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1. 发明授权

US6022851A Lantibiotic related to actagardine, and processes for the preparation and use thereof 有权
标题翻译：与阿达加丁有关的蓝霉素，以及其制备和使用的方法
公开(公告)号：US6022851A
公开(公告)日：2000-02-08
申请号：US172042
申请日：1998-10-14
申请人： Laszlo Vertesy , Herbert Kogler , Matthias Schiell , Joachim Wink
发明人： Laszlo Vertesy , Herbert Kogler , Matthias Schiell , Joachim Wink
IPC分类号： C12P21/02 , A61K31/00 , A61K38/00 , A61P31/00 , A61P31/04 , C07K7/08 , C07K14/365 , C12R1/045 , A61K38/04 , A61K38/12 , C07K1/107 , C07K4/04
CPC分类号： C07K7/08 , A61K38/00
摘要： The present invention relates to a novel lantibiotic having the formula NH.sub.2 --R-actagardine, where NH.sub.2 --R is the radical of the amino acid alanine, which is formed by the microorganism Actinoplanes liguriae, DSM 11797 or Actinoplanes garbadiensis, DSM 11796 during fermentation, chemical derivatives of the lantibiotic, a process for its preparation and the use of the lantibiotics as pharmaceuticals.
摘要翻译：本发明涉及一种新型的具有式NH2-R-卡那加丁的羊毛硫抗生素，其中NH2-R是氨基酸丙氨酸的基团，其由微生物活性荧光素，DSM 11797或Actinoplanes garbadiensis，DSM 11796在发酵过程中形成，羊毛硫抗生素的化学衍生物，其制备方法以及作为药物使用的羊毛硫抗生素。

2. 发明授权

US5994307A Methods of treatment with novel antibiotic feglymycin 失效
标题翻译：新型抗生素强力霉素治疗方法
公开(公告)号：US5994307A
公开(公告)日：1999-11-30
申请号：US203388
申请日：1998-12-02
申请人： Laszlo Vertesy , Martin Knauf , Joachim Wink , Dieter Isert , Wilhelm Stahl , Gunther Riess , Jozsef Aszodi , Dominique Le Beller
发明人： Laszlo Vertesy , Martin Knauf , Joachim Wink , Dieter Isert , Wilhelm Stahl , Gunther Riess , Jozsef Aszodi , Dominique Le Beller
IPC分类号： C12P1/06 , A61K38/00 , A61P31/00 , C07K7/08 , C12N1/20 , C12P21/02 , C12R1/465 , C12R1/645 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K7/08 , C12R1/465 , A61K38/00
摘要： This invention relates to the antibiotic feglymycin, as well as processes for its preparation and use. Feglymycin is represented by the structural formula (SEQ. ID. NO. 1) ##STR1##
摘要翻译：本发明涉及抗生素feglymycin，以及其制备和应用的方法。铁氰霉素由结构式（SEQ ID NO：1）表示，

3. 发明授权

US5939399A Polyene antibiotics, 3874 H1 to H6, processes for their preparation and use 失效
标题翻译：多烯抗生素，3874 H1至H6，其制备和使用过程
公开(公告)号：US5939399A
公开(公告)日：1999-08-17
申请号：US914652
申请日：1997-08-19
申请人： Laszlo Vertesy , Michael Kurz , Joachim Wink , Astrid Markus , Wilhelm Stahl
发明人： Laszlo Vertesy , Michael Kurz , Joachim Wink , Astrid Markus , Wilhelm Stahl
IPC分类号： C12P17/18 , A61K31/365 , A61P31/04 , A61P31/10 , A61P33/02 , C07D493/04 , C07H17/08 , C12N1/20 , C12P19/62 , C12R1/465 , A61K31/70 , C07G11/00 , C07H17/04 , C12P19/46
CPC分类号： C07H17/08 , C12P19/62 , Y10S435/886 , Y10S435/892
摘要： Novel polyene antibiotics, 3874 H1 to H6, processes for their preparation and use which are suitable for treating fungal diseases, trichomonad diseases, and for treating diseases associated with an increased steroid concentration.
摘要翻译：新型多烯抗生素，3874 H1至H6，其制备和使用方法适用于治疗真菌性疾病，毛滴虫病和用于治疗与增加的类固醇浓度相关的疾病。

