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1. 发明授权

US5994307A Methods of treatment with novel antibiotic feglymycin 失效
标题翻译：新型抗生素强力霉素治疗方法
公开(公告)号：US5994307A
公开(公告)日：1999-11-30
申请号：US203388
申请日：1998-12-02
申请人： Laszlo Vertesy , Martin Knauf , Joachim Wink , Dieter Isert , Wilhelm Stahl , Gunther Riess , Jozsef Aszodi , Dominique Le Beller
发明人： Laszlo Vertesy , Martin Knauf , Joachim Wink , Dieter Isert , Wilhelm Stahl , Gunther Riess , Jozsef Aszodi , Dominique Le Beller
IPC分类号： C12P1/06 , A61K38/00 , A61P31/00 , C07K7/08 , C12N1/20 , C12P21/02 , C12R1/465 , C12R1/645 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K7/08 , C12R1/465 , A61K38/00
摘要： This invention relates to the antibiotic feglymycin, as well as processes for its preparation and use. Feglymycin is represented by the structural formula (SEQ. ID. NO. 1) ##STR1##
摘要翻译：本发明涉及抗生素feglymycin，以及其制备和应用的方法。铁氰霉素由结构式（SEQ ID NO：1）表示，

2. 发明授权

US5891851A Antibiotic, feglymycin, processes for its preparation and its use 失效
标题翻译：抗生素，富马霉素，其制备方法及其用途
公开(公告)号：US5891851A
公开(公告)日：1999-04-06
申请号：US988552
申请日：1997-12-11
申请人： Laszlo Vertesy , Martin Knauf , Joachim Wink , Dieter Isert , Wilhelm Stahl , Gunther Riess , Jozsef Aszodi , Dominique Le Beller
发明人： Laszlo Vertesy , Martin Knauf , Joachim Wink , Dieter Isert , Wilhelm Stahl , Gunther Riess , Jozsef Aszodi , Dominique Le Beller
IPC分类号： C12P1/06 , A61K38/00 , A61P31/00 , C07K7/08 , C12N1/20 , C12P21/02 , C12R1/465 , C12R1/645 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K7/08 , C12R1/465 , A61K38/00
摘要： This invention relates to the antibiotic feglymycin, as well as processes for its preparation and use. Feglymycin is represented by the structural formula (SEQ ID NO:1): ##STR1##
摘要翻译：本发明涉及抗生素feglymycin，以及其制备和应用的方法。 Feglymycin由结构式（SEQ ID NO：1）表示： + TR

3. 发明授权

US6114349A Substituted quinoline derivatives with antiviral action 有权
标题翻译：取代喹啉衍生物与抗病毒作用
公开(公告)号：US6114349A
公开(公告)日：2000-09-05
申请号：US155647
申请日：1999-03-03
申请人： Reinhard Kirsch , Jorg-Peter Kleim , Gunther Riess , Bernd Rosenstock , Manfred Rosner , Irvin Winkler
发明人： Reinhard Kirsch , Jorg-Peter Kleim , Gunther Riess , Bernd Rosenstock , Manfred Rosner , Irvin Winkler
IPC分类号： A61K31/00 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61P31/00 , A61P31/12 , C07D215/22 , C07D215/227 , C07D215/50 , C07D401/12 , C07D491/04 , C07D491/06 , C07D215/12 , C07D215/16 , C07D215/20 , C07D215/38
CPC分类号： C07D215/227 , A61K31/47 , A61K31/4704 , A61K31/4709 , C07D215/50 , C07D401/12 , C07D491/04 , C07D491/06
摘要： Substituted quinoline derivatives, processes for their preparation, and their use.Compounds of the formula I ##STR1## and their tautomeric forms, of the formula Ia ##STR2## in which m, n and the substituents X and R.sup.1 to R.sup.5 have the meanings mentioned, have an action against viruses.
摘要翻译： PCT No.PCT / EP97 / 01496 Sec。 371日期1999年3月3日 102（e）1999年3月3日PCT 1997年3月25日PCT公布。公开号WO97 / 37977 PCT 日期1997年10月16日取代喹啉衍生物，其制备方法及其用途。其中m，n和取代基X和R 1至R 5具有上述含义的式Ⅰ化合物及其互变异构形式具有抗病毒作用。

