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1. 发明申请

WO2009013683A1 METHODS AND SYSTEMS FOR DETECTING 审中-公开
标题翻译：检测方法和系统
公开(公告)号：WO2009013683A1
公开(公告)日：2009-01-29
申请号：PCT/IB2008/052897
申请日：2008-07-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE THEIJE, Femke, K. , VAN DER WIJK, Thea , IMMINK, Albert, H., J. , PELSSERS, Eduard, G., M. , HARDEMAN, Wilhelmina, M. , MARLIN, Sandra , JOWETT, Gordon, T.
发明人： DE THEIJE, Femke, K. , VAN DER WIJK, Thea , IMMINK, Albert, H., J. , PELSSERS, Eduard, G., M. , HARDEMAN, Wilhelmina, M. , MARLIN, Sandra , JOWETT, Gordon, T.
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N27/745 , Y10T29/49885
摘要： A system and method is described wherein components of the reagent (4), e.g. labelled antibodies, are separated from the biologically active sensor surface (5) by depositing the reagent (4) on a carrier surface (3) distinct from the sensor surface (5) in the detection region (2), e.g. detection chamber. In this way, a high assay reproducibility is obtained. By allowing a short, well-defined and controlled, pre-incubation time between the particles of interest, e.g. drugs, in the sample fluid (20) and the reagent (4), the reproducibility will be increased, whereas the speed of the assay is guaranteed by having all components in one detection region (2), e.g. detection chamber.
摘要翻译：描述了一种系统和方法，其中试剂（4）的组分例如。通过将试剂（4）沉积在与检测区域（2）中的传感器表面（5）不同的载体表面（3）上，例如从生物活性传感器表面（5）分离。检测室。以这种方式，获得高的测定重现性。通过在感兴趣的颗粒之间允许短的，明确的和受控的预孵育时间，例如。药物在样品液体（20）和试剂（4）中的重现性将会增加，而测定的速度则通过在一个检测区域（2）中具有所有成分来保证。检测室。

2. 发明申请

WO2009072078A1 MAGNETIC WASHING FOR BIOSENSOR 审中-公开
标题翻译：生物传感器的磁性清洗
公开(公告)号：WO2009072078A1
公开(公告)日：2009-06-11
申请号：PCT/IB2008/055096
申请日：2008-12-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE THEIJE, Femke, K. , BRULS, Dominique, M. , VAN DER WIJK, Thea , VERSCHUREN, Coen, A. , IMMINK, Albert, H., J.
发明人： DE THEIJE, Femke, K. , BRULS, Dominique, M. , VAN DER WIJK, Thea , VERSCHUREN, Coen, A. , IMMINK, Albert, H., J.
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N21/552 , G01N21/648 , G01N27/745
摘要： Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components. The reapplication of the magnetic field acts as a magnetic washing step to release unwanted aspecific adsorption binding, leaving the targets, to improve sensitivity with simplified hardware and a reduction in cost and size.
摘要翻译：检测包含磁化或可磁化的目标部件的流体中的磁化或可磁化的目标部件在其他磁化或可磁化部件之间，使用磁场发生器（M1,28）将磁化或可磁化的部件吸引到装订表面。磁场控制器（C1）施加磁场以将磁化的或可磁化的组件在列中集中在结合表面上，随后减小磁场以使柱能够塌陷，以允许更多的部件到达结合表面，并重新应用磁场，以便使其他组分从结合表面上拉出，以便根据结合的目标组分重新制备柱。表面敏感传感器（S1,26,29）检测结合的磁化或可磁化的目标部件。磁场的重新应用充当磁性洗涤步骤以释放不期望的特异性吸附结合，留下目标，以通过简化的硬件提高灵敏度并降低成本和尺寸。

