专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08530047B2 Method for polymerizing a small oligonucleotide, and use of a high-molecular oligonucleotide prepared by the polymerization method 有权
标题翻译：聚合小寡核苷酸的方法，以及使用通过聚合法制备的高分子寡核苷酸
公开(公告)号：US08530047B2
公开(公告)日：2013-09-10
申请号：US13142876
申请日：2010-03-02
申请人： KwangMeyung Kim , Ick Chan Kwon , Kui Won Choi , Seung Young Lee , In Chan Youn , Myung Sook Huh , So Jin Lee
发明人： KwangMeyung Kim , Ick Chan Kwon , Kui Won Choi , Seung Young Lee , In Chan Youn , Myung Sook Huh , So Jin Lee
IPC分类号： B32B5/16
CPC分类号： C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/51 , C12N2320/32 , C12N2320/51
摘要： The oligonucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular weight oligonucleotides. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.
摘要翻译：本发明的寡聚体聚合方法的优点在于，可以容易地将分子量小的寡核苷酸聚合成高分子量寡核苷酸。此外，通过本发明的方法制备的高分子量寡核苷酸可以结合亲水性高分子材料或无机材料，然后可以稳定地递送到生物体。因此，通过本发明的方法制备的高分子寡核苷酸可广泛用于治疗各种疾病。

2. 发明授权

US09061068B2 Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding 有权
标题翻译：用于使用电荷相互作用和共价键的siRNA递送的聚合物纳米颗粒
公开(公告)号：US09061068B2
公开(公告)日：2015-06-23
申请号：US12905212
申请日：2010-10-15
申请人： Kwang Meyung Kim , Ick Chan Kwon , Kuiwon Choi , Myung Sook Huh , Seung Young Lee , So Jin Lee
发明人： Kwang Meyung Kim , Ick Chan Kwon , Kuiwon Choi , Myung Sook Huh , Seung Young Lee , So Jin Lee
IPC分类号： C07H21/02 , A61K47/48 , C12N15/11 , C12N15/87
CPC分类号： A61K47/4823 , A61K47/61 , A61K47/6939 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.
摘要翻译：公开了将siRNA与聚合物组合的聚合物-siRNA递送载体及其用途。更具体地，公开了一种稳定的体内聚合物-siRNA递送载体，其中通过使用电荷相互作用和可生物降解的共价键在同一时间将聚合物和siRNA组合起来，以及其用途。通过使用电荷相互作用和可生物降解的共价键合将聚合物和siRNA组合的聚合物-siRNA递送载体在体内对目标部分具有高的siRNA递送效率。因此，根据聚合物-siRNA粘合剂，即使施用相对低的浓度，也可以将治疗用siRNA有效地输送到诸如体内癌组织等目标部位，广泛用于各种治疗各种疾病

3. 发明授权

US08666499B2 Artificial nerve networking system and method for functional recovery of damaged nerve 有权
标题翻译：人工神经网络系统及受损神经功能恢复方法
公开(公告)号：US08666499B2
公开(公告)日：2014-03-04
申请号：US13166250
申请日：2011-06-22
申请人： In Chan Youn , Kui Won Choi , Jun Kyo Suh , Ji Yoon Kang , Jin Seok Kim , Jun Uk Chu , Ick Chan Kwon , Kwang Meyung Kim
发明人： In Chan Youn , Kui Won Choi , Jun Kyo Suh , Ji Yoon Kang , Jin Seok Kim , Jun Uk Chu , Ick Chan Kwon , Kwang Meyung Kim
IPC分类号： A61N1/00
CPC分类号： A61N1/36103 , A61N1/0551 , A61N1/0556 , A61N1/36057 , A61N1/36139 , A61N1/37288
摘要： Disclosed are a system and a method for artificial nerve networking capable of restoring a damaged nerve and allowing selective detection, analysis, transmission and stimulation of a signal from the damaged nerve. The artificial nerve networking system according to an embodiment of the present disclosure includes: a first nerve conduit connected at one end of a damaged nerve; a second nerve conduit connected at the other end of the damaged nerve; and an artificial nerve networking unit electrically connected to the first nerve conduit and the second nerve conduit and recovering the function of the damaged nerve by transmitting and receiving a signal to and from the damaged nerve.
摘要翻译：公开了一种用于人造神经网络的系统和方法，其能够恢复受损的神经，并允许选择性地检测，分析，传输和刺激来自受损神经的信号。根据本公开的实施例的人造神经网络系统包括：在受损神经的一端连接的第一神经导管; 在受损神经的另一端连接的第二神经管; 以及人造神经网络单元，电连接到第一神经导管和第二神经导管，并且通过向受损神经传导和接收信号来恢复受损神经的功能。

