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1. 发明申请

WO2009144660A1 DEVICE AND METHODS FOR DETECTING ANALYTES IN SALIVA 审中-公开
标题翻译：用于检测SALIVA中分析物的装置和方法
公开(公告)号：WO2009144660A1
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052196
申请日：2009-05-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COZART BIOSCIENCE LIMITED , NIEUWENHUIS, Jeroen, H. , JEHANLI, Ahmed, M., T. , DE THEIJE, Femke, K. , PELSSERS, Eduard, G., M.
发明人： NIEUWENHUIS, Jeroen, H. , JEHANLI, Ahmed, M., T. , DE THEIJE, Femke, K. , PELSSERS, Eduard, G., M.
IPC分类号： G01N33/543
CPC分类号： G01N33/9486 , B01L3/502753 , G01N27/745 , G01N33/54326 , G01N33/54393 , G01N33/946
摘要： The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the preence of on e or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one ormore analytes and/or analyte analogues.
摘要翻译：本发明提供了一种用于检测唾液中的药物或其他化合物的装置。因此，本发明提供了一种用于检测唾液样品中e或更多分析物的优先性的装置，其包括：（a）用于特异性或非特异性地去除唾液部分的至少一部分的一个或多个预处理区域样品干扰一种或多种分析物的检测; 和（b）包含生物传感器表面的检测区域，所述表面包括：能够特异性结合所述一种或多种分析物的分子; 或一种或多种分析物和/或分析物类似物。

2. 发明授权

EP2181333B1 METHODS AND SYSTEMS FOR DETECTING 有权转让
标题翻译：检测方法和系统
公开(公告)号：EP2181333B1
公开(公告)日：2012-05-23
申请号：EP08789360.8
申请日：2008-07-18
申请人： Koninklijke Philips Electronics N.V. , Cozart Bioscience Limited
发明人： DE THEIJE, Femke, K. , VAN DER WIJK, Thea , IMMINK, Albert, H., J. , PELSSERS, Eduard, G., M. , HARDEMAN, Wilhelmina, M. , MARLIN, Sandra , JOWETT, Gordon, T.
IPC分类号： G01N33/543 , G01N27/74
CPC分类号： G01N33/54366 , G01N27/745 , Y10T29/49885
摘要： A system and method is described wherein components of the reagent (4), e.g. labelled antibodies, are separated from the biologically active sensor surface (5) by depositing the reagent (4) on a carrier surface (3) distinct from the sensor surface (5) in the detection region (2), e.g. detection chamber. In this way, a high assay reproducibility is obtained. By allowing a short, well-defined and controlled, pre-incubation time between the particles of interest, e.g. drugs, in the sample fluid (20) and the reagent (4), the reproducibility will be increased, whereas the speed of the assay is guaranteed by having all components in one detection region (2), e.g. detection chamber.

3. 发明公开

EP2283361A1 DEVICE AND METHODS FOR DETECTING ANALYTES IN SALIVA 有权转让
标题翻译：装置和方法分析物中的SPIT检测
公开(公告)号：EP2283361A1
公开(公告)日：2011-02-16
申请号：EP09754286.4
申请日：2009-05-26
申请人： Koninklijke Philips Electronics N.V. , Cozart Bioscience Limited
发明人： NIEUWENHUIS, Jeroen, H. , JEHANLI, Ahmed, M., T. , DE THEIJE, Femke, K. , PELSSERS, Eduard, G., M.
IPC分类号： G01N33/543
CPC分类号： G01N33/9486 , B01L3/502753 , G01N27/745 , G01N33/54326 , G01N33/54393 , G01N33/946
摘要： The invention provides a device for detecting drugs of abuse or other compounds in saliva. The invention thus provides a device for detecting the preence of on e or more analytes in a saliva sample, comprising: (a) One or more pre-treatment regions for specifically or non-specifically removing at least a part of the fraction of the saliva sample interfering with detection of the one or more analytes; and (b) A detection region comprising a biosensor surface, the surface comprising: molecules capable of specifically binding the one or more analytes; or the one ormore analytes and/or analyte analogues.