3. 发明申请

WO2008107847A1 MAGNETIC SENSOR DEVICE 审中-公开
标题翻译：磁传感器装置
公开(公告)号：WO2008107847A1
公开(公告)日：2008-09-12
申请号：PCT/IB2008/050794
申请日：2008-03-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE THEIJE, Femke, K. , IMMINK, Albert, H., J. , PELSSERS, Eduard, G., M.
发明人： DE THEIJE, Femke, K. , IMMINK, Albert, H., J. , PELSSERS, Eduard, G., M.
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , B82Y25/00 , G01N27/745 , G01R33/093 , G01R33/1269
摘要： The present invention provides a magnetic sensor device (20) for determining the presence and/or amount of target moieties (32) in a sample fluid, the target moieties being labeled with magnetic or magnetizable objects (33). The magnetic sensor device (20) comprises a sensor surface (23) lying in a plane, at least one magnetic element (21) for providing a sensor signal and at least one structure (24) extending from the sensor surface (23) in a direction substantially perpendicular to the plane of the sensor surface (23), the at least one structure (24) having a height (h) and a binding surface (25) for binding the labeled target moieties (32). The height (h) of the at least one structure (24) is higher than zero and lower or equal to a distance (z) of the labeled target moieties (32) from the sensor surface (23) corresponding to a signal cross-over point (27) from positive to negative signal contribution of the labeled target moieties (32) to the sensor signal, the signal cross-over point (27) being the distance at which a homogeneous distribution of magnetic or magnetizable objects (33) between the sensor surface (23) and that distance has a signal contribution to the sensor signal equal to zero.
摘要翻译：本发明提供了一种用于确定样品流体中靶部分（32）的存在和/或量的磁传感器装置（20），目标部分用磁性或可磁化物体（33）标记。磁传感器装置（20）包括位于平面中的传感器表面（23），用于提供传感器信号的至少一个磁性元件（21）和至少一个从传感器表面（23）延伸的结构（24）基本上垂直于传感器表面（23）的平面的方向，所述至少一个结构（24）具有用于结合标记的目标部分（32）的高度（h）和结合表面（25）。所述至少一个结构（24）的高度（h）高于对应于信号交叉的传感器表面（23）的标记目标部分（32）的零度并且低于或等于距离（z）点（27）从标记的目标部分（32）的正信号到负信号贡献到传感器信号，信号交叉点（27）是磁性或可磁化物体（33）之间的均匀分布的距离传感器表面（23），并且该距离对传感器信号具有等于零的信号贡献。

4. 发明申请

WO2007132367A1 ACCURATE MAGNETIC BIOSENSOR 审中-公开
标题翻译：精密生物传感器
公开(公告)号：WO2007132367A1
公开(公告)日：2007-11-22
申请号：PCT/IB2007/051509
申请日：2007-04-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE THEIJE, Femke, K. , IMMINK, Albert, H., J.
发明人： DE THEIJE, Femke, K. , IMMINK, Albert, H., J.
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , B82Y25/00 , G01N27/745 , H01F1/0054
摘要： A method is provided for determining the concentration of target in a fluid sample using a magnetic label and a magnetic sensor for detection. It was surprisingly found that efficient and accurate measurements can be carried out by determination of a signal as soon as the signal has reached a specified threshold level. In an alternative embodiment, a displacement step is used as soon as the signal has reached a pre-defined threshold level.
摘要翻译：提供了一种用于使用磁性标签和用于检测的磁性传感器来确定流体样品中的靶的浓度的方法。令人惊讶地发现，一旦信号达到指定的阈值水平，就可以通过确定信号来执行有效和准确的测量。在替代实施例中，一旦信号达到预定义的阈值水平，就使用位移步骤。

