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1. 发明授权

US07917216B1 Multi-site pacing for atrial tachyarrhythmias 有权
标题翻译：多节段起搏用于房性快速性心律失常
公开(公告)号：US07917216B1
公开(公告)日：2011-03-29
申请号：US11458649
申请日：2006-07-19
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/18
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

2. 发明授权

US08750993B2 Multi-site pacing for atrial tachyarrhythmias 有权
标题翻译：多节段起搏用于房性快速性心律失常
公开(公告)号：US08750993B2
公开(公告)日：2014-06-10
申请号：US13029048
申请日：2011-02-16
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/18
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

3. 发明申请

US20110137364A1 MULTI-SITE PACING FOR ATRIAL TACHYARRHYTHMIAS 有权
标题翻译：多功能TACHYARRHYTHMIA的多地点
公开(公告)号：US20110137364A1
公开(公告)日：2011-06-09
申请号：US13029048
申请日：2011-02-16
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/36
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多部位电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组

4. 发明授权

US07917214B1 Methods and systems for identifying a preferred pacing configuration for a multi-electrode implantable cardiac electrotherapy device 有权
标题翻译：用于识别多电极可植入心脏电疗装置的优选起搏配置的方法和系统
公开(公告)号：US07917214B1
公开(公告)日：2011-03-29
申请号：US11851240
申请日：2007-09-06
申请人： Jong Gill , Annapurna Karicherla , Kyungmoo Ryu , Gene A. Bornzin
发明人： Jong Gill , Annapurna Karicherla , Kyungmoo Ryu , Gene A. Bornzin
IPC分类号： A61N1/362
CPC分类号： A61N1/372 , A61N1/3686
摘要： Methods and systems of identifying an electrode or combination of electrodes of a multi-electrode device for pacing include selecting a first electrode or electrode combination as a first candidate; delivering a pacing pulse through the first candidate and determining a measurement based on sensed cardiac electrical activity resulting from the first candidate pacing; selecting a second candidate; delivering a pacing pulse through the second candidate and determining a measurement based on sensed cardiac electrical activity resulting from the second candidate pacing; comparing the measurement for the first and second candidates; and identifying the first or second candidate for pacing based on the comparison. The measurement may be one or more of activation time ΔTact, activation recovery interval (ARI), a fractioned electrogram width, and a standard deviation of a fractioned electrogram feature.
摘要翻译：识别用于起搏的多电极装置的电极或电极组合的方法和系统包括选择第一电极或电极组合作为第一候选; 通过所述第一候选者发送起搏脉冲，并且基于由所述第一候选起搏产生的感测的心脏电活动来确定测量; 选择第二候选人; 通过所述第二候选者递送起搏脉冲，并且基于由所述第二候选起搏产生的感测到的心脏电活动来确定测量; 比较第一和第二候选人的测量; 以及基于所述比较来识别用于起搏的第一或第二候选者。测量可以是一个或多个激活时间＆Dgr; Tact，激活恢复间隔（ARI），分数的电描记图宽度和分数的电描记图特征的标准偏差。

5. 发明授权

US07632235B1 System and method for measuring cardiac output via thermal dilution using an implantable medical device with an external ultrasound power delivery system 有权
标题翻译：使用具有外部超声功率输送系统的可植入医疗装置通过热稀释测量心输出量的系统和方法
公开(公告)号：US07632235B1
公开(公告)日：2009-12-15
申请号：US11099888
申请日：2005-04-05
申请人： Annapurna Karicherla , Xiaoyi Min , Peter Boileau , Jong Gill , Gene A. Bornzin
发明人： Annapurna Karicherla , Xiaoyi Min , Peter Boileau , Jong Gill , Gene A. Bornzin
IPC分类号： A61B5/029 , A61B5/028 , A61B8/06
CPC分类号： A61B5/028 , A61B5/029 , A61B2560/0209 , A61B2560/0214 , A61N1/3627 , A61N1/3655
摘要： The implantable device is capable of performing thermal dilution analysis of the cardiac output of a patient using power delivered from an external source. By using power from an external source, the implantable device conserves its power resources for other purposes, such as for pacing or defibrillation therapy. In one example, an external programmer or bedside monitor provides power through a hand-held power delivery wand via electromagnetic induction, with the power routed from a subcutaneous coil to a heating element implanted in the right atrium, which heats blood as it passes through the right atrium. In another example, the heating element is formed of a material that generates heat in response to a beam of ultrasound provided by the wand. In either case, a downstream blood temperature profile is detected using a thermistor implanted in the pulmonary artery and cardiac output is then estimated by analyzing the temperature profile.
摘要翻译：可植入装置能够使用从外部源传递的功率来对患者的心输出量进行热稀释分析。通过使用来自外部来源的电力，可植入装置为其他目的节省其功率资源，例如用于起搏或除颤疗法。在一个示例中，外部编程器或床边监视器通过电磁感应通过手持式电力输送棒提供电力，电力从皮下线圈路由到植入右心房的加热元件，该加热元件在通过右心房。在另一个实例中，加热元件由响应于由魔杖提供的超声波束产生热量的材料形成。在任一情况下，使用植入肺动脉中的热敏电阻检测下游血液温度分布，然后通过分析温度分布来估计心输出量。

