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1. 发明授权

US4308210A Nanaomycin B and therapeutic compositions containing same 失效
标题翻译：纳那霉素B和含有其的治疗组合物
公开(公告)号：US4308210A
公开(公告)日：1981-12-29
申请号：US43396
申请日：1979-05-25
申请人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
发明人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
IPC分类号： C07D311/92 , A61K31/35 , A61K31/352 , A61P17/00 , A61P31/04 , C12P17/06 , C07D311/78
CPC分类号： C12R1/465 , C12P17/06
摘要： The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicament for infectious diseases of humans and animals caused by a parasite of trichophyton or mycoplasma etc. The acute toxicity (LD.sub.50, intra-penetrial injection) in mice of this compound is 169 mg/Kg.Nanaomycin B is produced by fermentation in which a nanaomycin-producing strain belonging to the genus Streptomyces is cultured in a medium under aerobic conditions and the accumulated nanaomycin B in the cultured broths is recovered therefrom.
摘要翻译：本发明涉及以通式表示的纳那霉素B的新化合物：＆lt; IMAGE＆gt; Nanaomycin B是醌类，对支原体，革兰氏阳性菌和真菌是有活性的。该化合物可用作由毛发虫或支原体寄生虫引起的人和动物感染性疾病的药物。该化合物小鼠的急性毒性（LD50，渗透内注射）为169mg / Kg。纳豆霉素B通过发酵生产，其中在需氧条件下培养在属于链霉菌属的纳米霉素生产菌株，并从其中回收培养肉汤中积累的纳诺霉素B.

2. 发明授权

US4324728A Compound nanaomycin A and derivatives thereof and a process for producing the same 失效
标题翻译：复方纳诺霉素A及其衍生物及其制备方法
公开(公告)号：US4324728A
公开(公告)日：1982-04-13
申请号：US47451
申请日：1979-06-11
申请人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
发明人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
IPC分类号： C07D311/92 , A61K31/35 , A61K31/352 , A61P31/04 , C12P7/66 , C12P17/06
CPC分类号： C12R1/465 , C12P17/06
摘要： The present invention relates to new compound nanaomycin A and derivatives thereof represented by general formula: ##STR1## in which (a) R is H and R' is OH (nanaomycin A),(b) R is H and R' is NH.sub.2 (nanaomycin C),(c) R is COCH.sub.3 and R' is OH (acetylnanaomycin A), and(d) R is H and R' is OCH.sub.3 (nanaomycin A methyl ester).Nanaomycin A is a new compound of quinone type and its acute toxicity (LD.sub.50, intra-penetrial injection) in mice is 28.2 mg/Kg. Nanaomycin A and derivatives thereof are active on Gram-positive bacteria, trichophyton and mycoplasma and are useful as a medicament for humans and animals. Nanaomycins A and C are produced by culturing a nanaomycin-producing strain belonging to the genus Streptomyces aerobically in a medium to accumulate nanaomycins A and C in the cultured broths. The derivatives acetylnanaomycin A and nanaomycin A methyl ester have similar properties to those of nanaomycin A.
摘要翻译：本发明涉及由以下通式表示的新化合物纳那霉素A及其衍生物：其中（a）R是H，R'是OH（纳那霉素A），（b）R是H和R' 是NH2（纳那霉素C），（c）R是COCH 3，R'是OH（乙酰氨基霉素A），和（d）R是H，R'是OCH 3（纳诺霉素A甲酯）。 Nanaomycin A是醌类的新化合物，其在小鼠中的急性毒性（LD50，内渗注射）为28.2mg / Kg。纳诺霉素A及其衍生物对革兰氏阳性菌，毛毛虫和支原体具有活性，可用作人和动物的药物。 Nanaomycins A和C通过在培养基中培养产生链霉菌属的链霉菌属的纳米霉素生产菌株在培养基中培养以在培养的肉汤中积累纳米菌素A和C而产生。乙酰纳他霉素A和纳那霉素A甲酯的衍生物具有与纳那霉素A相似的性质。

