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1. 发明授权

US5336688A Composition containing organogermanium compound and immunity adjusting agents comprising the compositions 失效
标题翻译：含有有机锗化合物的组合物和包含该组合物的免疫调节剂
公开(公告)号：US5336688A
公开(公告)日：1994-08-09
申请号：US8876
申请日：1993-01-25
申请人： Kiichi Sawai , Masayasu Kurono , Juichi Awaya , Akio Kojima , Hideako Ninomiya , Yoshiro Ishiwata , Masahiro Nakajima
发明人： Kiichi Sawai , Masayasu Kurono , Juichi Awaya , Akio Kojima , Hideako Ninomiya , Yoshiro Ishiwata , Masahiro Nakajima
IPC分类号： A61K31/28 , A01N55/02
CPC分类号： A61K31/28
摘要： A composition comprising an organogermanium compound represented by the formula ##STR1## wherein n is an integer of 1 or more, R is hydrogen, alkyl, --COOH, --COOR', phenyl, ##STR2## and R' is a lower alkyl and a high molecular carrier, as well as an immunity adjusting agent comprising the composition.
摘要翻译：一种组合物，其包含由式“IMAGE”表示的有机锗化合物，其中n为1以上的整数，R为氢，烷基，-COOH，-COOR'，苯基，R'为低级烷基，高分子载体，以及包含该组合物的免疫调节剂。

2. 发明授权

US5340806A Composition containing organogermanium compound and immunity adjusting agent comprising the composition 失效
标题翻译：含有有机锗化合物的组合物和包含该组合物的免疫调节剂
公开(公告)号：US5340806A
公开(公告)日：1994-08-23
申请号：US850720
申请日：1993-01-07
申请人： Kiichi Sawai , Masayasu Kurono , Juichi Awaya , Akio Kojima , Hideaki Ninomiya , Yoshiro Ishiwata , Masahiro Nakajima
发明人： Kiichi Sawai , Masayasu Kurono , Juichi Awaya , Akio Kojima , Hideaki Ninomiya , Yoshiro Ishiwata , Masahiro Nakajima
IPC分类号： A61K31/28 , A61K31/79 , A61K31/555
CPC分类号： A61K31/28
摘要： A composition comprising an organogermanium compound represented by the formula ##STR1## wherein n is an integer of 1 or more, R is hydrogen, alkyl, --COOH, --COOR', phenyl, ##STR2## and R' is a lower alkyl and a high molecular carrier, as well as an immunity adjusting agent comprising the composition. The treatment of hepatitis with compositions containing this germanium derivative.
摘要翻译：一种组合物，其包含由式（I）表示的有机锗化合物，其中n为1以上的整数，R为氢，烷基，-COOH，-COOR'，苯基，或者图像 >和R'是低级烷基和高分子载体，以及包含该组合物的免疫调节剂。用含锗衍生物的组合物治疗肝炎。

3. 发明授权

US4889715A Composition containing organogermanium compound and immunity adjusting agent comprising the composition 失效
标题翻译：含有有机锗化合物的组合物和包含该组合物的免疫调节剂
公开(公告)号：US4889715A
公开(公告)日：1989-12-26
申请号：US224279
申请日：1988-07-25
申请人： Kiichi Sawai , Masayasu Kurono , Juichi Awaya , Akio Kojima , Hideaki Ninomiya
发明人： Kiichi Sawai , Masayasu Kurono , Juichi Awaya , Akio Kojima , Hideaki Ninomiya
IPC分类号： A61K31/555 , A61K31/28 , A61K31/80 , A61P37/00 , C07F7/30
CPC分类号： A61K31/28
摘要： A composition comprising an organogermanium compound represented by the formula ##STR1## wherein n is an integer of 1 or more, R is hydrogen, alkyl, --COOH, --COOR', phenyl, ##STR2## and R' is a lower alkyl and a high molecular carrier, as well as an immunity adjusting agent comprising the composition.
摘要翻译：一种组合物，其包含由式“IMAGE”表示的有机锗化合物，其中n为1以上的整数，R为氢，烷基，-COOH，-COOR'，苯基，R'为低级烷基，高分子载体，以及包含该组合物的免疫调节剂。

