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1. 发明授权

US5912945A X-ray compass for determining device orientation 失效
标题翻译：用于确定设备方向的X光指南针
公开(公告)号：US5912945A
公开(公告)日：1999-06-15
申请号：US880850
申请日：1997-06-23
申请人： Luiz B. Da Silva , Dennis L. Matthews , Joseph P. Fitch , Matthew J. Everett , Billy W. Colston , Gary F. Stone
发明人： Luiz B. Da Silva , Dennis L. Matthews , Joseph P. Fitch , Matthew J. Everett , Billy W. Colston , Gary F. Stone
IPC分类号： G01T1/161 , A61B17/00
CPC分类号： G01T1/161
摘要： An apparatus and method for determining the orientation of a device with respect to an x-ray source. In one embodiment, the present invention is coupled to a medical device in order to determine the rotational orientation of the medical device with respect to the x-ray source. In such an embodiment, the present invention is comprised of a scintillator portion which is adapted to emit photons upon the absorption of x-rays emitted from the x-ray source. An x-ray blocking portion is coupled to the scintillator portion. The x-ray blocking portion is disposed so as to vary the quantity of x-rays which penetrate the scintillator portion based upon the particular rotational orientation of the medical device with respect to the x-ray source. A photon transport mechanism is also coupled to the scintillator portion. The photon transport mechanism is adapted to pass the photons emitted from the scintillator portion to an electronics portion. By analyzing the quantity of the photons, the electronics portion determines the rotational orientation of the medical device with respect to the x-ray source.
摘要翻译：一种用于确定装置相对于x射线源的取向的装置和方法。在一个实施例中，本发明被耦合到医疗装置，以便确定医疗装置相对于x射线源的旋转取向。在这样的实施例中，本发明包括闪烁体部分，其适于在吸收从X射线源发射的x射线时发射光子。 X射线阻挡部分耦合到闪烁体部分。 X射线阻挡部分被设置成基于医疗装置相对于x射线源的特定旋转取向来改变穿透闪烁体部分的X射线的量。光子传输机构也耦合到闪烁体部分。光子传输机构适于将从闪烁器部分发射的光子传递到电子部分。通过分析光子的数量，电子部分确定医疗装置相对于x射线源的旋转取向。

2. 发明授权

US06522407B2 Optical detection dental disease using polarized light 有权
标题翻译：光学检测牙病使用偏振光
公开(公告)号：US06522407B2
公开(公告)日：2003-02-18
申请号：US10100824
申请日：2002-03-18
申请人： Matthew J. Everett , Billy W. Colston, Jr. , Ujwal S. Sathyam , Luiz B. Da Silva , Daniel Fried
发明人： Matthew J. Everett , Billy W. Colston, Jr. , Ujwal S. Sathyam , Luiz B. Da Silva , Daniel Fried
IPC分类号： G01J400
CPC分类号： A61B5/0088 , A61B5/0066 , A61B5/0073 , G01B9/02091 , G01B2290/70 , G01N21/4795
摘要： A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.
摘要翻译：偏振敏感光学成像系统用于检测牙组织中极化的变化，以帮助牙科疾病如龋齿的诊断。通过用偏振光照射牙组织并测量背向散射光的偏振状态来测量去极化度。使用光学偏振成像技术分析该反射光的偏振状态。体内使用手持光纤牙科探针将入射光束引导到牙齿组织并收集反射光。为了提供牙科组织的深度分辨表征，偏振诊断可以被并入到光学相干畴反射测量和光学相干断层扫描（OCDR / OCT）系统中，其能够识别与釉质或骨的脱矿质相关的地下去极化位点。

3. 发明授权

US06179611B2 Dental optical coherence domain reflectometry explorer 有权
标题翻译：牙科光学相干畴反射探测器
公开(公告)号：US06179611B2
公开(公告)日：2001-01-30
申请号：US09315000
申请日：1999-05-19
申请人： Matthew J. Everett , Billy W. Colston, Jr. , Ujwal S. Sathyam , Luiz B. Da Silva
发明人： Matthew J. Everett , Billy W. Colston, Jr. , Ujwal S. Sathyam , Luiz B. Da Silva
IPC分类号： A61C100
CPC分类号： A61B5/0088 , A61B5/0066 , G01B9/02027 , G01B9/0205 , G01B9/02091 , G01N21/4795
摘要： A hand-held, fiber optic based dental device with optical coherence domain reflectometry (OCDR) sensing capabilities provides a profile of optical scattering as a function of depth in the tissue at the point where the tip of the dental explorer touches the tissue. This system provides information on the internal structure of the dental tissue, which is then used to detect caries and periodontal disease. A series of profiles of optical scattering or tissue microstructure are generated by moving the explorer across the tooth or other tissue. The profiles are combined to form a cross-sectional, or optical coherence tomography (OCT), image.
摘要翻译：具有光学相干畴反射测量（OCDR）感测能力的手持式基于光纤的牙齿设备提供了在牙科探险者的尖端接触组织的点处的组织中的深度的函数的光学散射的轮廓。该系统提供关于牙科组织的内部结构的信息，然后用于检测龋齿和牙周病。通过移动探查器穿过牙齿或其他组织，产生一系列光学散射或组织微结构。轮廓组合形成横截面或光学相干断层扫描（OCT）图像。

