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1. 发明申请

US20120128533A1 LIQUID SUPPLY DEVICE USING CHECK VALVE AND REACTIVE LIQUID CHROMATOGRAPHY SYSTEM 失效
标题翻译：使用检查阀和反应液相色谱系统的液体供应装置
公开(公告)号：US20120128533A1
公开(公告)日：2012-05-24
申请号：US13386789
申请日：2010-05-26
申请人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
发明人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
IPC分类号： G01N31/00 , F16K15/00
CPC分类号： F04B23/06 , F04B13/00 , F04B49/08 , F04B49/22 , F04B2205/05 , F16K15/04 , F16K37/0058 , G01N30/32 , G01N30/74 , G01N2030/328 , G01N2030/8435 , Y10T137/7838
摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.
摘要翻译：可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接检测到。止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

2. 发明授权

US08551423B2 Liquid supply device using check valve and reactive liquid chromatography system 失效
标题翻译：液体供应装置采用止回阀和反应液相色谱系统
公开(公告)号：US08551423B2
公开(公告)日：2013-10-08
申请号：US13386789
申请日：2010-05-26
申请人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
发明人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
IPC分类号： B01L3/02
CPC分类号： F04B23/06 , F04B13/00 , F04B49/08 , F04B49/22 , F04B2205/05 , F16K15/04 , F16K37/0058 , G01N30/32 , G01N30/74 , G01N2030/328 , G01N2030/8435 , Y10T137/7838
摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.
摘要翻译：可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接检测到。止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

3. 发明授权

US09410543B2 Pump for liquid chromatograph, and liquid chromatograph 有权
标题翻译：液相色谱泵，液相色谱仪
公开(公告)号：US09410543B2
公开(公告)日：2016-08-09
申请号：US13808660
申请日：2011-07-20
申请人： Kenichiro Tokuo , Kenji Hiraku , Hironori Kaji , Daisuke Akieda , Kimihiko Ishii , Naoya Yasuhara
发明人： Kenichiro Tokuo , Kenji Hiraku , Hironori Kaji , Daisuke Akieda , Kimihiko Ishii , Naoya Yasuhara
IPC分类号： F04B17/03 , F04B13/00 , F04B23/06 , F04B49/06 , G01N30/32 , G01N30/02 , F04B49/08 , G01N30/34
CPC分类号： F04B17/03 , F04B13/00 , F04B23/06 , F04B49/06 , F04B49/065 , F04B49/08 , F04B2203/0202 , F04B2205/03 , F04B2205/05 , G01N30/02 , G01N30/32 , G01N30/34 , G01N2030/326
摘要： A pump controller causes a first plunger pump and a second plunger pump connected in series or in parallel to perform intake and compression actions alternately at substantially constant cycles, sets a pressurizing chamber of one of the plunger pumps to a state of a higher pressure than the pressurizing chamber of the other plunger pump, and performs flow rate control by adjusting lift amounts of the first plunger and the second plunger. Thus, it is possible to provide a pump for liquid chromatograph, and a liquid chromatograph, which are capable of reducing pulsations even when an ejection flow rate is changed.
摘要翻译：泵控制器使得串联或并联连接的第一柱塞泵和第二柱塞泵以基本恒定的循环交替进行进入和压缩动作，将柱塞泵之一的加压室设定为比通过调节第一柱塞和第二柱塞的升程量来进行流量控制。因此，即使在喷射流量变化的情况下，也能够提供能够降低脉动的液相色谱泵和液相色谱仪。