4. 发明申请

US20130273519A1 COMPOSITION FOR TREATING BLOOD AND SET OF DIAGNOSTIC KIT COMPRISING THE SAME TO DETECT AUTOIMMUNE DISEASE 审中-公开
标题翻译：用于治疗血液的组合物和包含该组合物的诊断试剂盒用于检测自身免疫疾病
公开(公告)号：US20130273519A1
公开(公告)日：2013-10-17
申请号：US13669187
申请日：2012-11-05
申请人： In Chan Youn , Kwang Meyung Kim , Kui Won Choi , Ick Chan Kwon , Jun Uk Chu , Jong Woong Park , Soo Young Yoon , Sung Jae Choi , Ae Ju Lee , Young Mo Kang
发明人： In Chan Youn , Kwang Meyung Kim , Kui Won Choi , Ick Chan Kwon , Jun Uk Chu , Jong Woong Park , Soo Young Yoon , Sung Jae Choi , Ae Ju Lee , Young Mo Kang
IPC分类号： C12Q1/37 , C12N5/078
CPC分类号： C12Q1/37 , C12N5/0634 , G01N2333/96494 , G01N2800/102
摘要： The present invention relates to a composition for treating blood, a set of a diagnostic kit comprising the same to detect an autoimmune disease, and a method of monitoring an autoimmune disease using the same.An autoimmune disease such as rheumatoid arthritis can be early diagnosed, and disease progression and a treatment response can be precisely predicted, using a technique of amplifying enzyme by stimulating blood obtained from patient.
摘要翻译：本发明涉及一种用于治疗血液的组合物，一套包含该组合物以检测自身免疫疾病的诊断试剂盒，以及使用该组合物监测自身免疫疾病的方法。可以早期诊断自身免疫性疾病，例如类风湿性关节炎，并且可以使用通过刺激从患者获得的血液来扩增酶的技术来精确预测疾病进展和治疗反应。

5. 发明申请

US20120253423A1 Artificial Nerve Networking System and Method for Functional Recovery of Damaged Nerve 有权
标题翻译：人工神经网络系统和损伤神经功能恢复方法
公开(公告)号：US20120253423A1
公开(公告)日：2012-10-04
申请号：US13166250
申请日：2011-06-22
申请人： In Chan Youn , Kui Won Choi , Jun-Kyo Francis Suh , Ji Yoon Kang , Jin Seok Kim , Jun Uk Chu , Ick Chan Kwon , Kwang Meyung Kim
发明人： In Chan Youn , Kui Won Choi , Jun-Kyo Francis Suh , Ji Yoon Kang , Jin Seok Kim , Jun Uk Chu , Ick Chan Kwon , Kwang Meyung Kim
IPC分类号： A61N1/00 , A61B17/00
CPC分类号： A61N1/36103 , A61N1/0551 , A61N1/0556 , A61N1/36057 , A61N1/36139 , A61N1/37288
摘要： Disclosed are a system and a method for artificial nerve networking capable of restoring a damaged nerve and allowing selective detection, analysis, transmission and stimulation of a signal from the damaged nerve. The artificial nerve networking system according to an embodiment of the present disclosure includes: a first nerve conduit connected at one end of a damaged nerve; a second nerve conduit connected at the other end of the damaged nerve; and an artificial nerve networking unit electrically connected to the first nerve conduit and the second nerve conduit and recovering the function of the damaged nerve by transmitting and receiving a signal to and from the damaged nerve.
摘要翻译：公开了一种用于人造神经网络的系统和方法，其能够恢复受损的神经，并允许选择性地检测，分析，传输和刺激来自受损神经的信号。根据本公开的实施例的人造神经网络系统包括：在受损神经的一端连接的第一神经导管; 在受损神经的另一端连接的第二神经管; 以及人造神经网络单元，电连接到第一神经导管和第二神经导管，并且通过向受损神经传导和接收信号来恢复损伤的神经的功能。

