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1. 发明授权

US07901573B2 Separation column and liquid chromatography apparatus using the same 失效
标题翻译：分离柱和使用其的液相色谱仪
公开(公告)号：US07901573B2
公开(公告)日：2011-03-08
申请号：US12081572
申请日：2008-04-17
申请人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
发明人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
IPC分类号： B01D15/08
CPC分类号： B01D15/22 , B01D15/206 , B01J20/3236 , B01J2220/82 , B01J2220/86 , G01N30/52 , G01N30/6017 , G01N30/603 , G01N30/6047 , G01N30/6052 , G01N2030/528
摘要： Disclosed herein is a separation column comprising a porous block covered with a coating wherein space-free adhesion is attainable therebetween by low temperature process without releasing octadecylsilyl bases and others from the porous block. A monolith rod 1 is covered with a metal or resin coating 2. Then, the monolith rod 1 covered by the coating 2 is further covered with a rod retainer 3 made of a low melting point metal (melting point 100-200 degrees C.) to form a column body 19. Since the rod retainer 3 is formed by pressure molding at low temperature (100-200 degrees C.). It is therefore possible to absorb the surface irregularities of the monolith rod 1 by the coating 2 while octadecylsilyl bases and others from are released when the retainer 3 is formed. This allows the potential separation ability of the porous block to be brought out maximally.
摘要翻译：本文公开了一种分离柱，其包括用涂层覆盖的多孔块，其中通过低温工艺在其间实现无空隙粘合，而不从多孔块中释放十八烷基甲硅烷基等。整料棒1被金属或树脂涂层2覆盖。然后，用由低熔点金属（熔点100-200℃）制成的棒保持器3进一步覆盖由涂层2覆盖的整料棒1。以形成柱体19.由于杆保持器3通过在低温（100-200℃）下的模压而形成。因此，当保持器3形成时，可以通过涂层2吸收整料棒1的表面凹凸，同时十八烷基甲硅烷基等被释放。这允许最大限度地排出多孔块的潜在分离能力。

2. 发明申请

US20080283458A1 Separation column and liquid chromatography apparatus using the same 失效
标题翻译：分离柱和使用其的液相色谱仪
公开(公告)号：US20080283458A1
公开(公告)日：2008-11-20
申请号：US12081572
申请日：2008-04-17
申请人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
发明人： Kimihiko Ishii , Hironori Kaji , Masahito Ito , Yoshihiro Nagaoka , Kunihiko Takao
IPC分类号： B01D15/08 , B01D15/22
CPC分类号： B01D15/22 , B01D15/206 , B01J20/3236 , B01J2220/82 , B01J2220/86 , G01N30/52 , G01N30/6017 , G01N30/603 , G01N30/6047 , G01N30/6052 , G01N2030/528
摘要： Disclosed herein is a separation column comprising a porous block covered with a coating wherein space-free adhesion is attainable therebetween by low temperature process without releasing octadecylsilyl bases and others from the porous block.A monolith rod 1 is covered with a metal or resin coating 2. Then, the monolith rod 1 covered by the coating 2 is further covered with a rod retainer 3 made of a low melting point metal (melting point 100-200 degrees C.) to form a column body 19. Since the rod retainer 3 is formed by pressure molding at low temperature (100-200 degrees C.). It is therefore possible to absorb the surface irregularities of the monolith rod 1 by the coating 2 while octadecylsilyl bases and others from are released when the retainer 3 is formed. This allows the potential separation ability of the porous block to be brought out maximally.
摘要翻译：本文公开了一种分离柱，其包括用涂层覆盖的多孔块，其中通过低温工艺在其间实现无空隙粘合，而不从多孔块中释放十八烷基甲硅烷基等。整料棒1被金属或树脂涂层2覆盖。然后，用由低熔点金属（熔点为100-200℃）制成的棒保持器3进一步覆盖由涂层2覆盖的整料棒1，以形成柱体19。由于杆保持器3通过在低温（100-200℃）下进行压力成型而形成。因此，当保持器3形成时，可以通过涂层2吸收整料棒1的表面凹凸，同时十八烷基甲硅烷基等被释放。这允许最大限度地排出多孔块的潜在分离能力。

