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1. 发明授权

US08814808B2 Body fluid sampling device 有权
标题翻译：体液取样装置
公开(公告)号：US08814808B2
公开(公告)日：2014-08-26
申请号：US12879500
申请日：2010-09-10
申请人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
发明人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
IPC分类号： A61B5/151 , A61B5/15 , A61B5/145
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/15045 , A61B5/150503 , A61B5/15151 , A61B5/15163
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid. In one embodiment, the collection zone includes a plurality of holes, e.g., 3 or more holes, or 50 to 100 holes. The hole size may be small, e.g., having a diameter of 0.01 to 0.5 mm. The holes may or may not extend through the lancet. In some embodiments, the holes have a depth of 50 to 500 μm. In other embodiments, the collection zone is porous, or is a roughened area. The collection zone can take up a very small volume of body fluid, e.g., 3 to 10 nL, in a very short time period, e.g., less than 0.5 seconds. In other embodiments, the device further comprises a fluid receiving means spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially.
摘要翻译：体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件。在一个实施例中，收集区包括多个孔，例如3个或更多个孔，或50至100个孔。孔尺寸可以较小，例如具有0.01至0.5mm的直径。这些孔可以延伸穿过刺血针也可能不延伸穿过刺血针。在一些实施例中，孔的深度为50至500μm。在其它实施方案中，收集区是多孔的，或者是粗糙区域。收集区可以在非常短的时间段（例如小于0.5秒）内占据非常小体积的体液，例如3至10nL。在其他实施例中，该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液最初不会接触流体接收装置。

2. 发明授权

US08162854B2 Body fluid sampling device 有权
标题翻译：体液取样装置
公开(公告)号：US08162854B2
公开(公告)日：2012-04-24
申请号：US11470021
申请日：2006-09-05
申请人： Irio G. Calasso , Patrick Griss , Rainer Jaeggi , Emad Sarofim
发明人： Irio G. Calasso , Patrick Griss , Rainer Jaeggi , Emad Sarofim
IPC分类号： B65D81/00
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
摘要： Body fluid sampling device comprising a skin-piercing element (10) having a fluid pathway (11) for receiving body fluid, at least a portion of the fluid pathway is open to the environment and further comprising a fluid receiving element (40) being spaced from the fluid pathway so that fluid in the pathway will not contact the fluid receiving element initially. The fluid receiving element may have a test zone (45) for performing an analytical reaction. Fluid from the channel is contacted with the fluid receiving element either by bringing the fluid receiving element and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving element.
摘要翻译：体液取样装置包括具有用于接收体液的流体通道（11）的皮肤刺穿元件（10），所述流体通道的至少一部分对环境开放，并且还包括间隔开的流体接收元件（40）从流体通路使得通道中的流体最初不会接触流体接收元件。流体接收元件可以具有用于进行分析反应的测试区（45）。通过将流体接收元件和流体机械接触或将流体从通道电输送到流体接收元件上，来自通道的流体与流体接收元件接触。

3. 发明授权

US08087141B2 Method for producing a pricking element 有权
标题翻译：穿刺元件的制造方法
公开(公告)号：US08087141B2
公开(公告)日：2012-01-03
申请号：US11763266
申请日：2007-06-14
申请人： Patrick Griss , Marzellinus Zipfel , Angel Lopez
发明人： Patrick Griss , Marzellinus Zipfel , Angel Lopez
IPC分类号： B21D53/00
CPC分类号： A61M37/00 , A61B5/150022 , A61B5/150282 , A61B5/150419 , A61B5/15105 , A61B5/15142 , Y10T29/302 , Y10T29/304 , Y10T29/49812 , Y10T29/49995 , Y10T29/53339 , Y10T428/12188
摘要： The sheet metal or substrate material 22 is constructed by a photo-chemical machining or milling method. In this exemplary process, an etching mask 24 is applied to both sides of the substrate 22 and covers the structure of the flat-shaped member 12, which is to be uncovered in a subsequent etching step. The mask 24 is formed by coating the substrate 22 with a photoresist and is exposed through a photomask having the desired pattern that is arranged in front of the mask, whereby the photoresist is polymerized or hardened in the covered areas while the other areas are rinsed away after development.
摘要翻译：金属板或基板材料22通过光化学加工或研磨方法构成。在该示例性工艺中，将蚀刻掩模24施加到基板22的两侧，并且覆盖在随后的蚀刻步骤中未被覆盖的平坦形构件12的结构。掩模24通过用光致抗蚀剂涂覆基板22而形成，并且通过布置在掩模前面的具有所需图案的光掩模曝光，由此光致抗蚀剂在覆盖区域聚合或硬化，而其它区域被冲洗掉后发展。

