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1. 发明授权

US08671543B2 Microneedle and method for the production thereof 有权
标题翻译：微针及其制造方法
公开(公告)号：US08671543B2
公开(公告)日：2014-03-18
申请号：US13311705
申请日：2011-12-06
申请人： Hans-Peter Haar
发明人： Hans-Peter Haar
IPC分类号： B21D39/02 , B23P11/00 , B21G1/00 , A61B5/00 , A61B5/15 , A61B5/151
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150282 , A61B5/150419 , A61B5/150427 , A61B5/150511 , A61B5/685 , A61B17/205 , A61M2037/0053 , B21G1/08 , Y10T29/49826
摘要： In a process for producing a microneedle (12) that can be inserted into body tissue in which a needle tip (20) and a preferably capillary collecting channel (14) having a distal inlet for body fluid formed at the needle tip (20) are formed, it is provided that at least part of a preform (38) prefabricated from a flat material is shaped into a tubular structure (22) so that the collecting channel (14) is at least substantially annularly closed in the cross-section in the area of the tubular structure (22).
摘要翻译：在用于制造可插入体针组织中的微针（12）的方法中，其中在针尖（20）处形成有用于体液的远端入口的针尖（20）和优选的毛细收集通道（14）形成的是，从平坦材料预制的预成型件（38）的至少一部分成形为管状结构（22），使得收集通道（14）在截面中至少基本上环形封闭管状结构（22）的面积。

2. 发明授权

US08586377B2 Analytical test element and process for its production 有权
标题翻译：分析测试元件及其生产工艺
公开(公告)号：US08586377B2
公开(公告)日：2013-11-19
申请号：US13588494
申请日：2012-08-17
申请人： Otto Fuerst , Hans-Peter Haar
发明人： Otto Fuerst , Hans-Peter Haar
IPC分类号： G01N33/48
CPC分类号： G01N33/525 , B01L3/5023 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , Y10T156/10 , Y10T428/23986 , Y10T442/20 , Y10T442/2484
摘要： An analytical test element is provided having a surface comprising a chemical detection layer on which a spreading net is disposed, the spreading net being configured to provide for the planar distribution of a liquid sample on the detection layer. The spreading net generally comprises a filament structure coated with a metallic layer that is oxidized at least on one or more surface portions thereof facing the detection layer.
摘要翻译：提供一种分析测试元件，其具有包括其上设置有扩展网的化学检测层的表面，所述扩展网被配置为提供液体样品在检测层上的平面分布。扩展网通常包括涂覆有金属层的细丝结构，该金属层至少在其面向检测层的一个或多个表面部分被氧化。

3. 发明授权

US08394035B2 Multi-lancet device 有权
标题翻译：多刺血针装置
公开(公告)号：US08394035B2
公开(公告)日：2013-03-12
申请号：US12356908
申请日：2009-01-21
申请人： Hans-Peter Haar , Herbert Harttig , Joachim Hoenes , Hans-Juergen Kuhr , Ortrud Quarder , Dirk Voelkel , Volker Zimmer
发明人： Hans-Peter Haar , Herbert Harttig , Joachim Hoenes , Hans-Juergen Kuhr , Ortrud Quarder , Dirk Voelkel , Volker Zimmer
IPC分类号： A61B5/00
CPC分类号： A61B5/150458 , A61B5/150022 , A61B5/150175 , A61B5/150358 , A61B5/150419 , A61B5/150427 , A61B5/150465 , A61B5/150526 , A61B5/15115 , A61B5/15153 , A61B5/15161 , A61B5/15169 , A61B5/15171
摘要： The invention concerns a device for collecting body fluids which has at least one lancet comprising a lancet body with at least two tips of different lengths. The device is characterized in that it has a selection means with the aid of which only one tip is selected before the lancing. This selection means can have different functions and shapes. The selection means is used to select a tip from a plurality of lancet tips which have different lengths and make only this tip available for use in the lancing process. Since the various tips are attached to a lancet body, it is, for example, possible to use a bending element which bends one of the various tips out of the plane of the lancet body in order to provide only one lancet tip for use. This is especially preferable for lancet tips that are arranged linearly relative to one another.
摘要翻译：本发明涉及一种用于收集体液的装置，其具有至少一个刺血针，其包括具有不同长度的至少两个尖端的柳叶刀体。该装置的特征在于其具有选择装置，借助于在穿刺之前仅选择一个尖端。该选择方式可以具有不同的功能和形状。选择装置用于从具有不同长度的多个刺血针尖端选择尖端，并且仅使该尖端可用于采血过程。由于各种尖端附着于柳叶刀体，所以例如可以使用弯曲元件，该弯曲元件将各种尖端中的一个弯曲到柳叶刀体的平面内，以便仅提供一个刺血针头用于使用。这对于相对于彼此线性布置的刺血针尖特别优选。

