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1. 发明授权

US5340806A Composition containing organogermanium compound and immunity adjusting agent comprising the composition 失效
标题翻译：含有有机锗化合物的组合物和包含该组合物的免疫调节剂
公开(公告)号：US5340806A
公开(公告)日：1994-08-23
申请号：US850720
申请日：1993-01-07
申请人： Kiichi Sawai , Masayasu Kurono , Juichi Awaya , Akio Kojima , Hideaki Ninomiya , Yoshiro Ishiwata , Masahiro Nakajima
发明人： Kiichi Sawai , Masayasu Kurono , Juichi Awaya , Akio Kojima , Hideaki Ninomiya , Yoshiro Ishiwata , Masahiro Nakajima
IPC分类号： A61K31/28 , A61K31/79 , A61K31/555
CPC分类号： A61K31/28
摘要： A composition comprising an organogermanium compound represented by the formula ##STR1## wherein n is an integer of 1 or more, R is hydrogen, alkyl, --COOH, --COOR', phenyl, ##STR2## and R' is a lower alkyl and a high molecular carrier, as well as an immunity adjusting agent comprising the composition. The treatment of hepatitis with compositions containing this germanium derivative.
摘要翻译：一种组合物，其包含由式（I）表示的有机锗化合物，其中n为1以上的整数，R为氢，烷基，-COOH，-COOR'，苯基，或者图像 >和R'是低级烷基和高分子载体，以及包含该组合物的免疫调节剂。用含锗衍生物的组合物治疗肝炎。

2. 发明授权

US5336688A Composition containing organogermanium compound and immunity adjusting agents comprising the compositions 失效
标题翻译：含有有机锗化合物的组合物和包含该组合物的免疫调节剂
公开(公告)号：US5336688A
公开(公告)日：1994-08-09
申请号：US8876
申请日：1993-01-25
申请人： Kiichi Sawai , Masayasu Kurono , Juichi Awaya , Akio Kojima , Hideako Ninomiya , Yoshiro Ishiwata , Masahiro Nakajima
发明人： Kiichi Sawai , Masayasu Kurono , Juichi Awaya , Akio Kojima , Hideako Ninomiya , Yoshiro Ishiwata , Masahiro Nakajima
IPC分类号： A61K31/28 , A01N55/02
CPC分类号： A61K31/28
摘要： A composition comprising an organogermanium compound represented by the formula ##STR1## wherein n is an integer of 1 or more, R is hydrogen, alkyl, --COOH, --COOR', phenyl, ##STR2## and R' is a lower alkyl and a high molecular carrier, as well as an immunity adjusting agent comprising the composition.
摘要翻译：一种组合物，其包含由式“IMAGE”表示的有机锗化合物，其中n为1以上的整数，R为氢，烷基，-COOH，-COOR'，苯基，R'为低级烷基，高分子载体，以及包含该组合物的免疫调节剂。

3. 发明授权

US5260056A Composition for enhancing biosynthesis of interferon 失效
标题翻译：用于增强干扰素生物合成的组合物
公开(公告)号：US5260056A
公开(公告)日：1993-11-09
申请号：US640750
申请日：1991-01-14
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
IPC分类号： A61K31/28 , A61K31/70 , A61K37/66 , A61K31/79 , A61K59/16
CPC分类号： A61K31/28 , A61K31/70
摘要： An organic germanium compound to be effectively used for curing AIDS or making AIDS asymtomatic in various forms is expressed by the following rational formula: ##STR1## wherein n is an integer of 1 or 2 or more, is in the form of a white acicular or needle crystal, shows a solubility of 1.570/100 ml in water at 25.degree. C. and exhibits a melting (decomposition) point of 240.degree. C.
摘要翻译：有效地用于治疗AIDS或以各种形式产生AIDS的有机锗化合物由以下有理式表示：其中n为1或2或更大的整数，为白色针状或针状结晶，在25℃的水中的溶解度为1.570 / 100ml，熔点（分解）为240℃。