4. 发明公开

EP2181333A1 METHODS AND SYSTEMS FOR DETECTING 有权转让
标题翻译： ERKENNUNGSVERFAHREN UND -SYSTEME
公开(公告)号：EP2181333A1
公开(公告)日：2010-05-05
申请号：EP08789360.8
申请日：2008-07-18
申请人： Koninklijke Philips Electronics N.V. , Cozart Bioscience Limited
发明人： DE THEIJE, Femke, K. , VAN DER WIJK, Thea , IMMINK, Albert, H., J. , PELSSERS, Eduard, G., M. , HARDEMAN, Wilhelmina, M. , MARLIN, Sandra , JOWETT, Gordon, T.
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N27/745 , Y10T29/49885
摘要： A system and method is described wherein components of the reagent (4), e.g. labelled antibodies, are separated from the biologically active sensor surface (5) by depositing the reagent (4) on a carrier surface (3) distinct from the sensor surface (5) in the detection region (2), e.g. detection chamber. In this way, a high assay reproducibility is obtained. By allowing a short, well-defined and controlled, pre-incubation time between the particles of interest, e.g. drugs, in the sample fluid (20) and the reagent (4), the reproducibility will be increased, whereas the speed of the assay is guaranteed by having all components in one detection region (2), e.g. detection chamber.
摘要翻译：描述了一种系统和方法，其中试剂（4）的组分例如。通过将试剂（4）沉积在与检测区域（2）中的传感器表面（5）不同的载体表面（3）上，例如将标记的抗体与生物活性传感器表面（5）分离。检测室。以这种方式，可以获得高测定重现性。通过允许感兴趣的颗粒之间的短的，明确的和受控的预孵育时间，例如，药物在样品液体（20）和试剂（4）中的重现性将会增加，而测定速度则通过将检测区域（2）中的所有成分（例如，检测室。

5. 发明申请

WO2009013658A3 MICROFLUIDIC METHODS AND SYSTEMS FOR USE IN DETECTING ANALYTES 审中-公开
公开(公告)号：WO2009013658A3
公开(公告)日：2009-01-29
申请号：PCT/IB2008/052803
申请日：2008-07-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VERHOECKX, Godefridus, J. , VAN DAMME, Hendrik, S. , NIEUWENHUIS, Jeroen, H. , SHULEPOV, Sergei , WEEKAMP, Johannes, W. , SIJBERS, Mara, J., J. , BRANS, Harold, J., A. , DE THEIJE, Femke, K. , IMMINK, Albert, H, .J.
发明人： VERHOECKX, Godefridus, J. , VAN DAMME, Hendrik, S. , NIEUWENHUIS, Jeroen, H. , SHULEPOV, Sergei , WEEKAMP, Johannes, W. , SIJBERS, Mara, J., J. , BRANS, Harold, J., A. , DE THEIJE, Femke, K. , IMMINK, Albert, H, .J.
IPC分类号： B01L3/00
摘要： A microfluidic reactor arrangement (100) for use in detecting an analyte in a fluid sample (106) is described. The reactor arrangement is provided with a reagent providing means such that the reagent can be introduced after assembly of the reactor arrangement. The latter can be performed by introducing the reagent in the form of a solution or a dispersion and fixing it on a holding means (118) by removal of the liquid, i.e. by drying, the holding means comprising the reagent in a solid version in the detector chamber. Prior to the introduction of the reagent, components of the reactor arrangement already present, such as the sample inlet can be hydrophilised by a wetting hydrophilising technique. The invention relates to a manufacturing technique as well as to the resulting product. The invention furthermore relates to functionalizing of the reactor arrangement with a particular reagent for particular applications. The latter can be performed well after fabrication and assembly of the major reactor arrangement components.

6. 发明申请

WO2007132367A1 ACCURATE MAGNETIC BIOSENSOR 审中-公开
标题翻译：精密生物传感器
公开(公告)号：WO2007132367A1
公开(公告)日：2007-11-22
申请号：PCT/IB2007/051509
申请日：2007-04-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE THEIJE, Femke, K. , IMMINK, Albert, H., J.
发明人： DE THEIJE, Femke, K. , IMMINK, Albert, H., J.
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , B82Y25/00 , G01N27/745 , H01F1/0054
摘要： A method is provided for determining the concentration of target in a fluid sample using a magnetic label and a magnetic sensor for detection. It was surprisingly found that efficient and accurate measurements can be carried out by determination of a signal as soon as the signal has reached a specified threshold level. In an alternative embodiment, a displacement step is used as soon as the signal has reached a pre-defined threshold level.
摘要翻译：提供了一种用于使用磁性标签和用于检测的磁性传感器来确定流体样品中的靶的浓度的方法。令人惊讶地发现，一旦信号达到指定的阈值水平，就可以通过确定信号来执行有效和准确的测量。在替代实施例中，一旦信号达到预定义的阈值水平，就使用位移步骤。