4. 发明申请

US20090311796A1 MICROFLUIDIC ANALYTICAL DEVICE FOR ANALYSIS OF CHEMICAL OR BIOLOGICAL SAMPLES, METHOD AND SYSTEM THEREOF 审中-公开
标题翻译：用于化学或生物样品分析的微流化分析装置，其方法和系统
公开(公告)号：US20090311796A1
公开(公告)日：2009-12-17
申请号：US12482707
申请日：2009-06-11
申请人： Patrick Griss , Rainer Jaeggi , Goran Savatic , Vuk Siljegovic
发明人： Patrick Griss , Rainer Jaeggi , Goran Savatic , Vuk Siljegovic
IPC分类号： G01N21/75 , G01N33/00 , G01N9/30
CPC分类号： B01L3/50273 , B01L2200/10 , B01L2300/0654 , B01L2300/0803 , B01L2300/0887 , B01L2300/168 , B01L2400/0409 , B01L2400/0688 , C12Q1/54 , G01N21/07 , G01N33/491 , Y10T436/144444 , Y10T436/146666 , Y10T436/15 , Y10T436/166666 , Y10T436/171538 , Y10T436/175383 , Y10T436/201666 , Y10T436/204165
摘要： An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.
摘要翻译：公开了用于分析化学或生物样品的分析装置，基于装置的旋转，集成的样品计量和光学检测使用这种装置的方法，以及包括这种装置的系统。分析装置包括具有液体处理单元的装置主体。液体处理单元包括用于将样品与试剂混合的混合室，用于将限定体积的样品输送到混合室的样品计量室，以及用于输送要与样品混合的试剂的试剂通道，其中混合室也用作检测室。

5. 发明申请

US20070255205A1 Molded Micro-Needles 有权
标题翻译：成型微针
公开(公告)号：US20070255205A1
公开(公告)日：2007-11-01
申请号：US11661113
申请日：2005-08-30
申请人： Patrick Griss , Goran Stemme
发明人： Patrick Griss , Goran Stemme
IPC分类号： A61M37/00
CPC分类号： B29C45/2628 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C2045/0094 , B81B2201/055 , B81B2203/0361 , B81C99/0085 , B81C2201/034
摘要： Method of hollow micro-projections having side walls and at least one opening in a side wall, by a molding technique. The hollow micro-projections are defined by a first, negative mold defining the exterior shape of the micro-projections and a second, positive mold defining the hollow interior shape of the micro-projections. The method includes injecting a moldable material into the space between the two molds, in a state where they have been brought together. The positive and negative molds each have an essentially cylindrical geometry. In the process of bringing the molds together, the mold halves are laterally off-set with respect to each other, such that the distance between an inner wall of the negative mold and the positive mold in the area, ranges from zero to a finite distance. Micro-projections and arrays of micro-projections are also disclosed.
摘要翻译：通过成型技术的具有侧壁和侧壁中的至少一个开口的中空微型突起的方法。中空微突起由限定微突起的外部形状的第一负模具和限定微突起的中空内部形状的第二正模定义。该方法包括将可模塑材料注入到两个模具之间的空间中，并将它们合并在一起。正负模具各自具有基本上圆柱形的几何形状。在将模具合在一起的过程中，半模相对于彼此横向偏移，使得阴模的内壁和该区域中的正模之间的距离从零到有限距离。还公开了微突起和微突起的阵列。

6. 发明授权

US09022952B2 Body fluid sampling device 有权
标题翻译：体液取样装置
公开(公告)号：US09022952B2
公开(公告)日：2015-05-05
申请号：US13421163
申请日：2012-03-15
申请人： Irio Guiseppe Calasso , Patrick Griss , Rainer Jaeggi , Emad Sarofim
发明人： Irio Guiseppe Calasso , Patrick Griss , Rainer Jaeggi , Emad Sarofim
IPC分类号： A61B5/00 , A61B5/145 , A61B5/15 , A61B5/1486
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
摘要： Body fluid sampling device comprising a skin-piercing element having a fluid pathway for receiving body fluid, at least a portion of said fluid pathway is open to the environment and further comprising a fluid receiving means being spaced from said fluid pathway so that fluid in said pathway will not contact the fluid receiving means initially. Said fluid receiving means may have a test zone for performing an analytical reaction. Fluid from said channel is contacted with said fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.
摘要翻译：体液取样装置包括具有用于接收体液的流体通道的皮肤刺穿元件，所述流体通道的至少一部分对环境开放，并且还包括与所述流体通道间隔开的流体接收装置，通路最初不会接触流体接收装置。所述流体接收装置可以具有用于进行分析反应的测试区域。来自所述通道的流体与所述流体接收装置接触，通过使流体接收装置和流体进入机械接触或者将流体从通道电输送到流体接收装置上。

