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1. 发明申请

WO0223209A3 MRI METHOD INVOLVING THE USE OF A HYPERPOLARIZED CONTRAST AGENT 审中-公开
标题翻译：涉及使用超高效对比剂的MRI方法
公开(公告)号：WO0223209A3
公开(公告)日：2002-08-22
申请号：PCT/GB0104085
申请日：2001-09-12
申请人： AMERSHAM HEALTH AS , PETERSSON STEFAN , LEUNBACH IB , MANSSON SVEN , AXELSSON OSKAR , THANING MIKKEL , ANDERSSON SVEN , MOY DAVID
发明人： PETERSSON STEFAN , LEUNBACH IB , MANSSON SVEN , AXELSSON OSKAR , THANING MIKKEL , ANDERSSON SVEN
IPC分类号： G01R33/28 , A61B5/055 , A61K20060101 , A61K49/00 , C07C31/27 , C07C43/13 , C07C59/01 , C07C69/08 , C07C235/06 , C07C309/08 , C07C309/17 , C07C311/04 , C07C313/04 , G01R33/561 , G01R33/567
CPC分类号： G01R33/5601 , G01R33/56308 , G01R33/5673
摘要： The present invention provides a method of contrast enhanced magnetic resonance imaging of a sample, said method comprising: a) administering a hyperpolarised MR contrast agent comprising non-zero nuclear spin nuclei into said sample for fluid dynamic investigations of the vasculature, b) exposing said sample or part of the sample to radiation of a frequency selected to excite nuclear spin transitions in said non-zero nuclear spin nuclei, c) detecting MR signals from said sample using any suitable manipulation method including pulse sequences. The invention also provides novel compounds.
摘要翻译：本发明提供了一种样品的对比增强磁共振成像方法，所述方法包括：a）向所述样品施用包含非零核自旋核的超极化MR造影剂，用于脉管系统的流体动力学研究，b）将所述样本或部分样本，以选择以激发所述非零核自旋核中的核自旋跃迁的频率的辐射，c）使用包括脉冲序列的任何合适的操作方法来检测来自所述样本的MR信号。本发明还提供新的化合物。

2. 发明申请

WO1990013047A1 MAGNETIC RESONANCE IMAGING METHOD 审中-公开
标题翻译：磁共振成像方法
公开(公告)号：WO1990013047A1
公开(公告)日：1990-11-01
申请号：PCT/EP1990000604
申请日：1990-04-12
申请人： HAFSLUND NYCOMED INNOVATION AB , LEUNBACH, Ib
发明人： HAFSLUND NYCOMED INNOVATION AB
IPC分类号： G01R33/62
CPC分类号： G01R33/5615 , G01R33/5616 , G01R33/62
摘要： There is provided an improved magnetic resonance imaging procedure which essentially combines electron spin resonance enhanced MRI with echo planar imaging MRI.

3. 发明申请

WO1998001766A1 METHOD OF ELECTRON SPIN RESONANCE ENHANCED MAGNETIC RESONANCE IMAGING (ESREMRI) WITH EX VIVO DYNAMIC NUCLEAR POLARISATON OF AN MR IMAGING AGENT 审中-公开
标题翻译：电磁共振增强磁共振成像方法（ESREMRI）与MR成像剂的动态动态核磁共振成像
公开(公告)号：WO1998001766A1
公开(公告)日：1998-01-15
申请号：PCT/GB1997001804
申请日：1997-07-03
申请人： NYCOMED IMAGING AS , LEUNBACH, Ib , YOUNG, Ian , EHNHOLM, Gösta , HANSSON, Georg , PETERSSON, Stefan , WISTRAND, Lars-Goran , GOLMAN, Klaes
发明人： NYCOMED IMAGING AS
IPC分类号： G01R33/62
CPC分类号： G01R33/5601 , G01R33/282 , G01R33/62
摘要： The invention relates to a method of electron spin resonance enhanced magnetic resonance imaging comprising the steps of: (i) placing a composition comprising a contrast agent and an MR imaging agent in a first magnetic field; (ii) exciting ESR transitions in the contrast agent to generate dynamic nuclear polarisation of th e MR imaging agent; (iii) separating the contrast agent from the MR imaging agent; (iv) administering the MR imaging agent to the sample; (v) exciting NMR transitions of the MR imaging agent is a second magnetic field; and (vi) detecting MR response signals from the sample.
摘要翻译：本发明涉及电子自旋共振增强磁共振成像的方法，包括以下步骤：（i）将包含造影剂和MR成像剂的组合物放置在第一磁场中; （ii）造影剂中激发的ESR转变以产生MR成像剂的动态核极化; （iii）将造影剂与MR成像剂分离; （iv）向该样品施用MR成像剂; （v）MR成像剂的激发NMR转变是第二磁场; 和（vi）检测来自样品的MR响应信号。