3. 发明申请

US20120128533A1 LIQUID SUPPLY DEVICE USING CHECK VALVE AND REACTIVE LIQUID CHROMATOGRAPHY SYSTEM 失效
标题翻译：使用检查阀和反应液相色谱系统的液体供应装置
公开(公告)号：US20120128533A1
公开(公告)日：2012-05-24
申请号：US13386789
申请日：2010-05-26
申请人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
发明人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
IPC分类号： G01N31/00 , F16K15/00
CPC分类号： F04B23/06 , F04B13/00 , F04B49/08 , F04B49/22 , F04B2205/05 , F16K15/04 , F16K37/0058 , G01N30/32 , G01N30/74 , G01N2030/328 , G01N2030/8435 , Y10T137/7838
摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.
摘要翻译：可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接检测到。止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

4. 发明授权

US08551423B2 Liquid supply device using check valve and reactive liquid chromatography system 失效
标题翻译：液体供应装置采用止回阀和反应液相色谱系统
公开(公告)号：US08551423B2
公开(公告)日：2013-10-08
申请号：US13386789
申请日：2010-05-26
申请人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
发明人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
IPC分类号： B01L3/02
CPC分类号： F04B23/06 , F04B13/00 , F04B49/08 , F04B49/22 , F04B2205/05 , F16K15/04 , F16K37/0058 , G01N30/32 , G01N30/74 , G01N2030/328 , G01N2030/8435 , Y10T137/7838
摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.
摘要翻译：可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接检测到。止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

5. 发明申请

US20070084766A1 Pump for liquid chromatograph 审中-公开
标题翻译：泵用于液相色谱
公开(公告)号：US20070084766A1
公开(公告)日：2007-04-19
申请号：US11582455
申请日：2006-10-18
申请人： Kimihiko Ishii , Kiyotoshi Mori , Masahito Ito , Hironori Kaji , Takefumi Yokokura
发明人： Kimihiko Ishii , Kiyotoshi Mori , Masahito Ito , Hironori Kaji , Takefumi Yokokura
IPC分类号： B01D35/14
CPC分类号： G01N30/32 , G01N30/34 , G01N2030/322 , G01N2030/326
摘要： A pump device is realized, which accurately detects a flow rate of a pump, performs real-time control of the flow rate, and thus can suppress a flow rate error caused by occurrence of pulsation. Control of a pump rotation speed by a pressure sensor has low responsiveness in a low pressure region, and a correlation between a pressure and a flow rate is incomplete in a high flow rate region. With this taken into consideration, a flow rate sensor 10 is disposed at an outlet port 9 of a second pump 4. A position detection sensor 14 detects a point where a first pump 3 is shifted from a suction mode to a discharge mode. Moreover, the flow rate sensor 10 detects that there is no discharge from the pump 3, and that there is discharge from the pump 4 alone. Accordingly, a controller 15 sets a rotation speed of a motor 12 to a speed double the previous speed (double the normal rotation speed). When the flow rate sensor 10 detects an increase in the flow rate at the outlet port 9 of the second pump 4, the controller 15 returns the rotation speed of the motor 12 to a normal rotation speed. The rotation speed of the motor 12 is controlled by accurate flow rate detection by the flow rate sensor 10. Thus, occurrence of pulsation can be suppressed.
摘要翻译：实现了能够精确地检测泵的流量的泵装置，实现流量的实时控制，能够抑制由脉动发生引起的流量误差。通过压力传感器控制泵的转速在低压区域的响应性低，在高流量区域中压力与流量的相关性不完全。考虑到这一点，流量传感器10设置在第二泵4的出口9处。位置检测传感器14检测第一泵3从吸入模式移动到放电模式的点。此外，流量传感器10检测到没有来自泵3的排出，并且仅从泵4排出。因此，控制器15将电动机12的转速设定为与先前速度（正常转速两倍）的速度。当流量传感器10检测到第二泵4的出口9的流量增加时，控制器15将马达12的转速恢复到正常的转速。通过流量传感器10的精确的流量检测来控制电动机12的转速。因此，可以抑制脉动的发生。

6. 发明申请

US20090218267A1 SEPARATION COLUMN AND LIQUID CHROMATOGRAPH 审中-公开
标题翻译：分离柱和液相色谱
公开(公告)号：US20090218267A1
公开(公告)日：2009-09-03
申请号：US12392117
申请日：2009-02-25
申请人： Kiyotoshi MORI , Hironori Kaji , Masahito Ito , Kimihiko Ishii , Tomohiro Shoji , Kousaku Toyosaki
发明人： Kiyotoshi MORI , Hironori Kaji , Masahito Ito , Kimihiko Ishii , Tomohiro Shoji , Kousaku Toyosaki
IPC分类号： B01D15/10
CPC分类号： B01D15/22 , B01J20/28004 , B01J20/28042 , B01J2220/58 , B01J2220/82 , B01J2220/825 , G01N30/6065 , G01N2030/528
摘要： The present invention provides a separation column including a monolithic rod without a resin coating material. The separation column can prevent the monolithic rod from destroying, and a liquid can be delivered at a high pressure into the separation column. The separation column includes the monolithic rod (monolithic silica rod) in a tapered-columnar shape, and a clad with the interior formed in a tapered-columnar shape. The monolithic rod is built into the clad.
摘要翻译：本发明提供一种分离柱，其包括没有树脂涂层材料的整体棒。分离柱可以防止单块棒破坏，并且可以将液体以高压输送到分离塔中。分离柱包括呈锥形的整体式棒（整体式石英棒），内部形成为锥形的包层。整体式杆被装入包层。

