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1. 发明授权

US08496819B2 Separation column for liquid chromatograph apparatus and liquid chromatograph apparatus using thereof 失效
标题翻译：液相色谱仪分离柱及其使用的液相色谱仪
公开(公告)号：US08496819B2
公开(公告)日：2013-07-30
申请号：US12146912
申请日：2008-06-26
申请人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
发明人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
IPC分类号： B01D15/08 , G01N30/02 , C02F1/28
CPC分类号： B01D15/22 , B01J20/282 , B01J2220/82 , B01J2220/825 , G01N30/22 , G01N30/6047 , G01N30/6052 , G01N30/6069 , G01N2030/522 , G01N2030/528
摘要： Both a column having high-pressure resistance and capable of performing high-speed separation and analysis even with a small flow rate and a liquid chromatograph apparatus using the column are provided. A separation column according to the present invention has a monolithic rod being arranged in the center, being made of a porous material, and having a circular cross section, a filler layer arranged such that it encircles a circumferential surface of the monolithic rod, and a cylindrical support medium arranged outside the filler layer. The filler layer is formed by filling a tube-like gap between the monolithic rod and the support medium with particles or beads.
摘要翻译：提供了具有高耐压性并且即使以小流量进行高速分离和分析的柱和使用该柱的液相色谱装置。根据本发明的分离柱具有中心的整体式杆，由多孔材料制成，并且具有圆形横截面，填充层布置成使其围绕整体式杆的圆周表面，并且圆柱形支撑介质布置在填充层外部。通过在颗粒或珠粒之间填充整体棒和支撑介质之间的管状间隙来形成填充层。

2. 发明申请

US20090001007A1 SEPARATION COLUMN FOR LIQUID CHROMATOGRAPH APPARATUS AND LIQUID CHROMATOGRAPH APPARATUS USING THEREOF 失效
标题翻译：液相色谱仪和液相色谱仪的分离色谱柱
公开(公告)号：US20090001007A1
公开(公告)日：2009-01-01
申请号：US12146912
申请日：2008-06-26
申请人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
发明人： Katsutoshi Shimizu , Masahito Ito , Kimihiko Ishii , Yoshihiro Nagaoka , Kisaburo Deguchi , Takefumi Yokokura
IPC分类号： B01D15/08
CPC分类号： B01D15/22 , B01J20/282 , B01J2220/82 , B01J2220/825 , G01N30/22 , G01N30/6047 , G01N30/6052 , G01N30/6069 , G01N2030/522 , G01N2030/528
摘要： Both a column having high-pressure resistance and capable of performing high-speed separation and analysis even with a small flow rate and a liquid chromatograph apparatus using thereof are to be provided.A separation column according to the present invention has a monolithic rod being arranged in the center, being made of a porous material, and having a circular cross section, a filler layer arranged such that it encircles a circumferential surface of the monolithic rod, and a cylindrical support medium arranged outside the filler layer. The filler layer is formed by filling a tube-like gap between the monolithic rod and the support medium with particles or beads.
摘要翻译：提供具有高耐压性并且即使使用小流量也能够进行高速分离和分析的柱和使用其的液相色谱装置。根据本发明的分离柱具有中心的整体式杆，由多孔材料制成，并且具有圆形横截面，填充层布置成围绕整体式杆的圆周表面，并且圆柱形支撑介质布置在填充层外部。通过在颗粒或珠粒之间填充整体棒和支撑介质之间的管状间隙来形成填充层。

3. 发明申请

US20120128533A1 LIQUID SUPPLY DEVICE USING CHECK VALVE AND REACTIVE LIQUID CHROMATOGRAPHY SYSTEM 失效
标题翻译：使用检查阀和反应液相色谱系统的液体供应装置
公开(公告)号：US20120128533A1
公开(公告)日：2012-05-24
申请号：US13386789
申请日：2010-05-26
申请人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
发明人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
IPC分类号： G01N31/00 , F16K15/00
CPC分类号： F04B23/06 , F04B13/00 , F04B49/08 , F04B49/22 , F04B2205/05 , F16K15/04 , F16K37/0058 , G01N30/32 , G01N30/74 , G01N2030/328 , G01N2030/8435 , Y10T137/7838
摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.
摘要翻译：可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接检测到。止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

