), on which a channel (44), the binding chamber (15) or the amplification chamber (16) is situated, is covered by at least one wall (41) and these side-surfaces (50) are substantially vertical planes when the device (1) is operated in the nucleic acid amplification apparatus.
摘要翻译：本发明涉及一种一次性样品保持和处理装置（1），其尺寸适于在用于通过核酸扩增技术分析含有核酸的液体样品的核酸扩增装置中操作。设备（1）包括设计成执行在装置（1）内捕获，扩增和检测核酸以及任选还有裂解室（3）的步骤的室（15,16）和通道（44）。装订室（15）包含用于固定待分析样品的组分的固相（14），并且扩散室（16）通过流体通道（44）连接到装订室（15）。装置（1）包括刚体（42）和至少一个通道（44），装订室（15）和放大室（16）位于主体（42）的侧表面（50）上，其中通道（44），装订室（15）或放大室（16）所在的那些侧表面（50）中的每一个被至少一个壁（41）和这些侧表面 50）在装置（1）在核酸扩增装置中操作时是基本垂直的平面。

4. 发明申请

US20100003683A1 Disposable Device for Analyzing a Liquid Sample Containing a Nucleic Acid With a Nucleic Acid Amplification Apparatus 有权
标题翻译：用于分析含核酸扩增装置的含有核酸的液体样品的一次性装置
公开(公告)号：US20100003683A1
公开(公告)日：2010-01-07
申请号：US12373517
申请日：2007-07-05
申请人： Emad Sarofim , Olivier Elsenhans , Martin Kopp , Hans-Peter Wahl
发明人： Emad Sarofim , Olivier Elsenhans , Martin Kopp , Hans-Peter Wahl
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/34
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/10 , B01L2300/0809
摘要： The invention is directed to a disposable sample holding and processing device (1) dimensioned for being operated in a nucleic acid amplification apparatus for analyzing a liquid sample containing a nucleic acid by a nucleic acid amplification technique. The device (1) comprises chambers (15, 16) and channels (44) designed to perform the steps of capturing, amplification and detection of the nucleic acid within the device (1), and optionally also a lysis chamber (3). The binding chamber (15) contains a solid phase (14) for immobilization of a component of the sample to be analyzed, and the amplification chamber (16) is connected to the binding chamber (15) by a fluid channel (44). The device (1) comprises a rigid body (42) and at least one channel (44), the binding chamber (15) and the amplification chamber (16) are situated on side-surfaces (50) of the body (42), each of those side-surfaces (50), on which a channel (44), the binding chamber (15) or the amplification chamber (16) is situated, is covered by at least one wall (41) and these side-surfaces (50) are substantially vertical planes when the device (1) is operated in the nucleic acid amplification apparatus.
摘要翻译：本发明涉及一种一次性样品保持和处理装置（1），其尺寸适于在用于通过核酸扩增技术分析含有核酸的液体样品的核酸扩增装置中操作。设备（1）包括设计成执行在装置（1）内捕获，扩增和检测核酸以及任选还有裂解室（3）的步骤的室（15,16）和通道（44）。装订室（15）包含用于固定待分析样品的组分的固相（14），并且扩散室（16）通过流体通道（44）连接到装订室（15）。装置（1）包括刚体（42）和至少一个通道（44），装订室（15）和放大室（16）位于主体（42）的侧表面（50）上，其中通道（44），装订室（15）或放大室（16）所在的那些侧表面（50）中的每一个被至少一个壁（41）和这些侧表面 50）在装置（1）在核酸扩增装置中操作时是基本垂直的平面。

5. 发明申请

US20060235335A1 Device having a self sealing fluid port 审中-公开
标题翻译：具有自密封流体端口的装置
公开(公告)号：US20060235335A1
公开(公告)日：2006-10-19
申请号：US11389919
申请日：2006-03-27
申请人： Olivier Elsenhans , Emad Sarofim , Goran Savatic
发明人： Olivier Elsenhans , Emad Sarofim , Goran Savatic
IPC分类号： A61B5/00
CPC分类号： B29C45/1676 , B01L3/502707 , B01L3/502715 , B01L3/50825 , B01L7/52 , B01L2200/027 , B01L2200/12 , B01L2300/042 , B01L2300/044 , B01L2300/0816 , B01L2300/0887 , B29C65/02 , B29C65/08 , B29C65/16 , B29C65/1606 , B29C65/1616 , B29C65/1619 , B29C65/48 , B29C65/58 , B29C66/53461 , B29K2021/003 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2033/12 , B29K2069/00 , B29K2101/12 , G01N35/1079 , B29C66/71
摘要： Manufacture of a device having a body comprising a cavity with a fluid port made from an elastomeric material adhering to the body is disclosed. The device can be used advantageously in reliable analyses in automated procedures.
摘要翻译：公开了一种具有主体的装置，该主体包括具有由附着于主体的弹性体材料制成的流体端口的空腔。该装置可以有利地用于自动化程序中的可靠分析。