7. 发明授权

US08123496B2 Two-unit pump for liquid chromatograph with flow sensor arrangement 失效
标题翻译：液体色谱仪两单元泵，配有流量传感器
公开(公告)号：US08123496B2
公开(公告)日：2012-02-28
申请号：US12845487
申请日：2010-07-28
申请人： Kimihiko Ishii , Kiyotoshi Mori , Masahito Ito , Hironori Kaji , Takefumi Yokokura
发明人： Kimihiko Ishii , Kiyotoshi Mori , Masahito Ito , Hironori Kaji , Takefumi Yokokura
IPC分类号： F04B1/06 , F04B49/20 , B01D15/10
CPC分类号： G01N30/32 , G01N30/34 , G01N2030/322 , G01N2030/326
摘要： A pump device which accurately detects a flow rate of a pump, performs real-time control of the flow rate, and thus can suppress a flow rate error caused by occurrence of pulsation. Control of a pump rotation speed by a pressure sensor has low responsiveness in a low pressure region, and a correlation between a pressure and a flow rate is incomplete in a high flow rate region. With this taken into consideration, a flow rate sensor is disposed at an outlet port of a second pump. A position detection sensor detects a point where a first pump is shifted from a suction mode to a discharge mode. Moreover, the flow rate sensor detects that there is no discharge from the pump, and that there is discharge from the pump alone. Accordingly, a controller sets a rotation speed of a motor to a speed double the previous speed (double the normal rotation speed). When the flow rate sensor detects an increase in the flow rate at the outlet port of the second pump, the controller returns the rotation speed of the motor to a normal rotation speed. The rotation speed of the motor is controlled by accurate flow rate detection by the flow rate sensor. Thus, occurrence of pulsation can be suppressed.
摘要翻译：准确地检测泵的流量的泵装置，对流量进行实时控制，能够抑制由脉动发生引起的流量误差。通过压力传感器控制泵的转速在低压区域的响应性低，在高流量区域中压力与流量的相关性不完全。考虑到这一点，流量传感器设置在第二泵的出口处。位置检测传感器检测第一泵从吸入模式移动到排出模式的点。此外，流量传感器检测到没有来自泵的放电，并且仅从泵排出。因此，控制器将电动机的转速设定为与先前速度相同的速度（正常转速的两倍）。当流量传感器检测到第二泵的出口处的流量增加时，控制器将马达的转速恢复到正常的转速。通过流量传感器的精确流量检测来控制电动机的转速。因此，可以抑制脉动的发生。

8. 发明申请

US20100288027A1 PUMP FOR LIQUID CHROMATOGRAPH 失效
标题翻译：液相色谱泵
公开(公告)号：US20100288027A1
公开(公告)日：2010-11-18
申请号：US12845487
申请日：2010-07-28
申请人： Kimihiko Ishii , Kiyotoshi Mori , Masahito Ito , Hironori Kaji , Takefumi Yokokura
发明人： Kimihiko Ishii , Kiyotoshi Mori , Masahito Ito , Hironori Kaji , Takefumi Yokokura
IPC分类号： G01N30/00 , B01D35/157
CPC分类号： G01N30/32 , G01N30/34 , G01N2030/322 , G01N2030/326
摘要： A pump device is realized, which accurately detects a flow rate of a pump, performs real-time control of the flow rate, and thus can suppress a flow rate error caused by occurrence of pulsation. Control of a pump rotation speed by a pressure sensor has low responsiveness in a low pressure region, and a correlation between a pressure and a flow rate is incomplete in a high flow rate region. With this taken into consideration, a flow rate sensor 10 is disposed at an outlet port 9 of a second pump 4. A position detection sensor 14 detects a point where a first pump 3 is shifted from a suction mode to a discharge mode. Moreover, the flow rate sensor 10 detects that there is no discharge from the pump 3, and that there is discharge from the pump 4 alone. Accordingly, a controller 15 sets a rotation speed of a motor 12 to a speed double the previous speed (double the normal rotation speed). When the flow rate sensor 10 detects an increase in the flow rate at the outlet port 9 of the second pump 4, the controller 15 returns the rotation speed of the motor 12 to a normal rotation speed. The rotation speed of the motor 12 is controlled by accurate flow rate detection by the flow rate sensor 10. Thus, occurrence of pulsation can be suppressed.
摘要翻译：实现了能够精确地检测泵的流量的泵装置，实现流量的实时控制，能够抑制由脉动发生引起的流量误差。通过压力传感器控制泵的转速在低压区域的响应性低，在高流量区域中压力与流量的相关性不完全。考虑到这一点，流量传感器10设置在第二泵4的出口9处。位置检测传感器14检测第一泵3从吸入模式移动到放电模式的点。此外，流量传感器10检测到没有来自泵3的排出，并且仅从泵4排出。因此，控制器15将电动机12的转速设定为与先前速度（正常转速两倍）的速度。当流量传感器10检测到第二泵4的出口9处的流量增加时，控制器15将马达12的转速恢复到正常的转速。通过流量传感器10的精确的流量检测来控制电动机12的转速。因此，可以抑制脉动的发生。

