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1. 发明申请

US20120128533A1 LIQUID SUPPLY DEVICE USING CHECK VALVE AND REACTIVE LIQUID CHROMATOGRAPHY SYSTEM 失效
标题翻译：使用检查阀和反应液相色谱系统的液体供应装置
公开(公告)号：US20120128533A1
公开(公告)日：2012-05-24
申请号：US13386789
申请日：2010-05-26
申请人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
发明人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
IPC分类号： G01N31/00 , F16K15/00
CPC分类号： F04B23/06 , F04B13/00 , F04B49/08 , F04B49/22 , F04B2205/05 , F16K15/04 , F16K37/0058 , G01N30/32 , G01N30/74 , G01N2030/328 , G01N2030/8435 , Y10T137/7838
摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.
摘要翻译：可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接检测到。止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

2. 发明申请

US20120055581A1 LIQUID DELIVERY DEVIDE AND LIQUID CHROMATOGRAPHY DEVICE 审中-公开
标题翻译：液体输送和液相色谱装置
公开(公告)号：US20120055581A1
公开(公告)日：2012-03-08
申请号：US13319111
申请日：2010-05-24
申请人： Daisuke Akieda , Kisaburo Deguchi , Hironori Kaji
发明人： Daisuke Akieda , Kisaburo Deguchi , Hironori Kaji
IPC分类号： B65B1/04 , B01D15/08
CPC分类号： G01N30/32 , G01N2030/326
摘要： In a liquid delivery device, when an inlet-side check valve and an outlet-side check valve of a first cylinder are both closed, and compression of an eluent inside the first cylinder is started by means of a first plunger inside the first cylinder, a control unit doubles the rotational speed of a step motor, and measures the amount of change in the pressure inside the first cylinder which changes for a prescribed time by means of a first cylinder internal pressure detector. The time elapsed until the pressure inside the first cylinder is the same as the pressure inside a discharge-side flow passage is predicted using the rate of change over time of the pressure of the eluent. When the predicted elapsed time has elapsed, the rotational speed of the step motor is returned to the original speed, and the compression of the eluent inside the first cylinder is completed.
摘要翻译：在液体输送装置中，当第一气缸的入口侧止回阀和出口侧止回阀都被关闭时，借助于第一气缸内的第一柱塞开始第一气缸内的洗脱液的压缩，控制单元使步进电机的转速加倍，并且通过第一气缸内压检测器来测量第一气缸内的压力变化达规定时间的变化量。使用洗脱液的压力随时间的变化率预测在第一气缸内的压力与放电侧流路内的压力相同的时间。当预测经过时间过去时，步进电机的转速恢复到原来的速度，并且完成了第一气缸内的洗脱液的压缩。

3. 发明授权

US08551423B2 Liquid supply device using check valve and reactive liquid chromatography system 失效
标题翻译：液体供应装置采用止回阀和反应液相色谱系统
公开(公告)号：US08551423B2
公开(公告)日：2013-10-08
申请号：US13386789
申请日：2010-05-26
申请人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
发明人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
IPC分类号： B01L3/02
CPC分类号： F04B23/06 , F04B13/00 , F04B49/08 , F04B49/22 , F04B2205/05 , F16K15/04 , F16K37/0058 , G01N30/32 , G01N30/74 , G01N2030/328 , G01N2030/8435 , Y10T137/7838
摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.
摘要翻译：可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接检测到。止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

4. 发明授权

US09034789B2 Adsorption carbon, and adsorbent 有权
标题翻译：吸附碳和吸附剂
公开(公告)号：US09034789B2
公开(公告)日：2015-05-19
申请号：US13583181
申请日：2011-03-02
申请人： Masato Higuchi , Takao Kimura , Masayoshi Takeuchi , Kisaburo Deguchi
发明人： Masato Higuchi , Takao Kimura , Masayoshi Takeuchi , Kisaburo Deguchi
IPC分类号： B01J20/20 , A61K33/44 , B01J20/28 , B01J20/30
CPC分类号： A61K33/44 , B01J20/20 , B01J20/28069 , B01J20/2808 , B01J20/3078
摘要： Provided are an adsorptive carbon which can effectively adsorb vivotoxins such as advanced glycation end products (AGEs), and an adsorbent containing the adsorptive carbon as an active ingredient. The adsorptive carbon according to the present invention has a total pore volume of 0.10 to 1.0 mL/g, an average pore diameter of 1.0 to 2.0 nm, and an absorbance of an infrared absorption band at 1650-1800 cm−1 of no less than 0.005.
摘要翻译：提供了可以有效吸附诸如晚期糖基化终产物（AGEs）等生物毒素和含有吸附性碳的吸附剂作为活性成分的吸附碳。根据本发明的吸附碳的总孔体积为0.10〜1.0mL / g，平均孔径为1.0〜2.0nm，1650〜1800cm -1的红外吸收带的吸光度不小于 0.005。