4. 发明申请

WO1988010419A1 IMPROVEMENTS IN AND RELATING TO MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：磁共振成像中的改进和相关
公开(公告)号：WO1988010419A1
公开(公告)日：1988-12-29
申请号：PCT/GB1988000479
申请日：1988-06-22
申请人： COCKBAIN, Julian, Roderick, Michaelson , HAFSLUND NYCOMED INNOVATION AB , LEUNBACH, Ib
发明人： COCKBAIN, Julian, Roderick, Michaelson , HAFSLUND NYCOMED INNOVATION AB
IPC分类号： G01N24/12
CPC分类号： G01R33/5601 , A61K49/20 , G01R33/282 , G01R33/62 , Y10T436/24
摘要： A magnetic resonance image generating apparatus comprising a first radiation source capable of emitting a first radiation of a frequency selected to excite nuclear spin transitions in selected nuclei in a sample being imaged and means for detecting free induction decay signals from said selected nuclei, characterised in that said apparatus further comprises a second radiation source capable of emitting a second radiation of a frequency selected to excite electron spin transitions coupled to the nuclear spin transitions of at least some of said selected nuclei.

5. 发明申请

WO9605867A3 Compositions 审中-公开
标题翻译：成分
公开(公告)号：WO9605867A3
公开(公告)日：1996-07-11
申请号：PCT/GB9501969
申请日：1995-08-18
申请人： NYCOMED IMAGING AS , COCKBAIN JULIAN , GOLMAN KLAES , PETTERSSON GOERAN , BERG ARNE , KLAVENESS JO , RONGVED PAL , LEANDER PETER , LEUNBACH IB , GUNTHER WOLFGANG
发明人： GOLMAN KLAES , PETTERSSON GOERAN , BERG ARNE , KLAVENESS JO , RONGVED PAL , LEANDER PETER , LEUNBACH IB , GUNTHER WOLFGANG
IPC分类号： A61K49/06 , A61K49/18 , A61K49/00
CPC分类号： A61K49/08 , A61K49/18 , A61K49/1818 , A61K49/1863
摘要： There is provided a contrast medium composition comprising a physiologically tolerable manganese compound, an uptake promoter and a physiologically tolerable carrier or excipient, having a manganese concentration of at least 0.3mM or being in a dosage unit form containing at least 300 νmol manganese, wherein the uptake promoter comprises a physiologically tolerable reducing compound containing an α-hydroxy ketone group, a physiologically tolerable acid containing α- and/or β-hydroxy or amino groups, or a salt thereof, and/or vitamin D. Such compositions are particularly suitable for imaging of the liver.

6. 发明申请

WO1996009282A1 IODINATED X-RAY CONTRAST MEDIA 审中-公开
标题翻译： IODINATED X-RAY对比媒体
公开(公告)号：WO1996009282A1
公开(公告)日：1996-03-28
申请号：PCT/GB1995002265
申请日：1995-09-22
申请人： NYCOMED IMAGING A/S , REED, Michael, Antony , ALMÉN, Torsten , ANDERSSON, Sven , WISTRAND, Lars-Göran , GOLMAN, Klaes , ANTONSEN, Oyvind , FOSSHEIM, Rune , WIGGEN, Unni, Nordby , WIKSTRÖM, Håkan , KLINGSTEDT, Tomas , LEUNBACH, Ib , BERG, Arne , DUGSTAD, Harald
发明人： NYCOMED IMAGING A/S , REED, Michael, Antony
IPC分类号： C07C237/46
CPC分类号： C07C33/46 , A61K49/0433 , C07C33/483 , C07C235/16 , C07C237/46
摘要： The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula (I), wherein n is 0 or 1, and where n is 1 each C6R5 moiety may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M1, two or three non-adjacent R groups in each C6R5 moiety being iodine and at least one, and preferably two or three, R groups in each C6R5 moiety being M or M1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C6R5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M1 independently represents a C1-4alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M1 moiety; with the proviso that where n is zero either at least one M1 group other than a hydroxymethyl or 1,2-dihydroxyethyl group is present or then if one hydroxymethyl or 1,2-dihydroxyethyl M1 group is present at least one nitrogen-attached or hydroxylated-C3-4 alkyl moiety-containing M group is also present and isomers thereof.
摘要翻译：本发明提供了可用作式（I）的X射线造影剂的低粘度碘化芳基化合物，其中n为0或1，并且其中n为1，每个C 6 R 5部分可以相同或不同; 每个基团R是氢原子，碘原子或亲水部分M或M1，每个C 6 R 5部分中两个或三个不相邻的R基团是碘，并且每个C 6 R 5部分中至少一个，优选两个或三个R基团是M或M1部分; X表示键或提供连接两个C 6 R 5部分的1至7个原子链的基团，或其中n为0，X表示基团R; 每个M独立地是非离子亲水部分; 并且每个M1独立地表示被至少一个羟基取代的C 1-4烷基，并且任选地通过羰基，砜或亚砜基与苯环连接，至少一个R基团是M1部分; 条件是在n为0的情况下，至少一个除羟甲基或1,2-二羟乙基之外的M1基团存在或如果一个羟甲基或1,2 - 二羟乙基M1基团存在至少一个含氮连接或羟基化的含C3-4烷基部分的M基团以及其异构体。