4. 发明授权

US06875207B2 Liposuction cannula device and method 失效
标题翻译：吸脂套管装置及方法
公开(公告)号：US06875207B2
公开(公告)日：2005-04-05
申请号：US10427611
申请日：2003-04-30
申请人： Paul J. Weber , Steven R. Visuri , Matthew J. Everett , Luiz B. Da Silva , Alwin H. Kolster
发明人： Paul J. Weber , Steven R. Visuri , Matthew J. Everett , Luiz B. Da Silva , Alwin H. Kolster
IPC分类号： A61B17/32 , A61M1/00
CPC分类号： A61B17/320068 , A61B17/32002 , A61B2017/00738 , A61B2217/005 , A61M1/008 , A61M2202/08 , Y10S604/902
摘要： A liposuction apparatus and method optionally having a sonic or ultrasonic source with an axial lumen passage in which the shaft can be made to reciprocate (oscillate) in a non-rectilinear fashion. The apparatus may also contain the concomitant use of rectilinear reciprocation motion in addition to ultrasonic motion or energy along the shaft of the apparatus. The advantages of the liposuction apparatus are as follows: 1) non-rectilinear single shaft reciprocating cannula, 2) sonic or ultrasonic energy delivered to the distal tip, 3) rectilinear reciprocating cannula with ultrasonic energy along the shaft from the handle, and 4) any of the above reciprocating components powered by excess unused vacuum capacity in the liposuction aspirator (suction engine) apparatus. There are three (3) primary sources of energy applied to the cannula shaft: the first is the oscillating surgeon's arm motion (approximately 1-2 hertz); the reciprocating motion (of about 100 Hz); and the optional concomitant motion as delivered by the ultrasonic energy (e.g. 25 KHz).
摘要翻译：一种抽脂装置和方法，其可选地具有带轴向腔通道的声波或超声波源，其中轴可以以非直线方式往复运动（振荡）。该装置还可以包含除沿着装置的轴的超声波运动或能量之外的直线往复运动的伴随使用。吸脂装置的优点如下：1）非直线单轴往复式套管，2）输送到远端的声波或超声波能量，3）从手柄沿着轴的超声能量的直线往复插管，4）在吸脂抽吸器（吸引发动机）装置中由上述过度未使用的真空容量供电的上述往复运动部件中的任何一个。有三（3）个主要能源应用于插管轴：第一个是摆动外科医生的手臂运动（约1-2赫兹）; 往复运动（约100Hz）; 以及由超声能量（例如25KHz）传递的可选的伴随运动。

5. 发明授权

US06638238B1 Liposuction cannula device and method 失效
标题翻译：吸脂套管装置及方法
公开(公告)号：US06638238B1
公开(公告)日：2003-10-28
申请号：US09458134
申请日：1999-12-09
申请人： Paul J. Weber , Steven R. Visuri , Matthew J. Everett , Luiz B. Da Silva , Alwin H. Kolster
发明人： Paul J. Weber , Steven R. Visuri , Matthew J. Everett , Luiz B. Da Silva , Alwin H. Kolster
IPC分类号： A61B1720
CPC分类号： A61B17/320068 , A61B17/32002 , A61B2017/00738 , A61B2217/005 , A61M1/008 , A61M2202/08 , Y10S604/902
摘要： A liposuction apparatus and method optionally having a sonic or ultrasonic source with an axial lumen passage in which the shaft can be made to reciprocate (oscillate) in a non-rectilinear fashion. The apparatus may also contain the concomitant use of rectilinear reciprocation motion in addition to ultrasonic motion or energy along the shaft of the apparatus. The advantages of the liposuction apparatus are as follows: 1) non-rectilinear single shaft reciprocating cannula, 2) sonic or ultrasonic energy delivered to the distal tip, 3) rectilinear reciprocating cannula with ultrasonic energy along the shaft from the handle, and 4) any of the above reciprocating components powered by excess unused vacuum capacity in the liposuction aspirator (suction engine) apparatus. There are three (3) primary sources of energy applied to the cannula shaft: the first is the oscillating surgeon's arm motion (approximately 1-2 hertz); the reciprocating motion (of about 100 Hz); and the optional concomitant motion as delivered by the ultrasonic energy (e.g. 25 KHz).
摘要翻译：一种抽脂装置和方法，其可选地具有带轴向腔通道的声波或超声波源，其中轴可以以非直线方式往复运动（振荡）。该装置还可以包含除沿着装置的轴的超声波运动或能量之外的直线往复运动的伴随使用。吸脂装置的优点如下：1）非直线单轴往复式套管，2）输送到远端的声波或超声波能量，3）从手柄沿着轴的超声能量的直线往复插管，4）在吸脂抽吸器（吸引发动机）装置中由上述过度未使用的真空容量供电的上述往复运动部件中的任何一个。有三（3）个主要能源应用于插管轴：第一个是摆动外科医生的手臂运动（约1-2赫兹）; 往复运动（约100Hz）; 以及由超声能量（例如25KHz）传递的可选的伴随运动。

