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1. 发明申请

US20120276651A1 FLUORESCENT NANOPROBE FOR DETECTING HYDROGEN PEROXIDE AND FABRICATION METHOD THEREOF 有权
标题翻译：用于检测过氧化氢的荧光纳米微粒及其制备方法
公开(公告)号：US20120276651A1
公开(公告)日：2012-11-01
申请号：US13362183
申请日：2012-01-31
申请人： Sehoon KIM , Ick Chan Kwon , Jai Kyeong Kim , Chang-Keun Lim , Jeongyun Heo
发明人： Sehoon KIM , Ick Chan Kwon , Jai Kyeong Kim , Chang-Keun Lim , Jeongyun Heo
IPC分类号： G01N21/64 , C07C65/05 , C07C255/53 , C07C309/73 , C07C69/732 , C07C49/248 , C07C49/573 , C07D403/10 , C07C69/88 , C07C255/57
CPC分类号： C07D239/60 , C07C39/373 , C07C47/565 , C07C49/248 , C07C49/747 , C07C69/732 , C07C69/94 , C07C255/36 , C07C255/40 , C07C255/41 , C07C309/73 , C07C317/46 , C07C2602/08 , C07D403/10 , Y10T436/206664
摘要： The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water.
摘要翻译：本公开内容涉及通过与过氧化氢反应发射荧光的磺化苯化合物，适用于过氧化氢的实时检测的水分散荧光纳米探针和荧光纳米探针制造方法。荧光纳米探针含有以下磺化苯化合物和水。

2. 发明授权

US09012230B2 Fluorescent nanoprobe for detecting hydrogen peroxide and fabrication method thereof 有权
标题翻译：用于检测过氧化氢的荧光纳米探针及其制造方法
公开(公告)号：US09012230B2
公开(公告)日：2015-04-21
申请号：US13362183
申请日：2012-01-31
申请人： Sehoon Kim , Ick Chan Kwon , Jai Kyeong Kim , Chang-Keun Lim , Jeongyun Heo
发明人： Sehoon Kim , Ick Chan Kwon , Jai Kyeong Kim , Chang-Keun Lim , Jeongyun Heo
IPC分类号： G01N21/64 , C07D239/60 , C07C255/36 , C07C255/40 , C07C255/41 , C07C309/73 , C07C317/46 , C07D403/10 , C07C69/732 , C07C39/373 , C07C69/94 , C07C47/565 , C07C49/248 , C07C49/747
CPC分类号： C07D239/60 , C07C39/373 , C07C47/565 , C07C49/248 , C07C49/747 , C07C69/732 , C07C69/94 , C07C255/36 , C07C255/40 , C07C255/41 , C07C309/73 , C07C317/46 , C07C2602/08 , C07D403/10 , Y10T436/206664
摘要： The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water.
摘要翻译：本公开内容涉及通过与过氧化氢反应发射荧光的磺化苯化合物，适用于过氧化氢的实时检测的水分散荧光纳米探针和荧光纳米探针制造方法。荧光纳米探针含有以下磺化苯化合物和水。