7. 发明申请

WO2005051435A2 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2005051435A2
公开(公告)日：2005-06-09
申请号：PCT/NO2004000364
申请日：2004-11-26
申请人： AMERSHAM HEALTH AS , AXELSSON OSKAR , LEUNBACH IB , KARLSSON MAGNUS
发明人： AXELSSON OSKAR , LEUNBACH IB , KARLSSON MAGNUS
IPC分类号： A61K49/04 , B22F1/00 , B22F9/24
CPC分类号： A61K49/0428 , A61K49/0419 , B22F1/0018 , B22F1/0059 , B22F9/24 , B82Y5/00 , B82Y30/00
摘要： The present invention relates to particles comprising cores of tungsten or tungsten in mixture with other metallic elements as the contrast enhancing material wherein said core are coated, to pharmaceuticals containing such particles, and to the use of such pharmaceuticals specifically as contrast agents in diagnostic imaging, in particular in X-ray imaging.
摘要翻译：本发明涉及包含与其它金属元素作为对比增强材料的其它金属元素的钨或钨的核心的颗粒，其中所述芯被涂覆到包含这种颗粒的药物中，以及在诊断成像中特异性地用作造影剂的这种药物的用途，特别是在X射线成像中。

8. 发明申请

WO1997009633A1 A METHOD OF DETERMINING OXYGEN CONCENTRATION IN A SAMPLE 审中-公开
标题翻译：在样品中测定氧气浓度的方法
公开(公告)号：WO1997009633A1
公开(公告)日：1997-03-13
申请号：PCT/GB1996002198
申请日：1996-09-06
申请人： NYCOMED IMAGING A/S , COCKBAIN, Julian, Roderick, Michaelson , ARDENKJAER-LARSEN, Jan, Henrik , LEUNBACH, Ib
发明人： NYCOMED IMAGING A/S , COCKBAIN, Julian, Roderick, Michaelson
IPC分类号： G01R33/62
CPC分类号： A61K49/20 , G01R33/281 , G01R33/62
摘要： A method for determining the oxygen concentration of a sample using electron spin resonance enhanced magnetic resonance imaging.
摘要翻译：使用电子自旋共振增强磁共振成像确定样品的氧浓度的方法。

9. 发明申请

WO1990007719A1 IMPROVEMENTS IN AND RELATING TO MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：磁共振成像中的改进和相关
公开(公告)号：WO1990007719A1
公开(公告)日：1990-07-12
申请号：PCT/EP1989001611
申请日：1989-12-20
申请人： HAFSLUND NYCOMED INNOVATION AB , COCKBAIN, Julian, Roderick, Michaelson , LEUNBACH, Ib , GOLMAN, Klaes , KLAVENESS, Jo
发明人： HAFSLUND NYCOMED INNOVATION AB , COCKBAIN, Julian, Roderick, Michaelson
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , G01R33/62
摘要： The invention relates to a modification of electron spin resonance enhanced magnetic resonance imaging (ESREMRI) in which two magnetically responsive materials (contrast agents) are introduced into the sample being investigated, one contrast agent serving as an ESREMRI free induction decay signal enhancing agent and the other as enhancement suppressing agent. In this way image contrast may be enhanced futher for regions in which the suppressing agent distributes poorly or not at all or which the suppressing agent reaches at a later time than the enhancing agent.

10. 发明专利

DK607185D0 未知
公开(公告)号：DK607185D0
公开(公告)日：1985-12-30
申请号：DK607185
申请日：1985-12-30
申请人： LEUNBACH IB
发明人： LEUNBACH IB
IPC分类号： G01N20060101 , G01N

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