9. 发明申请

US20090001007A1 SEPARATION COLUMN FOR LIQUID CHROMATOGRAPH APPARATUS AND LIQUID CHROMATOGRAPH APPARATUS USING THEREOF 失效
标题翻译：液相色谱仪和液相色谱仪的分离色谱柱
公开(公告)号：US20090001007A1
公开(公告)日：2009-01-01
申请号：US12146912
申请日：2008-06-26
申请人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
发明人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
IPC分类号： B01D15/08
CPC分类号： B01D15/22 , B01J20/282 , B01J2220/82 , B01J2220/825 , G01N30/22 , G01N30/6047 , G01N30/6052 , G01N30/6069 , G01N2030/522 , G01N2030/528
摘要： Both a column having high-pressure resistance and capable of performing high-speed separation and analysis even with a small flow rate and a liquid chromatograph apparatus using thereof are to be provided.A separation column according to the present invention has a monolithic rod being arranged in the center, being made of a porous material, and having a circular cross section, a filler layer arranged such that it encircles a circumferential surface of the monolithic rod, and a cylindrical support medium arranged outside the filler layer. The filler layer is formed by filling a tube-like gap between the monolithic rod and the support medium with particles or beads.
摘要翻译：提供具有高耐压性并且即使使用小流量也能够进行高速分离和分析的柱和使用其的液相色谱装置。根据本发明的分离柱具有中心的整体式杆，由多孔材料制成，并且具有圆形横截面，填充层布置成围绕整体式杆的圆周表面，并且圆柱形支撑介质布置在填充层外部。通过在颗粒或珠粒之间填充整体棒和支撑介质之间的管状间隙来形成填充层。

10. 发明授权

US08496819B2 Separation column for liquid chromatograph apparatus and liquid chromatograph apparatus using thereof 失效
标题翻译：液相色谱仪分离柱及其使用的液相色谱仪
公开(公告)号：US08496819B2
公开(公告)日：2013-07-30
申请号：US12146912
申请日：2008-06-26
申请人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
发明人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
IPC分类号： B01D15/08 , G01N30/02 , C02F1/28
CPC分类号： B01D15/22 , B01J20/282 , B01J2220/82 , B01J2220/825 , G01N30/22 , G01N30/6047 , G01N30/6052 , G01N30/6069 , G01N2030/522 , G01N2030/528
摘要： Both a column having high-pressure resistance and capable of performing high-speed separation and analysis even with a small flow rate and a liquid chromatograph apparatus using the column are provided. A separation column according to the present invention has a monolithic rod being arranged in the center, being made of a porous material, and having a circular cross section, a filler layer arranged such that it encircles a circumferential surface of the monolithic rod, and a cylindrical support medium arranged outside the filler layer. The filler layer is formed by filling a tube-like gap between the monolithic rod and the support medium with particles or beads.
摘要翻译：提供了具有高耐压性并且即使以小流量进行高速分离和分析的柱和使用该柱的液相色谱装置。根据本发明的分离柱具有中心的整体式杆，由多孔材料制成，并且具有圆形横截面，填充层布置成使其围绕整体式杆的圆周表面，并且圆柱形支撑介质布置在填充层外部。通过在颗粒或珠粒之间填充整体棒和支撑介质之间的管状间隙来形成填充层。

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