6. 发明授权

US06882425B1 Method and apparatus for examining fluids of biological origin 失效
标题翻译：用于检查生物来源的流体的方法和装置
公开(公告)号：US06882425B1
公开(公告)日：2005-04-19
申请号：US10018080
申请日：2000-06-07
申请人： Olivier Elsenhans , Emad Sarofim , Urban Georg Schnell
发明人： Olivier Elsenhans , Emad Sarofim , Urban Georg Schnell
IPC分类号： G01N33/483 , G01N21/27 , G01N21/00
CPC分类号： G01N21/274
摘要： A quality test of fluids of biological origin can be performed optically with applying a suitable evaluation method. In case of two components to be determined in a such fluid, an extinction spectrum is approximated in a first wavelength range by a combination of a merely theoretical curve and the spectrum of the pure first substance in a first wavelength range, and this evaluation is repeated in a second wavelength range this time by approximating the measured spectrum (62) by a combination of a hypothetical curve, the spectrum (64) of the first component with the already determined concentration, and the spectrum (65) of the pure second component. Furthermore, it is feasible to subtract the first and second spectrum and analyze the so obtained differential spectrum (66) in view of anomalies. The hypothetical curves are preferably straight lines which are defined by slope and ordinate section. In the praxis of the quality test of blood, bilirubin and hemoglobin may be quantitatively be determined, whilst the background together with the lipid component can be qualitatively examined by means of the differential spectrum.
摘要翻译：可以通过适当的评估方法对生物来源的流体进行质量检验。在这种流体中要确定的两个成分的情况下，通过理论曲线和纯第一物质在第一波长范围内的光谱的组合，在第一波长范围内近似消光光谱，并重复该评价在第二波长范围内，通过将假设曲线，第一分量的光谱（64）与已经确定的浓度组合并与纯第二分量的光谱（65）的组合近似测量光谱（62）。此外，考虑到异常，可以减去第一和第二频谱并分析得到的差分谱（66）。假设曲线优选是由斜率和纵坐标表定义的直线。在对血液进行质量检测的实践中，可以定量测定胆红素和血红蛋白，同时通过差示谱定性检查背景和脂质成分。

7. 发明授权

US08814808B2 Body fluid sampling device 有权
标题翻译：体液取样装置
公开(公告)号：US08814808B2
公开(公告)日：2014-08-26
申请号：US12879500
申请日：2010-09-10
申请人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
发明人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
IPC分类号： A61B5/151 , A61B5/15 , A61B5/145
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/15045 , A61B5/150503 , A61B5/15151 , A61B5/15163
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid. In one embodiment, the collection zone includes a plurality of holes, e.g., 3 or more holes, or 50 to 100 holes. The hole size may be small, e.g., having a diameter of 0.01 to 0.5 mm. The holes may or may not extend through the lancet. In some embodiments, the holes have a depth of 50 to 500 μm. In other embodiments, the collection zone is porous, or is a roughened area. The collection zone can take up a very small volume of body fluid, e.g., 3 to 10 nL, in a very short time period, e.g., less than 0.5 seconds. In other embodiments, the device further comprises a fluid receiving means spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially.
摘要翻译：体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件。在一个实施例中，收集区包括多个孔，例如3个或更多个孔，或50至100个孔。孔尺寸可以较小，例如具有0.01至0.5mm的直径。这些孔可以延伸穿过刺血针也可能不延伸穿过刺血针。在一些实施例中，孔的深度为50至500μm。在其它实施方案中，收集区是多孔的，或者是粗糙区域。收集区可以在非常短的时间段（例如小于0.5秒）内占据非常小体积的体液，例如3至10nL。在其他实施例中，该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液最初不会接触流体接收装置。