6. 发明授权

US06466713B2 Optical fiber head for providing lateral viewing 有权
公开(公告)号：US06466713B2
公开(公告)日：2002-10-15
申请号：US09883513
申请日：2001-06-18
申请人： Matthew J. Everett , Billy W. Colston , Dale L. James , Steve Brown , Luiz Da Silva
发明人： Matthew J. Everett , Billy W. Colston , Dale L. James , Steve Brown , Luiz Da Silva
IPC分类号： G02B626
CPC分类号： G02B6/241 , A61B5/0066 , A61B5/0084 , G02B6/262
摘要： The head of an optical fiber comprising the sensing probe of an optical heterodyne sensing device includes a planar surface that intersects the perpendicular to axial centerline of the fiber at a polishing angle &thgr;. The planar surface is coated with a reflective material so that light traveling axially through the fiber is reflected transverse to the fiber's axial centerline, and is emitted laterally through the side of the fiber. Alternatively, the planar surface can be left uncoated. The polishing angle &thgr; must be no greater than 39° or must be at least 51°. The emitted light is reflected from adjacent biological tissue, collected by the head, and then processed to provide real-time images of the tissue. The method for forming the planar surface includes shearing the end of the optical fiber and applying the reflective material before removing the buffer that circumscribes the cladding and the core.

7. 发明授权

US6015969A Multiple-wavelength spectroscopic quantitation of light-absorbing species in scattering media 失效
标题翻译：散射介质中光吸收物质的多波长光谱定量
公开(公告)号：US6015969A
公开(公告)日：2000-01-18
申请号：US8234
申请日：1998-01-16
申请人： Howard Nathel , Harry E. Cartland , Billy W. Colston, Jr. , Matthew J. Everett , Jeffery N. Roe
发明人： Howard Nathel , Harry E. Cartland , Billy W. Colston, Jr. , Matthew J. Everett , Jeffery N. Roe
IPC分类号： G01N21/31 , G01B9/02
CPC分类号： G01N21/314
摘要： An oxygen concentration measurement system for blood hemoglobin comprises a multiple-wavelength low-coherence optical light source that is coupled by single mode fibers through a splitter and combiner and focused on both a target tissue sample and a reference mirror. Reflections from both the reference mirror and from the depths of the target tissue sample are carried back and mixed to produce interference fringes in the splitter and combiner. The reference mirror is set such that the distance traversed in the reference path is the same as the distance traversed into and back from the target tissue sample at some depth in the sample that will provide light attenuation information that is dependent on the oxygen in blood hemoglobin in the target tissue sample. Two wavelengths of light are used to obtain concentrations. The method can be used to measure total hemoglobin concentration [Hb.sub.deoxy +Hb.sub.oxy ] or total blood volume in tissue and in conjunction with oxygen saturation measurements from pulse oximetry can be used to absolutely quantify oxyhemoglobin [HbO.sub.2 ] in tissue. The apparatus and method provide a general means for absolute quantitation of an absorber dispersed in a highly scattering medium.
摘要翻译：用于血液血红蛋白的氧浓度测量系统包括多波长低相干光学光源，其由单模光纤通过分离器和组合器耦合并聚焦在目标组织样本和参考反射镜两者上。来自参考镜和来自目标组织样本的深度的反射被携带并混合以在分离器和组合器中产生干涉条纹。参考镜被设置为使得在参考路径中穿过的距离与在样本中的某个深度处从目标组织样本穿过的距离相同，其将提供取决于血液血红蛋白中的氧的光衰减信息在目标组织样本中。使用两个波长的光来获得浓度。该方法可用于测量组织中总血红蛋白浓度[Hbdeoxy + Hboxy]或总体积，并结合脉搏血氧饱和度测量结果，可用于绝对量化组织中的氧合血红蛋白[HbO2]。该装置和方法提供了用于绝对定量分散在高度散射介质中的吸收体的一般手段。