4. 发明授权

US5290679A Method of predicting threatened premature delivery in a pregnant woman 失效
标题翻译：孕妇威胁性早产的预测方法
公开(公告)号：US5290679A
公开(公告)日：1994-03-01
申请号：US898681
申请日：1992-06-15
申请人： Toshihiko Terao , Naohiro Kanayama , Akihiro Morioka , Yoshika Yasuda , Masami Kamiya , Juichi Awaya , Masayasu Kurono , Kiichi Sawai
发明人： Toshihiko Terao , Naohiro Kanayama , Akihiro Morioka , Yoshika Yasuda , Masami Kamiya , Juichi Awaya , Masayasu Kurono , Kiichi Sawai
IPC分类号： A61K49/00 , G01N33/573 , C12Q1/00 , C12Q1/37
CPC分类号： G01N33/573
摘要： Even when the specimen contains human granulocyte elastase in the form of a mixture of free elastase with an elastase-inhibitor complex or complexes, the present invention enables the total quantity of elastase in that specimen to be precisely detected. The inhibitor is added to free elastase to convert it into an elastase-inhibitor complex, whereby the quantity of elastase can be measured by immunoassay as the total amount including the previously existing elastase-inhibitor complex. It is possible to precisely measure the total amount of elastase in mucus collected from the cervical canal of a pregnant woman, sputum or a rinsed solution of bronchovesicular lavage in which free elastase is mixed with an elastase-inhibitor complex. It is thus possible to predict and prevent threatened premature delivery, premature delivery or premature rupture of membranes by immunoassay of mucus collected from the cervical canal of a pregnant woman, to make a diagnosis of chronic or repetitive airway infections and pulmonary emphysema based on chronic respiratory diseases by immunoassay of sputum and a rinsed solution of bronchovesicular lavage and to make a diagnosis of urinary tract infections by immunoassay of urine.
摘要翻译：即使样品含有游离弹性蛋白酶与弹性蛋白酶抑制剂复合物或复合物的混合物形式的人粒细胞弹性蛋白酶，本发明能够精确地检测该样本中弹性蛋白酶的总量。将抑制剂加入到游离弹性蛋白酶中以将其转化成弹性蛋白酶抑制剂复合物，由此弹性蛋白酶的量可以通过免疫测定来测量，包括先前存在的弹性蛋白酶抑制剂复合物的总量。可以精确测量从孕妇，痰液或冲洗的支气管泡灌洗液的宫颈管中收集的弹性蛋白酶的总量，其中游离弹性蛋白酶与弹性蛋白酶抑制剂复合物混合。因此，可以通过从孕妇的宫颈管收集的粘液的免疫测定来预测和预防受威胁的早产，早产或过早破裂，以诊断慢性或重复性气道感染和基于慢性呼吸的肺气肿通过免疫测定痰液的疾病和支气管泡灌洗液的清洗溶液，并通过免疫测定尿液来诊断尿路感染。

5. 发明授权

US4308210A Nanaomycin B and therapeutic compositions containing same 失效
标题翻译：纳那霉素B和含有其的治疗组合物
公开(公告)号：US4308210A
公开(公告)日：1981-12-29
申请号：US43396
申请日：1979-05-25
申请人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
发明人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
IPC分类号： C07D311/92 , A61K31/35 , A61K31/352 , A61P17/00 , A61P31/04 , C12P17/06 , C07D311/78
CPC分类号： C12R1/465 , C12P17/06
摘要： The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicament for infectious diseases of humans and animals caused by a parasite of trichophyton or mycoplasma etc. The acute toxicity (LD.sub.50, intra-penetrial injection) in mice of this compound is 169 mg/Kg.Nanaomycin B is produced by fermentation in which a nanaomycin-producing strain belonging to the genus Streptomyces is cultured in a medium under aerobic conditions and the accumulated nanaomycin B in the cultured broths is recovered therefrom.
摘要翻译：本发明涉及以通式表示的纳那霉素B的新化合物：＆lt; IMAGE＆gt; Nanaomycin B是醌类，对支原体，革兰氏阳性菌和真菌是有活性的。该化合物可用作由毛发虫或支原体寄生虫引起的人和动物感染性疾病的药物。该化合物小鼠的急性毒性（LD50，渗透内注射）为169mg / Kg。纳豆霉素B通过发酵生产，其中在需氧条件下培养在属于链霉菌属的纳米霉素生产菌株，并从其中回收培养肉汤中积累的纳诺霉素B.

