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1. 发明授权

US08367042B2 Nanoparticles of light emissive polymers and preparation method thereof 有权
标题翻译：光发射聚合物纳米颗粒及其制备方法
公开(公告)号：US08367042B2
公开(公告)日：2013-02-05
申请号：US12576193
申请日：2009-10-08
申请人： Sehoon Kim , Ick Chan Kwon , Kwangmeyung Kim , Kuiwon Choi , Chang-Keun Lim
发明人： Sehoon Kim , Ick Chan Kwon , Kwangmeyung Kim , Kuiwon Choi , Chang-Keun Lim
IPC分类号： A61B5/00
CPC分类号： A61K49/0019 , A61K49/0093
摘要： Disclosed are nanoparticles of a light emissive polymer, comprising nanoparticles of a cyano-substituted poly(arylene vinylene) polymer; and a biocompatible surfactant adsorbed to the surface of the nanoparticles of the polymer, and preparation method thereof, wherein the method comprises: (1) uniformly mixing a dialdehyde monomer represented by a general formula OHC—Ar1—CHO, a dicyanide monomer represented by a general formula NC—Ar2—CN, and a liquid surfactant; (2) adding water to the resulting mixture to prepare an aqueous micelle dispersion; and (3) adding a polymerization catalyst to the aqueous micelle dispersion, followed by carrying out colloidal polymerization of the resulting mixture at room temperature under an atmosphere. The nanoparticles of the light emissive polymer of the invention are stabilized with a biocompatible surfactant, so that it can form a stable aqueous dispersion phase, and has particle size and fluorescence efficiency suitable for a biomolecular marker or a cell or in vivo imaging; therefore, it can be used as a cell or in vivo light emission contrast agent.
摘要翻译：公开了包含氰基取代的聚（亚芳基亚乙烯基）聚合物的纳米颗粒的发光聚合物的纳米颗粒; 和吸附在聚合物纳米颗粒表面的生物相容性表面活性剂及其制备方法，其中所述方法包括：（1）均匀混合由通式OHC-Ar1-CHO表示的二醛单体，由通式NC-Ar2-CN和液体表面活性剂; （2）向所得混合物中加入水以制备水性胶束分散体; 和（3）将聚合催化剂加入到水性胶束分散体中，然后在室温下在气氛下进行所得混合物的胶体聚合。本发明的光发射聚合物的纳米颗粒用生物相容的表面活性剂稳定，从而可以形成稳定的水分散相，并具有适用于生物分子标记或细胞或体内成像的粒度和荧光效率; 因此，它可以用作细胞或体内发光造影剂。

2. 发明授权

US08513402B2 Human serum albumin-siRNA nano-sized carrier system 有权
标题翻译：人血清白蛋白siRNA siRNA纳米载体体系
公开(公告)号：US08513402B2
公开(公告)日：2013-08-20
申请号：US13245180
申请日：2011-09-26
申请人： Kwangmeyung Kim , Ick Chan Kwon , Kuiwon Choi , In Chan Youn , MyungSook Huh , Sojin Lee
发明人： Kwangmeyung Kim , Ick Chan Kwon , Kuiwon Choi , In Chan Youn , MyungSook Huh , Sojin Lee
IPC分类号： C07H21/04
CPC分类号： C12N15/111 , A61K47/643 , C12N2320/32
摘要： Disclosed are a human serum albumin-siRNA carrier system having siRNA bound to human serum albumin and a user thereof, and especially, human serum albumin-siRNA carrier system, which has a biodegradable covalent bond between human serum albumin polymer and siRNA and is stable in a living body, and a user thereof.The human serum albumin-siRNA carrier system having the biodegradable covalent bond between the human serum albumin and the siRNA exhibits high siRNA delivery efficiency to a target site in the living body. Therefore, the human serum albumin-siRNA carrier system may allow siRNA for therapy to be efficiently delivered to a target site such as cancer tissues in the living body even by being administrated in a relatively low concentration, which may result in a wide use for therapies of various diseases.
摘要翻译：公开了具有与人血清白蛋白结合的siRNA及其使用者的人血清白蛋白-siRNA载体体系，特别是人血清白蛋白-siRNA载体体系，其在人血清白蛋白聚合物和siRNA之间具有可生物降解的共价键，并且在生物体及其使用者。在人体血清白蛋白和siRNA之间具有可生物降解的共价键的人血清白蛋白-siRNA载体体系对生物体中的靶位点显示出高的siRNA递送效率。因此，人体血清白蛋白-siRNA载体体系可以使siRNA用于治疗有效地递送到目标部位如生物体中的癌组织，甚至通过以相对低的浓度施用，这可能导致广泛用于治疗的各种疾病。