8. 发明授权

US08580567B2 Method for the automated analysis of liquid samples using centrifugal force in a microfluidic structure 有权
标题翻译：在微流体结构中使用离心力自动分析液体样品的方法
公开(公告)号：US08580567B2
公开(公告)日：2013-11-12
申请号：US12903492
申请日：2010-10-13
申请人： Emad Sarofim , Edwin Oosterbroek , Claudio Cherubini , Nenad Milicevic
发明人： Emad Sarofim , Edwin Oosterbroek , Claudio Cherubini , Nenad Milicevic
IPC分类号： G01N21/07
CPC分类号： G01N35/00029 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/0673 , B01L2300/0829 , B01L2300/0864 , B01L2400/0409 , B01L2400/0677 , G01N21/07 , G01N2021/0325 , G01N2035/00099 , G01N2035/00495
摘要： A method for the automated analysis of liquid samples using at least one microfluidic structure is disclosed as well as microfluidic structures, a device having at least one of the microfluidic structures, a kit and a system including such microfluidic device. In one embodiment, the method may comprise: transferring a sample into a first fluid reservoir which is in fluid communication with a second fluid reservoir by a flow channel; spinning the microfluidic structure so as to transport the sample into one or more dead-end recesses or chambers; transferring a control fluid into the structure which generates a barrier to flow and diffusion of the sample contained in the one or more dead-end recesses or chambers; and analyzing the sample contained in the one or more dead-end recesses or chambers.
摘要翻译：公开了使用至少一个微流体结构自动分析液体样品的方法，以及微流体结构，具有至少一个微流体结构的装置，试剂盒和包括这种微流体装置的系统。在一个实施例中，该方法可以包括：将样品转移到通过流动通道与第二流体储存器流体连通的第一流体储存器中; 旋转微流体结构以将样品输送到一个或多个死端凹部或腔室中; 将控制流体转移到所述结构中，所述结构产生包含在所述一个或多个死端凹部或腔室中的样品的流动和扩散的阻挡层; 并分析包含在一个或多个死端凹部或腔室中的样品。

9. 发明申请

US20120295249A1 Instrument And Method For The Automated Thermal Treatment Of Liquid Samples 有权
标题翻译：液体样品自动热处理的仪器和方法
公开(公告)号：US20120295249A1
公开(公告)日：2012-11-22
申请号：US13295504
申请日：2011-11-14
申请人： Claudio Cherubini , Roger Iten , Emad Sarofim , Kurt Schildknecht
发明人： Claudio Cherubini , Roger Iten , Emad Sarofim , Kurt Schildknecht
IPC分类号： G01N21/75 , C12Q1/70 , C12Q1/06 , C12Q1/68 , C12M1/34
CPC分类号： B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/022 , B01L2300/041 , B01L2300/0654 , B01L2300/0829 , B01L2300/1805 , C12Q1/686 , G01N21/0332 , G01N21/253 , G01N21/645 , G01N21/6452 , G01N35/028 , G01N2021/6419 , G01N2021/6484 , G01N2035/00346 , G01N2035/00376 , G01N2201/0627
摘要： An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.
摘要翻译：公开了用于液体样品的自动热处理的仪器和方法。用于装载用于容纳样品和光纤的端部的多个容器的温度控制容器之间的距离可以变化，其中容器被配置为与加载的容器形成热连通，并且其中光纤具有第一和第二端部。每个光纤的第一端部和第二端部相对于彼此固定以透射光，其中间距的变化允许容器被装载或从插座卸载并且能够检测光从包含在一个或多个容器加载的容器中的样品。

10. 发明授权

US08162854B2 Body fluid sampling device 有权
标题翻译：体液取样装置
公开(公告)号：US08162854B2
公开(公告)日：2012-04-24
申请号：US11470021
申请日：2006-09-05
申请人： Irio G. Calasso , Patrick Griss , Rainer Jaeggi , Emad Sarofim
发明人： Irio G. Calasso , Patrick Griss , Rainer Jaeggi , Emad Sarofim
IPC分类号： B65D81/00
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
摘要： Body fluid sampling device comprising a skin-piercing element (10) having a fluid pathway (11) for receiving body fluid, at least a portion of the fluid pathway is open to the environment and further comprising a fluid receiving element (40) being spaced from the fluid pathway so that fluid in the pathway will not contact the fluid receiving element initially. The fluid receiving element may have a test zone (45) for performing an analytical reaction. Fluid from the channel is contacted with the fluid receiving element either by bringing the fluid receiving element and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving element.
摘要翻译：体液取样装置包括具有用于接收体液的流体通道（11）的皮肤刺穿元件（10），所述流体通道的至少一部分对环境开放，并且还包括间隔开的流体接收元件（40）从流体通路使得通道中的流体最初不会接触流体接收元件。流体接收元件可以具有用于进行分析反应的测试区（45）。通过将流体接收元件和流体机械接触或将流体从通道电输送到流体接收元件上，来自通道的流体与流体接收元件接触。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式