7. 发明授权

US08636675B2 Method and device for the extraction of a body fluid 有权
标题翻译：用于提取体液的方法和装置
公开(公告)号：US08636675B2
公开(公告)日：2014-01-28
申请号：US12901290
申请日：2010-10-08
申请人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
发明人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32 , B65D81/00
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.
摘要翻译：本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。在等待期开始和结束后的正向相位之后检测穿刺元件与体液之间的接触。

8. 发明申请

US20120174688A1 BODY FLUID SAMPLING DEVICE 有权
标题翻译：身体液体取样装置
公开(公告)号：US20120174688A1
公开(公告)日：2012-07-12
申请号：US13421163
申请日：2012-03-15
申请人： Irio Guiseppe Calasso , Patrick Griss , Rainer Jaeggi , Emad Sarofim
发明人： Irio Guiseppe Calasso , Patrick Griss , Rainer Jaeggi , Emad Sarofim
IPC分类号： G01N1/00
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
摘要： Body fluid sampling device comprising a skin-piercing element having a fluid pathway for receiving body fluid, at least a portion of said fluid pathway is open to the environment and further comprising a fluid receiving means being spaced from said fluid pathway so that fluid in said pathway will not contact the fluid receiving means initially. Said fluid receiving means may have a test zone for performing an analytical reaction. Fluid from said channel is contacted with said fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.
摘要翻译：体液取样装置包括具有用于接收体液的流体通道的皮肤刺穿元件，所述流体通道的至少一部分对环境开放，并且还包括与所述流体通道间隔开的流体接收装置，通路最初不会接触流体接收装置。所述流体接收装置可以具有用于进行分析反应的测试区域。来自所述通道的流体与所述流体接收装置接触，通过使流体接收装置和流体进入机械接触或者将流体从通道电输送到流体接收装置上。

9. 发明授权

US07981346B2 Molded micro-needles 有权
标题翻译：成型微针
公开(公告)号：US07981346B2
公开(公告)日：2011-07-19
申请号：US11661113
申请日：2005-08-30
申请人： Patrick Griss , Göran Stemme
发明人： Patrick Griss , Göran Stemme
IPC分类号： B28B1/14 , B28B1/48 , A61M35/00
CPC分类号： B29C45/2628 , A61K9/0021 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C2045/0094 , B81B2201/055 , B81B2203/0361 , B81C99/0085 , B81C2201/034
摘要： Method of hollow micro-projections having side walls and at least one opening in a side wall, by a molding technique. The hollow micro-projections are defined by a first, negative mold defining the exterior shape of the micro-projections and a second, positive mold defining the hollow interior shape of the micro-projections. The method includes injecting a moldable material into the space between the two molds, in a state where they have been brought together. The positive and negative molds each have an essentially cylindrical geometry. In the process of bringing the molds together, the mold halves are laterally off-set with respect to each other, such that the distance between an inner wall of the negative mold and the positive mold in the area, ranges from zero to a finite distance. Micro-projections and arrays of micro-projections are also disclosed.
摘要翻译：通过成型技术的具有侧壁和侧壁中的至少一个开口的中空微型突起的方法。中空微突起由限定微突起的外部形状的第一负模具和限定微突起的中空内部形状的第二正模定义。该方法包括将可模塑材料注入到两个模具之间的空间中，并将它们合并在一起。正负模具各自具有基本上圆柱形的几何形状。在将模具合在一起的过程中，半模相对于彼此横向偏移，使得阴模的内壁和该区域中的正模之间的距离从零到有限距离。还公开了微突起和微突起的阵列。

10. 发明授权

US07833172B2 Method and device for the extraction of a body fluid 有权
标题翻译：用于提取体液的方法和装置
公开(公告)号：US07833172B2
公开(公告)日：2010-11-16
申请号：US11868505
申请日：2007-10-07
申请人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
发明人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.
摘要翻译：本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。在等待期开始和结束后的正向相位之后检测穿刺元件与体液之间的接触。

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