6. 发明授权

US08513402B2 Human serum albumin-siRNA nano-sized carrier system 有权
标题翻译：人血清白蛋白siRNA siRNA纳米载体体系
公开(公告)号：US08513402B2
公开(公告)日：2013-08-20
申请号：US13245180
申请日：2011-09-26
申请人： Kwangmeyung Kim , Ick Chan Kwon , Kuiwon Choi , In Chan Youn , MyungSook Huh , Sojin Lee
发明人： Kwangmeyung Kim , Ick Chan Kwon , Kuiwon Choi , In Chan Youn , MyungSook Huh , Sojin Lee
IPC分类号： C07H21/04
CPC分类号： C12N15/111 , A61K47/643 , C12N2320/32
摘要： Disclosed are a human serum albumin-siRNA carrier system having siRNA bound to human serum albumin and a user thereof, and especially, human serum albumin-siRNA carrier system, which has a biodegradable covalent bond between human serum albumin polymer and siRNA and is stable in a living body, and a user thereof.The human serum albumin-siRNA carrier system having the biodegradable covalent bond between the human serum albumin and the siRNA exhibits high siRNA delivery efficiency to a target site in the living body. Therefore, the human serum albumin-siRNA carrier system may allow siRNA for therapy to be efficiently delivered to a target site such as cancer tissues in the living body even by being administrated in a relatively low concentration, which may result in a wide use for therapies of various diseases.
摘要翻译：公开了具有与人血清白蛋白结合的siRNA及其使用者的人血清白蛋白-siRNA载体体系，特别是人血清白蛋白-siRNA载体体系，其在人血清白蛋白聚合物和siRNA之间具有可生物降解的共价键，并且在生物体及其使用者。在人体血清白蛋白和siRNA之间具有可生物降解的共价键的人血清白蛋白-siRNA载体体系对生物体中的靶位点显示出高的siRNA递送效率。因此，人体血清白蛋白-siRNA载体体系可以使siRNA用于治疗有效地递送到目标部位如生物体中的癌组织，甚至通过以相对低的浓度施用，这可能导致广泛用于治疗的各种疾病。

7. 发明授权

US08367042B2 Nanoparticles of light emissive polymers and preparation method thereof 有权
标题翻译：光发射聚合物纳米颗粒及其制备方法
公开(公告)号：US08367042B2
公开(公告)日：2013-02-05
申请号：US12576193
申请日：2009-10-08
申请人： Sehoon Kim , Ick Chan Kwon , Kwangmeyung Kim , Kuiwon Choi , Chang-Keun Lim
发明人： Sehoon Kim , Ick Chan Kwon , Kwangmeyung Kim , Kuiwon Choi , Chang-Keun Lim
IPC分类号： A61B5/00
CPC分类号： A61K49/0019 , A61K49/0093
摘要： Disclosed are nanoparticles of a light emissive polymer, comprising nanoparticles of a cyano-substituted poly(arylene vinylene) polymer; and a biocompatible surfactant adsorbed to the surface of the nanoparticles of the polymer, and preparation method thereof, wherein the method comprises: (1) uniformly mixing a dialdehyde monomer represented by a general formula OHC—Ar1—CHO, a dicyanide monomer represented by a general formula NC—Ar2—CN, and a liquid surfactant; (2) adding water to the resulting mixture to prepare an aqueous micelle dispersion; and (3) adding a polymerization catalyst to the aqueous micelle dispersion, followed by carrying out colloidal polymerization of the resulting mixture at room temperature under an atmosphere. The nanoparticles of the light emissive polymer of the invention are stabilized with a biocompatible surfactant, so that it can form a stable aqueous dispersion phase, and has particle size and fluorescence efficiency suitable for a biomolecular marker or a cell or in vivo imaging; therefore, it can be used as a cell or in vivo light emission contrast agent.
摘要翻译：公开了包含氰基取代的聚（亚芳基亚乙烯基）聚合物的纳米颗粒的发光聚合物的纳米颗粒; 和吸附在聚合物纳米颗粒表面的生物相容性表面活性剂及其制备方法，其中所述方法包括：（1）均匀混合由通式OHC-Ar1-CHO表示的二醛单体，由通式NC-Ar2-CN和液体表面活性剂; （2）向所得混合物中加入水以制备水性胶束分散体; 和（3）将聚合催化剂加入到水性胶束分散体中，然后在室温下在气氛下进行所得混合物的胶体聚合。本发明的光发射聚合物的纳米颗粒用生物相容的表面活性剂稳定，从而可以形成稳定的水分散相，并具有适用于生物分子标记或细胞或体内成像的粒度和荧光效率; 因此，它可以用作细胞或体内发光造影剂。

