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1. 发明申请

WO2005123755A3 PURINE NUCLEOTIDE DERIVATIVES 审中-公开
标题翻译：嘌呤核苷衍生物
公开(公告)号：WO2005123755A3
公开(公告)日：2006-04-06
申请号：PCT/GB2005002418
申请日：2005-06-20
申请人： LAURAS AS , COCKBAIN JULIAN , UNDHEIM KJELL , TASKEN KJETIL , KLAVENESS JO , LANGLI GEIR , BJOERNSTAD VIDAR
发明人： UNDHEIM KJELL , TASKEN KJETIL , KLAVENESS JO , LANGLI GEIR , BJOERNSTAD VIDAR
IPC分类号： A61K31/7076 , C07H20060101 , C07H19/213
CPC分类号： C07H19/213 , Y10T436/143333
摘要： This invention provides novel 8-carbyl substituted Camps (adenosine 3', 5'-cyclic monophosphorothioate) and a novel procedures for the preparation of 8-Br-cAMP, a key starting material.
摘要翻译：本发明提供新的8-羰基取代的营养素（腺苷3'，5'-环状单硫代磷酸酯）和制备8-Br-cAMP（一种关键起始物质）的新方法。

2. 发明申请

WO0207721A3 USE OF COX-2 INHIBITORS FOR PREVENTING IMMUNODEFICIENCY 审中-公开
标题翻译：使用COX-2抑制剂免疫免疫
公开(公告)号：WO0207721A3
公开(公告)日：2002-04-18
申请号：PCT/GB0103284
申请日：2001-07-20
申请人： LAURAS AS , JONES ELIZABETH LOUISE , TASKEN KJETIL , MOUTSCHEN MICHEL , RAHMOUNI PIETTE SOUAD , AANDAHL EINAR MARTIN , AUKRUST PAAL , FROELAND STIG S , JOHANSSON CHRISTIAN CARL , HANSSON VIDAR , KLAVENESS JO
发明人： TASKEN KJETIL , MOUTSCHEN MICHEL , RAHMOUNI-PIETTE SOUAD , AANDAHL EINAR MARTIN , AUKRUST PAAL , FROELAND STIG S , JOHANSSON CHRISTIAN CARL , HANSSON VIDAR , KLAVENESS JO
IPC分类号： A61K45/00 , A61K31/18 , A61K31/341 , A61K31/365 , A61K31/381 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/5415 , A61K31/661 , A61K31/675 , A61K45/06 , A61P29/00 , A61P31/12 , A61P31/18 , A61P37/02 , A61P43/00
CPC分类号： A61K31/6615 , A61K31/18 , A61K31/365 , A61K31/381 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/5415 , A61K31/675
摘要： The present invention provides a method for treating or preventing a disorder typified by an immunodificiency (e.g. HIV), wherein the patient is administered a COX-2 inhibitor or derivative or pharmaceutically acceptable salt thereof, preferably diisopropylfluorophasphaate, L-745337, rofecoxi, NS 398, SC 58125, etodolac, meloxicam, celecoxib flusolide or nimesulide, and compositions and products containing the same or use of the same in preparing medicaments and for treatment.
摘要翻译：本发明提供了治疗或预防免疫力（例如HIV）代表的疾病的方法，其中给予患者COX-2抑制剂或其衍生物或药学上可接受的盐，优选氟化二异丙基酯，L-745337，罗非昔布，NS398 ，SC 58125，依托度酸，美洛昔康，氟替卡松或尼美舒利，以及含有相同或用于制备药物和治疗的组合物和产品。

3. 发明申请

WO2005025552A3 PROTEIN BINDING COMPOUNDS 审中-公开
标题翻译：蛋白质结合化合物
公开(公告)号：WO2005025552A3
公开(公告)日：2005-10-13
申请号：PCT/GB2004003939
申请日：2004-09-15
申请人： DRUG DISCOVERY LAB AS , KLAVENESS JO , BRUDELI BJARNE , COCKBAIN JULIAN
发明人： KLAVENESS JO , BRUDELI BJARNE
IPC分类号： A61K31/00 , A61K31/4164 , A61K31/513 , A61K31/52 , A61K31/7068 , A61K31/708 , A61K38/38 , A61K47/48 , A61P29/00 , A61P31/00 , A61P35/00
CPC分类号： A61K31/52 , A61K31/4164 , A61K31/513 , A61K31/7068 , A61K31/708 , A61K47/542 , A61K47/543
摘要： The present invention provides a prodrug compound comprising a therapeutically effective moiety coupled via a metabolically cleavable bond to a blood protein binding moiety.
摘要翻译：本发明提供了一种前药化合物，其包含通过代谢可裂解键与血液蛋白质结合部分偶联的治疗有效部分。

