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1. 发明授权

US06956061B2 Polyisoprenylbenzophenone derivatives, processes for their preparation and use thereof 有权
标题翻译：聚异戊二烯基二苯甲酮衍生物，其制备方法和用途
公开(公告)号：US06956061B2
公开(公告)日：2005-10-18
申请号：US10632064
申请日：2003-07-31
申请人： Matthias Schiell , Michael Kurz , Sabine Haag-Richter
发明人： Matthias Schiell , Michael Kurz , Sabine Haag-Richter
IPC分类号： C07C45/78 , C07C49/835 , C07C49/84 , A61K31/12 , A61P31/00 , C07C49/115
CPC分类号： C07C45/78 , C07C49/835 , C07C49/84
摘要： The present invention relates to compounds of the formula (I): which are produced by the plant Garcinia punctata, chemical derivatives derived therefrom, a process for their preparation, and their use as pharmaceuticals, in particular for the treatment and/or prophylaxis of bacterial infectious diseases.
摘要翻译：本发明涉及式（I）化合物：其由植物藤黄，由其衍生的化学衍生物，其制备方法及其作为药物的用途，特别是用于治疗和/或预防细菌传染性疾病。

2. 发明授权

US06962943B2 Gabusectin derivatives, processes for preparing them and their use 失效
标题翻译： Gabusectin衍生物，其制备方法及其用途
公开(公告)号：US06962943B2
公开(公告)日：2005-11-08
申请号：US10290607
申请日：2002-11-08
申请人： Matthias Schiell , Martin Knauf , Luigi Toti , Astrid Markus-Erb
发明人： Matthias Schiell , Martin Knauf , Luigi Toti , Astrid Markus-Erb
IPC分类号： C07D207/44 , A61K31/40 , C07D207/04 , A01P31/00
CPC分类号： C07D207/44
摘要： The present invention relates to compounds of the formula (I) which are formed by the microorganism ST 003236 (DSM 14476) during fermentation, to a process for preparing and derivatizing them, to a pharmaceutical which comprises a compound of the formula (I) and to the use thereof for producing a pharmaceutical.
摘要翻译：本发明涉及由发酵过程中的微生物ST-003236（DSM14476）形成的式（I）化合物，其制备方法和衍生化方法，其包含式（I）化合物和涉及其用于制备药物的用途。

3. 发明授权

US06627604B2 Memno peptides, process for their preparation and use thereof 有权
标题翻译： Memno肽，其制备方法和用途
公开(公告)号：US06627604B2
公开(公告)日：2003-09-30
申请号：US09794346
申请日：2001-02-28
申请人： Laszlo Vertesy , Herbert Kogler , Astrid Markus , Matthias Schiell
发明人： Laszlo Vertesy , Herbert Kogler , Astrid Markus , Matthias Schiell
IPC分类号： A61K3808
CPC分类号： C07K7/06 , A61K38/00
摘要： The invention relates to novel peptide derivatives, called memno peptides, of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8 and (A)n have the meaning herein, obtainable by cultivation of Memnoniella echinata FH2272, DSM 13195 or mutants and variants of this, a process for their preparation and the use of the compounds as pharmaceuticals, for example against cardiac insufficiency.
摘要翻译：本发明涉及式（I）所示的新型肽衍生物（称为memno肽）：其中R1，R2，R3，R4，R5，R6，R7，R8和（A）n具有本文的含义，可通过培养Memnoniella echinata FH2272，DSM 13195或其突变体和变体，其制备方法和化合物用作药物的方法，例如针对心脏功能不全。

