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1. 发明授权

US08614285B2 Photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy 有权
标题翻译：基于聚合物衍生物的光敏剂 - 用于光动力疗法的光敏剂共轭物
公开(公告)号：US08614285B2
公开(公告)日：2013-12-24
申请号：US12595103
申请日：2008-04-23
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
IPC分类号： C08F251/00 , A61K31/555
CPC分类号： A61K41/0071 , A61K47/61 , A61K47/6929
摘要： Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.
摘要翻译：公开了一种基于用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物的新型光敏剂，其能够选择性地积累在癌组织中并通过激光照射产生单线态氧或自由基。用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物制备为纳米尺寸颗粒，并且对于癌组织具有优异的选择和积累比。光敏剂共轭物可以通过特定的激光波长产生单线态氧或自由基。由于癌组织的优异的选择和积累比，共轭物使具有低分子量的常规光敏剂的光细胞毒性最小化。因此，缀合物对于具有降低的副作用和优异治疗有效性的光动力疗法的光敏剂是非常有用的。

2. 发明申请

US20110213121A1 NANOPARTICLE SENSOR FOR MEASURING PROTEASE ACTIVITY AND METHOD FOR MANUFACTURING THE SAME 有权
标题翻译：用于测量蛋白酶活性的纳米颗粒传感器及其制造方法
公开(公告)号：US20110213121A1
公开(公告)日：2011-09-01
申请号：US13060902
申请日：2009-08-27
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park , Dae-Hyuk Moon , Dae-Yoon Chi , Seung-Jin Lee , Seung-Jae Myung
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park , Dae-Hyuk Moon , Dae-Yoon Chi , Seung-Jin Lee , Seung-Jae Myung
IPC分类号： C07K9/00 , B82Y5/00
CPC分类号： C12Q1/37 , G01N33/54346 , Y10S977/773 , Y10S977/774 , Y10S977/807 , Y10S977/811 , Y10S977/953
摘要： Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.
摘要翻译：公开了用于测定蛋白酶活性的蛋白酶成像用纳米粒子传感器及其制备方法。更具体地，本发明涉及用于测量蛋白酶活性的纳米颗粒传感器，其中荧光团和猝灭剂缀合的肽底物与生物相容性聚合物纳米颗粒缀合。肽底物被蛋白酶特异性裂解。根据本发明的传感器能够抑制荧光材料上猝灭剂具有高灭绝活性的荧光发射。但是如果肽底物被特异性蛋白酶裂解，则强荧光是特异性发射的。因此，该传感器作为筛选新型药物如蛋白酶过表达抑制剂的方法，以及早期诊断不治之症以及各种疾病，如自身免疫性疾病，包括癌症，骨关节炎，类风湿性关节炎和痴呆症，都是特别有用的。

3. 发明授权

US08841085B2 Nanoparticle sensor for measuring protease activity and method for manufacturing the same 有权
标题翻译：用于测量蛋白酶活性的纳米粒子传感器及其制造方法
公开(公告)号：US08841085B2
公开(公告)日：2014-09-23
申请号：US13060902
申请日：2009-08-27
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park , Dae-Hyuk Moon , Dae-Yoon Chi , Seung-Jin Lee , Seung-Jae Myung
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park , Dae-Hyuk Moon , Dae-Yoon Chi , Seung-Jin Lee , Seung-Jae Myung
IPC分类号： C12Q1/34 , C12Q1/37 , G01N33/543 , C12Q1/04 , C12Q1/06
CPC分类号： C12Q1/37 , G01N33/54346 , Y10S977/773 , Y10S977/774 , Y10S977/807 , Y10S977/811 , Y10S977/953
摘要： Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.
摘要翻译：公开了用于测定蛋白酶活性的蛋白酶成像用纳米粒子传感器及其制备方法。更具体地，本发明涉及用于测量蛋白酶活性的纳米颗粒传感器，其中荧光团和猝灭剂缀合的肽底物与生物相容性聚合物纳米颗粒缀合。肽底物被蛋白酶特异性裂解。根据本发明的传感器能够抑制荧光材料上猝灭剂具有高灭绝活性的荧光发射。但是如果肽底物被特异性蛋白酶裂解，则强荧光是特异性发射的。因此，该传感器作为筛选新型药物如蛋白酶过表达抑制剂的方法，以及早期诊断不治之症以及各种疾病，如自身免疫性疾病，包括癌症，骨关节炎，类风湿性关节炎和痴呆症，都是特别有用的。