4. 发明授权

US5798365A Substituted quinoline derivatives, a process for their preparation, and their use 失效
标题翻译：取代的喹啉衍生物，其制备方法及其用途
公开(公告)号：US5798365A
公开(公告)日：1998-08-25
申请号：US515556
申请日：1995-08-14
申请人： Reinhard Kirsch , Jorg-Peter Kleim , Gunther Riess , Manfred Rosner , Irvin Winkler
发明人： Reinhard Kirsch , Jorg-Peter Kleim , Gunther Riess , Manfred Rosner , Irvin Winkler
IPC分类号： A61K31/47 , A61P31/12 , A61P31/18 , C07D215/22 , C07D215/227 , C07D215/24 , C07D215/26 , C07D215/36 , C07D215/38 , C07D215/58 , C07D221/20 , C07D401/06 , C07D401/12 , C07D401/14
CPC分类号： C07D215/227 , C07D215/22 , C07D215/26 , C07D215/36 , C07D215/38 , C07D221/20 , C07D401/06 , C07D401/12
摘要： Compounds of the formula I, ##STR1## and also their tautomeric forms of the formula Ia, ##STR2## in which the substituents R.sup.1 to R.sup.6 and X have said meanings, exhibit antiviral activity.
摘要翻译：式Ⅰ化合物，（Ⅰ）化合物及其互变异构形式的式Ia，其中取代基R 1至R 6和X具有所述含义，具有抗病毒活性。

5. 发明授权

US5723461A Quinoxalines, a process for their preparation and their use 失效
标题翻译：喹喔啉，它们的制备和使用过程
公开(公告)号：US5723461A
公开(公告)日：1998-03-03
申请号：US544290
申请日：1995-10-17
申请人： Manfred Rosner , Uta-Maria Billhardt-Troughton , Reinhard Kirsch , Jorg-Peter Kleim , Christoph Meichsner , Gunther Riess , Irvin Winkler
发明人： Manfred Rosner , Uta-Maria Billhardt-Troughton , Reinhard Kirsch , Jorg-Peter Kleim , Christoph Meichsner , Gunther Riess , Irvin Winkler
IPC分类号： A61K31/495 , A61P31/12 , C07D241/44 , C07F11/00
CPC分类号： C07D241/44
摘要： Disclosed are quinoxalinone compounds of the formula I or Ia ##STR1## and physiologically tolerated salts and prodrugs thereof, in which n=zero, one or two; R.sup.1 =fluorine, chlorine, hydroxyl or C.sub.1 -C.sub.3 -alkoxy; R.sup.2 =C.sub.1 -C.sub.4 -alkyl which is unsubstituted or is substituted by hydroxyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -alkylthio; R.sup.3 =C.sub.1 -C.sub.6 -alkyloxycarbonyl or C.sub.2 -C.sub.6 -alkenyloxycarbonyl, and X=oxygen, sulfur or selenium, a process for their preparation and pharmaceutical compositions containing the compounds.
摘要翻译：公开了式I或Ia的喹喔啉酮化合物及其生理学上可耐受的盐和前药，其中n = 0,1或2; R1 =氟，氯，羟基或C1-C3-烷氧基; R2 =未被取代或被羟基，C1-C4-烷氧基或C1-C4-烷硫基取代的C1-C4-烷基; R3 = C1-C6-烷氧基羰基或C2-C6-烯氧基羰基，X =氧，硫或硒，其制备方法和含有该化合物的药物组合物。

6. 发明授权

US5426036A Processes for the preparation of foreign proteins in streptomycetes 失效
标题翻译：在链霉菌中制备外源蛋白的方法
公开(公告)号：US5426036A
公开(公告)日：1995-06-20
申请号：US30731
申请日：1993-03-12
申请人： Klaus-Peter Koller , Gunther Riess , Eugen Uhlmann , Holger Wallmeier
发明人： Klaus-Peter Koller , Gunther Riess , Eugen Uhlmann , Holger Wallmeier
IPC分类号： C07K14/36 , C07K14/62 , C12N15/76 , C12N15/62
CPC分类号： C07K14/62 , C07K14/36 , C12N15/76 , C07K2319/02 , C07K2319/75
摘要： The tendamistat gene can be used for the construction of fused genes with which fusion proteins are expressed and excreted in Streptomycetes host cells. The tendamistat portion can be modified, in particular it can be C-terminal shortened. When a gene for a shortened proinsulin in which the insulin B chain is linked to the A chain only via Lys or Lys-Lys is coupled to the tendamistat gene, this gene construction is introduced into an expression vector, and the latter is used to transform a Streptomycetes host cell, there is expression and secretion of the corresponding fusion protein. The fusion protein can easily be cleaved to give insulin precursors because of correctly established disulfide bonds. Genetic structures which code for the signal sequence and about the first ten amino acids of tendamistat as well as a desired protein are expressed in streptomyces host cells with a high yield, and the fusion proteins are secreted into the medium.
摘要翻译：该趋化因子基因可用于构建融合蛋白的融合蛋白，其在链霉菌宿主细胞中表达和排泄。可以修改卷曲部分，特别是可以缩短C端。当胰岛素B链仅通过Lys或Lys-Lys与A链连接的缩短的胰岛素原的基因与趋化因子基因偶联时，将该基因构建引入表达载体中，并将后者用于转化链霉菌宿主细胞，有相应融合蛋白的表达和分泌。由于正确建立的二硫键，融合蛋白可以容易地被切割以产生胰岛素前体。编码信号序列和约10个氨基酸的趋化因子以及所需蛋白质的遗传结构以高产量在链霉菌宿主细胞中表达，融合蛋白分泌到培养基中。

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