4. 发明授权

US5356880A Glycyrrhetinic acid derivatives 失效
标题翻译：甘草次酸衍生物
公开(公告)号：US5356880A
公开(公告)日：1994-10-18
申请号：US889709
申请日：1992-05-28
申请人： Masayasu Kurono , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Takahiko Mitani , Takuji Kakigami , Noriyuki Iwata , Kougaku Isogawa , Yutaka Baba , Hiroyuki Ohwaki , Kiichi Sawai , Hiromoto Kimura , Masato Fukushima , Ryoichi Unno , Tamaki Ohtuka
发明人： Masayasu Kurono , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Takahiko Mitani , Takuji Kakigami , Noriyuki Iwata , Kougaku Isogawa , Yutaka Baba , Hiroyuki Ohwaki , Kiichi Sawai , Hiromoto Kimura , Masato Fukushima , Ryoichi Unno , Tamaki Ohtuka
IPC分类号： C07C61/35 , C07C62/38 , C07C323/41 , C07D295/185 , C07H15/256 , C07J63/00 , A61K31/58 , C07J43/00
CPC分类号： C07D295/185 , C07C323/41 , C07C61/35 , C07C62/38 , C07H15/256 , C07J63/008 , C07C2103/52
摘要： The invention provides a novel glycoside which contains as the aglycon a 4-(substituted phenyl)piperazine-1-yl derivative of glycyrrhetinic acid and 11-deoxo-glycyrrhetinic acid or their derivative as well as a composition for the treatment of virus infection, which contains these compounds as a main active component.
摘要翻译：本发明提供了一种新颖的糖苷，其含有作为糖苷配基的甘草次酸和11-脱氧甘草次酸或其衍生物的4-（取代苯基）哌嗪-1-基衍生物以及用于治疗病毒感染的组合物，其中含有这些化合物作为主要活性组分。

5. 发明授权

US5279835A Binder-free orally administrable tablet containing 3-oxygermylpropionic acid 失效
标题翻译：无粘合剂的含3-氧基甲基丙酸的口服片剂
公开(公告)号：US5279835A
公开(公告)日：1994-01-18
申请号：US906465
申请日：1992-06-30
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Yasuaki Kondo , Makoto Sato , Yoshiro Ishiwata , Syoji Yokochi , Toshiyuki Kouzaki
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Yasuaki Kondo , Makoto Sato , Yoshiro Ishiwata , Syoji Yokochi , Toshiyuki Kouzaki
IPC分类号： A61K9/20 , A61K31/28 , A61K31/80 , A61K47/02 , A61K47/26 , A61P43/00
CPC分类号： A61K31/80 , A61K31/28 , A61K9/2009 , A61K9/2018
摘要： A 3-oxygermylpropionic acid preparation is provided, which activates the action of 3-oxygermylpropionic acid having the general formula:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOH]n wherein n=an integer of at least 1 and is readily solubilized and disintegrated in vivo. The present preparation is manufactured by compression-molding at high pressure a composition comprising 3-oxygermylpropionic acid and two or more low-molecular substance of high solubility in water. The low-molecular substances are selected from the group consisting of white sugar, sorbitol, fructose, sucrose, glucose, lactose, mannitol and sodium chloride.
摘要翻译：提供了3-氧基甲基丙酸制剂，其活化具有以下通式的3-氧基甲基丙酸的作用：（（O1 / 2）3GeCH2CH2COOH）n，其中n =至少为1的整数，并且在体内容易溶解和分解。本制剂通过高压压缩成型制备，该组合物包含3-氧基甲基丙酸和两种或更多种在水中的高溶解度的低分子量物质。低分子物质选自白糖，山梨糖醇，果糖，蔗糖，葡萄糖，乳糖，甘露醇和氯化钠。