3. 发明授权

US08541378B2 Recombinant albumins fused with poly-cysteine peptide and the methods for preparing the same 有权
标题翻译：与多聚半胱氨酸肽融合的重组白蛋白及其制备方法
公开(公告)号：US08541378B2
公开(公告)日：2013-09-24
申请号：US12792186
申请日：2010-06-02
申请人： Hyung Jun Ahn , Ick Chan Kwon , Kuiwon Choi , Kwangmyeng Kim , Inchan Youn , Sehoon Kim
发明人： Hyung Jun Ahn , Ick Chan Kwon , Kuiwon Choi , Kwangmyeng Kim , Inchan Youn , Sehoon Kim
IPC分类号： A61K38/10
CPC分类号： C07K14/76 , A61K47/643 , C07K14/765 , C07K2319/20
摘要： The present invention relates to recombinant albumins fused with poly-cysteine peptide and methods for preparing the same, more precisely recombinant albumins in which cysteines that can be used for drug binding are amplified at N-terminal and C-terminal of the albumin and methods for preparing the same. The recombinant albumin of the present invention demonstrates improved albumin-drug conjugation efficiency when it is used for drug delivery system, indicating that it can effectively deliver a large amount of drug to a target tissue. At the same time, the recombinant albumin of the present invention can be used as an excellent drug deliverer with reduced side effects, compared with the conventional albumin carriers, by regulating the amount of drug conjugated to each unit of albumin by regulating the number of cysteine fused thereto. In addition, the recombinant albumin of the present invention can be used for the screening of a novel drug and for the non-invasive real-time diagnosis and treatment of disease by combining with a fluorescent material or a contrast agent for molecular imaging.
摘要翻译：本发明涉及与多聚半胱氨酸肽融合的重组白蛋白及其制备方法，更准确地说，重组白蛋白，其中可用于药物结合的半胱氨酸在白蛋白的N末端和C末端扩增，准备一样本发明的重组白蛋白在用于药物递送系统时表现出改善的白蛋白 - 药物共轭效率，表明其可有效地将大量药物递送至靶组织。同时，与常规白蛋白载体相比，本发明的重组白蛋白可以用作优异的药物递送剂，通过调节半胱氨酸数目调节与每单位白蛋白结合的药物量融合。此外，本发明的重组白蛋白可以用于筛选新药和用于分子成像的荧光材料或造影剂的非侵入性实时诊断和治疗疾病。

4. 发明授权

US09061068B2 Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding 有权
标题翻译：用于使用电荷相互作用和共价键的siRNA递送的聚合物纳米颗粒
公开(公告)号：US09061068B2
公开(公告)日：2015-06-23
申请号：US12905212
申请日：2010-10-15
申请人： Kwang Meyung Kim , Ick Chan Kwon , Kuiwon Choi , Myung Sook Huh , Seung Young Lee , So Jin Lee
发明人： Kwang Meyung Kim , Ick Chan Kwon , Kuiwon Choi , Myung Sook Huh , Seung Young Lee , So Jin Lee
IPC分类号： C07H21/02 , A61K47/48 , C12N15/11 , C12N15/87
CPC分类号： A61K47/4823 , A61K47/61 , A61K47/6939 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.
摘要翻译：公开了将siRNA与聚合物组合的聚合物-siRNA递送载体及其用途。更具体地，公开了一种稳定的体内聚合物-siRNA递送载体，其中通过使用电荷相互作用和可生物降解的共价键在同一时间将聚合物和siRNA组合起来，以及其用途。通过使用电荷相互作用和可生物降解的共价键合将聚合物和siRNA组合的聚合物-siRNA递送载体在体内对目标部分具有高的siRNA递送效率。因此，根据聚合物-siRNA粘合剂，即使施用相对低的浓度，也可以将治疗用siRNA有效地输送到诸如体内癌组织等目标部位，广泛用于各种治疗各种疾病

5. 发明授权

US06451348B1 Method of manufacturing porous matrix-type controlled release systems using emulsion technique 失效
标题翻译：使用乳液技术制造多孔基质型控释系统的方法
公开(公告)号：US06451348B1
公开(公告)日：2002-09-17
申请号：US09331991
申请日：2000-01-03
申请人： Seo Young Jeong , Kuiwon Choi , Ick-Chan Kwon , Yong-Hee Kim , Jae Bong Choi , Kyu Back Lee
发明人： Seo Young Jeong , Kuiwon Choi , Ick-Chan Kwon , Yong-Hee Kim , Jae Bong Choi , Kyu Back Lee
IPC分类号： A61K900
CPC分类号： A61K9/7007 , Y10S514/953 , Y10S514/964 , Y10S514/975
摘要： A method of manufacturing a porous matrix-type drug delivery system is provided. It comprises the steps of: dispersing, stirring, and emulsifying an aqueous solution of a drug in an organic solvent having a polymer compound and a surface active agent solved therein; thereafter forming it into a desirable matrix shape; lyophilizing or drying it at a low temperature or room temperature until the matrix surface is hardened; and drying it again in order to remove the water and the organic solvent.
摘要翻译：提供一种制造多孔基质型药物递送系统的方法。它包括以下步骤：将药物的水溶液分散，搅拌和乳化在溶解有高分子化合物和表面活性剂的有机溶剂中; 然后将其形成为期望的矩阵形状; 在低温或室温下冻干或干燥，直到基质表面硬化; 并再次干燥以除去水和有机溶剂。

