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1. 发明申请

WO2009069009A1 OPTICAL DETECTION OF PARTICLES IN A MAGNETIC BIOSENSOR USING A WAVEGUIDE 审中-公开
标题翻译：使用波导的磁性生物传感器中的颗粒的光学检测
公开(公告)号：WO2009069009A1
公开(公告)日：2009-06-04
申请号：PCT/IB2008/050412
申请日：2008-02-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , IMMINK, Albert, H., J. , DE BOER, Dirk, K., G. , PRINS, Menno, W., J. , NIEUWENHUIS, Jeroen, H. , VERSCHUREN, Coen, A.
发明人： JOHNSON, Mark, T. , IMMINK, Albert, H., J. , DE BOER, Dirk, K., G. , PRINS, Menno, W., J. , NIEUWENHUIS, Jeroen, H. , VERSCHUREN, Coen, A.
IPC分类号： G01N21/55 , G01N33/543 , G01N33/487
CPC分类号： G01N27/745 , G01N21/552 , G01N21/7703 , G01N33/54333 , G01N33/54373
摘要： The present invention provides a biosensor device comprising a sensor surface and an optical wave guide having an input, an output and first and second surfaces, said optical wave guide (5) being adapted to direct light entering the optical wave guide (5) through the input (20) to the output (21) via multiple reflections on said first and second surfaces (22, 23) including at least one reflection onsaid first surface (22) under an angle fulfilling the condition of total internal reflection, wherein the sensor surface is adjacent to the first surface of total internal reflection.
摘要翻译：本发明提供了一种生物传感器装置，其包括具有输入，输出和第一和第二表面的传感器表面和光波导，所述光波导（5）适于将进入光波导（5）的光引导通过通过在所述第一和第二表面（22,23）上的多个反射将输入（20）输入（20），所述第一和第二表面（22,23）包括在满足全内反射条件的角度下的至少一个反射的第一表面（22），其中传感器表面与全内反射的第一表面相邻。

2. 发明申请

WO2009066236A1 METHODS AND SYSTEMS FOR COUPLING A BIO-CARTRIDGE WITH AN OPTICAL READER 审中-公开
标题翻译：用于将生物盒与光学读取器耦合的方法和系统
公开(公告)号：WO2009066236A1
公开(公告)日：2009-05-28
申请号：PCT/IB2008/054827
申请日：2008-11-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , IMMINK, Albert, H., J. , PONJEE, Marc, W., G. , GILLIES, Murray, F.
发明人： JOHNSON, Mark, T. , IMMINK, Albert, H., J. , PONJEE, Marc, W., G. , GILLIES, Murray, F.
IPC分类号： G01N21/55 , G01N33/551
CPC分类号： G01N21/552
摘要： In order to obtain an appropriate coupling in a optical sensing system (100) for sensing particle properties of particles (111) in a sample fluid (117) using frustrated total internal reflection, the cartridge (110) and/or the optical catridge reader (130) is provided with an integrated means (150) that assists in providing an optical coupling. The integrated means (150) may for example be adapted for providing an optical coupling material (152) in the gap between the cartridge (110) and the optical cartridge reader (130), for generating a low pressure or vacuum or for generating a pressure on the cartridge (110) so that a light receiving surface (114) of the cartridge (110) is pressed to an optical component (132) of the reader (130). The latter may allow the use offlat cartridges (110) as the optical component (132) for guiding the light appropriately for having frustrated total internal reflection may be present in the reader (130) rather than being part of the cartridge (110).
摘要翻译：为了在光学感测系统（100）中获得适当的耦合，用于使用沮丧的全内反射感测样品流体（117）中的颗粒（111）的颗粒性质，盒（110）和/或光学读取器（ 130）设置有协助提供光耦合的集成装置（150）。集成装置（150）可以例如适于在盒（110）和光盒读取器（130）之间的间隙中提供光耦合材料（152），用于产生低压或真空或产生压力在盒（110）上，使得盒（110）的光接收表面（114）被按压到读取器（130）的光学部件（132）。后者可以允许使用离子盒（110）作为光学部件（132），用于适当地引导光，以使得沮丧的全内反射可能存在于读取器（130）中，而不是成像盒（110）的一部分。