4. 发明授权

US06756402B2 Cyclipostins, process for their preparation and use thereof 有权
标题翻译： Cyclipostins，其制备和使用的方法
公开(公告)号：US06756402B2
公开(公告)日：2004-06-29
申请号：US09886044
申请日：2001-06-22
申请人： Laszlo Vertesy , Klaus Ehrlich , Michael Kurz , Joachim Wink
发明人： Laszlo Vertesy , Klaus Ehrlich , Michael Kurz , Joachim Wink
IPC分类号： A61K31335
CPC分类号： C12R1/465 , C07F9/65744 , C12P9/00
摘要： The invention relates to compounds of formula I in which R1, R2, E, X1, X2, and X3 have the meaning as described in the specification and claims, obtained by culturing Streptomyces species HAG 004107 (DSM 13381), and their physiologically tolerable salts and chemical equivalents. The invention furthermore relates to a process for the preparation of the cyclipostins, the microorganism HAG 004107 (DSM 13381), the use of the cyclipostins and their physiologically tolerable salts and chemical equivalents as pharmaceuticals, in particular as inhibitors of lipases, and pharmaceutical preparations which contain cyclipostin or a physiologically tolerable salt or equivalent thereof.
摘要翻译：本发明涉及式Iin化合物，其中R 1，R 2，E，X 1，X 2和X 3具有如说明书和权利要求书中所述的含义，通过培养链霉菌种类HAG 004107（DSM 13381），及其生理上可耐受的盐和化学当量。本发明还涉及一种制备环肽酶，微生物HAG 004107（DSM 13381），环肽素及其生理上可耐受的盐和化学等价物作为药物，特别是作为脂肪酶抑制剂的药物制剂的方法，以及药物制剂含有Cycipostin或生理上可耐受的盐或其等同物。

5. 发明授权

US06500936B2 Pluraflavins and derivatives thereof, process for their preparation and use thereof 有权
标题翻译：多夫肝素及其衍生物，其制备方法和用途
公开(公告)号：US06500936B2
公开(公告)日：2002-12-31
申请号：US09784035
申请日：2001-02-16
申请人： Laszlo Vertesy , Klaus Ehrlich , Martin Knauf , Joachim Wink , Francis P. Barbone , Elaine A. Powers , Elizabeth A. Cashman
发明人： Laszlo Vertesy , Klaus Ehrlich , Martin Knauf , Joachim Wink , Francis P. Barbone , Elaine A. Powers , Elizabeth A. Cashman
IPC分类号： A61K3135
CPC分类号： C12R1/01 , C07H17/04 , C12P19/26 , C12P19/60
摘要： The invention relates to a compound of formula (I) wherein R1 is a sugar; R2 is —CH2—O—(R7)m, R7 representing a sugar, or is —COOH; R3 is an epoxide-comprising group, or is C1-C6-alkyl or C2-C6-alkenyl, unsubstituted or substituted by at least one OH; R5 is H, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl; R4R6, R8 and R10 independently of one another are H; C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, —X2H, or —X2R12, or R4 and R6 together and/or R8 and R10 together are =X2; X2 is O, NH, N—C1-C6-alkyl, N—C2-C6-alkenyl, N-C2-C6-alkynyl or S; R12 is C1-C6-alkyl, C2-C6—alkenyl, C2-C6-alkynyl, aryl or acyl; and m and n are 1 or 2; in any of its stereochemical forms and mixtures of these forms in any ratio, and a physiologically acceptable salt or derivative thereof. The compounds are obtainable from a culture of the microorganism Actinomycetales species HAG 003959, DSM 12931, by fermentation. Accordingly, the invention relates to a process for their preparation and to the use of the compounds as pharmaceuticals, for example as antitumor agents.
摘要翻译：本发明涉及式（I）化合物，其中R1是糖; R2是-CH2-O-（R7）m，R7代表糖，或是-COOH; R3是含环氧化物的基团，或是未被取代或被至少一个OH取代的C1-C6-烷基或C2-C6-烯基; R5是H，C1-C6-烷基，C2-C6-烯基或C2-C6-炔基; R4R6，R8和R10彼此独立地为H; C1-C6-烷基，C2-C6-烯基，C2-C6-炔基，-X2H或-X2R12或R4和R6一起和/或R8和R10一起为= X2; X 2是O，NH，N-C 1 -C 6 - 烷基，N-C 2 -C 6 - 烯基，N-C 2 -C 6 - 炔基或S; R 12是C 1 -C 6烷基，C 2 -C 6 - 烯基，C 2 -C 6炔基，芳基或酰基; m和n为1或2; 其任何立体化学形式和这些形式的任何比例的混合物及其生理上可接受的盐或其衍生物。这些化合物可通过发酵从放线菌种类HAG 003959，DSM 12931的培养物中获得。因此，本发明涉及其制备和使用化合物作为药物的方法，例如作为抗肿瘤剂。