8. 发明申请

US20120276651A1 FLUORESCENT NANOPROBE FOR DETECTING HYDROGEN PEROXIDE AND FABRICATION METHOD THEREOF 有权
标题翻译：用于检测过氧化氢的荧光纳米微粒及其制备方法
公开(公告)号：US20120276651A1
公开(公告)日：2012-11-01
申请号：US13362183
申请日：2012-01-31
申请人： Sehoon KIM , Ick Chan Kwon , Jai Kyeong Kim , Chang-Keun Lim , Jeongyun Heo
发明人： Sehoon KIM , Ick Chan Kwon , Jai Kyeong Kim , Chang-Keun Lim , Jeongyun Heo
IPC分类号： G01N21/64 , C07C65/05 , C07C255/53 , C07C309/73 , C07C69/732 , C07C49/248 , C07C49/573 , C07D403/10 , C07C69/88 , C07C255/57
CPC分类号： C07D239/60 , C07C39/373 , C07C47/565 , C07C49/248 , C07C49/747 , C07C69/732 , C07C69/94 , C07C255/36 , C07C255/40 , C07C255/41 , C07C309/73 , C07C317/46 , C07C2602/08 , C07D403/10 , Y10T436/206664
摘要： The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water.
摘要翻译：本公开内容涉及通过与过氧化氢反应发射荧光的磺化苯化合物，适用于过氧化氢的实时检测的水分散荧光纳米探针和荧光纳米探针制造方法。荧光纳米探针含有以下磺化苯化合物和水。

9. 发明授权

US09012230B2 Fluorescent nanoprobe for detecting hydrogen peroxide and fabrication method thereof 有权
标题翻译：用于检测过氧化氢的荧光纳米探针及其制造方法
公开(公告)号：US09012230B2
公开(公告)日：2015-04-21
申请号：US13362183
申请日：2012-01-31
申请人： Sehoon Kim , Ick Chan Kwon , Jai Kyeong Kim , Chang-Keun Lim , Jeongyun Heo
发明人： Sehoon Kim , Ick Chan Kwon , Jai Kyeong Kim , Chang-Keun Lim , Jeongyun Heo
IPC分类号： G01N21/64 , C07D239/60 , C07C255/36 , C07C255/40 , C07C255/41 , C07C309/73 , C07C317/46 , C07D403/10 , C07C69/732 , C07C39/373 , C07C69/94 , C07C47/565 , C07C49/248 , C07C49/747
CPC分类号： C07D239/60 , C07C39/373 , C07C47/565 , C07C49/248 , C07C49/747 , C07C69/732 , C07C69/94 , C07C255/36 , C07C255/40 , C07C255/41 , C07C309/73 , C07C317/46 , C07C2602/08 , C07D403/10 , Y10T436/206664
摘要： The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water.
摘要翻译：本公开内容涉及通过与过氧化氢反应发射荧光的磺化苯化合物，适用于过氧化氢的实时检测的水分散荧光纳米探针和荧光纳米探针制造方法。荧光纳米探针含有以下磺化苯化合物和水。

10. 发明申请

US20100041744A1 OILY PACLITAXEL COMPOSITION AND FORMULATION FOR CHEMOEMBOLIZATION AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：油酰胺组合物及其制备方法及其制备方法
公开(公告)号：US20100041744A1
公开(公告)日：2010-02-18
申请号：US12540207
申请日：2009-08-12
申请人： Hesson Chung , Seo Young Jeong , Ick Chan Kwon , Yeong Taek Park , In Hyun Lee , Jae Hyung Park , Jin Wook Chung , Young Man Kim
发明人： Hesson Chung , Seo Young Jeong , Ick Chan Kwon , Yeong Taek Park , In Hyun Lee , Jae Hyung Park , Jin Wook Chung , Young Man Kim
IPC分类号： A61K31/337 , A61P35/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K47/44 , A61K49/0452
摘要： Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof solubilizing paclitaxel in an oily contrast medium. The composition of the present invention solubilizes paclitaxel and has an advantage of delivering anticancer drug to the target cells by chemoembolization since it is possible to visualize the blood vessel during the chemoembolization process. The present invention also relates to oily paclitaxel composition and formulation additionally comprising chemicals that prevent paclitaxel precipitation for prolonged preservation and the preparation method thereof. Since the composition of the present invention solubilize paclitaxel effectively and can be visualized during chemoembolization, it can be used for TACE to treat hepatoma and other solid tumors.
摘要翻译：油性紫杉醇组合物和化疗栓塞制剂及其在油性造影剂中增溶紫杉醇的制备方法。本发明的组合物溶解紫杉醇，并且具有通过化学栓塞将抗癌药物递送至靶细胞的优点，因为在化学栓塞过程中可以使血管可视化。本发明还涉及另外包含防止紫杉醇沉淀用于延长保存的化学物质的油性紫杉醇组合物和制剂及其制备方法。由于本发明的组合物有效地溶解紫杉醇并且可以在化学栓塞期间可视化，所以可用于TACE治疗肝癌和其他实体瘤。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式