6. 发明申请

US20110098546A1 ASSESSING MEDICAL CONDITIONS BASED ON VENOUS OXYGEN SATURATION AND HEMATOCRIT INFORMATION 审中-公开
标题翻译：基于静脉氧饱和度和血压信息评估医疗条件
公开(公告)号：US20110098546A1
公开(公告)日：2011-04-28
申请号：US12976493
申请日：2010-12-22
申请人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Yelena Nabutovsky , Kyungmoo Ryu , Keith Victorine , Xiaoyi Min , John W. Poore
发明人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Yelena Nabutovsky , Kyungmoo Ryu , Keith Victorine , Xiaoyi Min , John W. Poore
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/0205 , A61B5/021 , A61B5/029 , A61B5/04001 , A61B5/0464 , A61B5/0816 , A61B5/14535 , A61B5/14539 , A61B5/7285 , A61N1/36557 , A61N1/36564 , A61N1/36585
摘要： Methods for assessing, diagnosing and treating medical conditions using SvO2 and hematocrit measurements alone, or in combination with other measurements related to cardiac activity are provided. These includes methods for distinguishing true anemia from diluted anemia, methods for anemia detection, methods for measuring disease progression based on anemia trending, methods for managing therapy delivery, methods for managing heart failure drug therapies, methods for cardiac output optimization based on SvO2, methods for cardiac resynchronization therapy lead placement, method for detection of heart failure decompensation, and methods to monitor and treat systolic versus diastolic heart failure are provided.
摘要翻译：提供了使用SvO2和血细胞比容测量单独评估，诊断和治疗医疗条件或与心脏活动相关的其他测量结合的方法。这些包括区分真正贫血与稀释性贫血的方法，贫血检测方法，基于贫血趋势测量疾病进展的方法，管理治疗递送的方法，管理心力衰竭药物治疗的方法，基于SvO2的心输出优化方法用于心脏再同步治疗铅放置，心脏失代偿失代偿检测方法以及监测和治疗心脏收缩期与舒张性心力衰竭的方法。

7. 发明授权

US08923965B2 Systems and methods for optimizing AV/VV pacing delays using combined IEGM/impedance-based techniques for use with implantable medical devices 有权
标题翻译：使用组合的基于IEGM /阻抗的技术优化AV / VV起搏延迟的系统和方法，用于可植入医疗设备
公开(公告)号：US08923965B2
公开(公告)日：2014-12-30
申请号：US12976322
申请日：2010-12-22
申请人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
发明人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
IPC分类号： A61B1/00 , A61N1/365
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36521
摘要： Systems and methods are provided wherein intracardiac electrogram (IEGM) signals are used to determine a set of preliminary optimized atrioventricular (AV/PV) and interventricular (VV) pacing delays. In one example, the preliminary optimized AV/VV pacing delays are used as a starting point for further optimization based on impedance signals such as impedance signals detected between a superior vena cava (SVC) coil electrode and a device housing electrode, which are influenced by changes in stroke volume within the patient. Ventricular pacing is thereafter delivered using the AV/VV pacing delays optimized via impedance. In another example, parameters derived from IEGM signals are used to limit the scope of an impedance-based optimization search to reduce the number of pacing tests needed during impedance-based optimization. Biventricular and multi-site left ventricular (MSLV) examples are described.
摘要翻译：提供了系统和方法，其中使用心内电描记图（IEGM）信号来确定一组初步优化的房室（AV / PV）和心室间（VV）起搏延迟。在一个示例中，使用初步优化的AV / VV起搏延迟作为进一步优化的起点，其基于阻抗信号，例如在上腔静电（SVC）线圈电极和器件壳体电极之间检测到的阻抗信号，其受患者体内搏动量的变化。此后，使用通过阻抗优化的AV / VV起搏延迟来递送心室起搏。在另一个示例中，从IEGM信号导出的参数用于限制基于阻抗的优化搜索的范围，以减少基于阻抗的优化期间所需的起搏测试次数。描述了双心室和多部位左心室（MSLV）的例子。