5. 发明申请

WO2009083862A1 MULTI-COMPARTMENT DEVICE WITH MAGNETIC PARTICLES 审中-公开
标题翻译：具有磁性颗粒的多间隔装置
公开(公告)号：WO2009083862A1
公开(公告)日：2009-07-09
申请号：PCT/IB2008/055330
申请日：2008-12-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PRINS, Menno, W., J. , MAAS, Joost, H. , IMMINK, Albert, H., J. , VAN DAM, Dirkjan, B. , KOETS, Maatje , BRUYNINCKX, Michel, J., M. , VAN DER WIJK, Thea , BOAMFA, Marius, I. , DEN DULK, Remco
发明人： PRINS, Menno, W., J. , MAAS, Joost, H. , IMMINK, Albert, H., J. , VAN DAM, Dirkjan, B. , KOETS, Maatje , BRUYNINCKX, Michel, J., M. , VAN DER WIJK, Thea , BOAMFA, Marius, I. , DEN DULK, Remco
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L2200/0647 , B01L2300/089 , B01L2300/161 , B01L2400/043 , B01L2400/0688 , B01L2400/088
摘要： The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.
摘要翻译：本发明公开了具有阀状结构（3）的微流体装置，通过该微流体装置可以以最少的流体输送运输磁性颗粒。这允许顺序处理磁性颗粒。

6. 发明申请

WO2009013668A2 SENSOR CARTRIDGE 审中-公开
标题翻译：传感器盒
公开(公告)号：WO2009013668A2
公开(公告)日：2009-01-29
申请号：PCT/IB2008/052844
申请日：2008-07-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
发明人： IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01R33/09
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译：本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b）的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

7. 发明申请

WO2008111013A2 BEAD ASSISTED ANALYTE DETECTION 审中-公开
标题翻译： BEAD辅助分析检测
公开(公告)号：WO2008111013A2
公开(公告)日：2008-09-18
申请号：PCT/IB2008/050967
申请日：2008-03-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE THEIJE, Femke, K. , BOHMER, Marcel, R. , SCHROEDERS, Richard, J., M. , IMMINK, Albert, H., J.
发明人： DE THEIJE, Femke, K. , BOHMER, Marcel, R. , SCHROEDERS, Richard, J., M. , IMMINK, Albert, H., J.
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , B82Y25/00 , G01N27/745 , H01F1/0054 , H01F13/00
摘要： The present invention relates to beads (7) for use in biotechnical applications such as biosensing. The beads (7) comprise at least one magnetic or magnetisable particle (34) and an organic moiety and are freeze-dried. The latter has the advantage that the reactivity of such particles is low, resulting in a longer shelf life. Furthermore, as the beads comprise a magnetic or magnetisable component, this allows accurately providing and positioning of the beads in a biosensor, e.g. by magnetic actuation. The magnetic or magnetisable component furthermore can be used as labels during biosensing. A method of manufacturing the beads, a method for analyzing sample fluid using the beads and a sensor system and method of manufacturing thereof also is disclosed.
摘要翻译：本发明涉及用于生物技术应用例如生物传感的珠粒（7）。珠粒（7）包含至少一种磁性或可磁化颗粒（34）和有机部分，并被冷冻干燥。后者的优点在于这种颗粒的反应性低，从而延长了保存期限。此外，由于珠粒包含磁性或可磁化的组分，这允许珠子准确地提供和定位在生物传感器中，例如，通过磁力驱动。此外，磁性或可磁化组分可以在生物传感期间用作标签。公开了一种制造珠的方法，使用该珠分析样品流体的方法和传感器系统及其制造方法。

8. 发明申请

WO2011001337A1 MAGNETIC SENSOR DEVICE, METHOD OF OPERATING SUCH A DEVICE AND SAMPLE 审中-公开
标题翻译：磁传感器装置，操作这种装置和样品的方法
公开(公告)号：WO2011001337A1
公开(公告)日：2011-01-06
申请号：PCT/IB2010/052880
申请日：2010-06-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , DITTMER, Wendy, U. , DE THEIJE, Femke, K. , IMMINK, Albert, H., J. , NIEWENHUIS, Jeroen, H. , VAN LANKVELT, Petrus, J., W.
发明人： DITTMER, Wendy, U. , DE THEIJE, Femke, K. , IMMINK, Albert, H., J. , NIEWENHUIS, Jeroen, H.
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N21/552 , G01N27/745 , G01N33/54366 , G01N33/54386
摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40'). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14') from the detection of the further detectable label (40') in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14') falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.
摘要翻译：公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生第二检测信号在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。