4. 发明申请

US20130104631A1 PUMP FOR LIQUID CHROMATOGRAPH, AND LIQUID CHROMATOGRAPH 有权
标题翻译：液相色谱泵和液相色谱
公开(公告)号：US20130104631A1
公开(公告)日：2013-05-02
申请号：US13808660
申请日：2011-07-20
申请人： Kenichiro Tokuo , Kenji Hiraku , Hironori Kaji , Daisuke Akieda , Kimihiko Ishii , Naoya Yasuhara
发明人： Kenichiro Tokuo , Kenji Hiraku , Hironori Kaji , Daisuke Akieda , Kimihiko Ishii , Naoya Yasuhara
IPC分类号： F04B17/03 , G01N30/02
CPC分类号： F04B17/03 , F04B13/00 , F04B23/06 , F04B49/06 , F04B49/065 , F04B49/08 , F04B2203/0202 , F04B2205/03 , F04B2205/05 , G01N30/02 , G01N30/32 , G01N30/34 , G01N2030/326
摘要： A pump controller causes a first plunger pump and a second plunger pump connected in series or in parallel to perform intake and compression actions alternately at substantially constant cycles, sets a pressurizing chamber of one of the plunger pumps to a state of a higher pressure than the pressurizing chamber of the other plunger pump, and performs flow rate control by adjusting lift amounts of the first plunger and the second plunger. Thus, it is possible to provide a pump for liquid chromatograph, and a liquid chromatograph, which are capable of reducing pulsations even when an ejection flow rate is changed.
摘要翻译：泵控制器使得串联或并联连接的第一柱塞泵和第二柱塞泵以基本恒定的循环交替进行进入和压缩动作，将柱塞泵之一的加压室设定为比通过调节第一柱塞和第二柱塞的升程量来进行流量控制。因此，即使在喷射流量变化的情况下也能够提供能够降低脉动的液相色谱泵和液相色谱仪。

5. 发明授权

US07901573B2 Separation column and liquid chromatography apparatus using the same 失效
标题翻译：分离柱和使用其的液相色谱仪
公开(公告)号：US07901573B2
公开(公告)日：2011-03-08
申请号：US12081572
申请日：2008-04-17
申请人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
发明人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
IPC分类号： B01D15/08
CPC分类号： B01D15/22 , B01D15/206 , B01J20/3236 , B01J2220/82 , B01J2220/86 , G01N30/52 , G01N30/6017 , G01N30/603 , G01N30/6047 , G01N30/6052 , G01N2030/528
摘要： Disclosed herein is a separation column comprising a porous block covered with a coating wherein space-free adhesion is attainable therebetween by low temperature process without releasing octadecylsilyl bases and others from the porous block. A monolith rod 1 is covered with a metal or resin coating 2. Then, the monolith rod 1 covered by the coating 2 is further covered with a rod retainer 3 made of a low melting point metal (melting point 100-200 degrees C.) to form a column body 19. Since the rod retainer 3 is formed by pressure molding at low temperature (100-200 degrees C.). It is therefore possible to absorb the surface irregularities of the monolith rod 1 by the coating 2 while octadecylsilyl bases and others from are released when the retainer 3 is formed. This allows the potential separation ability of the porous block to be brought out maximally.
摘要翻译：本文公开了一种分离柱，其包括用涂层覆盖的多孔块，其中通过低温工艺在其间实现无空隙粘合，而不从多孔块中释放十八烷基甲硅烷基等。整料棒1被金属或树脂涂层2覆盖。然后，用由低熔点金属（熔点100-200℃）制成的棒保持器3进一步覆盖由涂层2覆盖的整料棒1。以形成柱体19.由于杆保持器3通过在低温（100-200℃）下的模压而形成。因此，当保持器3形成时，可以通过涂层2吸收整料棒1的表面凹凸，同时十八烷基甲硅烷基等被释放。这允许最大限度地排出多孔块的潜在分离能力。

6. 发明申请

US20080283458A1 Separation column and liquid chromatography apparatus using the same 失效
标题翻译：分离柱和使用其的液相色谱仪
公开(公告)号：US20080283458A1
公开(公告)日：2008-11-20
申请号：US12081572
申请日：2008-04-17
申请人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
发明人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
IPC分类号： B01D15/08 , B01D15/22
CPC分类号： B01D15/22 , B01D15/206 , B01J20/3236 , B01J2220/82 , B01J2220/86 , G01N30/52 , G01N30/6017 , G01N30/603 , G01N30/6047 , G01N30/6052 , G01N2030/528
摘要： Disclosed herein is a separation column comprising a porous block covered with a coating wherein space-free adhesion is attainable therebetween by low temperature process without releasing octadecylsilyl bases and others from the porous block.A monolith rod 1 is covered with a metal or resin coating 2. Then, the monolith rod 1 covered by the coating 2 is further covered with a rod retainer 3 made of a low melting point metal (melting point 100-200 degrees C.) to form a column body 19. Since the rod retainer 3 is formed by pressure molding at low temperature (100-200 degrees C.). It is therefore possible to absorb the surface irregularities of the monolith rod 1 by the coating 2 while octadecylsilyl bases and others from are released when the retainer 3 is formed. This allows the potential separation ability of the porous block to be brought out maximally.
摘要翻译：本文公开了一种分离柱，其包括用涂层覆盖的多孔块，其中通过低温工艺在其间实现无空隙粘合，而不从多孔块中释放十八烷基甲硅烷基等。整料棒1被金属或树脂涂层2覆盖。然后，用由低熔点金属（熔点为100-200℃）制成的棒保持器3进一步覆盖由涂层2覆盖的整料棒1，以形成柱体19。由于杆保持器3通过在低温（100-200℃）下进行压力成型而形成。因此，当保持器3形成时，可以通过涂层2吸收整料棒1的表面凹凸，同时十八烷基甲硅烷基等被释放。这允许最大限度地排出多孔块的潜在分离能力。