4. 发明授权

US08551423B2 Liquid supply device using check valve and reactive liquid chromatography system 失效
标题翻译：液体供应装置采用止回阀和反应液相色谱系统
公开(公告)号：US08551423B2
公开(公告)日：2013-10-08
申请号：US13386789
申请日：2010-05-26
申请人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
发明人： Kisaburo Deguchi , Hironori Kaji , Kimihiko Ishii , Daisuke Akieda , Kunihiko Takao , Masaru Yamasaki , Kenji Hiraku , Yoshihiro Nagaoka
IPC分类号： B01L3/02
CPC分类号： F04B23/06 , F04B13/00 , F04B49/08 , F04B49/22 , F04B2205/05 , F16K15/04 , F16K37/0058 , G01N30/32 , G01N30/74 , G01N2030/328 , G01N2030/8435 , Y10T137/7838
摘要： It is possible to correctly determine whether a change in the pressure or flow rate is caused by normal opening and closing operations of a check valve and to monitor in real time whether an operation of a check valve is normal or abnormal in a liquid supply device. Light is introduced in the check valve and a change in the quantity of light transmitted through or reflected by the check valve, caused by the opening and closing of the valve is detected, so that the opening and closing operations of the check valve can be directly detected. The check valve is arranged in a pipe in the liquid supply device, and a change in the pressure in the pipe is monitored on the basis of a signal from a pressure sensor and a signal which represents the opening and closing of the check valve.
摘要翻译：可以正确地确定压力或流量的变化是否由止回阀的正常的打开和关闭操作引起，并且实时监测液体供应装置中止回阀的操作是否正常或异常。在止回阀中引入光，并且检测到由阀的打开和关闭引起的止回阀透过或反射的光量的变化，使得止回阀的打开和关闭操作可以直接检测到。止回阀布置在液体供应装置中的管道中，并且基于来自压力传感器的信号和表示止回阀的打开和关闭的信号来监测管道中的压力变化。

5. 发明申请

US20110303599A1 LIQUID CHROMATOGRAPH, LIQUID CHROMATOGRAPH COLUMN AND FILTER FOR LIQUID CHROMATOGRAPH COLUMN 有权
标题翻译：液相色谱，液相色谱柱和液相色谱柱过滤器
公开(公告)号：US20110303599A1
公开(公告)日：2011-12-15
申请号：US13202722
申请日：2010-03-10
申请人： Norimasa Minamoto , Masahito Ito , Kisaburo Deguchi , Hiroyuki Tanai , Kiyotoshi Mori
发明人： Norimasa Minamoto , Masahito Ito , Kisaburo Deguchi , Hiroyuki Tanai , Kiyotoshi Mori
IPC分类号： B01D15/08 , B01D39/10
CPC分类号： G01N30/603
摘要： In a liquid chromatograph, the disulfide adsorption of iron atoms in a filter for a column is avoided and thus peak tailing in a chromatogram is prevented to thereby prevent a lowering in the sample recovery rate. A liquid chromatograph column comprising a hollow tubular column body, a bead-shaped packing material which is packed in the hollow part of the column body, a filter provided with a mesh which has a mesh size smaller than the particle diameter of the packing material, and a cap which presses the filter against the packing material to thereby enclose the packing material within the column body, characterized in that the main component of the filter is nickel or hastelloy.
摘要翻译：在液相色谱仪中，避免了用于柱的过滤器中的铁原子的二硫键吸附，因此防止了色谱图中的峰值拖尾，从而防止了样品回收率的降低。一种液相色谱柱，包括中空管状柱体，填充在柱体中空部分中的珠状包装材料，具有筛网尺寸小于包装材料粒径的筛网的过滤器，以及将过滤器压靠在包装材料上的盖子，从而将包装材料包围在柱体内，其特征在于，过滤器的主要部件是镍或哈氏合金。