3. 发明授权

US4196266A Production of nanaomycin A and derivatives thereof 失效
标题翻译：生产纳诺霉素A及其衍生物
公开(公告)号：US4196266A
公开(公告)日：1980-04-01
申请号：US858215
申请日：1977-12-07
申请人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
发明人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
IPC分类号： C12P17/06 , C12D9/14
CPC分类号： C12R1/465 , C12P17/06 , Y10S435/886
摘要： The present invention relates to new compound nanaomycin A and derivatives thereof represented by general formula: ##STR1## in which (a) R is H and R' is OH (nanaomycin A),(b) R is H and R' is NH.sub.2 (nanaomycin C),(c) R is COCH.sub.3 and R' is CH (acetylnanaomycin A), and(d) R is H and R' is OCH.sub.3 (nanaomycin A methyl ester).Nanaomycin A is a new compound of quinone type and its acute toxicity (LD.sub.50, intra-penetrial injection) in mice is 28.2 mg/Kg. Nanaomycin A and derivatives thereof are active on Gram-positive bacteria, trichophyton and mycoplasma and are useful as a medicament for humans and animals. Nanaomycins A and C are produced by culturing a nanaomycin-producing strain belonging to the genus Streptomyces aerobically in a medium to accumulate nanaomycins A and C in the cultured broths. The derivatives acetylnanaomycin A and nanaomycin A methyl ester have similar properties to those of nanaomycin A.
摘要翻译：本发明涉及由以下通式表示的新化合物纳那霉素A及其衍生物：其中（a）R是H，R'是OH（纳那霉素A），（b）R是H和R' 是NH2（纳那霉素C），（c）R是COCH 3，R'是CH（乙酰氨基霉素A），和（d）R是H，R'是OCH 3（纳诺霉素A甲酯）。 Nanaomycin A是醌类的新化合物，其在小鼠中的急性毒性（LD50，内渗注射）为28.2mg / Kg。纳诺霉素A及其衍生物对革兰氏阳性菌，毛毛虫和支原体具有活性，可用作人和动物的药物。 Nanaomycins A和C通过在培养基中培养产生链霉菌属的链霉菌属的纳米霉素生产菌株在培养基中培养以在培养的肉汤中积累纳米菌素A和C而产生。乙酰纳他霉素A和纳那霉素A甲酯的衍生物具有与纳那霉素A相似的性质。

4. 发明授权

US4194064A Production of nanaomycin B 失效
标题翻译：生产纳诺霉素B
公开(公告)号：US4194064A
公开(公告)日：1980-03-18
申请号：US858216
申请日：1977-12-07
申请人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
发明人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Toju Hata
IPC分类号： C12P17/06 , C12D9/14
CPC分类号： C12R1/465 , C12P17/06 , Y10S435/886
摘要： The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicament for infectious diseases of humans and animals caused by a parasite of trichophyton or mycoplasma etc. The acute toxicity (LD.sub.50, intra-penetrial injection) in mice of this compound is 169 mg/kg. Nanaomycin B is produced by fermentation in which a nanaomycin-producing strain belonging to the genus Streptomyces is cultured in a medium under aerobic conditions and the accumulated nanaomycin B in the cultured broths is recovered therefrom.
摘要翻译：本发明涉及以通式表示的纳那霉素B的新化合物：＆lt; IMAGE＆gt; Nanaomycin B是醌类，对支原体，革兰氏阳性菌和真菌是有活性的。该化合物可用作由毛癣菌或支原体寄生虫等引起的人类和动物感染性疾病的药物。该化合物小鼠的急性毒性（LD50，内渗注射）为169mg / kg。纳豆霉素B通过发酵生产，其中在需氧条件下培养在属于链霉菌属的纳米霉素生产菌株，并从其中回收培养肉汤中积累的纳诺霉素B.

5. 发明授权

US4226879A Antibiotic composition 失效
标题翻译：抗生素组成
公开(公告)号：US4226879A
公开(公告)日：1980-10-07
申请号：US939102
申请日：1978-09-01
申请人： Satoshi Omura , Chiaki Kitao , Akira Nakagawa , Haruo Tanaka , Juichi Awaya , Ruiko Oiwa
发明人： Satoshi Omura , Chiaki Kitao , Akira Nakagawa , Haruo Tanaka , Juichi Awaya , Ruiko Oiwa
IPC分类号： A23K20/195 , A61K31/335 , A61K35/00 , C07D303/06
CPC分类号： A23K20/195
摘要： The present invention relates to a new composition designated as AM-1042 or asukamycin. AM-1042 has an antibiotic activity upon Gram-positive bacteria and Eimeria, and its acute toxicity (LD.sub.50 ' ip.) in mice was 48.5 mg./kg. AM-1042 has an excellent therapeutical effect on various infectious diseases caused by a parasite of Gram-positive bacteria and Eimeria. AM-1042 has been confirmed to be distinguishable from known antibiotics such as e.g. amicetin B, azomycin and manumycin. AM-1042 is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing AM-1042. A composition capable of preventing and curing coccidiosis of poultry containing AM-1042 as active ingredient.
摘要翻译：本发明涉及一种称为AM-1042或无菌素的新组合物。 AM-1042对革兰氏阳性菌和艾美球虫具有抗菌活性，其在小鼠中的急性毒性（LD50'ip。）为48.5mg./kg。 AM-1042对由革兰氏阳性菌和艾美球虫寄生虫引起的各种感染性疾病具有极好的治疗作用。已证实AM-1042可与已知的抗生素区别，例如： amicetin B，azomycin和manumycin。 AM-1042是通过发酵属于链霉菌属的微生物并产生AM-1042产生的。一种能够预防和治疗含有AM-1042作为活性成分的家禽的球虫病的组合物。