6. 发明授权

US5730971A Potentiator for interferon and an antiviral activity-potentiating composition containing interferon and its potentiator 失效
标题翻译：用于干扰素的增效剂和含有干扰素及其增效剂的抗病毒活性增强组合物
公开(公告)号：US5730971A
公开(公告)日：1998-03-24
申请号：US361442
申请日：1994-12-20
申请人： Yoshiro Ishiwata , Takahito Jomori , Hidetsugu Saito , Takahiko Mitani , Kiichi Sawai
发明人： Yoshiro Ishiwata , Takahito Jomori , Hidetsugu Saito , Takahiko Mitani , Kiichi Sawai
IPC分类号： A61K31/525 , A61K31/675 , A61K31/70 , A61K35/407 , A61K38/21 , A61P31/12 , A61P43/00
CPC分类号： A61K31/70 , A61K35/407 , A61K38/21
摘要： A potentiator for interferon and an antiviral activity-potentiating composition containing interferon and its potentiator are provided. The potentiator is a mixture of flavin adenine dinucleotide (FAD) and porcine liver extract.
摘要翻译：提供了一种干扰素增强剂和含有干扰素及其增效剂的抗病毒活性增强组合物。增效剂是黄素腺嘌呤二核苷酸（FAD）和猪肝提取物的混合物。

7. 发明授权

US4528184A Polymer-metal complexes containing quaternary nitrogen atoms used in the treatment of hypercholesteremia 失效
标题翻译：含有用于治疗高胆固醇血症的季氮原子的聚合物 - 金属络合物
公开(公告)号：US4528184A
公开(公告)日：1985-07-09
申请号：US438487
申请日：1982-11-02
申请人： Masayasu Kurono , Osamu Nakagawa , Takafumi Iida , Yoshiro Ishiwata , Tomio Ogasawara , Meiji Kuwayama
发明人： Masayasu Kurono , Osamu Nakagawa , Takafumi Iida , Yoshiro Ishiwata , Tomio Ogasawara , Meiji Kuwayama
IPC分类号： C08G59/00 , A61K31/785 , A61K31/80 , A61P9/10 , C08G73/00 , C08G73/02 , C08G79/00 , C08L63/00 , A61K31/74
CPC分类号： A61K31/80 , A61K31/785 , C08G73/0226
摘要： A novel polymer-metal complex containing quaternary nitrogen atoms, which is obtained by subjecting polyethylenepolyamine or polyethyleneimine to a reaction with a bifunctional compound represented by the formulaY--A--Zwherein Y and Z are same or different and are --CH.sub.2 X, --CH(OH)CH.sub.2 X or ##STR1## group, respectively, A is a single bond, --(CH.sub.2).sub.m --, --CH.sub.2 --O--CH.sub.2 -- or --CH.sub.2 --O--(CH.sub.2).sub.k --O--CH.sub.2 -- group, X is chlorine, bromine or iodine atom, m is an integral of 1 to 3, and k is an integral of 1 to 4, and then subjecting the resulting cross-linked polymer to a coordination of a polyvalent metal ion, a salt thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same.
摘要翻译：通过使聚亚乙基多胺或聚乙烯亚胺与式YAZ表示的双官能化合物进行反应，其中Y和Z相同或不同，为-CH 2 X，-CH（OH）CH 2 X，得到含有季氮原子的新型聚合物 - 金属配合物或基团，A是单键， - （CH 2）m - ， - CH 2 -O-CH 2 - 或-CH 2 -O-（CH 2）k O-CH 2 - 基，X是氯，溴或碘原子，m为1〜3的整数，k为1〜4的整数，然后使所得交联聚合物与多价金属离子，其盐，其制备方法和包含该药剂的药剂。

8. 发明授权

US5560925A Method of treating wart 失效
标题翻译：治疗疣的方法
公开(公告)号：US5560925A
公开(公告)日：1996-10-01
申请号：US316848
申请日：1994-10-03
申请人： Kiichi Sawai , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata
发明人： Kiichi Sawai , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata
IPC分类号： C07F7/30 , C08G79/00 , A61K9/20
CPC分类号： C07F7/30 , C08G79/00
摘要： Wart of human being is prevented or cured by administration of a pharmaceutical composition containing an eight structural polymer of 2-oxygermylpropionic acid having an empirical formula of C.sub.6 H.sub.10 Ge.sub.2 O.sub.7, a minimum constitutional unit of (O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOH and the following stereostructure: ##STR1## wherein R stands for --CH.sub.2 CH.sub.2 COOH and m is an integer of 137.+-.84.
摘要翻译：通过给药含有具有经验式为C 6 H 10 Ge 2 O 7的2-氧基甲基丙酸的八种结构聚合物的药物组合物，（O + E，fra 1/2 + EE）3GeCH 2 CH 2 COOH的最小结构单元和以下立体结构：其中R代表-CH2CH2COOH，m是137 +/- 84的整数。