4. 发明授权

US08551727B2 Gold nanoparticle based protease imaging probes and use thereof 有权
标题翻译：基于金纳米颗粒的蛋白酶成像探针及其用途
公开(公告)号：US08551727B2
公开(公告)日：2013-10-08
申请号：US12595078
申请日：2008-04-10
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , Cheol-Hee Ahn , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , Cheol-Hee Ahn , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park
IPC分类号： C12Q1/37 , C12Q1/34 , B82B3/00 , C12N11/14 , C12N11/18
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0065 , A61K49/0093 , C12Q1/37
摘要： Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner. Also, the metal nanoparticle is capable of being selectively absorbed into a cell and a tissue so as to be possibly used as a sensor for real-time cell imaging and early diagnosis of non-invasive diseases.
摘要翻译：公开了一种金属纳米颗粒，其上通过蛋白酶和荧光团特异性降解的肽底物被化学修饰以选择性地成像在细胞和人体组织中表达的蛋白酶及其用途。另外，提供了使用金属纳米粒子的蛋白酶的定量分析方法，细胞成像方法和抑制蛋白酶过表达的药物筛选方法。详细地说，本发明涉及一种具有肽底物和与其连接的荧光团的金属纳米颗粒，肽底物和荧光团由于在细胞和人体中以各种方式活化的蛋白酶而被特异性地降解以显示出荧光。因此，金属纳米颗粒可用于以成像方式快速筛选蛋白酶的活化和抑制。此外，金属纳米粒子能够被选择性地吸收到细胞和组织中，以便可能用作用于实时细胞成像和非侵入性疾病的早期诊断的传感器。

5. 发明申请

US20130253606A1 PERIPHERAL NERVE INTERFACE SYSTEM AND METHOD FOR PROSTHETIC HAND CONTROL 有权
标题翻译：外围神经接口系统和前置控制方法
公开(公告)号：US20130253606A1
公开(公告)日：2013-09-26
申请号：US13676598
申请日：2012-11-14
申请人： In Chan Youn , Kui Won Choi , Jun-Kyo Francis Suh , Kwang Meyung Kim , Jun Uk Chu , Sung Min Han , Kang Il Song , Heui Chang Lee , Jong Woong Park
发明人： In Chan Youn , Kui Won Choi , Jun-Kyo Francis Suh , Kwang Meyung Kim , Jun Uk Chu , Sung Min Han , Kang Il Song , Heui Chang Lee , Jong Woong Park
IPC分类号： A61N1/36
CPC分类号： A61N1/36003 , A61B5/04001 , A61B5/4041 , A61B5/6877 , A61F2/583 , A61F2/72 , A61F2002/704 , A61F2002/705 , A61N1/0551
摘要： The present disclosure relates to peripheral nerve interface system and method for prosthetic hand control, which may measure, analyze and control efferent motor nerve signals and afferent sensory nerve signals by regenerating a peripheral nerve and control an artificial prosthetic hand by means of the measurement, analysis and control of the signals. For this, the peripheral nerve interface system according to an embodiment of the present disclosure includes: a nerve conduit connected to a terminal of a damaged peripheral nerve at a cut body portion; a prosthesis for substituting for the cut body portion; and a peripheral nerve interface unit electrically connected to the nerve conduit and the prosthesis to restore a function of the damaged peripheral nerve and control operations of the prosthesis by transmitting and receiving signals of the damaged peripheral nerve.
摘要翻译：本公开涉及用于假肢手部控制的周围神经接口系统和方法，其可以通过再生周围神经并通过测量，分析来控制人造假手来测量，分析和控制传出的运动神经信号和传入感觉神经信号并控制信号。为此，根据本公开的实施方式的周围神经接口系统包括：连接到切割体部分的损伤的周围神经的末端的神经导管; 用于代替切割体部分的假体; 以及外周神经接口单元，其电连接到神经导管和假体，以通过发送和接收损伤的周围神经的信号来恢复损伤的周围神经的功能和假体的控制操作。