5. 发明授权

US08496819B2 Separation column for liquid chromatograph apparatus and liquid chromatograph apparatus using thereof 失效
标题翻译：液相色谱仪分离柱及其使用的液相色谱仪
公开(公告)号：US08496819B2
公开(公告)日：2013-07-30
申请号：US12146912
申请日：2008-06-26
申请人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
发明人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
IPC分类号： B01D15/08 , G01N30/02 , C02F1/28
CPC分类号： B01D15/22 , B01J20/282 , B01J2220/82 , B01J2220/825 , G01N30/22 , G01N30/6047 , G01N30/6052 , G01N30/6069 , G01N2030/522 , G01N2030/528
摘要： Both a column having high-pressure resistance and capable of performing high-speed separation and analysis even with a small flow rate and a liquid chromatograph apparatus using the column are provided. A separation column according to the present invention has a monolithic rod being arranged in the center, being made of a porous material, and having a circular cross section, a filler layer arranged such that it encircles a circumferential surface of the monolithic rod, and a cylindrical support medium arranged outside the filler layer. The filler layer is formed by filling a tube-like gap between the monolithic rod and the support medium with particles or beads.
摘要翻译：提供了具有高耐压性并且即使以小流量进行高速分离和分析的柱和使用该柱的液相色谱装置。根据本发明的分离柱具有中心的整体式杆，由多孔材料制成，并且具有圆形横截面，填充层布置成使其围绕整体式杆的圆周表面，并且圆柱形支撑介质布置在填充层外部。通过在颗粒或珠粒之间填充整体棒和支撑介质之间的管状间隙来形成填充层。

6. 发明申请

US20110303599A1 LIQUID CHROMATOGRAPH, LIQUID CHROMATOGRAPH COLUMN AND FILTER FOR LIQUID CHROMATOGRAPH COLUMN 有权
标题翻译：液相色谱，液相色谱柱和液相色谱柱过滤器
公开(公告)号：US20110303599A1
公开(公告)日：2011-12-15
申请号：US13202722
申请日：2010-03-10
申请人： Norimasa Minamoto , Masahito Ito , Kisaburo Deguchi , Hiroyuki Tanai , Kiyotoshi Mori
发明人： Norimasa Minamoto , Masahito Ito , Kisaburo Deguchi , Hiroyuki Tanai , Kiyotoshi Mori
IPC分类号： B01D15/08 , B01D39/10
CPC分类号： G01N30/603
摘要： In a liquid chromatograph, the disulfide adsorption of iron atoms in a filter for a column is avoided and thus peak tailing in a chromatogram is prevented to thereby prevent a lowering in the sample recovery rate. A liquid chromatograph column comprising a hollow tubular column body, a bead-shaped packing material which is packed in the hollow part of the column body, a filter provided with a mesh which has a mesh size smaller than the particle diameter of the packing material, and a cap which presses the filter against the packing material to thereby enclose the packing material within the column body, characterized in that the main component of the filter is nickel or hastelloy.
摘要翻译：在液相色谱仪中，避免了用于柱的过滤器中的铁原子的二硫键吸附，因此防止了色谱图中的峰值拖尾，从而防止了样品回收率的降低。一种液相色谱柱，包括中空管状柱体，填充在柱体中空部分中的珠状包装材料，具有筛网尺寸小于包装材料粒径的筛网的过滤器，以及将过滤器压靠在包装材料上的盖子，从而将包装材料包围在柱体内，其特征在于，过滤器的主要部件是镍或哈氏合金。

7. 发明申请

US20070199874A1 Three-dimensional liquid chromatography 审中-公开
标题翻译：三维液相色谱
公开(公告)号：US20070199874A1
公开(公告)日：2007-08-30
申请号：US11700844
申请日：2007-02-01
申请人： Masahito Ito , Junkichi Miura , Kisaburo Deguchi
发明人： Masahito Ito , Junkichi Miura , Kisaburo Deguchi
IPC分类号： B01D15/08
CPC分类号： G01N30/463 , G01N30/461 , G01N30/7233 , G01N30/96 , B01D15/322 , B01D15/362 , B01D15/325 , B01D15/363
摘要： In a liquid chromatography apparatus, a separation column of intermediate stage is additionally connected between a separation column of first stage and a separation column of second stage. Preferably, a switching unit and a liquid feed unit for mixing and feeding a plurality of solutions are added to improve a separation capability. A three-dimensional liquid chromatography apparatus capable of avoiding the “solution interference” can be realized. Even a complex sample containing a hydrophilic component and a hydrophobic component in a mixed state can be separated and analyzed satisfactorily on-line.
摘要翻译：在液相色谱装置中，中间级分离塔另外连接在第一级分离塔和第二级分离塔之间。优选地，添加用于混合和供给多个溶液的切换单元和液体进料单元以提高分离能力。可以实现能够避免“溶液干扰”的三维液相色谱仪。即使是含有亲水性成分和混合状态的疏水性成分的复合物，也可以在线进行分离和分析。