4. 发明授权

US07067112B2 Cephaibols: novel antiparasitics from Acremonium tubakii, process for their production, and use thereof 有权
标题翻译：头孢唑醇：来自Acremonium tubakii的新型抗寄生虫药，其生产方法及其用途
公开(公告)号：US07067112B2
公开(公告)日：2006-06-27
申请号：US10411144
申请日：2003-04-11
申请人： Laszlo Vertesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
发明人： Laszlo Vertesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
IPC分类号： A61K49/00 , A61K38/10 , C07K7/08
CPC分类号： C07K7/08 , A61K38/00
摘要： The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are Iva; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-lle-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser, (II) wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.
摘要翻译：本发明涉及式I化合物<？in-line-formula description =“In-line Formulas”end =“lead”→AcPhe-Aib-Aib-Aib-xw-Leu-y-Aib-Hyp-Gln -z-Hyp-Aib-Pro-R（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R是Phe-ol或Phe-al，w，x ，y和z具有以下含义：a）w是Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是Iva; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 或e）w是Gly; x和y是Aib，z是Iva; AcPhe-Iva-Gln-Aib-Lle-Thr-Aib-Leu-Aib-x-Gln-Aib，或者式II <？in-line-formula description =“In-line Formulas”end =“lead” -Hyp-Aib-Pro-Phe-Ser，（II）<？在线公式描述=“在线公式”end =“tail”？>其中x是Hyp或Pro，它们是由Acremonium tubakii FH 1685 DSM 12774在发酵过程中释放到培养基中，从培养基中分离头孢胆素的方法及其纯化，以及将头孢唑醇用作药物活性化合物，特别是用于控制寄生虫的方法。

5. 发明授权

US06582949B1 Cephaibols: novel antiparasitics from Acremonium tubakii process for their production, and use thereof 有权
标题翻译： Cephaibols：来自Acremonium tubakii方法的新型抗寄生虫药物的生产及其用途
公开(公告)号：US06582949B1
公开(公告)日：2003-06-24
申请号：US09563505
申请日：2000-05-03
申请人： László Vértesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
发明人： László Vértesy , Michael Kurz , Matthias Schiell , Joachim Hofmann
IPC分类号： C07K708
CPC分类号： C07K7/08 , A61K38/00
摘要： The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are va; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-Ile-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser (II), wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.
摘要翻译：本发明涉及式Iin化合物，其中R为Phe-ol或Phe-al，w，x，y和z具有以下含义：a）w为Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是va; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 矿石）w是Gly; x和y是Aib，z是Iva;或者其中X是Hyp或Pro的式II，其在发酵过程中被Acremonium tubakii FH 1685 DSM 12774合成并释放到培养基中，从头孢曲松培养基和它们的纯化，以及将头孢吡肟作为药理学活性化合物的用途，特别是用于控制寄生虫。

6. 发明授权

US6022851A Lantibiotic related to actagardine, and processes for the preparation and use thereof 有权
标题翻译：与阿达加丁有关的蓝霉素，以及其制备和使用的方法
公开(公告)号：US6022851A
公开(公告)日：2000-02-08
申请号：US172042
申请日：1998-10-14
申请人： Laszlo Vertesy , Herbert Kogler , Matthias Schiell , Joachim Wink
发明人： Laszlo Vertesy , Herbert Kogler , Matthias Schiell , Joachim Wink
IPC分类号： C12P21/02 , A61K31/00 , A61K38/00 , A61P31/00 , A61P31/04 , C07K7/08 , C07K14/365 , C12R1/045 , A61K38/04 , A61K38/12 , C07K1/107 , C07K4/04
CPC分类号： C07K7/08 , A61K38/00
摘要： The present invention relates to a novel lantibiotic having the formula NH.sub.2 --R-actagardine, where NH.sub.2 --R is the radical of the amino acid alanine, which is formed by the microorganism Actinoplanes liguriae, DSM 11797 or Actinoplanes garbadiensis, DSM 11796 during fermentation, chemical derivatives of the lantibiotic, a process for its preparation and the use of the lantibiotics as pharmaceuticals.
摘要翻译：本发明涉及一种新型的具有式NH2-R-卡那加丁的羊毛硫抗生素，其中NH2-R是氨基酸丙氨酸的基团，其由微生物活性荧光素，DSM 11797或Actinoplanes garbadiensis，DSM 11796在发酵过程中形成，羊毛硫抗生素的化学衍生物，其制备方法以及作为药物使用的羊毛硫抗生素。

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