6. 发明授权

US5891851A Antibiotic, feglymycin, processes for its preparation and its use 失效
标题翻译：抗生素，富马霉素，其制备方法及其用途
公开(公告)号：US5891851A
公开(公告)日：1999-04-06
申请号：US988552
申请日：1997-12-11
申请人： Laszlo Vertesy , Martin Knauf , Joachim Wink , Dieter Isert , Wilhelm Stahl , Gunther Riess , Jozsef Aszodi , Dominique Le Beller
发明人： Laszlo Vertesy , Martin Knauf , Joachim Wink , Dieter Isert , Wilhelm Stahl , Gunther Riess , Jozsef Aszodi , Dominique Le Beller
IPC分类号： C12P1/06 , A61K38/00 , A61P31/00 , C07K7/08 , C12N1/20 , C12P21/02 , C12R1/465 , C12R1/645 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K7/08 , C12R1/465 , A61K38/00
摘要： This invention relates to the antibiotic feglymycin, as well as processes for its preparation and use. Feglymycin is represented by the structural formula (SEQ ID NO:1): ##STR1##
摘要翻译：本发明涉及抗生素feglymycin，以及其制备和应用的方法。 Feglymycin由结构式（SEQ ID NO：1）表示： + TR

7. 发明授权

US06221844B1 Antifungal peptides from scleroderma texense 失效
标题翻译：来自硬皮病texense的抗真菌肽
公开(公告)号：US06221844B1
公开(公告)日：2001-04-24
申请号：US09155603
申请日：1999-05-18
申请人： Heike Stump , Wilhelm Stahl , Joachim Wink , Astrid Markus , Herbert Kogler , Jürgen Backhaus
发明人： Heike Stump , Wilhelm Stahl , Joachim Wink , Astrid Markus , Herbert Kogler , Jürgen Backhaus
IPC分类号： A61K3800
CPC分类号： C07K7/02 , A61K38/00
摘要： The invention relates to novel peptides, namely texenomycins, from Scleroderma texense, a process for their preparation and their use as pharmaceuticals, in particular as antimycotics. The texenomycins according to the present invention are distinguished in particular by the amino acid sequence I in which FS is an oxo fatty acid radical, Aib is aminoisobutyric acid and Arg-ol=argininol.
摘要翻译：本发明涉及来自硬皮病texense的新型肽，即泰克星菌素，其制备方法及其作为药物，特别是抗真菌剂的用途。根据本发明的泰克星霉素特别是由以下的氨基酸序列Iin区分：其中FS是氧代脂肪酸基，Aib是氨基异丁酸，Ar-ol =精氨醇。