6. 发明授权

US3974273A Compound NA-337 and a process for producing the same by fermentation 失效
标题翻译：化合物NA-337及其制备方法
公开(公告)号：US3974273A
公开(公告)日：1976-08-10
申请号：US558573
申请日：1975-03-14
申请人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Yaeko Konda , Yoshitsugu Narimatsu , Masayuki Onda
发明人： Satoshi Omura , Haruo Tanaka , Juichi Awaya , Yaeko Konda , Yoshitsugu Narimatsu , Masayuki Onda
IPC分类号： C07D207/20 , C07D211/70 , C12P1/06 , C12P17/10 , C12P17/12 , A61K35/66 , C12B1/00 , C12K1/00
CPC分类号： C12P17/10 , C07D207/20 , Y10S435/886
摘要： This invention relates to a new compound NA-337 and a process for producing the same by fermentation. NA-337 is positive in Dragendorff's reagent. NA-337 is confirmed to be a new compound having a fat-clearing activity. This compound is produced by fermentation, in which an NA-337-producing strain is cultured aerobically in a medium and the accumulated NA-337 is recovered from the cultured matters.
摘要翻译：本发明涉及一种新的化合物NA-337及其通过发酵生产该化合物的方法。在Dragendorff的试剂中，NA-337是阳性的。 NA-337被证实是具有脂肪清除活性的新化合物。该化合物通过发酵生产，其中NA-337生产菌株在培养基中有氧培养，并从培养物中回收累积的NA-337。

7. 发明申请

US20080254507A1 Anti-Hiv Drug, Polypeptide Constituting the Same, Gene Encoding the Polypeptide and Method of Producing the Anti-Hiv Drug 审中-公开
标题翻译：构建其的抗-HIV药物，多肽，编码多肽的基因及产生抗-HIV药物的方法
公开(公告)号：US20080254507A1
公开(公告)日：2008-10-16
申请号：US11791862
申请日：2005-11-30
申请人： Haruo Tanaka , Junji Inokoshi , Satoshi Omura
发明人： Haruo Tanaka , Junji Inokoshi , Satoshi Omura
IPC分类号： C12P21/00 , C07K14/00 , C07H21/00 , C12N1/21
CPC分类号： C07K14/36 , A61K38/00
摘要： It is intended to provide an anti-HIV drug characterized by containing multimeric actinohivin, a polypeptide which is multimeric actinohivin; a gene encoding the same; and a method of producing the anti-HIV drug. The anti-HIV drug inhibits the synctium formation and has an enhanced effect
摘要翻译：旨在提供一种抗HIV药物，其特征在于含有多聚肌动蛋白，多聚肌动蛋白多肽; 编码该基因的基因; 以及产生抗HIV药物的方法。抗艾滋病毒药物可以抑制游离体的形成并具有增强的作用