8. 发明申请

US20120165892A1 SYSTEMS AND METHODS FOR OPTIMIZING AV/VV PACING DELAYS USING COMBINED IEGM/IMPEDANCE-BASED TECHNIQUES FOR USE WITH IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：使用组合的IEGM /基于阻抗的技术优化AV / VV延迟的系统和方法与可植入医疗设备的使用
公开(公告)号：US20120165892A1
公开(公告)日：2012-06-28
申请号：US12976322
申请日：2010-12-22
申请人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
发明人： Xiaoyi Min , Gene A. Bornzin , Martin Cholette , Kyungmoo Ryu , Catherine Tan
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36521
摘要： Systems and methods are provided wherein intracardiac electrogram (IEGM) signals are used to determine a set of preliminary optimized atrioventricular (AV/PV) and interventricular (VV) pacing delays. In one example, the preliminary optimized AV/VV pacing delays are used as a starting point for further optimization based on impedance signals such as impedance signals detected between a superior vena cava (SVC) coil electrode and a device housing electrode, which are influenced by changes in stroke volume within the patient. Ventricular pacing is thereafter delivered using the AV/VV pacing delays optimized via impedance. In another example, parameters derived from IEGM signals are used to limit the scope of an impedance-based optimization search to reduce the number of pacing tests needed during impedance-based optimization. Biventricular and multi-site left ventricular (MSLV) examples are described.
摘要翻译：提供了系统和方法，其中使用心内电描记图（IEGM）信号来确定一组初步优化的房室（AV / PV）和心室间（VV）起搏延迟。在一个示例中，使用初步优化的AV / VV起搏延迟作为进一步优化的起点，其基于阻抗信号，例如在上腔静电（SVC）线圈电极和器件壳体电极之间检测到的阻抗信号，其受患者体内搏动量的变化。此后，使用通过阻抗优化的AV / VV起搏延迟来递送心室起搏。在另一个示例中，从IEGM信号导出的参数用于限制基于阻抗的优化搜索的范围，以减少基于阻抗的优化期间所需的起搏测试次数。描述了双心室和多部位左心室（MSLV）的例子。

9. 发明申请

US20130204312A1 SYSTEMS AND METHODS FOR CONTROLLING PACING INDUCED DYSSYNCHRONY TO REDUCE ISCHEMIC INJURY USING AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：使用可植入医疗装置来控制皮肤诱导性神经元以减少异常损伤的系统和方法
公开(公告)号：US20130204312A1
公开(公告)日：2013-08-08
申请号：US13365061
申请日：2012-02-02
申请人： Jong Gill , Kwangdeok Lee , Kyungmoo Ryu , Gene A. Bornzin
发明人： Jong Gill , Kwangdeok Lee , Kyungmoo Ryu , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36557 , A61N1/3682 , A61N1/3684 , A61N1/3686
摘要： Techniques are provided for use by an implantable medical device for optimizing the amount of ventricular dyssynchrony induced within a patient during protective pacing. In one example, the device analyzes intracardiac electrogram signals to detect an ischemic event within the heart. The device then delivers pacing stimulus in accordance with adjustable pacing parameters to induce ventricular dyssynchrony within the heart and adjusts the pacing parameters within a range of permissible values to achieve a preferred degree of ventricular dyssynchrony within the patient, so long as there is no significant reduction in left ventricular pumping functionality. Preferably, the pacing parameters are adjusted to maximize or otherwise optimize the degree of dyssynchrony induced within the patient. If a significant reduction in LV pumping functionality is detected, the dyssynchrony-inducing pacing is preferably suspended to avoid any deterioration in the condition of the heart. Techniques for detecting early onset of ischemia are also disclosed.
摘要翻译：技术被提供用于由可植入医疗装置用于在保护性起搏期间优化患者内引起的心室不同步的量。在一个实例中，该装置分析心内电描记信号以检测心脏内的缺血事件。然后，该装置根据可调整的起搏参数提供起搏刺激，以诱导心脏内的心室不同步，并在允许值的范围内调整起搏参数，以在患者体内达到优选的心室不同步程度，只要没有显着的减少在左心室泵功能。优选地，起搏参数被调整以最大化或以其他方式优化患者内诱发的不同步程度。如果检测到LV泵送功能的显着降低，则优选暂停不同步的起搏，以避免心脏状况的任何恶化。还公开了用于检测早期发作缺血的技术。

10. 发明授权

US08449472B2 Neurostimulation and neurosensing techniques to optimize atrial anti-tachycardia pacing for prevention of atrial tachyarrhythmias 有权
标题翻译：神经刺激和神经感应技术优化房性心动过速起搏预防房性快速性心律失常
公开(公告)号：US08449472B2
公开(公告)日：2013-05-28
申请号：US12891429
申请日：2010-09-27
申请人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61B5/02 , A61N1/00
CPC分类号： A61N1/3621 , A61N1/36114 , A61N1/3624
摘要： Implantable systems and method for use therewith are provided that take advantage of various neuromodulation and neurosensing techniques for either preventing atrial fibrillation (AF) or terminating AF. Specific embodiments are for use with an implantable device that includes one or more atrial electrode for sensing atrial fibrillation (AF) and/or delivering Atrial Anti-Tachycardia Pacing (AATP) and one or more electrode for monitoring and/or stimulating atrial vagal fat pads.
摘要翻译：提供了可植入系统及其使用的方法，其利用各种神经调节和神经感应技术来预防心房颤动（AF）或终止AF。具体实施方案用于可植入装置，其包括一个或多个心房电极，用于感测心房颤动（AF）和/或递送心房抗心动过速起搏（AATP）和用于监测和/或刺激心房迷走神经脂肪垫的一个或多个电极。

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