6. 发明授权

US3974273A Compound NA-337 and a process for producing the same by fermentation 失效
标题翻译：化合物NA-337及其制备方法
公开(公告)号：US3974273A
公开(公告)日：1976-08-10
申请号：US558573
申请日：1975-03-14
申请人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Yaeko Konda , Yoshitsugu Narimatsu , Masayuki Onda
发明人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Yaeko Konda , Yoshitsugu Narimatsu , Masayuki Onda
IPC分类号： C07D207/20 , C07D211/70 , C12P1/06 , C12P17/10 , C12P17/12 , A61K35/66 , C12B1/00 , C12K1/00
CPC分类号： C12P17/10 , C07D207/20 , Y10S435/886
摘要： This invention relates to a new compound NA-337 and a process for producing the same by fermentation. NA-337 is positive in Dragendorff's reagent. NA-337 is confirmed to be a new compound having a fat-clearing activity. This compound is produced by fermentation, in which an NA-337-producing strain is cultured aerobically in a medium and the accumulated NA-337 is recovered from the cultured matters.
摘要翻译：本发明涉及一种新的化合物NA-337及其通过发酵生产该化合物的方法。在Dragendorff的试剂中，NA-337是阳性的。 NA-337被证实是具有脂肪清除活性的新化合物。该化合物通过发酵生产，其中NA-337生产菌株在培养基中有氧培养，并从培养物中回收累积的NA-337。

7. 发明授权

US3995028A Antibiotic OS-3256-B 失效
标题翻译：抗生素OS-3256-B
公开(公告)号：US3995028A
公开(公告)日：1976-11-30
申请号：US606687
申请日：1975-08-21
申请人： Satoshi Omura , Iwao Umezawa , Keiki Satoh , Juichi Awaya , Kanki Komiyama , Ruiko Oiwa
发明人： Satoshi Omura , Iwao Umezawa , Keiki Satoh , Juichi Awaya , Kanki Komiyama , Ruiko Oiwa
IPC分类号： C07G11/00 , A61K35/74
CPC分类号： A61K36/06 , C07G11/00 , Y10S435/892
摘要： The present invention relates to a new antibiotic designated as OS-3256-B. OS-3256-B exhibits excellent inhibitory activities against animal tumors such as leukemia L-1210, Sarcoma-180 and Hela cells and gram-positive bacteria and is classified into the diazocompounds group. However, chromatographic analysis, Rf value and other experimental data reveal that OS-3256-B is a new compound of the type of azaamino acid derivatives. The present invention also provides a process for producing OS-3256-B by fermentation, in which OS-3256-B is produced by culturing a microorganism belonging to Streptomyces candidus var. azaticus in a culture medium conventionally used for culturing Streptomyces strain microorganisms.
摘要翻译：本发明涉及一种称为OS-3256-B的新型抗生素。 OS-3256-B对动物肿瘤例如白血病L-1210，肉瘤180和Hela细胞和革兰氏阳性细菌具有优异的抑制活性，并被分类为重氮化合物组。然而，色谱分析，Rf值等实验数据表明，OS-3256-B是一种新型的氮杂氨基酸衍生物化合物。本发明还提供了通过发酵生产OS-3256-B的方法，其中OS-3256-B是通过培养属于Streptomyces candidus var。通常用于培养链霉菌菌株微生物的培养基中的azaticus。

8. 发明授权

US3956487A Novel antifungal antibiotic substance, and agricultural and horticultural fungicidal composition containing said substance 失效
标题翻译：新型抗真菌抗生素，以及含有该物质的农业和园艺杀真菌组合物
公开(公告)号：US3956487A
公开(公告)日：1976-05-11
申请号：US453041
申请日：1974-03-20
申请人： Toju Hata , Satoshi Omura , Michiko Katagiri , Juichi Awaya , Shimpei Kuyama , Shizuo Higashikawa , Kazuomi Yasui , Haruko Terada
发明人： Toju Hata , Satoshi Omura , Michiko Katagiri , Juichi Awaya , Shimpei Kuyama , Shizuo Higashikawa , Kazuomi Yasui , Haruko Terada
IPC分类号： C07H13/04 , A01N9/00
CPC分类号： C07H13/04
摘要： The antifungal antibiotic substance "F-1028" having the following formula, ##EQU1## or an acid salt thereof, a process for the production of the same by fermentation, and a fungicidal composition useful for agricultural and horticultural use.
摘要翻译：具有下式的抗真菌抗生素物质“F-1028”，HCOH || HCNH 2 || HO 2 || CH 3 CHCONHCH ||| NH 2 CH 2或其酸式盐，通过发酵生产该方法用于农业和园艺用途的杀真菌组合物。