8. 发明授权

US5869675A Lactacystin derivatives 失效
标题翻译：乳酸衍生物
公开(公告)号：US5869675A
公开(公告)日：1999-02-09
申请号：US979637
申请日：1997-11-28
申请人： Satoshi Omura , Toshiaki Sunazuka , Haruo Tanaka
发明人： Satoshi Omura , Toshiaki Sunazuka , Haruo Tanaka
IPC分类号： C07D207/12 , C07D207/28 , C07D401/12
CPC分类号： C07D401/12 , C07D207/28
摘要： Novel lactacystin derivatives other than lactacystin per se, with superior activity for the genesis of neurites and highly selective toxicity and low cytotoxicity as compared with known lactacystin have been prepared, of the formula ##STR1## wherein R is lower alkoxy, --S--(CH.sub.2).sub.n R.sup.1 or --S--(CH.sub.2) .sub.n --CH(R.sup.2)-(R.sup.3), in which R.sup.1 is branched or straight-chain lower alkyl, hydroxy, carboxyl, lower alkoxycarbonyl, optionally substituted phenyl, substituted or unsubstituted amino or pyridyl, R.sup.2 is substituted or unsubstituted amino, lower alkyl or amino acid residue, R.sup.3 is carboxyl, lower alkoxycarbonyl, lower alkenyloxycarbonyl or amino acid residue, and n is 0-4, or a pharmacologically acceptable salt thereof.
摘要翻译：与已知的乳胞蛋白相比，已经制备了除了乳糖蛋白本身以外的新型乳胞素衍生物，具有优异的神经突发生活性和高选择性毒性和低细胞毒性，其中R为低级烷氧基，-S - （CH2）nR1或-S-（CH2）n-CH（R2） - （R3），其中R1是支链或直链低级烷基，羟基，羧基，低级烷氧基羰基，任选取代的苯基，取代或未取代的氨基或吡啶基，R2为取代或未取代的氨基，低级烷基或氨基酸残基，R3为羧基，低级烷氧基羰基，低级链烯氧基羰基或氨基酸残基，n为0-4，或其药理学上可接受的盐。

9. 发明授权

US4296040A Antibiotic nanaomycin E and a process for producing the same 失效
标题翻译：抗生素纳米霉素E及其制备方法
公开(公告)号：US4296040A
公开(公告)日：1981-10-20
申请号：US97001
申请日：1970-11-23
申请人： Satoshi Omura , Haruo Tanaka , Itaru Takahashi , Shinzo Ishii , Kazuyuki Mineura , Kunikatsu Shirahata , Masaji Kasai
发明人： Satoshi Omura , Haruo Tanaka , Itaru Takahashi , Shinzo Ishii , Kazuyuki Mineura , Kunikatsu Shirahata , Masaji Kasai
IPC分类号： A61K31/35 , A61P31/04 , C07D493/08 , C12P17/18 , C12R1/465 , C07D311/78
CPC分类号： C07D493/08 , C12P17/181 , Y10S435/886
摘要： The present invention teaches a new antibiotic nanaomycin E represented by the formula: ##STR1## Nanaomycin E is active against Gram-positive bacteria, Trichophyton and Mycoplasma and may be used as antibacterial and therapeutic agents for humans and animals. Nanaomycin E is also a useful starting maerial for the preparation of nanaomycin A which latter nanaomycin has the highest activity among the various nanaomycin-type compounds. Nanaomycin E is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing nanaomycin E, especially Streptomyces rosa variant notoensis (FERM-P 2209; ATCC 31135) and recovering the same from the fermented liquor.
摘要翻译：本发明教导了由下式表示的新型抗生素纳那霉素E：Nanaomycin E对革兰氏阳性菌，毛癣菌和支原体具有活性，可用作人和动物的抗菌剂和治疗剂。纳豆霉素E也是制备纳诺霉素A的有用起始物，后者纳那霉素在各种纳诺霉素型化合物中活性最高。纳豆霉素E是通过发酵属于链霉菌属的微生物产生的，并且能够产生纳诺霉素E，特别是罗氏变形链霉菌（FERM-P 2209; ATCC 31135），并从发酵液中回收。

10. 发明授权

US4613355A Antibiotic having herbicidal activity 失效
标题翻译：具有除草活性的抗生素
公开(公告)号：US4613355A
公开(公告)日：1986-09-23
申请号：US636643
申请日：1984-08-01
申请人： Satoshi Omura , Haruo Tanaka , Kiyoizumi Hinotozawa , Masatsune Murata , Yuzuru Iwai
发明人： Satoshi Omura , Haruo Tanaka , Kiyoizumi Hinotozawa , Masatsune Murata , Yuzuru Iwai
IPC分类号： A01N57/20 , C07K5/08 , A01N57/00
CPC分类号： C07K5/0827 , A01N57/20 , C12R1/01
摘要： A compound of the formula ##STR1## and salts thereof, exhibits herbicidal activity against many herbaceous and woody plants. The compound may be formulated for agricultural use in conventional manner.The compound may be made by fermentation of a suitable strain of a microorganism of the genus Kitasatosporia, especially the novel strain Actinomycetes KA-338 (FERM BP-358).
摘要翻译：式（Ⅰ）化合物及其盐的化合物对许多草本植物和木本植物表现出除草活性。化合物可以以常规方式配制用于农业用途。该化合物可以通过发酵一种适宜的Kitasatosporia属微生物菌株，特别是新型放线菌KA-338菌株（FERM BP-358）来制备。

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