6. 发明申请

US20100124757A1 GOLD NANOPARTICLE BASED PROTEASE IMAGING PROBES AND USE THEREOF 有权
标题翻译：基于金纳米粒子的蛋白成像探针及其应用
公开(公告)号：US20100124757A1
公开(公告)日：2010-05-20
申请号：US12595078
申请日：2008-04-10
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , Cheol-Hee Ahn , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , Cheol-Hee Ahn , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park
IPC分类号： C12Q1/37 , C07K2/00
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0065 , A61K49/0093 , C12Q1/37
摘要： Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner. Also, the metal nanoparticle is capable of being selectively absorbed into a cell and a tissue so as to be possibly used as a sensor for real-time cell imaging and early diagnosis of non-invasive diseases.
摘要翻译：公开了一种金属纳米颗粒，其上通过蛋白酶和荧光团特异性降解的肽底物被化学修饰以选择性地成像在细胞和人体组织中表达的蛋白酶及其用途。另外，提供了使用金属纳米粒子的蛋白酶的定量分析方法，细胞成像方法和抑制蛋白酶过表达的药物筛选方法。详细地说，本发明涉及一种具有肽底物和与其连接的荧光团的金属纳米颗粒，肽底物和荧光团由于在细胞和人体中以各种方式活化的蛋白酶而被特异性地降解以显示出荧光。因此，金属纳米颗粒可用于以成像方式快速筛选蛋白酶的活化和抑制。此外，金属纳米粒子能够被选择性地吸收到细胞和组织中，以便可能用作用于实时细胞成像和非侵入性疾病的早期诊断的传感器。

7. 发明授权

US08513402B2 Human serum albumin-siRNA nano-sized carrier system 有权
标题翻译：人血清白蛋白siRNA siRNA纳米载体体系
公开(公告)号：US08513402B2
公开(公告)日：2013-08-20
申请号：US13245180
申请日：2011-09-26
申请人： Kwangmeyung Kim , Ick Chan Kwon , Kuiwon Choi , In Chan Youn , MyungSook Huh , Sojin Lee
发明人： Kwangmeyung Kim , Ick Chan Kwon , Kuiwon Choi , In Chan Youn , MyungSook Huh , Sojin Lee
IPC分类号： C07H21/04
CPC分类号： C12N15/111 , A61K47/643 , C12N2320/32
摘要： Disclosed are a human serum albumin-siRNA carrier system having siRNA bound to human serum albumin and a user thereof, and especially, human serum albumin-siRNA carrier system, which has a biodegradable covalent bond between human serum albumin polymer and siRNA and is stable in a living body, and a user thereof.The human serum albumin-siRNA carrier system having the biodegradable covalent bond between the human serum albumin and the siRNA exhibits high siRNA delivery efficiency to a target site in the living body. Therefore, the human serum albumin-siRNA carrier system may allow siRNA for therapy to be efficiently delivered to a target site such as cancer tissues in the living body even by being administrated in a relatively low concentration, which may result in a wide use for therapies of various diseases.
摘要翻译：公开了具有与人血清白蛋白结合的siRNA及其使用者的人血清白蛋白-siRNA载体体系，特别是人血清白蛋白-siRNA载体体系，其在人血清白蛋白聚合物和siRNA之间具有可生物降解的共价键，并且在生物体及其使用者。在人体血清白蛋白和siRNA之间具有可生物降解的共价键的人血清白蛋白-siRNA载体体系对生物体中的靶位点显示出高的siRNA递送效率。因此，人体血清白蛋白-siRNA载体体系可以使siRNA用于治疗有效地递送到目标部位如生物体中的癌组织，甚至通过以相对低的浓度施用，这可能导致广泛用于治疗的各种疾病。