4. 发明申请

WO2004084920A3 ANTI-INFLAMMATORY TREATMENT BASED ON STRONTIUM COMPOUNDS 审中-公开
标题翻译：基于锶化合物的抗炎治疗
公开(公告)号：WO2004084920A3
公开(公告)日：2004-12-29
申请号：PCT/GB2004001369
申请日：2004-03-29
申请人： SANTOSOLVE AS , JELLUM EGIL , FAGERLUND BJOERN JARL , KJOELBERG CLAS MAGNE , KLAVENESS JO , EGE THORFINN , COCKBAIN JULIAN
发明人： JELLUM EGIL , FAGERLUND BJOERN JARL , KJOELBERG CLAS MAGNE , KLAVENESS JO , EGE THORFINN
IPC分类号： A61K31/10 , A61K31/28 , A61K33/24 , A61P29/00
CPC分类号： A61K31/10 , A61K31/28 , A61K33/24 , A61K2300/00
摘要： The invention provides a method of treatment of a human or non-human animal subject to combat inflammation arising from a condition associated with pain or a condition not associated with pain, said method comprising administering to said subject an effective amount of a physiologically tolerable strontium compound.

5. 发明申请

WO9818497A3 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO9818497A3
公开(公告)日：1998-07-16
申请号：PCT/GB9702957
申请日：1997-10-28
申请人： NYCOMED IMAGING AS , COCKBAIN JULIAN , KLAVENESS JO , NAEVESTAD ANNE , CUTHBERTSON ALAN , SOLBAKKEN MAGNE
发明人： KLAVENESS JO , NAEVESTAD ANNE , CUTHBERTSON ALAN , SOLBAKKEN MAGNE
IPC分类号： A61K47/48 , A61K49/00 , A61K49/10 , A61K49/18 , A61K49/22 , A61K51/04 , A61K51/12
CPC分类号： A61K49/0052 , A61K47/542 , A61K47/6925 , A61K49/10 , A61K49/101 , A61K49/223 , A61K51/04 , A61K51/0497 , A61K51/1255
摘要： The invention provides a composition of matter of the formula (I): V - L - R where V is a non-peptidic organic group having binding affinity for an endothelin receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body. This composition of matter may be used to image diseases and disorders, particularly of the cardiovascular system. 00000
摘要翻译：本发明提供式（I）的物质组合物：V-L-R其中V是对内皮素受体位点具有结合亲和力的非肽类有机基团，L是连接体部分或键，R是在人或动物身体的体内成像中可检测的部分。物质的这种组成可以用于成像疾病和病症，特别是心血管系统。 00000

6. 发明申请

WO9605867A3 Compositions 审中-公开
标题翻译：成分
公开(公告)号：WO9605867A3
公开(公告)日：1996-07-11
申请号：PCT/GB9501969
申请日：1995-08-18
申请人： NYCOMED IMAGING AS , COCKBAIN JULIAN , GOLMAN KLAES , PETTERSSON GOERAN , BERG ARNE , KLAVENESS JO , RONGVED PAL , LEANDER PETER , LEUNBACH IB , GUNTHER WOLFGANG
发明人： GOLMAN KLAES , PETTERSSON GOERAN , BERG ARNE , KLAVENESS JO , RONGVED PAL , LEANDER PETER , LEUNBACH IB , GUNTHER WOLFGANG
IPC分类号： A61K49/06 , A61K49/18 , A61K49/00
CPC分类号： A61K49/08 , A61K49/18 , A61K49/1818 , A61K49/1863
摘要： There is provided a contrast medium composition comprising a physiologically tolerable manganese compound, an uptake promoter and a physiologically tolerable carrier or excipient, having a manganese concentration of at least 0.3mM or being in a dosage unit form containing at least 300 νmol manganese, wherein the uptake promoter comprises a physiologically tolerable reducing compound containing an α-hydroxy ketone group, a physiologically tolerable acid containing α- and/or β-hydroxy or amino groups, or a salt thereof, and/or vitamin D. Such compositions are particularly suitable for imaging of the liver.

7. 发明申请

WO2007063335A3 AMPHOTERICIN B SALT 审中-公开
标题翻译：两性霉素B盐
公开(公告)号：WO2007063335A3
公开(公告)日：2007-09-20
申请号：PCT/GB2006004514
申请日：2006-12-04
申请人： DRUG DISCOVERY LAB AS , COCKBAIN JULIAN , KLAVENESS JO
发明人： KLAVENESS JO
IPC分类号： C07H17/08 , A61K9/00 , A61K31/13 , A61K31/133
CPC分类号： A61K9/0019 , A61K31/13 , A61K31/133 , C07H17/08
摘要： The invention provides a salt of amphotericin B and meglumine in which the molar ratio of amphotericin B to meglumine is about 1:1.
摘要翻译：本发明提供了两性霉素B和葡甲胺的盐，其中两性霉素B与葡甲胺的摩尔比为约1：1。