8. 发明授权

US06194383B1 Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof 失效
标题翻译：来自动物平面的脂肽具有药理作用，其制备方法及其用途
公开(公告)号：US06194383B1
公开(公告)日：2001-02-27
申请号：US08811843
申请日：1997-03-05
申请人： Peter Hammann , Johannes Meiwes , Gerhard Seibert , László Vertesy , Joachim Wink , Astrid Markus
发明人： Peter Hammann , Johannes Meiwes , Gerhard Seibert , László Vertesy , Joachim Wink , Astrid Markus
IPC分类号： A61K3800
CPC分类号： C07K7/60 , A61K38/00 , Y10S435/827
摘要： The invention relates to lipopeptides with very homologous amino-acid sequences but different fatty acid residues (lipid portion) which are synthesized by Actinoplanes sp. during fermentation and are released into the culture medium, to a process for isolating the lipopeptides from the culture medium and purifying them, to the use of the lipopeptides as pharmacologically active substances, in particular against Gram-positive bacteria, and to Actinoplanes sp. DSM 7358 for producing the abovementioned lipopeptides.
摘要翻译：本发明涉及具有非常同源的氨基酸序列但不同脂肪酸残基（脂质部分）的脂肽，其由Actinoplanes sp。在发酵过程中释放到培养基中，从分离来自培养基中的脂肽并纯化它们的方法，使用脂肽作为药理活性物质，特别是抗革兰氏阳性细菌，以及使用Actinoplanes sp。 DSM 7358用于生产上述脂肽。

9. 发明授权

US5100921A Angucyclinones from Streptomycetes, a process for the preparation thereof, and the use thereof 失效
标题翻译：来自溶酶体的神经球蛋白，其制备方法及其用途
公开(公告)号：US5100921A
公开(公告)日：1992-03-31
申请号：US342936
申请日：1989-04-25
申请人： Susanne Grabley , Joachim Wink , Carlo Giani , Gerhard Seibert , Wolfgang Raether , Susanne Dobreff , Axel Zeeck
发明人： Susanne Grabley , Joachim Wink , Carlo Giani , Gerhard Seibert , Wolfgang Raether , Susanne Dobreff , Axel Zeeck
IPC分类号： A61K31/05 , A61K31/12 , A61P31/04 , C07C49/747 , C07C50/36 , C07C69/00 , C12N1/20 , C12P15/00 , C12R1/465
CPC分类号： C07C69/00 , C07C49/747 , C07C50/36 , C12P15/00 , C07C2103/00 , C07C2103/42
摘要： New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.
摘要翻译：借助于链霉菌属的菌株可以制备具有治疗作用的新的角叉菜碱。

10. 发明授权

US5013655A Process for the preparation of colorants or monacolin K in a sterile fluidized bed of low water content 失效
标题翻译：在低含水量的无菌流化床中制备着色剂或莫纳可林K的方法
公开(公告)号：US5013655A
公开(公告)日：1991-05-07
申请号：US492796
申请日：1990-03-13
申请人： Thomas Bayer , Rainer Buchholz , Hans-Matthias Deger , Joachim Wink
发明人： Thomas Bayer , Rainer Buchholz , Hans-Matthias Deger , Joachim Wink
IPC分类号： A23L5/41 , A61K31/365 , A61K36/06 , C09B61/00 , C12N1/14 , C12P1/02 , C12R1/645
CPC分类号： C12N1/14 , C12P1/02 , Y10S435/911
摘要： The invention relates to a process for the preparation of colorants and/or active compounds by culturing a microorganism of the genus Monascus in a sterilizable fluidized-bed fermenter of low water content, such as was proposed in German Patent Application P 3,625,698.6. The fluidizable particle used here is the microorganism itself--in pellet form or grown on carriers--which can be supplied with nutrients by spraying in substrate solutions. The colorants and/or active compounds are isolated by extraction with organic solvents.
摘要翻译：本发明涉及通过在德国专利申请P 3,625,698.6中提出的在低水含量的可灭菌流化床发酵罐中培养红曲霉属的微生物来制备着色剂和/或活性化合物的方法。这里使用的可流化颗粒是微生物本身 - 以颗粒形式或在载体上生长 - 其可以通过在底物溶液中喷雾而被供应营养。通过用有机溶剂萃取分离着色剂和/或活性化合物。

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