4. 发明授权

US08280642B2 Analysis system for determining an analyte in a body fluid 有权
标题翻译：用于测定体液中分析物的分析系统
公开(公告)号：US08280642B2
公开(公告)日：2012-10-02
申请号：US12233889
申请日：2008-09-19
申请人： Hans-Peter Haar
发明人： Hans-Peter Haar
IPC分类号： G01N33/48 , G06F11/00
CPC分类号： G01N33/48792 , G01N21/78 , G01N21/8483
摘要： An analysis system for determining an analyte of a body fluid comprises a test element and an analysis instrument having a measurement and evaluation unit. The test element has a sample application zone and two analysis zones and a reagent system, whose reaction with the analyte results in a detectable change characteristic for the desired analytical result. The measurement and evaluation unit comprises two analog measuring units, in each of which an analog measurement signal corresponding to one of the analysis zones is generated, two analog-digital converters for digitizing the analog measurement signal, a comparator unit for comparing control data values based on the digitized measurement signals, and a final processing unit, in which, if the determined deviation between the control data values of the digitized measurement signals is less than a predefined value, at least one of the control data values is allowed to pass for further processing into the desired analytical result.
摘要翻译：用于确定体液分析物的分析系统包括测试元件和具有测量和评估单元的分析仪器。测试元件具有样品应用区域和两个分析区域和试剂系统，其与分析物的反应产生可检测的变化特征以用于期望的分析结果。测量和评估单元包括两个模拟测量单元，每个模拟测量单元分别产生与分析区之一相对应的模拟测量信号，两个用于数字化模拟测量信号的模数转换器，用于比较控制数据值的比较单元对于数字化的测量信号，以及最终处理单元，其中如果所确定的数字化测量信号的控制数据值之间的偏差小于预定值，则允许控制数据值中的至少一个进一步通过加工成所需的分析结果。

5. 发明授权

US08052618B2 Diagnostic test element and process for its production 失效
标题翻译：诊断测试元件及其生产过程
公开(公告)号：US08052618B2
公开(公告)日：2011-11-08
申请号：US12389778
申请日：2009-02-20
申请人： Hans-Peter Haar , Karin Schwind , Michael Marquant , Nigel A. Surridge
发明人： Hans-Peter Haar , Karin Schwind , Michael Marquant , Nigel A. Surridge
IPC分类号： A61B5/151
CPC分类号： A61B5/15174 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150335 , A61B5/150358 , A61B5/150419 , A61B5/150427 , A61B5/150519 , A61B5/15115 , A61B5/15153 , A61B5/685
摘要： The invention concerns a process for producing a diagnostic test element for analyzing a body fluid in which a lancing member that can puncture a body part is provided with a collecting channel for body fluid obtained by the puncture, wherein the collecting channel exhibits capillary action, and wherein a sensor member for an optical or electrochemical measurement is connected to the lancing member. According to the invention, the sensor member and the lancing member can be joined together as interlocking connecting components wherein a measuring element of the sensor member is inserted into the collecting channel through an insertion opening of the lancing member.
摘要翻译：本发明涉及一种生产用于分析身体液体的诊断测试元件的方法，其中穿刺身体部位的穿刺部件设置有通过穿刺获得的体液收集通道，其中收集通道具有毛细作用，并且其中用于光学或电化学测量的传感器构件连接到所述穿刺构件。根据本发明，传感器构件和采血构件可以作为互锁连接部件接合在一起，其中传感器构件的测量元件通过穿刺构件的插入孔插入收集通道中。