7. 发明申请

WO2004034482A2 ELECTRIC DEVICE COMPRISING PHASE CHANGE MATERIAL 审中-公开
标题翻译：包含相变材料的电动装置
公开(公告)号：WO2004034482A2
公开(公告)日：2004-04-22
申请号：PCT/IB2003/003865
申请日：2003-08-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LANKHORST, Martijn, H., R. , DE THEIJE, Femke, K. , MEINDERS, Erwin, R. , WOLF, Ronald, M.
发明人： LANKHORST, Martijn, H., R. , DE THEIJE, Femke, K. , MEINDERS, Erwin, R. , WOLF, Ronald, M.
IPC分类号： H01L45/00
CPC分类号： H01L45/06 , G11C13/0004 , H01L27/2409 , H01L27/2436 , H01L45/122 , H01L45/1233 , H01L45/126 , H01L45/1293 , H01L45/144
摘要： The electric device (1, 100) comprises a resistor (36, 250) comprising a phase change material which is able to be in a first phase and in a second phase. The resistor (36, 250) has an electrical resistance which has a first value when the phase change material is in the first phase and a second value when the phase change material is in the second phase. The resistor (36, 250) is electrically connected to a first conductor (3, 130A, 130B) and a second conductor (4, 270), which are able to conduct a current for heating of the phase change material to enable a transition from the first phase to the second phase. The electric device (1, 100) further comprises a layer (20, 39, 126, 140, 260) of a dielectric material for reducing a heat flow to parts of the body (2, 101) free of the resistor (36, 250) during the heating, which dielectric material according to the invention comprises a porous material with pores having a size between 0.5 and 50 nm.
摘要翻译：电装置（1,100）包括电阻器（36,250），电阻器（36,250）包括能够处于第一阶段和第二阶段的相变材料。电阻器（36,250）具有当相变材料处于第一阶段时具有第一值的电阻和当相变材料处于第二阶段时具有第二值。电阻器（36,250）电连接到能够传导用于加热相变材料的电流的第一导体（3,130A，130B）和第二导体（4,270），以实现从第一阶段到第二阶段。电器件（1,100）还包括电介质材料层（20,39,126,140,260），用于减少到没有电阻器（36,250）的本体（2,101）的部分的热流），根据本发明的电介质材料包括具有尺寸在0.5和50nm之间的孔的多孔材料。

8. 发明申请

WO2009072078A1 MAGNETIC WASHING FOR BIOSENSOR 审中-公开
标题翻译：生物传感器的磁性清洗
公开(公告)号：WO2009072078A1
公开(公告)日：2009-06-11
申请号：PCT/IB2008/055096
申请日：2008-12-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE THEIJE, Femke, K. , BRULS, Dominique, M. , VAN DER WIJK, Thea , VERSCHUREN, Coen, A. , IMMINK, Albert, H., J.
发明人： DE THEIJE, Femke, K. , BRULS, Dominique, M. , VAN DER WIJK, Thea , VERSCHUREN, Coen, A. , IMMINK, Albert, H., J.
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N21/552 , G01N21/648 , G01N27/745
摘要： Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components. The reapplication of the magnetic field acts as a magnetic washing step to release unwanted aspecific adsorption binding, leaving the targets, to improve sensitivity with simplified hardware and a reduction in cost and size.
摘要翻译：检测包含磁化或可磁化的目标部件的流体中的磁化或可磁化的目标部件在其他磁化或可磁化部件之间，使用磁场发生器（M1,28）将磁化或可磁化的部件吸引到装订表面。磁场控制器（C1）施加磁场以将磁化的或可磁化的组件在列中集中在结合表面上，随后减小磁场以使柱能够塌陷，以允许更多的部件到达结合表面，并重新应用磁场，以便使其他组分从结合表面上拉出，以便根据结合的目标组分重新制备柱。表面敏感传感器（S1,26,29）检测结合的磁化或可磁化的目标部件。磁场的重新应用充当磁性洗涤步骤以释放不期望的特异性吸附结合，留下目标，以通过简化的硬件提高灵敏度并降低成本和尺寸。