3. 发明申请

WO2009024922A2 METHOD OF DIRECTING MAGNETIC OR MAGNETISABLE OBJECTS TO PREPARE BIO-SENSOR DEVICE 审中-公开
标题翻译：指导磁性或磁性物体以准备生物传感器装置的方法
公开(公告)号：WO2009024922A2
公开(公告)日：2009-02-26
申请号：PCT/IB2008/053313
申请日：2008-08-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , SCHROEDERS, Richard, J., M. , IMMINK, Albert, H., J. , BRANS, Harold, J., A.
发明人： SCHROEDERS, Richard, J., M. , IMMINK, Albert, H., J. , BRANS, Harold, J., A.
IPC分类号： G01N33/543 , G01R33/09
CPC分类号： G01N33/54333 , B82Y25/00 , G01N27/745 , G01N33/54373 , G01R33/093 , G01R33/1269
摘要： A method of preparing a biosensor device having magnetic or magnetisable particles (60) for binding to a target being detected, and having a magnetic field sensor (40) for detecting the magnetic or magnetisable particles (60) after binding, by depositing (410) the magnetic or magnetisable particles (60) on the device, and using a magnetic field to direct (420) the magnetic or magnetisable particles (60) to a free area on the device away from the magnetic field sensor (40), to be available for later use in binding and detecting. This can improve precision of location of the magnetic or magnetisable particles (60) or reduce manufacturing time. The device can be an integrated micro-fluidic device. It can have a built in magnetic field generation means comprising a wire (260, 270) integrated on an integrated circuit (10, 30) of the device.
摘要翻译：制备具有用于结合被检测目标的磁性或可磁化颗粒（60）的生物传感器装置的方法，以及具有用于检测磁性或可磁化颗粒（60）的磁场传感器（40）的生物传感器装置的方法，在结合之后，通过在器件上沉积（410）磁性或可磁化颗粒（60），并且使用磁场将磁性或可磁化颗粒（60）引导（420）到远离磁场的器件上的自由区域传感器（40），以供以后用于装订和检测。这可以提高磁性或可磁化粒子（60）的定位精度或减少制造时间。该装置可以是集成的微流体装置。它可以具有内置的磁场产生装置，该装置包括集成在设备的集成电路（10,30）上的导线（260,270）。

4. 发明申请

WO2007072460A1 SENSING DEVICE AND METHOD FOR DETERMINATION OF THE AMOUNT OF TARGET MOLECULE IN AN ANALYTE 审中-公开
标题翻译：用于确定分析仪中目标分子量的感测装置和方法
公开(公告)号：WO2007072460A1
公开(公告)日：2007-06-28
申请号：PCT/IB2006/055017
申请日：2006-12-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VOSSENAAR, Erik, R. , IMMINK, Albert, H., J.
发明人： VOSSENAAR, Erik, R. , IMMINK, Albert, H., J.
IPC分类号： G01N33/68 , G01N33/543 , G01N33/58 , G01N35/00 , C07K16/42
CPC分类号： G01N33/54326 , G01N33/54373 , G01N33/686 , G01N35/0098
摘要： A sensing device is provided which has a universal sensor surface. This allows easy modification of the detection properties without the need for investigation of the binding properties of a new target to the sensor surface. The device comprises a sensor surface, which has attached thereto a primary capture molecule. The invention further relates to a method for measurement of a target wherein this device is used.
摘要翻译：提供了一种具有通用传感器表面的感测装置。这允许容易地修改检测性能，而不需要研究新的靶标与传感器表面的结合特性。该装置包括传感器表面，其附接有主要捕获分子。本发明还涉及一种用于测量其中使用该装置的目标的方法。

5. 发明申请

WO2005074176A2 FEEDBACK CONTROL LOOP FOR BIT DETECTION IN AN N-DIMENSIONAL DATA BLOCK 审中-公开
标题翻译：用于在N维数据块中进行位检测的反馈控制环
公开(公告)号：WO2005074176A2
公开(公告)日：2005-08-11
申请号：PCT/IB2005050263
申请日：2005-01-24
申请人： KONINKL PHILIPS ELECTRONICS NV , BERGMANS JOHANNES W M , IMMINK ALBERT H J , RIANI JAMAL , COENE WILLEM M J M , VAN BENEDEN STEVEN J-M L , CIACCI MASSIMO , NOWBAKHT IRANI ALI
发明人： BERGMANS JOHANNES W M , IMMINK ALBERT H J , RIANI JAMAL , COENE WILLEM M J M , VAN BENEDEN STEVEN J-M L , CIACCI MASSIMO , NOWBAKHT IRANI ALI
IPC分类号： G11B20/10 , G11B20/18 , H03M13/41 , H04J3/00
CPC分类号： G11B20/10046 , G11B20/10 , G11B20/10009 , G11B20/18 , G11B2020/1275 , G11B2020/1288 , G11B2020/1863 , H03M13/41 , H03M13/6331
摘要： On existing DVD and CD players a control loop is required for the adaptation and timing recovery. For Two-Dimensional Optical Storage such a control loop has drawbacks because PRML detection in the form of a stripe-wise Viterbi detector is used. Such a detector introduces an increasing detection delay when going from the outer rows towards the center of the broad spiral. A feedback loop is arranged to determine an error signal from a first area of the data block where the first area is that area where the error signal can be determined within the shortest period of time. This reduces the duration of the detection step and thus increases the stability of the control loop.
摘要翻译：在现有的DVD和CD播放机上，适配和定时恢复需要一个控制环路。对于二维光学存储，这样的控制回路具有缺点，因为使用了带状维特比检测器形式的PRML检测。这种检测器在从外排朝向宽螺旋的中心时引入增加的检测延迟。反馈环路被布置成确定来自数据块的第一区域的误差信号，其中第一区域是可以在最短时间内确定误差信号的区域。这减少了检测步骤的持续时间，从而增加了控制回路的稳定性。