7. 发明申请

US20120055581A1 LIQUID DELIVERY DEVIDE AND LIQUID CHROMATOGRAPHY DEVICE 审中-公开
标题翻译：液体输送和液相色谱装置
公开(公告)号：US20120055581A1
公开(公告)日：2012-03-08
申请号：US13319111
申请日：2010-05-24
申请人： Daisuke Akieda , Kisaburo Deguchi , Hironori Kaji
发明人： Daisuke Akieda , Kisaburo Deguchi , Hironori Kaji
IPC分类号： B65B1/04 , B01D15/08
CPC分类号： G01N30/32 , G01N2030/326
摘要： In a liquid delivery device, when an inlet-side check valve and an outlet-side check valve of a first cylinder are both closed, and compression of an eluent inside the first cylinder is started by means of a first plunger inside the first cylinder, a control unit doubles the rotational speed of a step motor, and measures the amount of change in the pressure inside the first cylinder which changes for a prescribed time by means of a first cylinder internal pressure detector. The time elapsed until the pressure inside the first cylinder is the same as the pressure inside a discharge-side flow passage is predicted using the rate of change over time of the pressure of the eluent. When the predicted elapsed time has elapsed, the rotational speed of the step motor is returned to the original speed, and the compression of the eluent inside the first cylinder is completed.
摘要翻译：在液体输送装置中，当第一气缸的入口侧止回阀和出口侧止回阀都被关闭时，借助于第一气缸内的第一柱塞开始第一气缸内的洗脱液的压缩，控制单元使步进电机的转速加倍，并且通过第一气缸内压检测器来测量第一气缸内的压力变化达规定时间的变化量。使用洗脱液的压力随时间的变化率预测在第一气缸内的压力与放电侧流路内的压力相同的时间。当预测经过时间过去时，步进电机的转速恢复到原来的速度，并且完成了第一气缸内的洗脱液的压缩。

8. 发明申请

US20130091933A1 LIQUID MIXING DEVICE AND LIQUID CHROMATOGRAPH 有权
标题翻译：液体混合装置和液相色谱
公开(公告)号：US20130091933A1
公开(公告)日：2013-04-18
申请号：US13704247
申请日：2011-05-18
申请人： Nobuhiro Tsukada , Yoshihiro Nagaoka , Hironori Kaji , Daisuke Akieda
发明人： Nobuhiro Tsukada , Yoshihiro Nagaoka , Hironori Kaji , Daisuke Akieda
IPC分类号： G01N30/02
CPC分类号： G01N30/02 , B01F5/0646 , G01N30/34
摘要： A liquid mixing device that decreases a concentration non-uniformity in the flow direction of a mobile phase and a liquid chromatograph that uses the liquid mixing device are provided. The liquid mixing device is configured to include a flow channel unit that is made from an introduction channel, a branch portion that is positioned in a downstream of the introduction channel, multiple branched flow channels that branch from the branch portion, a junction portion in which the multiple branched flow channels join together, and a discharge channel of the downstream of the junction portion. The multiple branched flow channels are different in terms of any one of, or several of width, depth, and length that are associated with an external shape, and a structure filling the inside of the flow channel and thus the times for the liquid to pass through the branched flow channels are different from each other.
摘要翻译：提供了降低流动相的流动方向的浓度不均匀性和使用液体混合装置的液相色谱仪的液体混合装置。液体混合装置被构造成包括由引入通道制成的流动通道单元，位于引入通道下游的分支部分，从分支部分分支的多个分支流动通道，其中连接部分多个分支流动通道连接在一起，以及连接部分下游的排出通道。多个分支流动通道在与外部形状相关联的宽度，深度和长度中的任何一个或几个方面是不同的，以及填充流动通道内部的结构，因此液体通过的时间通过分支流动通道彼此不同。