3. 发明授权

US08367042B2 Nanoparticles of light emissive polymers and preparation method thereof 有权
标题翻译：光发射聚合物纳米颗粒及其制备方法
公开(公告)号：US08367042B2
公开(公告)日：2013-02-05
申请号：US12576193
申请日：2009-10-08
申请人： Sehoon Kim , Ick Chan Kwon , Kwangmeyung Kim , Kuiwon Choi , Chang-Keun Lim
发明人： Sehoon Kim , Ick Chan Kwon , Kwangmeyung Kim , Kuiwon Choi , Chang-Keun Lim
IPC分类号： A61B5/00
CPC分类号： A61K49/0019 , A61K49/0093
摘要： Disclosed are nanoparticles of a light emissive polymer, comprising nanoparticles of a cyano-substituted poly(arylene vinylene) polymer; and a biocompatible surfactant adsorbed to the surface of the nanoparticles of the polymer, and preparation method thereof, wherein the method comprises: (1) uniformly mixing a dialdehyde monomer represented by a general formula OHC—Ar1—CHO, a dicyanide monomer represented by a general formula NC—Ar2—CN, and a liquid surfactant; (2) adding water to the resulting mixture to prepare an aqueous micelle dispersion; and (3) adding a polymerization catalyst to the aqueous micelle dispersion, followed by carrying out colloidal polymerization of the resulting mixture at room temperature under an atmosphere. The nanoparticles of the light emissive polymer of the invention are stabilized with a biocompatible surfactant, so that it can form a stable aqueous dispersion phase, and has particle size and fluorescence efficiency suitable for a biomolecular marker or a cell or in vivo imaging; therefore, it can be used as a cell or in vivo light emission contrast agent.
摘要翻译：公开了包含氰基取代的聚（亚芳基亚乙烯基）聚合物的纳米颗粒的发光聚合物的纳米颗粒; 和吸附在聚合物纳米颗粒表面的生物相容性表面活性剂及其制备方法，其中所述方法包括：（1）均匀混合由通式OHC-Ar1-CHO表示的二醛单体，由通式NC-Ar2-CN和液体表面活性剂; （2）向所得混合物中加入水以制备水性胶束分散体; 和（3）将聚合催化剂加入到水性胶束分散体中，然后在室温下在气氛下进行所得混合物的胶体聚合。本发明的光发射聚合物的纳米颗粒用生物相容的表面活性剂稳定，从而可以形成稳定的水分散相，并具有适用于生物分子标记或细胞或体内成像的粒度和荧光效率; 因此，它可以用作细胞或体内发光造影剂。

4. 发明申请

US20100290999A1 NANOPARTICLES OF LIGHT EMISSIVE POLYMERS AND PREPARATION METHOD THEREOF 有权
标题翻译：光散射聚合物纳米微粒及其制备方法
公开(公告)号：US20100290999A1
公开(公告)日：2010-11-18
申请号：US12576193
申请日：2009-10-08
申请人： Sehoon KIM , Ick Chan KWON , Kwangmeyung KIM , Kuiwon CHOI , Chang-Keun LIM
发明人： Sehoon KIM , Ick Chan KWON , Kwangmeyung KIM , Kuiwon CHOI , Chang-Keun LIM
IPC分类号： A61K49/00 , C08G14/02 , C12Q1/02
CPC分类号： A61K49/0019 , A61K49/0093
摘要： Disclosed are nanoparticles of a light emissive polymer, comprising nanoparticles of a cyano-substituted poly(arylene vinylene) polymer; and a biocompatible surfactant adsorbed to the surface of the nanoparticles of the polymer, and preparation method thereof, wherein the method comprises: (1) uniformly mixing a dialdehyde monomer represented by a general formula OHC—Ar1—CHO, a dicyanide monomer represented by a general formula NC—Ar2—CN, and a liquid surfactant; (2) adding water to the resulting mixture to prepare an aqueous micelle dispersion; and (3) adding a polymerization catalyst to the aqueous micelle dispersion, followed by carrying out colloidal polymerization of the resulting mixture at room temperature under an atmosphere. The nanoparticles of the light emissive polymer of the invention are stabilized with a biocompatible surfactant, so that it can form a stable aqueous dispersion phase, and has particle size and fluorescence efficiency suitable for a biomolecular marker or a cell or in vivo imaging; therefore, it can be used as a cell or in vivo light emission contrast agent.
摘要翻译：公开了包含氰基取代的聚（亚芳基亚乙烯基）聚合物的纳米颗粒的发光聚合物的纳米颗粒; 和吸附在聚合物纳米颗粒表面的生物相容性表面活性剂及其制备方法，其中所述方法包括：（1）均匀混合由通式OHC-Ar1-CHO表示的二醛单体，由通式NC-Ar2-CN，和液体表面活性剂; （2）向所得混合物中加入水以制备水性胶束分散体; 和（3）将聚合催化剂加入到水性胶束分散体中，然后在室温下在气氛下进行所得混合物的胶体聚合。本发明的光发射聚合物的纳米颗粒用生物相容的表面活性剂稳定，从而可以形成稳定的水分散相，并具有适用于生物分子标记或细胞或体内成像的粒度和荧光效率; 因此，它可以用作细胞或体内发光造影剂。

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