9. 发明授权

US5464818A Protein having cell growth-stimulating and macrophage chemotactic actions, preparative method therefor and use thereof 失效
标题翻译：具有细胞生长刺激和巨噬细胞趋化作用的蛋白质，其制备方法及其用途
公开(公告)号：US5464818A
公开(公告)日：1995-11-07
申请号：US365820
申请日：1994-12-29
申请人： Tadashi Yamaguchi , Hiroshi Uesaka , Kazuo Watanabe , Juichi Awaya
发明人： Tadashi Yamaguchi , Hiroshi Uesaka , Kazuo Watanabe , Juichi Awaya
IPC分类号： A61K38/00 , C07K14/33 , C07K14/475 , C12N9/52 , C12P21/00 , A61K38/02
CPC分类号： C07K14/33 , C07K14/475 , C12N9/52 , A61K38/00 , Y10S435/842
摘要： There are described a novel protein derived from Clostridium perfringens FERM BP-4584 method of obtaining the same and use thereof as an effective ingredient for treating wounds and ulcers. The protein has a molecular weight of 420,000.+-.40,000 by a GPC, isoelectric point of 4.8, and consists of a single subunit having a molecular weight of 130,000.+-.20,000 by a SDS-polyacrylamide gel electrophoresis, and shows cell growth-stimulating activity as well as macrophage chemotactic action. The protein can be extracted and separated by conventional techniques for obtaining a protein from general microorganisms, by taking an inhibition of decomposition into consideration, since the protein is not so stable.
摘要翻译：描述了产生产气荚膜梭菌FERM BP-4584的新型蛋白质，其获得相同的作用和用作治疗伤口和溃疡的有效成分。该蛋白质通过GPC，等电点为4.8，分子量为420,000 +/- 40,000，通过SDS-聚丙烯酰胺凝胶电泳由分子量为130,000 +/- 20,000的单个亚基组成，并显示出细胞生长 - 刺激活性以及巨噬细胞趋化作用。蛋白质可以通过常规技术提取和分离，以通过考虑抑制分解来获得一般微生物的蛋白质，因为蛋白质不是如此稳定。

10. 发明授权

US4226879A Antibiotic composition 失效
标题翻译：抗生素组成
公开(公告)号：US4226879A
公开(公告)日：1980-10-07
申请号：US939102
申请日：1978-09-01
申请人： Satoshi Omura , Chiaki Kitao , Akira Nakagawa , Haruo Tanaka , Juichi Awaya , Ruiko Oiwa
发明人： Satoshi Omura , Chiaki Kitao , Akira Nakagawa , Haruo Tanaka , Juichi Awaya , Ruiko Oiwa
IPC分类号： A23K20/195 , A61K31/335 , A61K35/00 , C07D303/06
CPC分类号： A23K20/195
摘要： The present invention relates to a new composition designated as AM-1042 or asukamycin. AM-1042 has an antibiotic activity upon Gram-positive bacteria and Eimeria, and its acute toxicity (LD.sub.50 ' ip.) in mice was 48.5 mg./kg. AM-1042 has an excellent therapeutical effect on various infectious diseases caused by a parasite of Gram-positive bacteria and Eimeria. AM-1042 has been confirmed to be distinguishable from known antibiotics such as e.g. amicetin B, azomycin and manumycin. AM-1042 is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing AM-1042. A composition capable of preventing and curing coccidiosis of poultry containing AM-1042 as active ingredient.
摘要翻译：本发明涉及一种称为AM-1042或无菌素的新组合物。 AM-1042对革兰氏阳性菌和艾美球虫具有抗菌活性，其在小鼠中的急性毒性（LD50'ip。）为48.5mg./kg。 AM-1042对由革兰氏阳性菌和艾美球虫寄生虫引起的各种感染性疾病具有极好的治疗作用。已证实AM-1042可与已知的抗生素区别，例如： amicetin B，azomycin和manumycin。 AM-1042是通过发酵属于链霉菌属的微生物并产生AM-1042产生的。一种能够预防和治疗含有AM-1042作为活性成分的家禽的球虫病的组合物。

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