9. 发明授权

US09128071B2 Liquid mixing device and liquid chromatograph 有权
标题翻译：液体混合装置和液相色谱仪
公开(公告)号：US09128071B2
公开(公告)日：2015-09-08
申请号：US13704247
申请日：2011-05-18
申请人： Nobuhiro Tsukada , Yoshihiro Nagaoka , Hironori Kaji , Daisuke Akieda
发明人： Nobuhiro Tsukada , Yoshihiro Nagaoka , Hironori Kaji , Daisuke Akieda
IPC分类号： G01N30/02 , B01F5/06 , G01N30/34
CPC分类号： G01N30/02 , B01F5/0646 , G01N30/34
摘要： A liquid mixing device that decreases a concentration non-uniformity in the flow direction of a mobile phase and a liquid chromatograph that uses the liquid mixing device are provided. The liquid mixing device is configured to include a flow channel unit that is made from an introduction channel, a branch portion that is positioned in a downstream of the introduction channel, multiple branched flow channels that branch from the branch portion, a junction portion in which the multiple branched flow channels join together, and a discharge channel of the downstream of the junction portion. The multiple branched flow channels are different in terms of any one of, or several of width, depth, and length that are associated with an external shape, and a structure filling the inside of the flow channel and thus the times for the liquid to pass through the branched flow channels are different from each other.
摘要翻译：提供了降低流动相的流动方向的浓度不均匀性和使用液体混合装置的液相色谱仪的液体混合装置。液体混合装置被构造成包括由引入通道制成的流动通道单元，位于引入通道下游的分支部分，从分支部分分支的多个分支流动通道，其中连接部分多个分支流动通道连接在一起，以及连接部分下游的排出通道。多个分支流动通道在与外部形状相关联的宽度，深度和长度中的任何一个或几个方面是不同的，以及填充流动通道内部的结构，因此液体通过的时间通过分支流动通道彼此不同。

10. 发明申请

US20050023205A1 Pump for liquid chromatography 失效
标题翻译：泵用于液相色谱
公开(公告)号：US20050023205A1
公开(公告)日：2005-02-03
申请号：US10902028
申请日：2004-07-30
申请人： Kenji Hiraku , Kunihiko Takao , Hironori Kaji , Masahito Ito
发明人： Kenji Hiraku , Kunihiko Takao , Hironori Kaji , Masahito Ito
IPC分类号： G01N30/32 , B01D15/08 , B01D15/14 , F04B1/02 , F04B11/00 , F04B13/02 , F04B23/06 , F04B53/06
CPC分类号： F04B11/0058 , B01D15/14 , F04B11/0083 , F04B13/02 , F04B53/06 , F04B2205/09 , G01N2030/326
摘要： The invention provides a pump for liquid chromatography excellent in feeding liquid stably at an extremely low flow rate with high accuracy and in discharging bubbles at startup. At startup, a first plunger feeds solvent at a large flow rate to discharge bubbles in a pump and to fill the solvent into the pump in a short time and in a normal operation, the first plunger is stopped and the second plunger is pushed into a second pressure chamber at a low speed to feed the solvent at a low flow rate. When the second plunger reaches full stroke, the second plunger is pulled back at a high speed and at the same time the first plunger is pushed into a first pressure chamber in synchronization with the pullback of the second plunger to control the flow rate passing a discharge passage to a constant value at all times by a controller. Further, while the second plunger feeds the solvent, the first plunger is slightly pushed into the first pressure chamber to keep pressure in the first pressure chamber at pressure equal to or less than pressure in the second pressure chamber.
摘要翻译：本发明提供了一种液体色谱泵，其具有以极高的精度稳定地以极低的流量供给液体并在起动时排出气泡的液体色谱。在启动时，第一柱塞以大流量供给溶剂以排出泵中的气泡并在短时间内和正常操作中将溶剂填充到泵中，使第一柱塞停止，将第二柱塞推入第二压力室以低速进料以低流量进料溶剂。当第二柱塞达到全行程时，第二柱塞被高速拉回，同时第一柱塞与第二柱塞的回退同步地被推入第一压力室，以控制通过排放的流量任何时候都由控制器传递给恒定值。此外，当第二柱塞进料溶剂时，第一柱塞稍微推入第一压力室，以将第一压力室中的压力保持在第二压力室中等于或小于压力的压力。

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