8. 发明授权

US09033510B2 Systems and methods for efficiently obtaining measurements of the human eye using tracking 有权
标题翻译：使用跟踪有效获得人眼测量的系统和方法
公开(公告)号：US09033510B2
公开(公告)日：2015-05-19
申请号：US13433127
申请日：2012-03-28
申请人： Harihar Narasimha-Iyer , Matthew J. Everett
发明人： Harihar Narasimha-Iyer , Matthew J. Everett
IPC分类号： A61B3/00 , A61B3/10 , A61B3/14 , A61B5/00 , G06T7/20
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/0033 , A61B3/113 , A61B3/12 , A61B3/145 , A61B5/0066 , G06T7/246 , G06T2207/10101 , G06T2207/20081 , G06T2207/30041 , G06T2210/41
摘要： Systems and methods for efficiently obtaining optical coherence tomography (OCT) measurement data with reduced effects of motion are presented. One embodiment involves determining the amount of motion present during the collection of an OCT data set based on images of the eye collected at the same time as the OCT data, and recollecting select portions of the OCT data set when the amount of eye motion is determined to exceed a predetermined threshold. Another embodiment includes enabling or disabling a tracking feature based on the quality of the images available for tracking. Another embodiment includes reducing the effect of motion in the axial direction based on a comparison to a model of the eye constructed from OCT data. The method can also be used to reduce the presence of mirror image artifacts in an OCT image.
摘要翻译：提出了有效获得具有减少的运动影响的光学相干断层扫描（OCT）测量数据的系统和方法。一个实施例涉及基于与OCT数据同时收集的眼睛的图像来确定OCT收集OCT数据集期间的运动量，以及当确定眼睛运动量时，重新收集OCT数据集的选择部分超过预定阈值。另一个实施例包括基于可用于跟踪的图像的质量启用或禁用跟踪特征。另一实施例包括基于与由OCT数据构造的眼睛模型的比较来减小轴向运动的影响。该方法还可用于减少OCT图像中镜像伪影的存在。

9. 发明授权

US08711366B2 Method of motion correction in optical coherence tomography imaging 有权
标题翻译：光学相干断层扫描成像中的运动校正方法
公开(公告)号：US08711366B2
公开(公告)日：2014-04-29
申请号：US13357097
申请日：2012-01-24
申请人： Matthew J. Everett , Keith E. O'Hara
发明人： Matthew J. Everett , Keith E. O'Hara
IPC分类号： G01B11/02
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/113 , A61B3/1233 , A61B5/0059 , A61B5/0066 , G01B9/02048 , G01B9/02077 , G01B9/02087 , G01B9/02091 , G01N21/4795 , G01N2021/1787
摘要： An image data set acquired by an optical coherence tomography (OCT) system is corrected for effects due to motion of the sample. A first set of A-scans is acquired within a time short enough to avoid any significant motion of the sample. A second more extensive set of A-scans is acquired over an overlapping region on the sample. A-scans from the first set are matched with A-scans from the second set. Comparison of the OCT scanner coordinates that produced each A-scan in a matching pair reveals the displacement of the sample between acquisition of the first and second A-scans in the pair. Estimates of the sample displacement are used to correct the transverse and longitudinal coordinates of the A-scans in the second set, to form a motion-corrected OCT data set.
摘要翻译：通过光学相干断层摄影（OCT）系统获得的图像数据集由于样品的运动而被校正。在足够短的时间内获取第一组A扫描，以避免样品的任何显着运动。在样本上的重叠区域获取第二组更广泛的A扫描。来自第一组的A扫描与来自第二组的A扫描进行匹配。在匹配对中产生每个A扫描的OCT扫描器坐标的比较显示样品在获得对中的第一和第二次A-扫描之间的位移。使用样本位移的估计来校正第二组中的A扫描的横向和纵向坐标，以形成运动校正的OCT数据集。

10. 发明授权

US08500279B2 Variable resolution optical coherence tomography scanner and method for using same 有权
标题翻译：可变分辨率光学相干断层扫描仪及其使用方法
公开(公告)号：US08500279B2
公开(公告)日：2013-08-06
申请号：US12611994
申请日：2009-11-04
申请人： Matthew J. Everett , Keith E. O'Hara
发明人： Matthew J. Everett , Keith E. O'Hara
IPC分类号： A61B3/14 , A61B3/10 , A61B3/00
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/14 , G01B9/02009
摘要： The invention relates generally to optical tomographic imaging and in particular to systems and methods for adapting the resolution of imaging. One embodiment of the present invention is an apparatus for optical coherence tomography imaging, characterized by its ability to vary the axial resolution and scanning speed during imaging.
摘要翻译：本发明一般涉及光学层析成像技术，尤其涉及用于适应成像分辨率的系统和方法。本发明的一个实施例是用于光学相干断层摄影成像的装置，其特征在于其在成像期间改变轴向分辨率和扫描速度的能力。

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