8. 发明授权

US07211790B2 Mass spectrometer and method of analyzing isomers 有权
公开(公告)号：US07211790B2
公开(公告)日：2007-05-01
申请号：US11132174
申请日：2005-05-19
申请人： Izumi Ogata , Shinya Ito , Shin-Ichiro Nishimura , Kisaburo Deguchi , Yasuhiro Takegawa
发明人： Izumi Ogata , Shinya Ito , Shin-Ichiro Nishimura , Kisaburo Deguchi , Yasuhiro Takegawa
IPC分类号： H01J49/14 , G01N30/02 , H01J49/04
CPC分类号： G01N30/8675 , G01N30/8679 , H01J49/0036
摘要： The invention intends to determine a presence ratio between mixed compounds which are difficult to separate from each other by a separation unit and cannot be discriminated by MS. In a mass spectrometer with an MSn analysis function for ionizing a sample eluted from a separation unit for separating the sample into individual components, fragmenting an ion of a desired mass number, and performing a mass analysis of fragment ions, the mass spectrometer includes a database storing correlation information between an isomer presence ratio and a particular ion intensity ratio in a mass spectrum per isomer. An isomer ratio can be clarified even for a mixed sample of isomers, such as enantiomers, which are difficult to separate from each other by the separation unit and cannot be discriminated by MS.

9. 发明申请

US20060271310A1 Method and apparatus for analyzing multi-channel chromatogram 失效
标题翻译：用于分析多通道色谱图的方法和装置
公开(公告)号：US20060271310A1
公开(公告)日：2006-11-30
申请号：US11501750
申请日：2006-08-10
申请人： Masahito Ito , Kisaburo Deguchi
发明人： Masahito Ito , Kisaburo Deguchi
IPC分类号： G01N31/00
CPC分类号： G01N30/8624 , G01N30/8631 , G01N30/8679 , G01N2201/1293
摘要： A method for analyzing a multi-channel chromatogram is realized for accurately resolving overlapping peaks on a multi-channel chromatogram to permit analysis of the composition of a sample. First, components of overlapping peaks are specified. A data matrix Dij is determined, and compressed in the wavelength direction to obtain a data matrix vector Di. Next, the two-dimensional data is deconvoluted, final standard deviation s0 is registered, and the deconvoluted two-dimensional data is reconvoluted to a retention intensity matrix. A quantitative spectral intensity matrix is computed, components are identified, and the identified components are quantified. Subsequently, an eigenvalue problem is solved, and the number n of components is estimated. The deconvolution and computation of the eigenvalue problem are iteratively executed until the peaks are isolated. Then, elution profiles are calculated, the components are identified, and the identified components are quantified.
摘要翻译：实现了分析多通道色谱图的方法，用于准确地分辨多通道色谱图上的重叠峰，以便分析样品的组成。首先，指定重叠峰的分量。确定数据矩阵Dij，并在波长方向上压缩以获得数据矩阵向量Di。接下来，对二维数据进行解卷积，记录最终标准偏差s0，并将解卷积的二维数据重新卷积到保留强度矩阵。计算定量光谱强度矩阵，识别组件，并对所识别的组分进行量化。随后，解决了特征值问题，并且估计了分量的数量n。迭代执行反褶积和特征值问题的计算，直到峰被隔离。然后，计算洗脱曲线，识别组分，并对所鉴定的组分进行定量。

10. 发明申请

US20050159902A1 Apparatus for library searches in mass spectrometry 审中-公开
标题翻译：用于质谱检索的仪器
公开(公告)号：US20050159902A1
公开(公告)日：2005-07-21
申请号：US11037043
申请日：2005-01-19
申请人： Izumi Ogata , Shinya Ito , Yasuhiro Takegawa , Kisaburo Deguchi , Hiroaki Nakagawa , Shin-Ichiro Nishimura
发明人： Izumi Ogata , Shinya Ito , Yasuhiro Takegawa , Kisaburo Deguchi , Hiroaki Nakagawa , Shin-Ichiro Nishimura
IPC分类号： G01N27/62 , H01J49/26 , G06F19/00
CPC分类号： H01J49/0036 , G16C20/20
摘要： In a database MSn spectrum search, search of a known compound whose principal chain is identical to that of an unknown compound is enabled, thereby allowing analysis of an entire structure even if the entire structures of the known compound in database and that of the measured unknown compound are not identical. The MSn spectrum obtained in the MSn measurement of the unknown compound is compared with all the MSm spectra (m≧1) in the database regardless of MSn generation. In the MSn measurement of a series of related compounds including various types of different side chains of the same principal chain, such as in the case of biopolymers, it becomes possible to determine the structure of the principal chain using a database search even if the entire structure is not clear. And the estimation of the entire structure is made possible on the basis of the principal chain structure.
摘要翻译：在数据库MS搜索中，搜索其主链与未知化合物的主链相同的已知化合物，从而允许分析整个结构，即使已知化合物的整个结构在数据库中和测量的未知化合物的数据不相同。将未知化合物的MS 测量中获得的MS 光谱与所有MS谱（m> = 1）进行比较数据库，无论MS ^{n 生成。在一系列相关化合物（包括同一主链的各种不同侧链的相关化合物）的测定中，例如在生物聚合物的情况下，可以确定主链的结构使用数据库搜索即使整个结构不清楚。而整个结构的估计是可以在主链结构的基础上进行的。}

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