6. 发明申请

WO2004109927A1 BIT-DETECTION ARRANGEMENT AND APPARATUS FOR REPRODUCING INFORMATION 审中-公开
标题翻译：检测安排和复制信息的装置
公开(公告)号：WO2004109927A1
公开(公告)日：2004-12-16
申请号：PCT/IB2004/050771
申请日：2004-05-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , RUTTEN, Albertus, J., A. , VAN BEURDEN, Nicolaas, J., H., M. , KAHLMAN, Josephus, A., H., M. , IMMINK, Albert, H., J.
发明人： RUTTEN, Albertus, J., A. , VAN BEURDEN, Nicolaas, J., H., M. , KAHLMAN, Josephus, A., H., M. , IMMINK, Albert, H., J.
IPC分类号： H03L7/06
CPC分类号： G11B20/10037 , G11B20/10009 , G11B20/1403 , H03L7/07 , H03L7/0994 , H04L7/0029 , H04L7/0334
摘要： Disclosed is a bit-detection arrangement able to convert an analog signal (AS) having an amplitude into a digital signal (DS) representing a bit sequence from which the analog signal (AS) is derived. The bit-detection arrangement has a phase detector which detect the phase difference between a quantized analog signal and a clock signal C 2 . The phase difference is sampled by an AD converter. The AD converter can sample at a relatively slow rate as the phase difference is a low frequency signal. The sampled phase difference is fed to a digital PLL which outputs a phase signal PHI. The phase signal and the quantized analog signal are used to recreate the digital signal (DS). The current invention is characterized in that the bit decision unit further comprises - at least one additional sample and hold unit SH 2 able to sample the output signal S 1 , using a clock signal C SH2 and wherein the frequency of the clock signal C SH2 is equal to the frequency of clock signal C SH1 and the phase of clock signal C SH2 is substantially different from the phase of clock signal C SH1 , and an output unit for outputting samples of either the sample and hold units SH 1 or SH 2 , wherein the samples of the sample and hold unit SH 1 are outputted when the phase signal PH 1 indicates that the phase difference ΔP 1 is in a first region and the samples of the additional sample and hold unit SH 2 are outputted when the phase signal PH 1 indicates that the phase difference ΔP 1 is in a second region. This has the advantage that the change of bit errors occurring in the presence of phase jitter is reduced.
摘要翻译：公开了一种能够将具有振幅的模拟信号（AS）转换为表示从其中导出模拟信号（AS）的比特序列的数字信号（DS）的比特检测装置。位检测装置具有检测量化模拟信号和时钟信号C2之间的相位差的相位检测器。相位差由AD转换器采样。 AD转换器可以以相对较慢的速率进行采样，因为相位差是低频信号。采样相位差被馈送到输出相位信号PHI的数字PLL。相位信号和量化的模拟信号用于重建数字信号（DS）。本发明的特征在于，比特判定单元还包括：使用时钟信号CSH2对至少一个附加的采样和保持单元SH2进行采样，其中时钟信号CSH2的频率等于频率时钟信号CSH1的相位和时钟信号CSH2的相位与时钟信号CSH1的相位基本不同，以及用于输出采样和保持单元SH1或SH2的采样的输出单元，其中采样和保持单元SH1的采样当相位信号PH1指示相位差ΔP1在第一区域中时，输出相位信号PH1，并且当相位信号PH1指示相位差DeltaP1处于第二区域时，输出附加采样和保持单元SH2的采样。这具有如下优点：在存在相位抖动的情况下发生的位错误的变化被减少。

