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1. 发明授权

US6002097A System and method for producing nebulized sample analyte containing solution for introduction to sample analysis systems 失效
标题翻译：用于产生雾化样品分析物的系统和方法，用于引入样品分析系统
公开(公告)号：US6002097A
公开(公告)日：1999-12-14
申请号：US144893
申请日：1998-09-01
申请人： Akihiro Morioka , Junichi Takahashi , Toshikazu Amano , William J. Stein , Robert C. Fry
发明人： Akihiro Morioka , Junichi Takahashi , Toshikazu Amano , William J. Stein , Robert C. Fry
IPC分类号： H01J49/04 , G01N1/28 , G01N21/71 , G01N27/62 , B23K9/00
CPC分类号： G01N21/714
摘要： The present invention is a system for nebulizing sample analyte containing solutions which allows liquid solution and gas entry, and is tyically utilized in combination or integration with an interface for directing sample analyte containing solution which is nebulized. The present invention provides improvement in the form of system design that prevents sample delivery tube component damage, sample solution electrical charging, sample solution "re-nebulization" effects, and sample analyte carry-over memory effects during a present invention method of use for introducing nebulized sample analyte containing solution into, for instance, a mass-spectrometer sample analysis system.
摘要翻译：本发明是一种用于雾化含有溶液的溶液的系统，其允许液体溶液和气体进入，并且与用于引导被雾化的样品分析物含有溶液的界面组合或整合地暴露性地使用。本发明提供了在本发明的引入方法中使用的系统设计形式的改进，其防止样品输送管组分损伤，样品溶液充电，样品溶液“再雾化”效应和样品分析物携带记忆效应将含有溶液的雾化样品分析物加入到例如质谱仪样品分析系统中。

2. 发明授权

US5290679A Method of predicting threatened premature delivery in a pregnant woman 失效
标题翻译：孕妇威胁性早产的预测方法
公开(公告)号：US5290679A
公开(公告)日：1994-03-01
申请号：US898681
申请日：1992-06-15
申请人： Toshihiko Terao , Naohiro Kanayama , Akihiro Morioka , Yoshika Yasuda , Masami Kamiya , Juichi Awaya , Masayasu Kurono , Kiichi Sawai
发明人： Toshihiko Terao , Naohiro Kanayama , Akihiro Morioka , Yoshika Yasuda , Masami Kamiya , Juichi Awaya , Masayasu Kurono , Kiichi Sawai
IPC分类号： A61K49/00 , G01N33/573 , C12Q1/00 , C12Q1/37
CPC分类号： G01N33/573
摘要： Even when the specimen contains human granulocyte elastase in the form of a mixture of free elastase with an elastase-inhibitor complex or complexes, the present invention enables the total quantity of elastase in that specimen to be precisely detected. The inhibitor is added to free elastase to convert it into an elastase-inhibitor complex, whereby the quantity of elastase can be measured by immunoassay as the total amount including the previously existing elastase-inhibitor complex. It is possible to precisely measure the total amount of elastase in mucus collected from the cervical canal of a pregnant woman, sputum or a rinsed solution of bronchovesicular lavage in which free elastase is mixed with an elastase-inhibitor complex. It is thus possible to predict and prevent threatened premature delivery, premature delivery or premature rupture of membranes by immunoassay of mucus collected from the cervical canal of a pregnant woman, to make a diagnosis of chronic or repetitive airway infections and pulmonary emphysema based on chronic respiratory diseases by immunoassay of sputum and a rinsed solution of bronchovesicular lavage and to make a diagnosis of urinary tract infections by immunoassay of urine.
摘要翻译：即使样品含有游离弹性蛋白酶与弹性蛋白酶抑制剂复合物或复合物的混合物形式的人粒细胞弹性蛋白酶，本发明能够精确地检测该样本中弹性蛋白酶的总量。将抑制剂加入到游离弹性蛋白酶中以将其转化成弹性蛋白酶抑制剂复合物，由此弹性蛋白酶的量可以通过免疫测定来测量，包括先前存在的弹性蛋白酶抑制剂复合物的总量。可以精确测量从孕妇，痰液或冲洗的支气管泡灌洗液的宫颈管中收集的弹性蛋白酶的总量，其中游离弹性蛋白酶与弹性蛋白酶抑制剂复合物混合。因此，可以通过从孕妇的宫颈管收集的粘液的免疫测定来预测和预防受威胁的早产，早产或过早破裂，以诊断慢性或重复性气道感染和基于慢性呼吸的肺气肿通过免疫测定痰液的疾病和支气管泡灌洗液的清洗溶液，并通过免疫测定尿液来诊断尿路感染。

3. 发明授权

US4447309A pH Sensor 失效
标题翻译： pH传感器
公开(公告)号：US4447309A
公开(公告)日：1984-05-08
申请号：US406513
申请日：1982-08-09
申请人： Akihiro Morioka , Yuji Maeda , Tetsuro Matsumoto , Masakazu Yukinari , Eiichi Kishida
发明人： Akihiro Morioka , Yuji Maeda , Tetsuro Matsumoto , Masakazu Yukinari , Eiichi Kishida
IPC分类号： G01N27/30 , G01N27/38 , G01N27/403
CPC分类号： G01N27/38 , G01N27/4035
摘要： A pH sensor comprising a sleeve assembly having at least first and second spaces, a partition separating the two spaces from each other with a water tight seal, and a barrel including a flange, a reference electrode accommodated in the first space and including a liquid junction, a glass electrode having a sensor unit disposed adjacent to the liquid junction, liquid grounding means mounted adjacent to the liquid junction, and a cable disposed in the second space with a watertight seal, the cable being electrically connected to the reference electrode, glass electrode and liquid grounding means. The pH sensor can be used for continuous flow, immersion or submersion types of installations, and can be fabricated inexpensively and is easily maintained. The sensor unit of the pH sensor can be easily cleaned by a cleaning unit which includes a rotatable shaft to which is connected a vane and a brush at one end. Fluid is impinged on the vane to cause rotation of the shaft and brush, lifts the brush against the sensor unit, and is ejected out of the shaft to clean the sensor unit and brush. A simple attachment can be used to connect the cleaning unit to the pH sensor to enable rapid, easily and reliable cleaning, and to enable rapid replacement of such cleaning unit.
摘要翻译：一种pH传感器，其包括具有至少第一和第二空间的套筒组件，用两个空间彼此隔开防水密封的隔板，以及容纳在所述第一空间中的包括凸缘，参考电极并包括液体接头具有邻近液体接点设置的传感器单元的玻璃电极，邻近液体接合处安装的液体接地装置，以及设置在第二空间中的水密密封的电缆，该电缆电连接到参考电极，玻璃电极和液体接地装置。 pH传感器可用于连续流动，浸入式或浸没型安装，并且可以廉价地制造并且易于维护。 pH传感器的传感器单元可以通过清洁单元容易地清洁，该清洁单元包括在一端连接有叶片和刷子的可旋转轴。流体撞击在叶片上以引起轴和刷子的旋转，将刷子提升到传感器单元上，并将其从轴中排出以清洁传感器单元和刷子。可以使用简单的附件将清洁单元连接到pH传感器，以实现快速，容易和可靠的清洁，并能够快速更换这种清洁单元。

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