6. 发明授权

US07510866B2 Hybrid bioreactor for cell culture 失效
标题翻译：用于细胞培养的混合生物反应器
公开(公告)号：US07510866B2
公开(公告)日：2009-03-31
申请号：US10535141
申请日：2003-10-29
申请人： Kuiwon Choi , Tae Soo Bae , Jung Kyu Kim , Chang Yang Lee
发明人： Kuiwon Choi , Tae Soo Bae , Jung Kyu Kim , Chang Yang Lee
IPC分类号： C12M1/00
CPC分类号： C12M27/10 , C12M23/08 , C12M23/46 , Y10S623/911 , Y10S623/917 , Y10S623/924
摘要： A hybrid bioreactor for cell culture is disclosed. To simultaneously apply compressive strain for cell differentiation and shear strain for cell proliferation to cells, the hybrid bioreactor includes a plurality of reactor tube assemblies (100), a compressive strain motor (5), a shear strain motor (25), a lower anchor mount (20) having a plurality of toothed anchors (70) to respectively anchor the lower ends of the reactor tube assemblies (100) to the lower anchor mount (20), a ball screw (90) operated in conjunction with the compressive strain motor (5), an upper anchor mount (60) which engages with the ball screw (90) to vertically move upward and downward and having a plurality of compressive strain anchors (80) to anchor the upper ends of the reactor tube assemblies (100) to the upper anchor mount (60), a power transmission unit to transmit the rotating force of the shear strain motor (25) to the toothed anchors (70).
摘要翻译：公开了用于细胞培养的杂交生物反应器。为了同时将细胞分化的压缩应变和细胞增殖的剪切应变施加到细胞，混合生物反应器包括多个反应器管组件（100），压缩应变马达（5），剪切应变马达（25），下锚安装件（20）具有多个齿形锚固件（70），以将反应器管组件（100）的下端分别锚固到下部锚固件安装件（20）;滚珠丝杠（90），与压缩应变马达（5），与所述滚珠丝杠（90）接合以垂直向上和向下移动并具有多个压缩应变锚（80）以锚固所述反应器管组件（100）的上端的上锚固支架（60）到上锚固装置（60），用于将剪切应变马达（25）的旋转力传递到齿形锚杆（70）的动力传递单元。

7. 发明申请

US20060068492A1 Hybrid bioreactor for cell culture 失效
标题翻译：用于细胞培养的混合生物反应器
公开(公告)号：US20060068492A1
公开(公告)日：2006-03-30
申请号：US10535141
申请日：2003-10-29
申请人： Kuiwon Choi , Jung Kim , Tae Bae , Chang Lee
发明人： Kuiwon Choi , Jung Kim , Tae Bae , Chang Lee
IPC分类号： C12M3/00
CPC分类号： C12M27/10 , C12M23/08 , C12M23/46 , Y10S623/911 , Y10S623/917 , Y10S623/924
摘要： A hybrid bioreactor for cell culture is disclosed. To simultaneously apply compressive strain for cell differentiation and shear strain for cell proliferation to cells, the hybrid bioreactor includes a plurality of reactor tube assemblies (100), a compressive strain motor (5), a shear strain motor (25), a lower anchor mount (20) having a plurality of toothed anchors (70) to respectively anchor the lower ends of the reactor tube assemblies (100) to the lower anchor mount (20), a ball screw (90) operated in conjunction with the compressive strain motor (5), an upper anchor mount (60) which engages with the ball screw (90) to vertically move upward and downward and having a plurality of compressive strain anchors (80) to anchor the upper ends of the reactor tube assemblies (100) to the upper anchor mount (60), a power transmission unit to transmit the rotating force of the shear strain motor (25) to the toothed anchors (70).
摘要翻译：公开了用于细胞培养的杂交生物反应器。为了同时将细胞分化的压缩应变和细胞增殖的剪切应变施加到细胞，混合生物反应器包括多个反应器管组件（100），压缩应变马达（5），剪切应变马达（25），下锚安装件（20）具有多个齿形锚固件（70），以将反应器管组件（100）的下端分别锚固到下部锚固件安装件（20）;滚珠丝杠（90），与压缩应变马达（5），与所述滚珠丝杠（90）接合以垂直向上和向下移动并具有多个压缩应变锚（80）以锚固所述反应器管组件（100）的上端的上锚固支架（60）到上锚固装置（60），用于将剪切应变马达（25）的旋转力传递到齿形锚杆（70）的动力传递单元。

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