9. 发明授权

US5621003A Maillard reaction inhibitor 失效
标题翻译：美拉德反应抑制剂
公开(公告)号：US5621003A
公开(公告)日：1997-04-15
申请号：US515330
申请日：1995-08-15
申请人： Kiichi Sawai , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata
发明人： Kiichi Sawai , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata
IPC分类号： A61K31/28 , A61K31/80 , A61P3/08 , A61P3/10
CPC分类号： A61K31/80
摘要： A maillard reaction inhibitor comprising, as the principal component, an eight-structural polymer of 3-oxygermylpropionic acid represented by the following stereostructure (I): ##STR1## wherein R represents --CH.sub.2 CH.sub.2 COOH, and m is a weight average polymerization degree calculated on the basis of the weight average molecular weight of propagermanium propyl ester and is 137.+-.84 (137 on average with a standard deviation of .+-.3.sigma.); and having the following minimum constitutional unit:(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOHand the following empirical formula:C.sub.6 H.sub.10 Ge.sub.2 O.sub.7,a method for inhibiting the Maillard reaction, and a method for preventing and treating diseases caused by Maillard reaction such as diabetes and concurrent diseases thereof.
摘要翻译：一种美拉德反应抑制剂，其包含由以下立体结构（I）表示的3-氧基甲基丙酸的8-结构聚合物作为主要组分：其中R表示-CH 2 CH 2 COOH，m表示重均聚合度基于丙基丙基酯的重均分子量计算，为137 +/- 84（平均137个，标准偏差为+/- 3西格玛）; 并具有以下最小结构单元：（O + E，fra 1/2 + EE）3GeCH 2 CH 2 COOH和以下经验式：C 6 H 10 Ge 2 O 7，抑制美拉德反应的方法，以及预防和治疗美拉德反应引起的疾病的方法作为糖尿病及其并发疾病。

10. 发明授权

US06962926B2 Antagonist of MCP-1 function, and compositions and methods of use thereof 失效
标题翻译： MCP-1功能的拮抗剂及其组合物及其使用方法
公开(公告)号：US06962926B2
公开(公告)日：2005-11-08
申请号：US10637746
申请日：2003-08-08
申请人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Wenli Ma , Yukiharu Matsumoto , Kunihisa Baba , Hideaki Inagaki , Katsumasa Tanaka , Yoshiro Ishiwata , Shoji Yokochi , Masayuki Okamoto , Takashi Nakamura , Atsushi Miyachi , Mitsuaki Takeuchi , Kouji Matsushima
发明人： Edgardo Laborde , Louise Robinson , Fanying Meng , Brian T. Peterson , Hugo O. Villar , Steven E. Anuskiewicz , Wenli Ma , Yukiharu Matsumoto , Kunihisa Baba , Hideaki Inagaki , Katsumasa Tanaka , Yoshiro Ishiwata , Shoji Yokochi , Masayuki Okamoto , Takashi Nakamura , Atsushi Miyachi , Mitsuaki Takeuchi , Kouji Matsushima
IPC分类号： A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , A61P29/00 , C07D471/04 , C07D498/04 , C07D519/00 , C61K31/5377
CPC分类号： A61K31/437 , A61K9/0019 , A61K9/2054 , A61K9/4866 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D231/56 , C07D471/04 , A61K2300/00
摘要： Compounds of formula A and formula B: and their pharmaceutically acceptable salts, compositions comprising them, methods for their use, and their use in the preparation of medicaments. The compounds are antagonists of MCP-1 function, and are useful in the prevention and treatment of chronic or acute inflammatory or autoimmune diseases, such as multiple sclerosis, and in the prevention and treatment of allergic hypersensitivity disorders.
摘要翻译：式A和式B化合物及其药学上可接受的盐，包含它们的组合物，其使用方法及其在制备药物中的用途。该化合物是MCP-1功能的拮抗剂，可用于预防和治疗慢性或急性炎性或自身免疫性疾病如多发性硬化，以及预防和治疗过敏性超敏反应性疾病。

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