9. 发明申请

WO2009013683A1 METHODS AND SYSTEMS FOR DETECTING 审中-公开
标题翻译：检测方法和系统
公开(公告)号：WO2009013683A1
公开(公告)日：2009-01-29
申请号：PCT/IB2008/052897
申请日：2008-07-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE THEIJE, Femke, K. , VAN DER WIJK, Thea , IMMINK, Albert, H., J. , PELSSERS, Eduard, G., M. , HARDEMAN, Wilhelmina, M. , MARLIN, Sandra , JOWETT, Gordon, T.
发明人： DE THEIJE, Femke, K. , VAN DER WIJK, Thea , IMMINK, Albert, H., J. , PELSSERS, Eduard, G., M. , HARDEMAN, Wilhelmina, M. , MARLIN, Sandra , JOWETT, Gordon, T.
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N27/745 , Y10T29/49885
摘要： A system and method is described wherein components of the reagent (4), e.g. labelled antibodies, are separated from the biologically active sensor surface (5) by depositing the reagent (4) on a carrier surface (3) distinct from the sensor surface (5) in the detection region (2), e.g. detection chamber. In this way, a high assay reproducibility is obtained. By allowing a short, well-defined and controlled, pre-incubation time between the particles of interest, e.g. drugs, in the sample fluid (20) and the reagent (4), the reproducibility will be increased, whereas the speed of the assay is guaranteed by having all components in one detection region (2), e.g. detection chamber.
摘要翻译：描述了一种系统和方法，其中试剂（4）的组分例如。通过将试剂（4）沉积在与检测区域（2）中的传感器表面（5）不同的载体表面（3）上，例如从生物活性传感器表面（5）分离。检测室。以这种方式，获得高的测定重现性。通过在感兴趣的颗粒之间允许短的，明确的和受控的预孵育时间，例如。药物在样品液体（20）和试剂（4）中的重现性将会增加，而测定的速度则通过在一个检测区域（2）中具有所有成分来保证。检测室。

10. 发明申请

WO2009115951A1 CARTRIDGE FOR ASSAYS WITH MAGNETIC PARTICLES 审中-公开
标题翻译：用于磁性颗粒测定的盒子
公开(公告)号：WO2009115951A1
公开(公告)日：2009-09-24
申请号：PCT/IB2009/051021
申请日：2009-03-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SIJBERS, Mara, J., J. , VAN LANKVELT, Petrus, J., W. , DE THEIJE, Femke, K. , NIEUWENHUIS, Jeroen, H.
发明人： SIJBERS, Mara, J., J. , VAN LANKVELT, Petrus, J., W. , DE THEIJE, Femke, K. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01N33/53
CPC分类号： G01N33/54333 , B03C1/282 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N27/745 , G01N33/54373 , G01N33/946 , G01N33/948 , G01N33/9486
摘要： The invention relates to a cartridge (100) and a corresponding sensor device for the detection of target components in a liquid sample. The cartridge (100) comprises a sample chamber(SC), at least two reservoirs(131, 132) that can be furnished with magnetic particles(MP, MP'), and at least two corresponding sensitive zones (121, 122) in which solved magnetic particles and/or target components can be detected. When a magnetic actuation field(B) of a given configuration is established in the sample chamber, the magnetic particles of different reservoirs migrate predominantly to different sensitive zones. Thus a mixing of magnetic particles can be avoided.
摘要翻译：本发明涉及一种用于检测液体样品中的目标组分的盒（100）和相应的传感器装置。盒（100）包括样品室（SC），至少两个可以配备有磁性颗粒（MP，MP'）和至少两个对应的敏感区域（121,122）的储存器（131,132），其中可以检测到溶解的磁性颗粒和/或目标成分。当在样品室中建立给定构造的磁致动场（B）时，不同储层的磁性颗粒主要迁移到不同的敏感区域。因此，可以避免磁性颗粒的混合。

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