6. 发明授权

US07985057B2 Micropump for peristaltic pumping of a liquid medium 有权
标题翻译：用于蠕动泵送液体介质的微泵
公开(公告)号：US07985057B2
公开(公告)日：2011-07-26
申请号：US11686176
申请日：2007-03-14
申请人： Hans-Peter Haar
发明人： Hans-Peter Haar
IPC分类号： F04B43/12
CPC分类号： A61M5/14232 , A61M5/14228 , A61M5/14244 , A61M5/16886 , A61M5/365 , A61M2205/0294 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3317 , A61M2205/3331 , A61M2205/3375 , F04B43/082
摘要： The invention relates to a micropump for peristaltic pumping of a liquid medium and to a device which contains a peristaltic micropump and which is for metered administration of a liquid drug.
摘要翻译：本发明涉及一种用于液体介质的蠕动泵送的微型泵和包含蠕动式微型泵的装置，其用于计量给药液体药物。

7. 发明授权

US07811236B2 Puncturing system for collecting body fluid sample 有权
标题翻译：用于收集体液样品的穿刺系统
公开(公告)号：US07811236B2
公开(公告)日：2010-10-12
申请号：US12122908
申请日：2008-05-19
申请人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham , Michael Eusemann
发明人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham , Michael Eusemann
IPC分类号： A61B5/00 , A61B5/15 , A61B5/157 , A61B17/32
CPC分类号： A61B5/15196 , A61B5/14514 , A61B5/150022 , A61B5/150152 , A61B5/150175 , A61B5/15019 , A61B5/150419 , A61B5/150519 , A61B5/15113 , A61B5/15117 , A61B5/15119 , A61B5/15128 , A61B5/1519 , A61B5/15194
摘要： A microsampler puncturing system for collecting a body fluid from a body part is described, comprising a sample collection unit having a piercing element, and a puncturing instrument having a drive, by which a sample collection unit is movable on a movement path for piercing the piercing element into the skin of the body part and withdrawing it in a piercing and retraction movement, a setting device for setting the puncturing depth of the piercing wound to be generated, and a control device for controlling the piercing and retraction movement having the following sequentially executed movement phases: a forward phase, a retraction phase, and a collecting phase (S). The setting device is settable independently of the chronological mean of the defined residual puncturing depth (dr), with reference to the collecting phase.
摘要翻译：描述了一种用于从身体部分收集体液的微量取样器穿刺系统，包括具有刺穿元件的样本收集单元和具有驱动器的穿刺器械，通过该穿刺器具，样本收集单元可在用于刺穿穿孔的移动路径上移动元件进入身体部分的皮肤并且在穿刺和收缩运动中取出，用于设定要产生的穿刺伤口的穿刺深度的设置装置，以及用于控制穿刺和缩回运动的控制装置，其具有以下顺序执行移动阶段：前进阶段，退回阶段和收集阶段（S）。参考收集阶段，设定装置可独立于定义的残留穿刺深度（dr）的时间平均值来设定。

8. 发明申请

US20100227348A1 METHOD AND DEVICE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE USING FLUORESCENCE MEASUREMENT 审中-公开
标题翻译：使用荧光测量法确定分析仪浓度的方法和装置
公开(公告)号：US20100227348A1
公开(公告)日：2010-09-09
申请号：US12696665
申请日：2010-01-29
申请人： Wolfgang Petrich , Hans-Peter Haar , Joachim Hoenes , Carina Horn
发明人： Wolfgang Petrich , Hans-Peter Haar , Joachim Hoenes , Carina Horn
IPC分类号： C12Q1/54 , C12M1/34
CPC分类号： C12Q1/32 , C12Q1/54
摘要： A method is presented for determining the concentration of an analyte in a liquid sample using a reagent system. The reaction of the sample with the reagent system results in a change of the quantity of a fluorophore, the quantity of the fluorophore correlating with the concentration of the analyte, a characteristic measurement variable for the quantity of the fluorophore being measured, and the concentration of the analyte being determined using an evaluation algorithm on the basis of the measurement variable. The reagent system is integrated in an analysis system and the fluorescence lifetime of the fluorophore is used in the ascertainment of the concentration of the analyte.
摘要翻译：提出了一种使用试剂系统确定液体样品中分析物浓度的方法。样品与试剂系统的反应导致荧光团量的变化，荧光团的量与分析物的浓度相关，测量的荧光团的量的特征测量变量和浓度使用基于测量变量的评估算法确定分析物。试剂系统集成在分析系统中，荧光团的荧光寿命用于确定分析物的浓度。