6. 发明申请

US20070199874A1 Three-dimensional liquid chromatography 审中-公开
标题翻译：三维液相色谱
公开(公告)号：US20070199874A1
公开(公告)日：2007-08-30
申请号：US11700844
申请日：2007-02-01
申请人： Masahito Ito , Junkichi Miura , Kisaburo Deguchi
发明人： Masahito Ito , Junkichi Miura , Kisaburo Deguchi
IPC分类号： B01D15/08
CPC分类号： G01N30/463 , G01N30/461 , G01N30/7233 , G01N30/96 , B01D15/322 , B01D15/362 , B01D15/325 , B01D15/363
摘要： In a liquid chromatography apparatus, a separation column of intermediate stage is additionally connected between a separation column of first stage and a separation column of second stage. Preferably, a switching unit and a liquid feed unit for mixing and feeding a plurality of solutions are added to improve a separation capability. A three-dimensional liquid chromatography apparatus capable of avoiding the “solution interference” can be realized. Even a complex sample containing a hydrophilic component and a hydrophobic component in a mixed state can be separated and analyzed satisfactorily on-line.
摘要翻译：在液相色谱装置中，中间级分离塔另外连接在第一级分离塔和第二级分离塔之间。优选地，添加用于混合和供给多个溶液的切换单元和液体进料单元以提高分离能力。可以实现能够避免“溶液干扰”的三维液相色谱仪。即使是含有亲水性成分和混合状态的疏水性成分的复合物，也可以在线进行分离和分析。

7. 发明申请

US20060271310A1 Method and apparatus for analyzing multi-channel chromatogram 失效
标题翻译：用于分析多通道色谱图的方法和装置
公开(公告)号：US20060271310A1
公开(公告)日：2006-11-30
申请号：US11501750
申请日：2006-08-10
申请人： Masahito Ito , Kisaburo Deguchi
发明人： Masahito Ito , Kisaburo Deguchi
IPC分类号： G01N31/00
CPC分类号： G01N30/8624 , G01N30/8631 , G01N30/8679 , G01N2201/1293
摘要： A method for analyzing a multi-channel chromatogram is realized for accurately resolving overlapping peaks on a multi-channel chromatogram to permit analysis of the composition of a sample. First, components of overlapping peaks are specified. A data matrix Dij is determined, and compressed in the wavelength direction to obtain a data matrix vector Di. Next, the two-dimensional data is deconvoluted, final standard deviation s0 is registered, and the deconvoluted two-dimensional data is reconvoluted to a retention intensity matrix. A quantitative spectral intensity matrix is computed, components are identified, and the identified components are quantified. Subsequently, an eigenvalue problem is solved, and the number n of components is estimated. The deconvolution and computation of the eigenvalue problem are iteratively executed until the peaks are isolated. Then, elution profiles are calculated, the components are identified, and the identified components are quantified.
摘要翻译：实现了分析多通道色谱图的方法，用于准确地分辨多通道色谱图上的重叠峰，以便分析样品的组成。首先，指定重叠峰的分量。确定数据矩阵Dij，并在波长方向上压缩以获得数据矩阵向量Di。接下来，对二维数据进行解卷积，记录最终标准偏差s0，并将解卷积的二维数据重新卷积到保留强度矩阵。计算定量光谱强度矩阵，识别组件，并对所识别的组分进行量化。随后，解决了特征值问题，并且估计了分量的数量n。迭代执行反褶积和特征值问题的计算，直到峰被隔离。然后，计算洗脱曲线，识别组分，并对所鉴定的组分进行定量。

8. 发明授权

US06393368B1 Method and apparatus for analyzing multi-channel chromatogram 失效
公开(公告)号：US06393368B1
公开(公告)日：2002-05-21
申请号：US08811486
申请日：1997-03-05
申请人： Masahito Ito , Kisaburo Deguchi
发明人： Masahito Ito , Kisaburo Deguchi
IPC分类号： G01N3000
CPC分类号： G01N30/8624 , G01N30/8631 , G01N30/8679 , G01N2201/1293
摘要： A method for analyzing a multichannel chromatogram is realized for accurately resolving overlapping peaks on a multichannel chromatogram to permit analysis of the composition of a sample. First, components of overlapping peaks are specified. A data matrix Dij is determined, and compressed in the wavelength direction to obtain a data matrix vector Di. By compressing three-dimensional data in the wavelength direction, noise components cancel with each other to obtain noise free two-dimensional data Di&bgr;. Next, the two-dimensional data is deconvoluted, final standard deviation s0 is registered, and the deconvoluted two-dimensional data is reconvoluted to a retention intensity matrix. A quantitative spectral intensity matrix is computed, components are identified, and the identified components are quantified. The quantified data is displayed on a screen. Since noise components cancel with each other, it is possible to realize an analyzing method which is capable of accurately resolving and analyzing the components. Also, overlapping peaks are specified, and a data matrix D is determined. Subsequently, an eigenvalue problem is solved, and the number n of components is estimated. The deconvolution and computation of the eigenvalue problem are iteratively executed until the peaks are isolated. Then, elution profiles are calculated, the components are identified, and the identified components are quantified.