8. 发明申请

WO2006030217A3 DRUG CONJUGATES OF LONG CHAIN FATTY ACID OR ESTER MOIETIES AS PROTEIN BINDING PRODRUGS 审中-公开
标题翻译：长链脂肪酸或酯酶作为蛋白质结合原料的药物联合
公开(公告)号：WO2006030217A3
公开(公告)日：2007-03-22
申请号：PCT/GB2005003559
申请日：2005-09-15
申请人： DRUG DISCOVERY LAB AS , COCKBAIN JULIAN , KLAVENESS JO , BRUDELI BJARNE
发明人： KLAVENESS JO , BRUDELI BJARNE
IPC分类号： A61K47/48 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00
CPC分类号： A61K47/555 , A61K47/542
摘要： The invention provides a water-soluble prodrug compound comprising a therapeutically effective moiety coupled via a metabolically cleavable bond to a protein binding moiety, wherein said therapeutically effective moiety has an anticancer, antiinflammatory, antiinfective or antipain effect, said protein binding moiety binds non-covalently to blood proteins, and the protein binding of said compound is at least 100 % higher than that of the therapeutically effective moiety itself, with the exclusion of (i) the monoester of gemcitabine with azelaic acid, (ii) the monoester of dideoxycytidine with 1,12-dodecanedicarboxylic acid, (iii) 2-amino-l,9-dihydro-9(2'-(1-(10-acetyl-decanoyloxy)ethoxymethyl))-guanine, (iv) 5'-cytarabine monoester with 1,4-phenylene diacetic acid, (v) the monoester of metronidazole with 1,4-butanedicarboxylic acid, and (vi) the monoester of metronidazole with 1,6-phenylene diacetic acid; and pre-prodrugs metabolizable thereto.
摘要翻译：本发明提供了一种水溶性前药化合物，其包含通过可代谢切割键与蛋白质结合部分相连的治疗有效部分，其中所述治疗有效部分具有抗癌，抗炎，抗感染或抗胰蛋白酶作用，所述蛋白质结合部分非共价结合并且所述化合物的蛋白质结合比治疗有效部分本身的蛋白质结合至少高100％，排除（i）吉西他滨与壬二酸的单酯，（ii）双脱氧胞苷的单酯与1 ，12-十二烷二羧酸，（iii）2-氨基-1,9-二氢-9（2' - （1-（10-乙酰基 - 癸酰氧基）乙氧基甲基）） - 鸟嘌呤，（iv）5'-阿糖胞苷单酯与1 ，4-亚苯基二乙酸，（v）甲硝唑与1,4-丁烷二羧酸的单酯，和（vi）甲硝唑与1,6-亚苯基二乙酸的单酯; 和其可代谢的前药前药。

9. 发明申请

WO2004087229A3 BONE CEMENT COMPOSITIONS 审中-公开
标题翻译：骨水泥组合物
公开(公告)号：WO2004087229A3
公开(公告)日：2005-02-17
申请号：PCT/GB2004001509
申请日：2004-04-05
申请人： TA CONTRAST AB , ALMEN TORSTEN , KLAVENESS JO , BRUDELI BJARNE , COCKBAIN JULIAN
发明人： ALMEN TORSTEN , KLAVENESS JO , BRUDELI BJARNE
IPC分类号： A61L24/00 , A61L24/06 , A61L27/50 , A61L24/04
CPC分类号： A61L27/50 , A61L24/001 , A61L24/06 , A61L2430/02
摘要： The present invention provides a bone cement comprising in admixture a monomer-containing liquid portion and a particulate polymer portion, characterized in that at least one of said portions comprises a dissolved nonpolymerizable organoiodine compound.
摘要翻译：本发明提供了一种含有含单体的液体部分和粒状聚合物部分的骨水泥，其特征在于，所述部分中的至少一个包含溶解的不可聚合的有机碘化合物。

10. 发明申请

WO02070014A8 COMPOSITIONS COMPRISING AN O/W EMULSION CONTAINING CONJUGATED LINOLEIC ACID 审中-公开
标题翻译：包含含有联氨酸的O / W乳液的组合物
公开(公告)号：WO02070014A8
公开(公告)日：2003-11-27
申请号：PCT/GB0200996
申请日：2002-03-07
申请人： NATURAL ASA , REMMEREIT JAN , KLAVENESS JO , COCKBAIN JULIAN
发明人： REMMEREIT JAN , KLAVENESS JO
IPC分类号： A61K9/00 , A61K9/107 , A61K9/48 , A61K31/201 , A61K31/231 , A61K47/12 , A61K47/14
CPC分类号： A61K31/201 , A61K9/0019 , A61K9/0095 , A61K9/1075 , A61K9/4858 , A61K31/231 , A61K47/12 , A61K47/14
摘要： The present invention provides a method of treatment of a human or non-human (e.g. mammalian, avian or reptilian) animal subject by the parenteral administration of a lipophilic pharmaceutical agent, the improvement comprising administering said pharmaceutical agent in an oil-in-water emulsion containing a conjugated linoleic acid or a physiologically tolerable derivative thereof.
摘要翻译：本发明提供通过肠外给药亲脂性药剂治疗人或非人（例如哺乳动物，禽类或爬行动物）动物受试者的方法，该改进包括将所述药剂施用于水包油乳剂含有共轭亚油酸或其生理上可耐受的衍生物。

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