7. 发明申请

WO2004100151A2 ITERATIVE STRIPWISE TRELLIS-BASED SYMBOL DETECTION METHOD AND DEVICE FOR MULTI-DIMENSIONAL RECORDING SYSTEMS 审中-公开
标题翻译：用于多维记录系统的基于条带的基于条纹的符号检测方法和装置
公开(公告)号：WO2004100151A2
公开(公告)日：2004-11-18
申请号：PCT/IB2004050635
申请日：2004-05-11
申请人： KONINKL PHILIPS ELECTRONICS NV , COENE WILLEM M J M , HEKSTRA ANDRIES P , IMMINK ALBERT H J
发明人： COENE WILLEM M J M , HEKSTRA ANDRIES P , IMMINK ALBERT H J
IPC分类号： G11B20/10 , H03M13/41 , G11B20/00
CPC分类号： H03M13/3905 , G11B20/10009 , G11B20/10296 , G11B20/1217 , G11B2020/1249 , G11B2020/1288 , G11B2220/2541 , H03M13/3961 , H03M13/41 , H03M13/4146 , H03M13/6343 , H03M13/6502 , H03M13/6505
摘要： When processing a two dimensional data area it is known to be advantageous to divide the two dimensional are into stripes and process each stripe using a stripe-wise detector. When processing a data area delimited by more than one guard band it is advantageous to start a subset of bit detectors from each guard band in order to propagate the improved reliability of the side information obtained from the guard band through the subset of detectors. Because the subsets can start processing at the same time the overall detection delay is reduced.
摘要翻译：当处理二维数据区域时，已知有利的是将二维划分成条纹并使用条带式检测器处理每个条带。当处理由多于一个保护带限定的数据区时，有利的是从每个保护带开始位检测器的子集，以便通过检测器子集传播从保护带获得的侧信息的改进的可靠性。因为子集可以同时开始处理，所以整体检测延迟降低。

8. 发明申请

WO2004100150A2 ITERATIVE STRIPEWISE TRELLIS-BASED SYMBOL DETECTION METHOD AND DEVICE FOR MULTI-DIMENSIONAL RECORDING SYSTEMS 审中-公开
标题翻译：用于多维记录系统的基于特征的基于条纹的符号检测方法和装置
公开(公告)号：WO2004100150A2
公开(公告)日：2004-11-18
申请号：PCT/IB2004/050633
申请日：2004-05-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HEKSTRA, Andries, P. , COENE, Willem, M., J., M. , IMMINK, Albert, H., J.
发明人： HEKSTRA, Andries, P. , COENE, Willem, M., J., M. , IMMINK, Albert, H., J.
IPC分类号： G11B20/00
CPC分类号： G11B20/1217 , G11B20/10009 , G11B20/10287 , G11B2020/1249 , G11B2020/1288 , G11B2220/2541
摘要： When processing a two dimensional data area it is known to be advantageous to divide the two dimensional are into stripes and process each stripe using a stripe-wise detector. The stripe being processed shifts row per row downwards. Each stripe has as its output the bit-decisions of the top bit-row of the stripe which is the most reliable. That output bit-row is also used as side-information for the bit detection of the next stripe which is the stripe which is shifted one bit-row downwards. The bit-row just across the bottom of the stripe on the other hand still needs to be determined in the current iteration, so only the initialisation bit-values can be used in the first iteration of the stripe-wise bit-detector. In order to prevent the propagation of errors towards the top bit row of the stripe the relative weight for the bottom branch bit in the figure-of-merit is reduced from the full 100% to a lower fraction.
摘要翻译：当处理二维数据区域时，已知有利的是将二维划分成条纹并使用条带式检测器处理每个条带。正在处理的条带将每行的行向下移动。每个条带作为其输出的最可靠的条纹的顶部位行的位决定。该输出位行还用作下一个条带的位检测的侧信息，该条带是向下移位一个位行的条带。另一方面，恰好跨条纹底部的位行仍然需要在当前迭代中确定，因此只有初始化位值可以在分段位检测器的第一次迭代中使用。为了防止错误向条纹的顶部位行的传播，使得品质因数中的底部分支位的相对权重从全部100％降低到较低的分数。