9. 发明授权

US6148266A Data processing apparatus for chromatograph 失效
公开(公告)号：US6148266A
公开(公告)日：2000-11-14
申请号：US605416
申请日：1996-02-22
申请人： Masahito Ito , Kisaburo Deguchi , Yoshiaki Seki
发明人： Masahito Ito , Kisaburo Deguchi , Yoshiaki Seki
IPC分类号： G01N30/86 , G06F17/10 , G06F19/00
CPC分类号： G06F17/10 , G01N30/8641
摘要： A method of properly correcting a base line. A concept of flexibility of a base line is introduced as an input index and a gravitation is presumed between the base line and signal data which is measured, thereby constructing a method of correcting the base line which changes gentler than a change in signal with respect to time in a peak area and which is sensitive to an area where a value of the signal data is small. A base line like a natural and smooth curve which isn't easily influenced by a local change in signal such as noise or the like can be set by an input of the flexibility.

10. 发明授权

US5644503A Methods and apparatuses for analyzing multichannel chromatogram 失效
标题翻译：分析多通道色谱图的方法和装置
公开(公告)号：US5644503A
公开(公告)日：1997-07-01
申请号：US409986
申请日：1995-03-24
申请人： Masahito Ito , Kisaburo Deguchi
发明人： Masahito Ito , Kisaburo Deguchi
IPC分类号： G01N27/447 , G01N30/86 , G01N31/00 , G01N30/00 , G06F17/16
CPC分类号： G01N30/8624 , G01N2201/1293 , G01N30/8631 , G01N30/8679
摘要： A method for analyzing a multichannel chromatogram is realized for accurately resolving overlapping peaks on a multichannel chromatogram to permit analysis of the composition of a sample. First, components of overlapping peaks are specified. A data matrix Dij is determined, and compressed in the wavelength direction to obtain a data matrix vector Di. By compressing three-dimensional data in the wavelength direction, noise components cancel with each other to obtain noise free two-dimensional data Di.beta.. Next, the two-dimensional data is deconvoluted, final standard deviation s0 is registered, and the deconvoluted two-dimensional data is reconvoluted to a retention intensity matrix. A quantitative spectral intensity matrix is computed, components are identified, and the identified components are quantified. The quantified data is displayed on a screen. Since noise components cancel with each other, it is possible to realize an analyzing method which is capable of accurately resolving and analyzing the components. Also, overlapping peaks are specified, and a data matrix D is determined. Subsequently, an eigenvalue problem is solved, and the number n of components is estimated. The deconvolution and computation of the eigenvalue problem are iteratively executed until the peaks are isolated. Then, elution profiles are calculated, the components are identified, and the identified components are quantified.
摘要翻译：实现了用于分析多通道色谱图的方法，用于准确地分辨多通道色谱图上的重叠峰，以允许分析样品的组成。首先，指定重叠峰的分量。确定数据矩阵Dij，并在波长方向上压缩以获得数据矩阵向量Di。通过在波长方向压缩三维数据，噪声分量彼此抵消，以获得无噪声的二维数据Diβ。接下来，对二维数据进行解卷积，记录最终标准偏差s0，并将解卷积的二维数据重新卷积到保留强度矩阵。计算定量光谱强度矩阵，识别组件，并对所识别的组分进行量化。量化的数据显示在屏幕上。由于噪声分量彼此抵消，因此可以实现能够精确地分析和分析组件的分析方法。此外，指定重叠的峰值，并且确定数据矩阵D. 随后，解决了特征值问题，估计了组件的数量+ E，uns n + EE。迭代执行反褶积和特征值问题的计算，直到峰被隔离。然后，计算洗脱曲线，识别组分，并对所鉴定的组分进行定量。

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