9. 发明申请

WO2008072192A2 BIOLOGICAL ASSAY SUBSTRATE AND METHOD AND DEVICE FOR PRODUCING SUCH SUBSTRATE 审中-公开
标题翻译：生物测定底物和生产这种底物的方法和装置
公开(公告)号：WO2008072192A2
公开(公告)日：2008-06-19
申请号：PCT/IB2007/055039
申请日：2007-12-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , DIJKSMAN, Johan, F. , SCHROEDERS, Richard, J., M. , PIERIK, Anke , WISMANS, Antonius, J., J.
发明人： IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , DIJKSMAN, Johan, F. , SCHROEDERS, Richard, J., M. , PIERIK, Anke , WISMANS, Antonius, J., J.
IPC分类号： G01N33/543 , C12Q1/68 , G01N27/00
CPC分类号： G01N27/3275
摘要： The invention provides a biological assay substrate suitable for detecting at least one analyte in at least one sample fluid. The substrate comprises one or more capture probes able to each specifically bind at least one target analyte, and further comprises verification means which can detect the state of at least part of the capture probes. The invention also relates to a method and device for producing the biological assay substrate, and to a method for examining analyte fluids using the substrate.
摘要翻译：本发明提供适于检测至少一种样品流体中的至少一种分析物的生物测定基底。所述底物包含一种或多种捕获探针，所述捕获探针能够各自特异性结合至少一种目标分析物，并且还包含能够检测至少部分捕获探针的状态的验证装置。本发明还涉及生产生物测定底物的方法和装置，以及使用该底物检查分析物流体的方法。

10. 发明申请

WO2009069009A1 OPTICAL DETECTION OF PARTICLES IN A MAGNETIC BIOSENSOR USING A WAVEGUIDE 审中-公开
标题翻译：使用波导的磁性生物传感器中的颗粒的光学检测
公开(公告)号：WO2009069009A1
公开(公告)日：2009-06-04
申请号：PCT/IB2008/050412
申请日：2008-02-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , IMMINK, Albert, H., J. , DE BOER, Dirk, K., G. , PRINS, Menno, W., J. , NIEUWENHUIS, Jeroen, H. , VERSCHUREN, Coen, A.
发明人： JOHNSON, Mark, T. , IMMINK, Albert, H., J. , DE BOER, Dirk, K., G. , PRINS, Menno, W., J. , NIEUWENHUIS, Jeroen, H. , VERSCHUREN, Coen, A.
IPC分类号： G01N21/55 , G01N33/543 , G01N33/487
CPC分类号： G01N27/745 , G01N21/552 , G01N21/7703 , G01N33/54333 , G01N33/54373
摘要： The present invention provides a biosensor device comprising a sensor surface and an optical wave guide having an input, an output and first and second surfaces, said optical wave guide (5) being adapted to direct light entering the optical wave guide (5) through the input (20) to the output (21) via multiple reflections on said first and second surfaces (22, 23) including at least one reflection onsaid first surface (22) under an angle fulfilling the condition of total internal reflection, wherein the sensor surface is adjacent to the first surface of total internal reflection.
摘要翻译：本发明提供了一种生物传感器装置，其包括具有输入，输出和第一和第二表面的传感器表面和光波导，所述光波导（5）适于将进入光波导（5）的光引导通过通过在所述第一和第二表面（22,23）上的多个反射将输入（20）输入（20），所述第一和第二表面（22,23）包括在满足全内反射条件的角度下的至少一个反射的第一表面（22），其中传感器表面与全内反射的第一表面相邻。

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