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    • 6. 发明授权
    • Multiple-wavelength spectroscopic quantitation of light-absorbing
species in scattering media
    • 散射介质中光吸收物质的多波长光谱定量
    • US6015969A
    • 2000-01-18
    • US8234
    • 1998-01-16
    • Howard NathelHarry E. CartlandBilly W. Colston, Jr.Matthew J. EverettJeffery N. Roe
    • Howard NathelHarry E. CartlandBilly W. Colston, Jr.Matthew J. EverettJeffery N. Roe
    • G01N21/31G01B9/02
    • G01N21/314
    • An oxygen concentration measurement system for blood hemoglobin comprises a multiple-wavelength low-coherence optical light source that is coupled by single mode fibers through a splitter and combiner and focused on both a target tissue sample and a reference mirror. Reflections from both the reference mirror and from the depths of the target tissue sample are carried back and mixed to produce interference fringes in the splitter and combiner. The reference mirror is set such that the distance traversed in the reference path is the same as the distance traversed into and back from the target tissue sample at some depth in the sample that will provide light attenuation information that is dependent on the oxygen in blood hemoglobin in the target tissue sample. Two wavelengths of light are used to obtain concentrations. The method can be used to measure total hemoglobin concentration [Hb.sub.deoxy +Hb.sub.oxy ] or total blood volume in tissue and in conjunction with oxygen saturation measurements from pulse oximetry can be used to absolutely quantify oxyhemoglobin [HbO.sub.2 ] in tissue. The apparatus and method provide a general means for absolute quantitation of an absorber dispersed in a highly scattering medium.
    • 用于血液血红蛋白的氧浓度测量系统包括多波长低相干光学光源,其由单模光纤通过分离器和组合器耦合并聚焦在目标组织样本和参考反射镜两者上。 来自参考镜和来自目标组织样本的深度的反射被携带并混合以在分离器和组合器中产生干涉条纹。 参考镜被设置为使得在参考路径中穿过的距离与在样本中的某个深度处从目标组织样本穿过的距离相同,其将提供取决于血液血红蛋白中的氧的光衰减信息 在目标组织样本中。 使用两个波长的光来获得浓度。 该方法可用于测量组织中总血红蛋白浓度[Hbdeoxy + Hboxy]或总体积,并结合脉搏血氧饱和度测量结果,可用于绝对量化组织中的氧合血红蛋白[HbO2]。 该装置和方法提供了用于绝对定量分散在高度散射介质中的吸收体的一般手段。