8. 发明申请

US20100222538A1 NOVEL PHOTOSENSITIZER BASED ON POLYMER DERIVATIVES-PHOTOSENSITIZER CONJUGATES FOR PHOTODYNAMIC THERAPY 有权
标题翻译：基于聚合物衍生物的新型光敏剂 - 光致变色治疗光敏剂
公开(公告)号：US20100222538A1
公开(公告)日：2010-09-02
申请号：US12595103
申请日：2008-04-23
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
IPC分类号： C08F251/00
CPC分类号： A61K41/0071 , A61K47/61 , A61K47/6929
摘要： Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.
摘要翻译：公开了一种基于用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物的新型光敏剂，其能够选择性地积累在癌组织中并通过激光照射产生单线态氧或自由基。用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物制备为纳米尺寸颗粒，并且对于癌组织具有优异的选择和积累比。光敏剂共轭物可以通过特定的激光波长产生单线态氧或自由基。由于癌组织的优异的选择和积累比，共轭物使具有低分子量的常规光敏剂的光细胞毒性最小化。因此，缀合物对于具有降低的副作用和优异治疗有效性的光动力疗法的光敏剂是非常有用的。

9. 发明申请

US20130273519A1 COMPOSITION FOR TREATING BLOOD AND SET OF DIAGNOSTIC KIT COMPRISING THE SAME TO DETECT AUTOIMMUNE DISEASE 审中-公开
标题翻译：用于治疗血液的组合物和包含该组合物的诊断试剂盒用于检测自身免疫疾病
公开(公告)号：US20130273519A1
公开(公告)日：2013-10-17
申请号：US13669187
申请日：2012-11-05
申请人： In Chan Youn , Kwang Meyung Kim , Kui Won Choi , Ick Chan Kwon , Jun Uk Chu , Jong Woong Park , Soo Young Yoon , Sung Jae Choi , Ae Ju Lee , Young Mo Kang
发明人： In Chan Youn , Kwang Meyung Kim , Kui Won Choi , Ick Chan Kwon , Jun Uk Chu , Jong Woong Park , Soo Young Yoon , Sung Jae Choi , Ae Ju Lee , Young Mo Kang
IPC分类号： C12Q1/37 , C12N5/078
CPC分类号： C12Q1/37 , C12N5/0634 , G01N2333/96494 , G01N2800/102
摘要： The present invention relates to a composition for treating blood, a set of a diagnostic kit comprising the same to detect an autoimmune disease, and a method of monitoring an autoimmune disease using the same.An autoimmune disease such as rheumatoid arthritis can be early diagnosed, and disease progression and a treatment response can be precisely predicted, using a technique of amplifying enzyme by stimulating blood obtained from patient.
摘要翻译：本发明涉及一种用于治疗血液的组合物，一套包含该组合物以检测自身免疫疾病的诊断试剂盒，以及使用该组合物监测自身免疫疾病的方法。可以早期诊断自身免疫性疾病，例如类风湿性关节炎，并且可以使用通过刺激从患者获得的血液来扩增酶的技术来精确预测疾病进展和治疗反应。

10. 发明授权

US08530047B2 Method for polymerizing a small oligonucleotide, and use of a high-molecular oligonucleotide prepared by the polymerization method 有权
标题翻译：聚合小寡核苷酸的方法，以及使用通过聚合法制备的高分子寡核苷酸
公开(公告)号：US08530047B2
公开(公告)日：2013-09-10
申请号：US13142876
申请日：2010-03-02
申请人： KwangMeyung Kim , Ick Chan Kwon , Kui Won Choi , Seung Young Lee , In Chan Youn , Myung Sook Huh , So Jin Lee
发明人： KwangMeyung Kim , Ick Chan Kwon , Kui Won Choi , Seung Young Lee , In Chan Youn , Myung Sook Huh , So Jin Lee
IPC分类号： B32B5/16
CPC分类号： C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/51 , C12N2320/32 , C12N2320/51
摘要： The oligonucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular weight oligonucleotides. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.
摘要翻译：本发明的寡聚体聚合方法的优点在于，可以容易地将分子量小的寡核苷酸聚合成高分子量寡核苷酸。此外，通过本发明的方法制备的高分子量寡核苷酸可以结合亲水性高分子材料或无机材料，然后可以稳定地递送到生物体。因此，通过本发明的方法制备的高分子寡核苷酸可广泛用于治疗各种疾病。

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