9. 发明申请

WO2004070951A2 SERVO SYSTEM, APPARATUS COMPRISING A SERVO SYSTEM, SIGMA DELTA MODULATOR, AND INTEGRATED CIRCUIT COMPRISING A SIGMA DELTA MODULATOR 审中-公开
标题翻译：伺服系统，包括伺服系统，SIGMA DELTA调制器的装置以及包括SIGMA DELTA调制器的集成电路
公开(公告)号：WO2004070951A2
公开(公告)日：2004-08-19
申请号：PCT/IB2004050082
申请日：2004-02-06
申请人： KONINKL PHILIPS ELECTRONICS NV , IMMINK ALBERT H J , VAN DEN HOMBERG JOHANNES A T M , STEK AALBERT
发明人： IMMINK ALBERT H J , VAN DEN HOMBERG JOHANNES A T M , STEK AALBERT
IPC分类号： G06J1/00 , G11B7/09 , H03M
CPC分类号： G11B7/0941 , G11B7/094
摘要： A servo system comprising an analog sigma delta modulator for generating a normalized digital error correction signal from first and second analog control signals. The sigma delta modulator comprises an analog low-pass filter, a quantizer delivering the digital error correction signal and a multiplying DA-converter in feedback arrangement between the output of the quantizer and the input of the low-pass filter for multiplying the feedback signals with the sum of the analog control signals.
摘要翻译：一种伺服系统，包括一个模拟西格玛德尔塔调制器，用于从第一和第二模拟控制信号中产生标准化数字纠错信号。 Σ-Δ调制器包括模拟低通滤波器，传送数字误差校正信号的量化器和在量化器的输出与低通滤波器的输入之间的反馈布置中的乘法DA转换器，用于将反馈信号与模拟控制信号的总和。

10. 发明申请

WO2004032334A1 BIT DETECTION METHOD AND DEVICE 审中-公开
标题翻译：位检测方法和装置
公开(公告)号：WO2004032334A1
公开(公告)日：2004-04-15
申请号：PCT/IB2003/004148
申请日：2003-09-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COENE, Willem, M., J., M. , IMMINK, Albert, H., J. , BERGMANS, Johannes, W., M.
发明人： COENE, Willem, M., J., M. , IMMINK, Albert, H., J. , BERGMANS, Johannes, W., M.
IPC分类号： H03M5/14
CPC分类号： G11B20/1217 , G11B20/10009 , G11B20/1426 , G11B2020/1249 , G11B2020/1288 , G11B2220/2541 , H03M5/145
摘要： The present invention relates to a bit detection method for detecting the bit values of bits of a channel data stream stored on a record carrier, wherein the channel data stream resides on an N-dimensional lattice of bits and comprises a plurality of contiguous bit units, each bit unit comprising at least one bit, wherein bit detection for the channel data stream is performed by an iterative procedure, each iteration being carried out on the basis of said bit units, wherein the bit values of the bits of a bit unit are detected by said iterative procedure based on the received HF signal values of the bits of said bit unit. The proposed method comprises an initialisation step, an updating step and an iteration such the method the bits are detected in an iterative but non-recursive way which allow for a high level of parallel processing in the implementation. In the proposed bit detection method, an evaluation criterion is used which is based on the difference between the received HF-signal and a reference HF-signal for each bit of a bit unit consisting of a plurality of bits, where the reference HF-signal depends on the bit value of the bit to be updated, and on its neighbouring bits, for which bit decisions in a previous iteration step are used. Thus, a high capacity, in particular in two-dimensional optical storage, can be achieved which substantially improves the performance of a threshold detector. Hence, the bit detection method according to the invention does not prohibit implementations aimed for high data-rates.
摘要翻译：本发明涉及一种用于检测存储在记录载体上的信道数据流的比特值的比特检测方法，其中信道数据流驻留在比特的N维网格上，并且包括多个连续比特单元，每个比特单元包括至少一个比特，其中通过迭代过程执行所述信道数据流的比特检测，每个迭代是基于所述比特单元执行的，其中检测比特单元的比特的比特值通过所述迭代过程，基于所接收的所述比特单元的比特的HF信号值。所提出的方法包括初始化步骤，更新步骤和迭代，使得该方法以迭代但非递归方式检测比特，这允许在实现中进行高水平的并行处理。在提出的比特检测方法中，使用基于由多个比特组成的比特单元的每个比特的接收HF信号和参考HF信号之间的差异的评估标准，其中参考HF信号取决于要更新的位的位值，以及在其相邻位中使用先前迭代步骤中哪个位决定。因此，可以实现高容量，特别是二维光学存储，这大大提高了阈值检测器的性能。因此，根据本发明的比特检测方法不禁止针对高数据速率的实现。

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