9. 发明申请

US20100211011A1 Infusion system 有权
标题翻译：输液系统
公开(公告)号：US20100211011A1
公开(公告)日：2010-08-19
申请号：US12542047
申请日：2009-08-17
申请人： Hans-Peter Haar
发明人： Hans-Peter Haar
IPC分类号： A61M5/142
CPC分类号： A61M5/14248 , A61B5/14532 , A61M5/14566 , A61M5/16854 , A61M2205/3561 , A61M2205/3569 , A61M2205/3592 , A61M2205/52 , A61M2205/8206 , A61M2209/045 , A61M2209/086
摘要： Disclosed is an infusion system for administering a liquid medicament, particularly insulin. Said infusion system comprises a cannula support unit which is properly attached to a patient's body, an infusion cannula to be inserted into the patient's body, and a pump unit that can be connected to the cannula support unit and encompasses a pump, a battery for supplying power to the pump, and a storage volume for the medicament that is to be administered. The pump unit and the cannula support unit are adapted to one another in such a way that the pump unit rests against the cannula support unit once the pump unit has been connected to the cannula support unit. The disclosed infusion system also comprises a charging station for the pump unit in order to recharge the battery of the pump unit.
摘要翻译：公开了一种用于施用液体药物，特别是胰岛素的输注系统。所述输注系统包括适当地附接到患者身体的插管支撑单元，插入到患者体内的输液套管以及能够连接到套管支撑单元并包围泵，用于供应的电池的泵单元泵的功率以及待施用的药物的储存体积。泵单元和插管支撑单元彼此适配，使得一旦泵单元已经连接到插管支撑单元，泵单元就靠在套管支撑单元上。所公开的输注系统还包括用于泵单元的充电站，以便为泵单元的电池再充电。

10. 发明申请

US20100094172A1 Test system for measuring the concentration of an analyte in a body fluid 有权
标题翻译：用于测量体液中分析物浓度的测试系统
公开(公告)号：US20100094172A1
公开(公告)日：2010-04-15
申请号：US12619384
申请日：2009-11-16
申请人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham
发明人： Hans List , Hans-Peter Haar , George Bevan Kirby Meacham
IPC分类号： A61B5/151
CPC分类号： A61B5/150198 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150511 , A61B5/15107 , A61B5/15117 , A61B5/15146 , A61B5/15151 , A61B5/15161 , A61B5/15176
摘要： An actuator for driving a test element is disclosed. The test element can comprise a lancet for perforating the skin of a living organism. The actuator can comprise an engaging part for engaging and driving the test element in a lancing motion. The actuator can further comprise a lancing actuator and a lancing spring. The lancing actuator can bias the lancing spring by executing a forward movement and thereby can exert a biasing force on the engaging part. The actuator can further comprise a latch element. The latch element can be a force-sensitive latch element for exerting a retention force to hold back the engaging part. The retention force can counteract the biasing force. The latch element can release the engaging part when the biasing force exerted by the lancing actuator exceeds the retention force exerted by the latch element, thereby allowing the test element to perform the lancing motion.
摘要翻译：公开了用于驱动测试元件的致动器。测试元件可以包括用于穿孔活体的皮肤的刺血针。致动器可以包括用于以穿刺运动接合和驱动测试元件的接合部分。致动器还可包括穿刺致动器和穿刺弹簧。穿刺致动器可以通过执行向前运动来偏压穿刺弹簧，从而可以在接合部件上施加偏置力。致动器还可以包括闩锁元件。闩锁元件可以是用于施加保持力以阻止接合部分的力敏锁定元件。保持力可以抵消偏置力。当由穿刺致动器施加的偏压力超过由闩锁元件施加的保持力时，闩锁元件可以释放接合部件，从而允许测试元件执行穿刺运动。

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